An aneugen is a substance that causes a daughter cell to have an abnormal number of chromosomes or aneuploidy. A substance's aneugenicity reflects its ability to induce aneuploidy.[1] Unlike clastogens, aneugenic events do not damage the physical structure of the chromosome, but represent a deletion or insertion of an additional copy of a whole chromosome (i.e. with an intact Centromere). Aneugens and clastogens can be differentiated via certain stains, using the technique of Fluorescence in situ hybridization.
Males, if exposed to certain environmental and/or occupational chemical hazards may face an increased risk of spermatozoaaneuploidy.[2] Tobacco smoke contains chemicals that cause DNA damage (see Tobacco smoking#Health).[3] Smoking also can induce aneuploidy. In this study of men with a moderate smoking habit showed an association with increased chromosome 13 disomy in spermatozoa by 3-fold[4] and YY disomy by 2-fold.[5]
Occupational exposure to benzene is associated with a 2.8-fold increase of XX disomy and a 2.6-fold increase of YY disomy in spermatozoa.[6]
Pesticides are released to the environment in large quantities so that most individuals have some degree of exposure. The insecticidesfenvalerate and carbaryl have been reported to increase spermatozoa aneuploidy. Occupational exposure of pesticide factory workers to fenvalerate is associated with increased spermatozoa DNA damage.[7] Exposure to fenvalerate raised sex chromosome disomy 1.9-fold and disomy of chromosome 18 by 2.6-fold (Xia et al., 2004). Exposure of male workers to carbaryl increased DNA fragmentation in spermatozoa, and also increased sex chromosome disomy by 1.7-fold and chromosome 18 disomy by 2.2-fold.[8]
Humans are exposed to perfluorinated compounds (PFCs) in many commercial products.[9] Men contaminated with PFCs in whole blood or seminal plasma have spermatozoa with increased levels of DNA fragmentation and chromosomal aneuploidies.[9]
^Plante, N. (2003). Molecular toxicology. Taylor & Francis. pp. 63–65. ISBN978-1-85996-345-6. Retrieved 12 April 2013.
^Templado C, Uroz L, Estop A (2013). "New insights on the origin and relevance of aneuploidy in human spermatozoa". Mol. Hum. Reprod. 19 (10): 634–43. doi:10.1093/molehr/gat039. PMID 23720770.
^Humans, IARC Working Group on the Evaluation of Carcinogenic Risks to (2012), "TOBACCO SMOKING", Personal Habits and Indoor Combustions, International Agency for Research on Cancer, retrieved 2024-02-16
^Shi Q, Ko E, Barclay L, Hoang T, Rademaker A, Martin R (2001). "Cigarette smoking and aneuploidy in human sperm". Mol. Reprod. Dev. 59 (4): 417–21. doi:10.1002/mrd.1048. PMID 11468778. S2CID 35230655.
^Rubes J, Lowe X, Moore D, Perreault S, Slott V, Evenson D, Selevan SG, Wyrobek AJ (1998). "Smoking cigarettes is associated with increased sperm disomy in teenage men". Fertil. Steril. 70 (4): 715–23. doi:10.1016/S0015-0282(98)00261-1. PMID 9797104.
^Xing C, Marchetti F, Li G, Weldon RH, Kurtovich E, Young S, Schmid TE, Zhang L, Rappaport S, Waidyanatha S, Wyrobek AJ, Eskenazi B (2010). "Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy". Environ. Health Perspect. 118 (6): 833–9. doi:10.1289/ehp.0901531. PMC2898861. PMID 20418200.
^Bian Q, Xu LC, Wang SL, Xia YK, Tan LF, Chen JF, Song L, Chang HC, Wang XR (2004). "Study on the relation between occupational fenvalerate exposure and spermatozoa DNA damage of pesticide factory workers". Occup Environ Med. 61 (12): 999–1005. doi:10.1136/oem.2004.014597. PMC1740696. PMID 15550606.
^Xia Y, Cheng S, Bian Q, Xu L, Collins MD, Chang HC, Song L, Liu J, Wang S, Wang X (2005). "Genotoxic effects on spermatozoa of carbaryl-exposed workers". Toxicol. Sci. 85 (1): 615–23. doi:10.1093/toxsci/kfi066. PMID 15615886.
^ abGovernini L, Guerranti C, De Leo V, Boschi L, Luddi A, Gori M, Orvieto R, Piomboni P (2015). "Chromosomal aneuploidies and DNA fragmentation of human spermatozoa from patients exposed to perfluorinated compounds". Andrologia. 47 (9): 1012–9. doi:10.1111/and.12371. PMID 25382683. S2CID 13484513.
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aneugen, aneugen, substance, that, causes, daughter, cell, have, abnormal, number, chromosomes, aneuploidy, substance, aneugenicity, reflects, ability, induce, aneuploidy, unlike, clastogens, aneugenic, events, damage, physical, structure, chromosome, represen. An aneugen is a substance that causes a daughter cell to have an abnormal number of chromosomes or aneuploidy A substance s aneugenicity reflects its ability to induce aneuploidy 1 Unlike clastogens aneugenic events do not damage the physical structure of the chromosome but represent a deletion or insertion of an additional copy of a whole chromosome i e with an intact Centromere Aneugens and clastogens can be differentiated via certain stains using the technique of Fluorescence in situ hybridization Males if exposed to certain environmental and or occupational chemical hazards may face an increased risk of spermatozoa aneuploidy 2 Tobacco smoke contains chemicals that cause DNA damage see Tobacco smoking Health 3 Smoking also can induce aneuploidy In this study of men with a moderate smoking habit showed an association with increased chromosome 13 disomy in spermatozoa by 3 fold 4 and YY disomy by 2 fold 5 Occupational exposure to benzene is associated with a 2 8 fold increase of XX disomy and a 2 6 fold increase of YY disomy in spermatozoa 6 Pesticides are released to the environment in large quantities so that most individuals have some degree of exposure The insecticides fenvalerate and carbaryl have been reported to increase spermatozoa aneuploidy Occupational exposure of pesticide factory workers to fenvalerate is associated with increased spermatozoa DNA damage 7 Exposure to fenvalerate raised sex chromosome disomy 1 9 fold and disomy of chromosome 18 by 2 6 fold Xia et al 2004 Exposure of male workers to carbaryl increased DNA fragmentation in spermatozoa and also increased sex chromosome disomy by 1 7 fold and chromosome 18 disomy by 2 2 fold 8 Humans are exposed to perfluorinated compounds PFCs in many commercial products 9 Men contaminated with PFCs in whole blood or seminal plasma have spermatozoa with increased levels of DNA fragmentation and chromosomal aneuploidies 9 See also editChromosome segregation Clastogen Non disjunctionReferences edit Plante N 2003 Molecular toxicology Taylor amp Francis pp 63 65 ISBN 978 1 85996 345 6 Retrieved 12 April 2013 Templado C Uroz L Estop A 2013 New insights on the origin and relevance of aneuploidy in human spermatozoa Mol Hum Reprod 19 10 634 43 doi 10 1093 molehr gat039 PMID 23720770 Humans IARC Working Group on the Evaluation of Carcinogenic Risks to 2012 TOBACCO SMOKING Personal Habits and Indoor Combustions International Agency for Research on Cancer retrieved 2024 02 16 Shi Q Ko E Barclay L Hoang T Rademaker A Martin R 2001 Cigarette smoking and aneuploidy in human sperm Mol Reprod Dev 59 4 417 21 doi 10 1002 mrd 1048 PMID 11468778 S2CID 35230655 Rubes J Lowe X Moore D Perreault S Slott V Evenson D Selevan SG Wyrobek AJ 1998 Smoking cigarettes is associated with increased sperm disomy in teenage men Fertil Steril 70 4 715 23 doi 10 1016 S0015 0282 98 00261 1 PMID 9797104 Xing C Marchetti F Li G Weldon RH Kurtovich E Young S Schmid TE Zhang L Rappaport S Waidyanatha S Wyrobek AJ Eskenazi B 2010 Benzene exposure near the U S permissible limit is associated with sperm aneuploidy Environ Health Perspect 118 6 833 9 doi 10 1289 ehp 0901531 PMC 2898861 PMID 20418200 Bian Q Xu LC Wang SL Xia YK Tan LF Chen JF Song L Chang HC Wang XR 2004 Study on the relation between occupational fenvalerate exposure and spermatozoa DNA damage of pesticide factory workers Occup Environ Med 61 12 999 1005 doi 10 1136 oem 2004 014597 PMC 1740696 PMID 15550606 Xia Y Cheng S Bian Q Xu L Collins MD Chang HC Song L Liu J Wang S Wang X 2005 Genotoxic effects on spermatozoa of carbaryl exposed workers Toxicol Sci 85 1 615 23 doi 10 1093 toxsci kfi066 PMID 15615886 a b Governini L Guerranti C De Leo V Boschi L Luddi A Gori M Orvieto R Piomboni P 2015 Chromosomal aneuploidies and DNA fragmentation of human spermatozoa from patients exposed to perfluorinated compounds Andrologia 47 9 1012 9 doi 10 1111 and 12371 PMID 25382683 S2CID 13484513 nbsp This genetics article is a stub You can help Wikipedia by expanding it vte nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Aneugen amp oldid 1212150349, wikipedia, wiki, book, books, library,
