Calcitonin[1] is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones, alpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids, called calcitonin gene-related peptide (CGRP), beta type. CGRP induces vasodilatation in a variety of vessels, including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
Islet amyloid polypeptide (IAPP)[2] (also known as diabetes-associated peptide (DAP), or amylin) is a peptide of 37 amino acids that selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyteglucose metabolism. Structurally, IAPP is closely related to CGRP.
^Breimer LH, Zaidi M, MacIntyre I (1988). "Peptides from the calcitonin genes: molecular genetics, structure and function". Biochem. J. 255 (2): 377–390. doi:10.1042/bj2550377. PMC1135239. PMID 3060108.
^Bell GI, Steiner DF, Nishi M, Sanke T, Nagamatsu S (1990). "Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits". J. Biol. Chem. 265 (8): 4173–4176. doi:10.1016/S0021-9258(19)39539-0. PMID 2407732.
^Breimer LH, MacIntyre I, Zaidi M (October 1988). "Peptides from the calcitonin genes: molecular genetics, structure and function". Biochem. J. 255 (2): 377–90. doi:10.1042/bj2550377. PMC1135239. PMID 3060108.
^Nishi M, Sanke T, Nagamatsu S, Bell GI, Steiner DF (March 1990). "Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits". J. Biol. Chem. 265 (8): 4173–6. doi:10.1016/S0021-9258(19)39539-0. PMID 2407732.
This article incorporates text from the public domain Pfam and InterPro: IPR021116
January 01, 1970
amylin, family, molecular, biology, amylin, protein, family, calcitonin, cgrp, iapp, protein, family, family, proteins, which, includes, precursors, calcitonin, calcitonin, gene, related, peptide, cgrp, islet, amyloid, polypeptide, iapp, adrenomedullin, calc, . In molecular biology the amylin protein family or calcitonin CGRP IAPP protein family is a family of proteins which includes the precursors of calcitonin calcitonin gene related peptide CGRP islet amyloid polypeptide IAPP and adrenomedullin Calc CGRP IAPPsolution conformation of salmon calcitonin in sodium dodecyl sulfate micellesIdentifiersSymbolCalc CGRP IAPPPfamPF00214InterProIPR021116PROSITEPDOC00231SCOP21bzb SCOPe SUPFAMTCDB1 C 49OPM superfamily243OPM protein2jxzAvailable protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary Calcitonin 1 is a 32 amino acid polypeptide hormone that causes a rapid but short lived drop in the level of calcium and phosphate in the blood by promoting the incorporation of these ions in the bones alpha type Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids called calcitonin gene related peptide CGRP beta type CGRP induces vasodilatation in a variety of vessels including the coronary cerebral and systemic vasculature Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role Islet amyloid polypeptide IAPP 2 also known as diabetes associated peptide DAP or amylin is a peptide of 37 amino acids that selectively inhibits insulin stimulated glucose utilization and glycogen deposition in muscle while not affecting adipocyte glucose metabolism Structurally IAPP is closely related to CGRP Two conserved cysteines in the N terminal of these peptides are known to be involved in a disulfide bond The C terminal amino acid of all three peptides is amidated 3 4 xCxxxxxCxxxxxxxxxxxxxxxxxxxxxxxxxxxx NH 2 Amide group Subfamilies editCalcitonin alpha type InterPro IPR001935 Calcitonin beta type InterPro IPR002163Human proteins containing this domain editCALCA CALCB IAPPReferences edit Breimer LH Zaidi M MacIntyre I 1988 Peptides from the calcitonin genes molecular genetics structure and function Biochem J 255 2 377 390 doi 10 1042 bj2550377 PMC 1135239 PMID 3060108 Bell GI Steiner DF Nishi M Sanke T Nagamatsu S 1990 Islet amyloid polypeptide A new beta cell secretory product related to islet amyloid deposits J Biol Chem 265 8 4173 4176 doi 10 1016 S0021 9258 19 39539 0 PMID 2407732 Breimer LH MacIntyre I Zaidi M October 1988 Peptides from the calcitonin genes molecular genetics structure and function Biochem J 255 2 377 90 doi 10 1042 bj2550377 PMC 1135239 PMID 3060108 Nishi M Sanke T Nagamatsu S Bell GI Steiner DF March 1990 Islet amyloid polypeptide A new beta cell secretory product related to islet amyloid deposits J Biol Chem 265 8 4173 6 doi 10 1016 S0021 9258 19 39539 0 PMID 2407732 This article incorporates text from the public domain Pfam and InterPro IPR021116 Retrieved from https en wikipedia org w index php title Amylin family amp oldid 1182754538, wikipedia, wiki, book, books, library,
