Immunofluorescence staining pattern of anti-centromere antibodies on HEp-20-10 cells
Anti-centromere antibodies are found in approximately 60% of patients with limited systemic scleroderma and in 15% of those with the diffuse form of scleroderma. The specificity of this test is >98%. Thus, a positive anti-centromere antibody finding is strongly suggestive of limited systemic scleroderma. Anti-centromere antibodies present early in the course of disease and are notably predictive of limited cutaneous involvement and a decreased likelihood of aggressive internal organ involvement, such as fibrosis in the lungs.[1]
When present in primary biliary cirrhosis, ACAs are prognostic of portal hypertension such that serum ACA levels correlate with the severity of portal hypertension.[2]
^JB Imboden, DB Hellmann, JH Stone. Current Rheumatology Diagnosis & Treatment, Second Edition. McGraw-Hill, 2007.
^Nakamura M, Kondo H, Mori T, et al. (2007). "Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis". Hepatology. 45 (1): 118–27. doi:10.1002/hep.21472. PMID 17187436.
^Al-Mughales JA (2022). "Anti-Nuclear Antibodies Patterns in Patients With Systemic Lupus Erythematosus and Their Correlation With Other Diagnostic Immunological Parameters". Front Immunol. 13: 850759. doi:10.3389/fimmu.2022.850759. PMC8964090. PMID 35359932. Minor edits by Mikael Häggström, MD - Attribution 4.0 International (CC BY 4.0) license
April 10, 2024
anti, centromere, antibodies, acas, often, styled, solid, anticentromere, autoantibodies, specific, centromere, kinetochore, function, they, occur, some, autoimmune, diseases, frequently, limited, systemic, scleroderma, formerly, called, crest, syndrome, occas. Anti centromere antibodies ACAs often styled solid anticentromere are autoantibodies specific to centromere and kinetochore function They occur in some autoimmune diseases frequently in limited systemic scleroderma formerly called CREST syndrome and occasionally in the diffuse form of scleroderma They are rare in other rheumatic diseases and in healthy persons Immunofluorescence staining pattern of anti centromere antibodies on HEp 20 10 cellsAnti centromere antibodies are found in approximately 60 of patients with limited systemic scleroderma and in 15 of those with the diffuse form of scleroderma The specificity of this test is gt 98 Thus a positive anti centromere antibody finding is strongly suggestive of limited systemic scleroderma Anti centromere antibodies present early in the course of disease and are notably predictive of limited cutaneous involvement and a decreased likelihood of aggressive internal organ involvement such as fibrosis in the lungs 1 When present in primary biliary cirrhosis ACAs are prognostic of portal hypertension such that serum ACA levels correlate with the severity of portal hypertension 2 Main antinuclear antibody patterns on immunofluorescence 3 A schematic representation of an antibodyReferences edit JB Imboden DB Hellmann JH Stone Current Rheumatology Diagnosis amp Treatment Second Edition McGraw Hill 2007 Nakamura M Kondo H Mori T et al 2007 Anti gp210 and anti centromere antibodies are different risk factors for the progression of primary biliary cirrhosis Hepatology 45 1 118 27 doi 10 1002 hep 21472 PMID 17187436 Al Mughales JA 2022 Anti Nuclear Antibodies Patterns in Patients With Systemic Lupus Erythematosus and Their Correlation With Other Diagnostic Immunological Parameters Front Immunol 13 850759 doi 10 3389 fimmu 2022 850759 PMC 8964090 PMID 35359932 Minor edits by Mikael Haggstrom MD Attribution 4 0 International CC BY 4 0 license Retrieved from https en wikipedia org w index php title Anti centromere antibodies amp oldid 1203498764, wikipedia, wiki, book, books, library,
