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Arbaclofen placarbil

April 12, 2024

Arbaclofen placarbil (/ɑːrˈbækloʊfɛn pləˈkɑːrbɪl/ ar-BAK-loh-fen plə-KAR-bil, also known as XP19986) is a prodrug of R-baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials.[1]

Arbaclofen placarbil
Clinical data
Pregnancy
category
  • N/A
ATC code
  • none
Legal status
Legal status
  • Development terminated
Identifiers
  • (3R)-3-(4-chlorophenyl)-4-[[[(1S)-2-methyl-1-[(2-methylpropanoyl)oxy]propoxy]carbonyl]amino]butanoic acid
CAS Number
  • 847353-30-4
PubChem CID
  • 11281011
ChemSpider
  • 9456008
UNII
  • W89H91R7VX
KEGG
  • D08861 Y
ChEMBL
  • ChEMBL2107312 Y
CompTox Dashboard (EPA)
  • DTXSID40233754
ECHA InfoCard100.221.150
Chemical and physical data
FormulaC19H26ClNO6
Molar mass399.87 g·mol−1
3D model (JSmol)
  • Interactive image
  • CC(C)C(=O)O[C@@H](OC(=O)NC[C@H](CC(=O)O)c1ccc(Cl)cc1)C(C)C
  • InChI=1S/C19H26ClNO6/c1-11(2)17(24)26-18(12(3)4)27-19(25)21-10-14(9-16(22)23)13-5-7-15(20)8-6-13/h5-8,11-12,14,18H,9-10H2,1-4H3,(H,21,25)(H,22,23)/t14-,18-/m0/s1
  • Key:JXTAALBWJQJLGN-KSSFIOAISA-N

It is being developed as an addiction medicine to treat alcoholism. [2] It is also studied as a potential therapeutic for some autistic subjects.[3]

See also edit

References edit

  1. ^ . XenoPort, Inc. May 20, 2013. Archived from the original on 2013-12-02. Retrieved 2013-06-03.
  2. ^ Anderson E (3 July 2020). "Pill that replaces alcohol aims to end 'glass of wine' craving". The i newspaper. Associated Newspapers Limited.
  3. ^ Huang Q, Pereira AC, Velthuis H, Wong NM, Ellis CL, Ponteduro FM, et al. (January 2022). "GABAB receptor modulation of visual sensory processing in adults with and without autism spectrum disorder" (PDF). Science Translational Medicine. 14 (626): eabg7859. doi:10.1126/scitranslmed.abg7859. PMID 34985973. S2CID 245771626.
 

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April 12, 2024
arbaclofen, placarbil, ɑːr, ɑːr, plə, also, known, xp19986, prodrug, baclofen, possesses, more, favorable, pharmacokinetic, profile, than, baclofen, with, less, fluctuations, plasma, drug, levels, being, developed, potential, treatment, patients, with, gerd, s. Arbaclofen placarbil ɑːr ˈ b ae k l oʊ f ɛ n p l e ˈ k ɑːr b ɪ l ar BAK loh fen ple KAR bil also known as XP19986 is a prodrug of R baclofen Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen with less fluctuations in plasma drug levels It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis however in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials 1 Arbaclofen placarbilClinical dataPregnancycategoryN AATC codenoneLegal statusLegal statusDevelopment terminatedIdentifiersIUPAC name 3R 3 4 chlorophenyl 4 1S 2 methyl 1 2 methylpropanoyl oxy propoxy carbonyl amino butanoic acidCAS Number847353 30 4PubChem CID11281011ChemSpider9456008UNIIW89H91R7VXKEGGD08861 YChEMBLChEMBL2107312 YCompTox Dashboard EPA DTXSID40233754ECHA InfoCard100 221 150Chemical and physical dataFormulaC 19H 26Cl N O 6Molar mass399 87 g mol 13D model JSmol Interactive imageSMILES CC C C O O C H OC O NC C H CC O O c1ccc Cl cc1 C C CInChI InChI 1S C19H26ClNO6 c1 11 2 17 24 26 18 12 3 4 27 19 25 21 10 14 9 16 22 23 13 5 7 15 20 8 6 13 h5 8 11 12 14 18H 9 10H2 1 4H3 H 21 25 H 22 23 t14 18 m0 s1Key JXTAALBWJQJLGN KSSFIOAISA NIt is being developed as an addiction medicine to treat alcoholism 2 It is also studied as a potential therapeutic for some autistic subjects 3 See also editGabapentin enacarbil LesogaberanReferences edit XenoPort Reports Top Line Results of Phase 3 Trial of Arbaclofen Placarbil for Spasticity in Multiple Sclerosis Patients XenoPort Inc May 20 2013 Archived from the original on 2013 12 02 Retrieved 2013 06 03 Anderson E 3 July 2020 Pill that replaces alcohol aims to end glass of wine craving The i newspaper Associated Newspapers Limited Huang Q Pereira AC Velthuis H Wong NM Ellis CL Ponteduro FM et al January 2022 GABAB receptor modulation of visual sensory processing in adults with and without autism spectrum disorder PDF Science Translational Medicine 14 626 eabg7859 doi 10 1126 scitranslmed abg7859 PMID 34985973 S2CID 245771626 nbsp This drug article relating to the gastrointestinal system is a stub You can help Wikipedia by expanding it vte nbsp This drug article relating to the musculoskeletal system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Arbaclofen placarbil amp oldid 1175940462, wikipedia, wiki, book, books, library,

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