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Anti-Scl-70 antibodies

January 07, 2023

Anti-Scl-70 (also called anti-topoisomerase I after the type I topoisomerase target[1]) is an anti-topoisomerase antibody-type of anti-nuclear autoantibodies, seen mainly in diffuse systemic scleroderma (with a sensitivity of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called CREST syndrome.[2] Anti Scl-70 antibodies are associated with more severe scleroderma disease.[3]

The etymology of scl-70 consists of an abbreviation of scleroderma and a 70 kD extractable immunoreactive fragment that can be obtained from the otherwise larger (100–105 kD) target topoisomerase antigen (called the SCL-70 Antigen) of the antibodies.[4]

References

  1. ^ Guldner HH, Szostecki C, Vosberg HP, Lakomek HJ, Penner E, Bautz FA (1986). "Scl 70 autoantibodies from scleroderma patients recognize a 95 kDa protein identified as DNA topoisomerase I". Chromosoma. 94 (2): 132–8. doi:10.1007/BF00286991. PMID 2428564.
  2. ^ Table 5-9 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007). Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
  3. ^ de Rooij DJ, Van de Putte LB, Habets WJ, Van Venrooij WJ (1989). "Marker antibodies in scleroderma and polymyositis: clinical associations". Clin. Rheumatol. 8 (2): 231–7. doi:10.1007/BF02030079. PMID 2547546.
  4. ^ Product Name: SCL-70 Antigen 2006-03-19 at the Wayback Machine at ImmunoVision.com, retrieved April 2011

January 07, 2023
anti, antibodies, anti, also, called, anti, topoisomerase, after, type, topoisomerase, target, anti, topoisomerase, antibody, type, anti, nuclear, autoantibodies, seen, mainly, diffuse, systemic, scleroderma, with, sensitivity, also, seen, cases, more, limited. Anti Scl 70 also called anti topoisomerase I after the type I topoisomerase target 1 is an anti topoisomerase antibody type of anti nuclear autoantibodies seen mainly in diffuse systemic scleroderma with a sensitivity of 28 70 but is also seen in 10 18 of cases of the more limited form of systemic scleroderma called CREST syndrome 2 Anti Scl 70 antibodies are associated with more severe scleroderma disease 3 The etymology of scl 70 consists of an abbreviation of scleroderma and a 70 kD extractable immunoreactive fragment that can be obtained from the otherwise larger 100 105 kD target topoisomerase antigen called the SCL 70 Antigen of the antibodies 4 References Edit Guldner HH Szostecki C Vosberg HP Lakomek HJ Penner E Bautz FA 1986 Scl 70 autoantibodies from scleroderma patients recognize a 95 kDa protein identified as DNA topoisomerase I Chromosoma 94 2 132 8 doi 10 1007 BF00286991 PMID 2428564 Table 5 9 in Mitchell Richard Sheppard Kumar Vinay Abbas Abul K Fausto Nelson 2007 Robbins Basic Pathology Philadelphia Saunders ISBN 1 4160 2973 7 8th edition de Rooij DJ Van de Putte LB Habets WJ Van Venrooij WJ 1989 Marker antibodies in scleroderma and polymyositis clinical associations Clin Rheumatol 8 2 231 7 doi 10 1007 BF02030079 PMID 2547546 Product Name SCL 70 Antigen Archived 2006 03 19 at the Wayback Machine at ImmunoVision com retrieved April 2011 Retrieved from https en wikipedia org w index php title Anti Scl 70 antibodies amp oldid 1095501915, wikipedia, wiki, book, books, library,

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