Nardulli joined the university's lab run by Benita Katzenellenbogen, and eventually became a professor of the Department of Molecular and Integrative Physiology with her own lab, teaching and studying the effects of estrogen in women.[1][3][5]
Notable researchedit
Nardulli's work concentrated on the specifics of estrogen activities, including the proteins it binds with, and the mechanisms that the hormone uses to manipulate chromatin and DNA. According to Katzenellenbogen,
“Dr. Nardulli did pioneering work that identified the protein complexes with which the estrogen receptor associated, many previously unknown, and she and her laboratory associates went on to elucidate how these proteins collaborated with and modulated the activities of the estrogen receptor in breast cancer cells and tumors."[3]
Among the research topics explored by her team were the plasma membrane proteins and their effect on breast cancer cells as well as the proteins that these cells secrete. Later research focused on the brain and estrogen action in it.[3]
At the university, Nardulli "was particularly fond of spending time with the Hormone Chixx, a group of women from across campus who studied the effects of hormones in the body. She discovered that introducing students to the wonders of human physiology and endocrinology was extremely rewarding and was recognized for her teaching excellence."[1][2][3]
Advocacyedit
As an active member of the Endocrine Society, she served as "chair of the Advocacy and Public Outreach Core Committee and visited Washington, D.C., numerous times to meet with legislators on Capitol Hill and lobby for increased scientific research funding." She was also a member of the society's Scientific Statements Task Force and a member of the editorial board for the academic journalEndocrine Reviews and Molecular Endocrinology.[2]
Nardulli died at her home of cancer in 2018, aged 69.[1][3]
Select publicationsedit
Ziegler, Y. S.; Moresco, J. J.; Tu, P. G.; Yates Jr, 3rd; Nardulli, A. M. (2014). "Plasma membrane proteomics of human breast cancer cell lines identifies potential targets for breast cancer diagnosis and treatment". PLOS ONE. 9 (7): e102341. Bibcode:2014PLoSO...9j2341Z. doi:10.1371/journal.pone.0102341. PMC4100819. PMID 25029196.{{cite journal}}: CS1 maint: numeric names: authors list (link)
Dietrich, Alicia K.; Humphreys, Gwendolyn I.; Nardulli, Ann M. (2013). "17β-Estradiol increases expression of the oxidative stress response and DNA repair protein apurinic endonuclease (Ape1) in the cerebral cortex of female mice following hypoxia". The Journal of Steroid Biochemistry and Molecular Biology. 138: 410–420. doi:10.1016/j.jsbmb.2013.07.007. PMC3825811. PMID 23907014.
Yuan, L.; Dietrich, A. K.; Nardulli, A. M. (2014). "17β-Estradiol alters oxidative stress response protein expression and oxidative damage in the uterus". Molecular and Cellular Endocrinology. 382 (1): 218–226. doi:10.1016/j.mce.2013.09.023. PMC3900311. PMID 24103313.
Shim, J.; Humphreys, G. I.; Venkatesan, B. M.; Munz, J. M.; Zou, X.; Sathe, C.; Schulten, K.; Kosari, F.; Nardulli, A. M.; Vasmatzis, G.; Bashir, R. (2013). "Detection and quantification of methylation in DNA using solid-state nanopores". Scientific Reports. 3: 1389. Bibcode:2013NatSR...3E1389S. doi:10.1038/srep01389. PMC3593219. PMID 23474808.
Schultz-Norton, J. R.; Ziegler, Y. S.; Nardulli, A. M. (2011). "ERα-associated protein networks". Trends in Endocrinology and Metabolism. 22 (4): 124–9. doi:10.1016/j.tem.2010.11.005. PMID 21371903. S2CID 28219981.
Curtis, C. D.; Thorngren, D. L.; Nardulli, A. M. (2010). "Immunohistochemical analysis of oxidative stress and DNA repair proteins in normal mammary and breast cancer tissues". BMC Cancer. 10: 9. doi:10.1186/1471-2407-10-9. PMC2830938. PMID 20064251.
Curtis CD, Thorngren DL, Ziegler YS, Sarkeshik A, Yates JR, Nardulli AM 2009 Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen responsive gene expression. Mol Endocrinol 23:1346-1359.
Bonéy-Montoya, J.; Ziegler, Y. S.; Curtis, C. D.; Montoya, J. A.; Nardulli, A. M. (2010). "Long-range transcriptional control of progesterone receptor gene expression". Molecular Endocrinology. 24 (2): 346–58. doi:10.1210/me.2009-0429. PMC2817601. PMID 19952285.
^ abc"Remembering Ann Nardulli". Endocrine News. 2018-07-02. Retrieved 2020-07-28.
^ abcdefGrens, Kerry (July 24, 2018). "Endocrinologist Ann Nardulli Dies". The Scientist.
^"Nardulli | Cancer Center at Illinois". cancer.illinois.edu. Retrieved 2020-07-28.
^anardulli. . Archived from the original on 2018-07-08. Retrieved 2020-07-28.
External linksedit
(archived) at University of Illinois, School of Molecular and Cellular Biology
April 16, 2024
nardulli, nardulli, november, 1948, june, 2018, american, endocrinologist, known, research, into, role, estrogen, breast, cancer, nardullibornann, wannemachernovember, 1948morrison, illinoisdiedjune, 2018nationalityamericanalma, materuniversity, illinois, urba. Ann M Nardulli November 28 1948 June 27 2018 was an American endocrinologist known for her research into the role of estrogen in breast cancer Ann M NardulliBornAnn WannemacherNovember 28 1948Morrison IllinoisDiedJune 27 2018NationalityAmericanAlma materUniversity of Illinois at Urbana ChampaignOccupationendocrinologistKnown forBreast cancer researchSpousePeter NardulliChildrenMarc Nardulli and Beth Conlon Contents 1 Biography 1 1 Notable research 1 2 Advocacy 2 Select publications 3 References 4 External linksBiography editAnn Wannemacher was born in 1948 in Morrison Illinois to Rita and Rudolph Wannemacher of Hooppole 1 2 She received a Bachelor of Science degree in education at Northern Illinois University and taught elementary school in Addison before earning master s and doctoral degrees at the University of Illinois at Urbana Champaign and completing postdoctoral work there in biochemistry 1 3 4 Nardulli joined the university s lab run by Benita Katzenellenbogen and eventually became a professor of the Department of Molecular and Integrative Physiology with her own lab teaching and studying the effects of estrogen in women 1 3 5 Notable research editNardulli s work concentrated on the specifics of estrogen activities including the proteins it binds with and the mechanisms that the hormone uses to manipulate chromatin and DNA According to Katzenellenbogen Dr Nardulli did pioneering work that identified the protein complexes with which the estrogen receptor associated many previously unknown and she and her laboratory associates went on to elucidate how these proteins collaborated with and modulated the activities of the estrogen receptor in breast cancer cells and tumors 3 Among the research topics explored by her team were the plasma membrane proteins and their effect on breast cancer cells as well as the proteins that these cells secrete Later research focused on the brain and estrogen action in it 3 At the university Nardulli was particularly fond of spending time with the Hormone Chixx a group of women from across campus who studied the effects of hormones in the body She discovered that introducing students to the wonders of human physiology and endocrinology was extremely rewarding and was recognized for her teaching excellence 1 2 3 Advocacy edit As an active member of the Endocrine Society she served as chair of the Advocacy and Public Outreach Core Committee and visited Washington D C numerous times to meet with legislators on Capitol Hill and lobby for increased scientific research funding She was also a member of the society s Scientific Statements Task Force and a member of the editorial board for the academic journal Endocrine Reviews and Molecular Endocrinology 2 Nardulli died at her home of cancer in 2018 aged 69 1 3 Select publications editZiegler Y S Moresco J J Tu P G Yates Jr 3rd Nardulli A M 2014 Plasma membrane proteomics of human breast cancer cell lines identifies potential targets for breast cancer diagnosis and treatment PLOS ONE 9 7 e102341 Bibcode 2014PLoSO 9j2341Z doi 10 1371 journal pone 0102341 PMC 4100819 PMID 25029196 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint numeric names authors list link Dietrich Alicia K Humphreys Gwendolyn I Nardulli Ann M 2013 17b Estradiol increases expression of the oxidative stress response and DNA repair protein apurinic endonuclease Ape1 in the cerebral cortex of female mice following hypoxia The Journal of Steroid Biochemistry and Molecular Biology 138 410 420 doi 10 1016 j jsbmb 2013 07 007 PMC 3825811 PMID 23907014 Yuan L Dietrich A K Nardulli A M 2014 17b Estradiol alters oxidative stress response protein expression and oxidative damage in the uterus Molecular and Cellular Endocrinology 382 1 218 226 doi 10 1016 j mce 2013 09 023 PMC 3900311 PMID 24103313 Shim J Humphreys G I Venkatesan B M Munz J M Zou X Sathe C Schulten K Kosari F Nardulli A M Vasmatzis G Bashir R 2013 Detection and quantification of methylation in DNA using solid state nanopores Scientific Reports 3 1389 Bibcode 2013NatSR 3E1389S doi 10 1038 srep01389 PMC 3593219 PMID 23474808 Schultz Norton J R Ziegler Y S Nardulli A M 2011 ERa associated protein networks Trends in Endocrinology and Metabolism 22 4 124 9 doi 10 1016 j tem 2010 11 005 PMID 21371903 S2CID 28219981 Curtis C D Thorngren D L Nardulli A M 2010 Immunohistochemical analysis of oxidative stress and DNA repair proteins in normal mammary and breast cancer tissues BMC Cancer 10 9 doi 10 1186 1471 2407 10 9 PMC 2830938 PMID 20064251 Curtis CD Thorngren DL Ziegler YS Sarkeshik A Yates JR Nardulli AM 2009 Apurinic apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen responsive gene expression Mol Endocrinol 23 1346 1359 Boney Montoya J Ziegler Y S Curtis C D Montoya J A Nardulli A M 2010 Long range transcriptional control of progesterone receptor gene expression Molecular Endocrinology 24 2 346 58 doi 10 1210 me 2009 0429 PMC 2817601 PMID 19952285 References edit a b c d e Ann Nardulli The News Gazette July 15 2018 a b c Remembering Ann Nardulli Endocrine News 2018 07 02 Retrieved 2020 07 28 a b c d e f Grens Kerry July 24 2018 Endocrinologist Ann Nardulli Dies The Scientist Nardulli Cancer Center at Illinois cancer illinois edu Retrieved 2020 07 28 anardulli MCB School of Molecular amp Cellular Biology Archived from the original on 2018 07 08 Retrieved 2020 07 28 External links editAnn M Nardulli faculty profile archived at University of Illinois School of Molecular and Cellular Biology Retrieved from https en wikipedia org w index php title Ann Nardulli amp oldid 1174878819, wikipedia, wiki, book, books, library,
