^ abcGRCh38: Ensembl release 89: ENSG00000234906 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000002992 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kim SY, Park SM, Lee ST (2006). "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Biochem. Biophys. Res. Commun. 339 (1): 47–54. doi:10.1016/j.bbrc.2005.10.182. PMID 16314153.
Jackson RL, Baker HN, Gilliam EB, Gotto AM (1977). "Primary structure of very low density apolipoprotein C-II of human plasma". Proc. Natl. Acad. Sci. U.S.A. 74 (5): 1942–5. Bibcode:1977PNAS...74.1942J. doi:10.1073/pnas.74.5.1942. PMC431048. PMID 194244.
Lycksell PO, Ohman A, Bengtsson-Olivecrona G, et al. (1992). "Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII". Eur. J. Biochem. 205 (1): 223–31. doi:10.1111/j.1432-1033.1992.tb16772.x. PMID 1555583.
Hegele RA, Connelly PW, Maguire GF, et al. (1992). "An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia". Dis. Markers. 9 (2): 73–80. PMID 1782747.
Crecchio C, Capurso A, Pepe G (1990). "Identification of the mutation responsible for a case of plasmatic apolipoprotein CII deficiency (Apo CII-Bari)". Biochem. Biophys. Res. Commun. 168 (3): 1118–27. doi:10.1016/0006-291X(90)91145-I. PMID 1971748.
Bengtsson-Olivecrona G, Sletten K (1990). "Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing". Eur. J. Biochem. 192 (2): 515–21. doi:10.1111/j.1432-1033.1990.tb19255.x. PMID 2209608.
Wei CF, Tsao YK, Robberson DL, et al. (1986). "The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes". J. Biol. Chem. 260 (28): 15211–21. doi:10.1016/S0021-9258(18)95724-8. PMID 2415514.
Fojo SS, Lohse P, Parrott C, et al. (1989). "A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency". J. Clin. Invest. 84 (4): 1215–9. doi:10.1172/JCI114287. PMC329780. PMID 2477392.
Jackson CL, Bruns GA, Breslow JL (1986). "Isolation of cDNA and genomic clones for apolipoprotein C-II". In Segrest JP, Albers JA (eds.). Plasma Lipoproteins Part A: Preparation, Structure, and Molecular Biology. Methods in Enzymology. Vol. 128. Elsevier. pp. 788–800. doi:10.1016/0076-6879(86)28106-9. ISBN9780121820282. PMID 3014272.
Fojo SS, Law SW, Brewer HB (1987). "The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization". FEBS Lett. 213 (1): 221–6. doi:10.1016/0014-5793(87)81495-3. PMID 3030808. S2CID 42223577.
Fojo SS, Stalenhoef AF, Marr K, et al. (1989). "A deletion mutation in the ApoC-II gene (ApoC-II Nijmegen) of a patient with a deficiency of apolipoprotein C-II". J. Biol. Chem. 263 (34): 17913–6. doi:10.1016/S0021-9258(19)81302-9. PMID 3192518.
Fojo SS, Beisiegel U, Beil U, et al. (1988). "Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II deficiency". J. Clin. Invest. 82 (5): 1489–94. doi:10.1172/JCI113756. PMC442713. PMID 3263393.
Connelly PW, Maguire GF, Hofmann T, Little JA (1987). "Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein". Proc. Natl. Acad. Sci. U.S.A. 84 (1): 270–3. Bibcode:1987PNAS...84..270C. doi:10.1073/pnas.84.1.270. PMC304185. PMID 3467353.
Fairwell T, Hospattankar AV, Brewer HB, Khan SA (1987). "Human plasma apolipoprotein C-II: total solid-phase synthesis and chemical and biological characterization". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4796–800. Bibcode:1987PNAS...84.4796F. doi:10.1073/pnas.84.14.4796. PMC305192. PMID 3474626.
Fojo SS, Taam L, Fairwell T, et al. (1986). "Human preproapolipoprotein C-II. Analysis of major plasma isoforms". J. Biol. Chem. 261 (21): 9591–4. doi:10.1016/S0021-9258(18)67554-4. PMID 3525527.
Das HK, Jackson CL, Miller DA, et al. (1987). "The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron". J. Biol. Chem. 262 (10): 4787–93. doi:10.1016/S0021-9258(18)61264-5. PMID 3558370.
Connelly PW, Maguire GF, Little JA (1988). "Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease". J. Clin. Invest. 80 (6): 1597–606. doi:10.1172/JCI113246. PMC442428. PMID 3680515.
Baggio G, Manzato E, Gabelli C, et al. (1986). "Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients". J. Clin. Invest. 77 (2): 520–7. doi:10.1172/JCI112332. PMC423374. PMID 3944267.
Menzel HJ, Kane JP, Malloy MJ, Havel RJ (1986). "A variant primary structure of apolipoprotein C-II in individuals of African descent". J. Clin. Invest. 77 (2): 595–601. doi:10.1172/JCI112342. PMC423392. PMID 3944271.
Sharpe CR, Sidoli A, Shelley CS, et al. (1984). "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance". Nucleic Acids Res. 12 (9): 3917–32. doi:10.1093/nar/12.9.3917. PMC318799. PMID 6328445.
Jackson CL, Bruns GA, Breslow JL (1984). "Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII". Proc. Natl. Acad. Sci. U.S.A. 81 (10): 2945–9. Bibcode:1984PNAS...81.2945J. doi:10.1073/pnas.81.10.2945. PMC345197. PMID 6328478.
External linksedit
Human APOC2 genome location and APOC2 gene details page in the UCSC Genome Browser.
April 10, 2024
apolipoprotein, apoc, apolipoprotein, protein, that, humans, encoded, apoc2, gene, apoc2available, structurespdbortholog, search, pdbe, rcsblist, codes1soh, 1by6, 1i5j, 1o8tidentifiersaliasesapoc2, apoc, apolipoprotein, c2external, idsomim, 608083, 88054, homo. Apolipoprotein C II Apo CII or Apoc II or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene APOC2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1SOH 1BY6 1I5J 1O8TIdentifiersAliasesAPOC2 APO CII APOC II apolipoprotein C2External IDsOMIM 608083 MGI 88054 HomoloGene 47928 GeneCards APOC2Gene location Human Chr Chromosome 19 human 1 Band19q13 32Start44 946 035 bp 1 End44 949 565 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 A3 7 9 94 cMStart19 405 504 bp 2 End19 411 866 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright lobe of liversubstantia nigraduodenumcaudate nucleusputamenamygdalanucleus accumbenshypothalamushippocampus properprefrontal cortexTop expressed inyolk sacduodenumliverjejunumileumspermatocytecolonmorulastomachbone marrowMore reference expression dataBioGPSn aGene ontologyMolecular functionlipase inhibitor activity phospholipase binding protein homodimerization activity lipoprotein lipase activator activity phospholipase activator activity enzyme activator activity lipid bindingCellular componentchylomicron very low density lipoprotein particle spherical high density lipoprotein particle extracellular region early endosome low density lipoprotein particle high density lipoprotein particle intermediate density lipoprotein particle extracellular spaceBiological processhigh density lipoprotein particle clearance lipid transport positive regulation of triglyceride catabolic process chylomicron remnant clearance lipid metabolism phospholipid efflux positive regulation of lipoprotein lipase activity positive regulation of fatty acid biosynthetic process negative regulation of very low density lipoprotein particle clearance retinoid metabolic process negative regulation of receptor mediated endocytosis lipid catabolic process positive regulation of phospholipase activity positive regulation of phospholipid catabolic process cholesterol efflux very low density lipoprotein particle remodeling negative regulation of cholesterol transport cholesterol homeostasis positive regulation of very low density lipoprotein particle remodeling triglyceride rich lipoprotein particle remodeling triglyceride homeostasis negative regulation of lipid metabolic process reverse cholesterol transport negative regulation of catalytic activity lipoprotein transport chylomicron remodeling high density lipoprotein particle remodeling chylomicron assembly positive regulation of catalytic activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez34411813EnsemblENSG00000234906ENSMUSG00000002992UniProtP02655Q05020RefSeq mRNA NM 000483NM 001277944NM 001309795RefSeq protein NP 000474NP 000474 2NP 001296728NP 001264873NP 001296724Location UCSC Chr 19 44 95 44 95 MbChr 7 19 41 19 41 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseApo CIInmr structure of human apolipoprotein c ii in the presence of sdsIdentifiersSymbolApo CIIPfamPF05355InterProIPR008019SCOP21by6 SCOPe SUPFAMAvailable protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryThe protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons This protein activates the enzyme lipoprotein lipase in capillaries 5 which hydrolyzes triglycerides and thus provides free fatty acids for cells Mutations in this gene cause hyperlipoproteinemia type IB characterized by xanthomas pancreatitis and hepatosplenomegaly but no increased risk for atherosclerosis Lab tests will show elevated blood levels of triglycerides cholesterol and chylomicrons 6 Contents 1 Interactive pathway map 2 See also 3 References 4 External linksInteractive pathway map editClick on genes proteins and metabolites below to link to respective articles 1 File nbsp nbsp alt Statin Pathway edit Statin Pathway edit The interactive pathway map can be edited at WikiPathways Statin Pathway WP430 See also editApolipoprotein CReferences edit a b c GRCh38 Ensembl release 89 ENSG00000234906 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000002992 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kim SY Park SM Lee ST 2006 Apolipoprotein C II is a novel substrate for matrix metalloproteinases Biochem Biophys Res Commun 339 1 47 54 doi 10 1016 j bbrc 2005 10 182 PMID 16314153 Entrez Gene APOC2 apolipoprotein C II Jackson RL Baker HN Gilliam EB Gotto AM 1977 Primary structure of very low density apolipoprotein C II of human plasma Proc Natl Acad Sci U S A 74 5 1942 5 Bibcode 1977PNAS 74 1942J doi 10 1073 pnas 74 5 1942 PMC 431048 PMID 194244 Lycksell PO Ohman A Bengtsson Olivecrona G et al 1992 Sequence specific 1H NMR assignments and secondary structure of a carboxy terminal functional fragment of apolipoprotein CII Eur J Biochem 205 1 223 31 doi 10 1111 j 1432 1033 1992 tb16772 x PMID 1555583 Hegele RA Connelly PW Maguire GF et al 1992 An apolipoprotein CII mutation CIILys19 Thr identified in patients with hyperlipidemia Dis Markers 9 2 73 80 PMID 1782747 Crecchio C Capurso A Pepe G 1990 Identification of the mutation responsible for a case of plasmatic apolipoprotein CII deficiency Apo CII Bari Biochem Biophys Res Commun 168 3 1118 27 doi 10 1016 0006 291X 90 91145 I PMID 1971748 Bengtsson Olivecrona G Sletten K 1990 Primary structure of the bovine analogues to human apolipoproteins CII and CIII Studies on isoforms and evidence for proteolytic processing Eur J Biochem 192 2 515 21 doi 10 1111 j 1432 1033 1990 tb19255 x PMID 2209608 Wei CF Tsao YK Robberson DL et al 1986 The structure of the human apolipoprotein C II gene Electron microscopic analysis of RNA DNA hybrids complete nucleotide sequence and identification of 5 homologous sequences among apolipoprotein genes J Biol Chem 260 28 15211 21 doi 10 1016 S0021 9258 18 95724 8 PMID 2415514 Fojo SS Lohse P Parrott C et al 1989 A nonsense mutation in the apolipoprotein C IIPadova gene in a patient with apolipoprotein C II deficiency J Clin Invest 84 4 1215 9 doi 10 1172 JCI114287 PMC 329780 PMID 2477392 Jackson CL Bruns GA Breslow JL 1986 Isolation of cDNA and genomic clones for apolipoprotein C II In Segrest JP Albers JA eds Plasma Lipoproteins Part A Preparation Structure and Molecular Biology Methods in Enzymology Vol 128 Elsevier pp 788 800 doi 10 1016 0076 6879 86 28106 9 ISBN 9780121820282 PMID 3014272 Fojo SS Law SW Brewer HB 1987 The human preproapolipoprotein C II gene Complete nucleic acid sequence and genomic organization FEBS Lett 213 1 221 6 doi 10 1016 0014 5793 87 81495 3 PMID 3030808 S2CID 42223577 Fojo SS Stalenhoef AF Marr K et al 1989 A deletion mutation in the ApoC II gene ApoC II Nijmegen of a patient with a deficiency of apolipoprotein C II J Biol Chem 263 34 17913 6 doi 10 1016 S0021 9258 19 81302 9 PMID 3192518 Fojo SS Beisiegel U Beil U et al 1988 Donor splice site mutation in the apolipoprotein Apo C II gene Apo C IIHamburg of a patient with Apo C II deficiency J Clin Invest 82 5 1489 94 doi 10 1172 JCI113756 PMC 442713 PMID 3263393 Connelly PW Maguire GF Hofmann T Little JA 1987 Structure of apolipoprotein C IIToronto a nonfunctional human apolipoprotein Proc Natl Acad Sci U S A 84 1 270 3 Bibcode 1987PNAS 84 270C doi 10 1073 pnas 84 1 270 PMC 304185 PMID 3467353 Fairwell T Hospattankar AV Brewer HB Khan SA 1987 Human plasma apolipoprotein C II total solid phase synthesis and chemical and biological characterization Proc Natl Acad Sci U S A 84 14 4796 800 Bibcode 1987PNAS 84 4796F doi 10 1073 pnas 84 14 4796 PMC 305192 PMID 3474626 Fojo SS Taam L Fairwell T et al 1986 Human preproapolipoprotein C II Analysis of major plasma isoforms J Biol Chem 261 21 9591 4 doi 10 1016 S0021 9258 18 67554 4 PMID 3525527 Das HK Jackson CL Miller DA et al 1987 The human apolipoprotein C II gene sequence contains a novel chromosome 19 specific minisatellite in its third intron J Biol Chem 262 10 4787 93 doi 10 1016 S0021 9258 18 61264 5 PMID 3558370 Connelly PW Maguire GF Little JA 1988 Apolipoprotein CIISt Michael Familial apolipoprotein CII deficiency associated with premature vascular disease J Clin Invest 80 6 1597 606 doi 10 1172 JCI113246 PMC 442428 PMID 3680515 Baggio G Manzato E Gabelli C et al 1986 Apolipoprotein C II deficiency syndrome Clinical features lipoprotein characterization lipase activity and correction of hypertriglyceridemia after apolipoprotein C II administration in two affected patients J Clin Invest 77 2 520 7 doi 10 1172 JCI112332 PMC 423374 PMID 3944267 Menzel HJ Kane JP Malloy MJ Havel RJ 1986 A variant primary structure of apolipoprotein C II in individuals of African descent J Clin Invest 77 2 595 601 doi 10 1172 JCI112342 PMC 423392 PMID 3944271 Sharpe CR Sidoli A Shelley CS et al 1984 Human apolipoproteins AI AII CII and CIII cDNA sequences and mRNA abundance Nucleic Acids Res 12 9 3917 32 doi 10 1093 nar 12 9 3917 PMC 318799 PMID 6328445 Jackson CL Bruns GA Breslow JL 1984 Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII Proc Natl Acad Sci U S A 81 10 2945 9 Bibcode 1984PNAS 81 2945J doi 10 1073 pnas 81 10 2945 PMC 345197 PMID 6328478 External links editHuman APOC2 genome location and APOC2 gene details page in the UCSC Genome Browser Retrieved from https en wikipedia org w index php title Apolipoprotein C II amp oldid 1198651100, wikipedia, wiki, book, books, library,
