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Anagliptin

Anagliptin (INN; trade name Suiny) is a pharmaceutical drug for the treatment of type 2 diabetes mellitus. It is approved for use in Japan.[1] It belongs to the class of anti-diabetic drugs known as dipeptidyl peptidase-4 inhibitors or "gliptins".[2]

Anagliptin
Clinical data
Trade namesSuiny
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • Approved in Japan
Identifiers
  • N-[2-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS Number
  • 739366-20-2
ChemSpider
  • 28492667
UNII
  • K726J96838
Chemical and physical data
FormulaC19H25N7O2
Molar mass383.456 g·mol−1
3D model (JSmol)
  • Interactive image
  • CC1=NN2C=C(C=NC2=C1)C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N
  • InChI=1S/C19H25N7O2/c1-13-7-16-21-9-14(11-26(16)24-13)18(28)22-12-19(2,3)23-10-17(27)25-6-4-5-15(25)8-20/h7,9,11,15,23H,4-6,10,12H2,1-3H3,(H,22,28)/t15-/m0/s1
  • Key:LDXYBEHACFJIEL-HNNXBMFYSA-N

References edit

  1. ^ Graul AI, Lupone B, Cruces E, Stringer M (January 2013). (PDF). Drugs of Today. 49 (1): 33–68. doi:10.1358/dot.2013.49.1.1933991. PMID 23362494. Archived from the original (PDF) on 2013-11-03.
  2. ^ Kato N, Oka M, Murase T, Yoshida M, Sakairi M, Yamashita S, et al. (December 2011). "Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor". Bioorganic & Medicinal Chemistry. 19 (23): 7221–7. doi:10.1016/j.bmc.2011.09.043. PMID 22019046.

anagliptin, trade, name, suiny, pharmaceutical, drug, treatment, type, diabetes, mellitus, approved, japan, belongs, class, anti, diabetic, drugs, known, dipeptidyl, peptidase, inhibitors, gliptins, clinical, datatrade, namessuinyroutes, ofadministrationoralat. Anagliptin INN trade name Suiny is a pharmaceutical drug for the treatment of type 2 diabetes mellitus It is approved for use in Japan 1 It belongs to the class of anti diabetic drugs known as dipeptidyl peptidase 4 inhibitors or gliptins 2 AnagliptinClinical dataTrade namesSuinyRoutes ofadministrationOralATC codenoneLegal statusLegal statusApproved in JapanIdentifiersIUPAC name N 2 2 2S 2 Cyanopyrrolidin 1 yl 2 oxoethyl amino 2 methylpropyl 2 methylpyrazolo 1 5 a pyrimidine 6 carboxamideCAS Number739366 20 2ChemSpider28492667UNIIK726J96838Chemical and physical dataFormulaC 19H 25N 7O 2Molar mass383 456 g mol 13D model JSmol Interactive imageSMILES CC1 NN2C C C NC2 C1 C O NCC C C NCC O N3CCC C H 3C NInChI InChI 1S C19H25N7O2 c1 13 7 16 21 9 14 11 26 16 24 13 18 28 22 12 19 2 3 23 10 17 27 25 6 4 5 15 25 8 20 h7 9 11 15 23H 4 6 10 12H2 1 3H3 H 22 28 t15 m0 s1Key LDXYBEHACFJIEL HNNXBMFYSA NReferences edit Graul AI Lupone B Cruces E Stringer M January 2013 2012 in review part I the year s new drugs amp biologics PDF Drugs of Today 49 1 33 68 doi 10 1358 dot 2013 49 1 1933991 PMID 23362494 Archived from the original PDF on 2013 11 03 Kato N Oka M Murase T Yoshida M Sakairi M Yamashita S et al December 2011 Discovery and pharmacological characterization of N 2 2 2S 2 cyanopyrrolidin 1 yl 2 oxoethyl amino 2 methylpropyl 2 methylpyrazolo 1 5 a pyrimidine 6 carboxamide hydrochloride anagliptin hydrochloride salt as a potent and selective DPP IV inhibitor Bioorganic amp Medicinal Chemistry 19 23 7221 7 doi 10 1016 j bmc 2011 09 043 PMID 22019046 nbsp This drug article relating to the gastrointestinal system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Anagliptin amp oldid 1131622826, wikipedia, wiki, book, books, library,

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