The alpha-1D adrenergic receptor (α1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[5]
There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.
Geneedit
This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.[5]
^Buckner SA, Milicic I, Daza A, Lynch JJ, Kolasa T, Nakane M, Sullivan JP, Brioni JD (2001). "A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity". Eur. J. Pharmacol. 433 (1): 123–7. doi:10.1016/s0014-2999(01)01519-9. PMID 11755142.
^Cleary L, Murad K, Bexis S, Docherty JR (2005). "The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist". Autonomic and Autacoid Pharmacology. 25 (4): 135–41. doi:10.1111/j.1474-8673.2005.00342.x. PMID 16176444.
External linksedit
Human ADRA1A genome location and ADRA1A gene details page in the UCSC Genome Browser.
Human ADRA1D genome location and ADRA1D gene details page in the UCSC Genome Browser.
Further readingedit
Schwinn DA, Lomasney JW (1992). "Pharmacologic characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype". Eur. J. Pharmacol. 227 (4): 433–6. doi:10.1016/0922-4106(92)90162-O. PMID 1359975.
Bruno JF, Whittaker J, Song JF, Berelowitz M (1991). "Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor". Biochem. Biophys. Res. Commun. 179 (3): 1485–90. doi:10.1016/0006-291X(91)91740-4. PMID 1656955.
Esbenshade TA, Hirasawa A, Tsujimoto G, et al. (1995). "Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells". Mol. Pharmacol. 47 (5): 977–85. PMID 7746284.
Schwinn DA, Johnston GI, Page SO, et al. (1995). "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues". J. Pharmacol. Exp. Ther. 272 (1): 134–42. PMID 7815325.
Weinberg DH, Trivedi P, Tan CP, et al. (1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem. Biophys. Res. Commun. 201 (3): 1296–304. doi:10.1006/bbrc.1994.1845. PMID 8024574.
Loftus SK, Shiang R, Warrington JA, et al. (1994). "Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5". Cytogenet. Cell Genet. 67 (2): 69–74. doi:10.1159/000133802. PMID 8039425.
Yang-Feng TL, Han H, Lomasney JW, Caron MG (1994). "Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13". Cytogenet. Cell Genet. 66 (3): 170–1. doi:10.1159/000133693. PMID 8125015.
Forray C, Bard JA, Wetzel JM, et al. (1994). "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype". Mol. Pharmacol. 45 (4): 703–8. PMID 8183249.
Minneman KP, Lee D, Zhong H, et al. (2000). "Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes". J. Neurochem. 74 (6): 2392–400. doi:10.1046/j.1471-4159.2000.0742392.x. PMID 10820200. S2CID 16002509.
Keffel S, Alexandrov A, Goepel M, Michel MC (2000). "alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells". Biochem. Biophys. Res. Commun. 272 (3): 906–11. doi:10.1006/bbrc.2000.2850. PMID 10860850.
Kyprianou N, Benning CM (2000). "Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis". Cancer Res. 60 (16): 4550–5. PMID 10969806.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Shibata K, Katsuma S, Koshimizu T, et al. (2003). "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1". J. Biol. Chem. 278 (1): 672–8. doi:10.1074/jbc.M201375200. PMID 12409310.
Pupo AS, Minneman KP (2004). "Specific interactions between gC1qR and alpha1-adrenoceptor subtypes". J. Recept. Signal Transduct. Res. 23 (2–3): 185–95. doi:10.1081/RRS-120025200. PMID 14626446. S2CID 29600903.
Hague C, Uberti MA, Chen Z, et al. (2004). "Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors". J. Biol. Chem. 279 (15): 15541–9. doi:10.1074/jbc.M314014200. PMID 14736874.
Gonzalez-Cabrera PJ, Shi T, Yun J, et al. (2004). "Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes". Endocrinology. 145 (11): 5157–67. doi:10.1210/en.2004-0728. PMID 15297446.
Zhang T, Xu Q, Chen FR, et al. (2005). "Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors". Acta Pharmacol. Sin. 25 (11): 1471–8. PMID 15525470.
Sigala S, Dellabella M, Milanese G, et al. (2005). "Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter". Neurourol. Urodyn. 24 (2): 142–8. doi:10.1002/nau.20097. PMID 15690361. S2CID 23187341.
Chen Z, Hague C, Hall RA, Minneman KP (2006). "Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction". J. Biol. Chem. 281 (18): 12414–20. doi:10.1074/jbc.M508651200. PMID 16533813.
Michelotti GA, Brinkley DM, Morris DP, et al. (2007). "Epigenetic regulation of human α1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation". FASEB J. 21 (9): 1979–93. doi:10.1096/fj.06-7118com. PMC2279228. PMID 17384146.
alpha, adrenergic, receptor, alpha, adrenergic, receptor, α1d, adrenoreceptor, also, known, adra1d, alpha, adrenergic, receptor, also, denotes, human, gene, encoding, adra1didentifiersaliasesadra1d, adra1, adra1a, adra1r, alpha1, dj779e11, adrenoceptor, alpha,. The alpha 1D adrenergic receptor a1D adrenoreceptor also known as ADRA1D is an alpha 1 adrenergic receptor and also denotes the human gene encoding it 5 ADRA1DIdentifiersAliasesADRA1D ADRA1 ADRA1A ADRA1R ALPHA1 DAR dJ779E11 2 adrenoceptor alpha 1DExternal IDsOMIM 104219 MGI 106673 HomoloGene 551 GeneCards ADRA1DGene location Human Chr Chromosome 20 human 1 Band20p13Start4 220 630 bp 1 End4 249 287 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 F1 2 63 5 cMStart131 387 770 bp 2 End131 404 203 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inascending aortacanal of the cervixstromal cell of endometriumprefrontal cortextibial nervegastric mucosaupper lobe of left lungsural nervedorsolateral prefrontal cortexcingulate gyrusTop expressed inhippocampus properolfactory bulbsuperior frontal gyruswhite adipose tissueadrenal glandcerebellar cortexquadriceps femoris muscleheartyolk saclungMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionG protein coupled receptor activity signal transducer activity adrenergic receptor activity protein binding alpha1 adrenergic receptor activityCellular componentintegral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structureBiological processG protein coupled receptor signaling pathway norepinephrine epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure adenylate cyclase modulating G protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell cell signaling DNA metabolic process multicellular organism development adenylate cyclase activating adrenergic receptor signaling pathway phospholipase C activating G protein coupled receptor signaling pathway positive regulation of vasoconstriction positive regulation of cell population proliferation cell population proliferation positive regulation of smooth muscle contraction signal transduction neuron glial cell signaling adrenergic receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez14611550EnsemblENSG00000171873ENSMUSG00000027335UniProtP25100P97714RefSeq mRNA NM 000678NM 013460RefSeq protein NP 000669NP 000669 1NP 038488Location UCSC Chr 20 4 22 4 25 MbChr 2 131 39 131 4 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Receptor 2 Gene 3 Ligands 4 See also 5 References 6 External links 7 Further readingReceptor editThere are 3 alpha 1 adrenergic receptor subtypes alpha 1A 1B and 1D all of which signal through the Gq 11 family of G proteins and different subtypes show different patterns of activation They activate mitogenic responses and regulate growth and proliferation of many cells Gene editThis gene encodes alpha 1D adrenergic receptor Similar to alpha 1B adrenergic receptor gene this gene comprises 2 exons and a single intron that interrupts the coding region 5 Ligands editAntagonists A 315456 6 BMY 7378 also a2C antagonist 7 See also editAdrenergic receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000171873 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000027335 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene ADRA1D adrenergic alpha 1D receptor Buckner SA Milicic I Daza A Lynch JJ Kolasa T Nakane M Sullivan JP Brioni JD 2001 A 315456 a selective alpha 1D adrenoceptor antagonist with minimal dopamine D 2 and 5 HT 1A receptor affinity Eur J Pharmacol 433 1 123 7 doi 10 1016 s0014 2999 01 01519 9 PMID 11755142 Cleary L Murad K Bexis S Docherty JR 2005 The alpha 1D adrenoceptor antagonist BMY 7378 is also an alpha 2C adrenoceptor antagonist Autonomic and Autacoid Pharmacology 25 4 135 41 doi 10 1111 j 1474 8673 2005 00342 x PMID 16176444 External links editHuman ADRA1A genome location and ADRA1A gene details page in the UCSC Genome Browser Human ADRA1D genome location and ADRA1D gene details page in the UCSC Genome Browser Further reading editSchwinn DA Lomasney JW 1992 Pharmacologic characterization of cloned alpha 1 adrenoceptor subtypes selective antagonists suggest the existence of a fourth subtype Eur J Pharmacol 227 4 433 6 doi 10 1016 0922 4106 92 90162 O PMID 1359975 Bruno JF Whittaker J Song JF Berelowitz M 1991 Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor Biochem Biophys Res Commun 179 3 1485 90 doi 10 1016 0006 291X 91 91740 4 PMID 1656955 Esbenshade TA Hirasawa A Tsujimoto G et al 1995 Cloning of the human alpha 1d adrenergic receptor and inducible expression of three human subtypes in SK N MC cells Mol Pharmacol 47 5 977 85 PMID 7746284 Schwinn DA Johnston GI Page SO et al 1995 Cloning and pharmacological characterization of human alpha 1 adrenergic receptors sequence corrections and direct comparison with other species homologues J Pharmacol Exp Ther 272 1 134 42 PMID 7815325 Weinberg DH Trivedi P Tan CP et al 1994 Cloning expression and characterization of human alpha adrenergic receptors alpha 1a alpha 1b and alpha 1c Biochem Biophys Res Commun 201 3 1296 304 doi 10 1006 bbrc 1994 1845 PMID 8024574 Loftus SK Shiang R Warrington JA et al 1994 Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5 Cytogenet Cell Genet 67 2 69 74 doi 10 1159 000133802 PMID 8039425 Yang Feng TL Han H Lomasney JW Caron MG 1994 Localization of the cDNA for an alpha 1 adrenergic receptor subtype ADRA1D to chromosome band 20p13 Cytogenet Cell Genet 66 3 170 1 doi 10 1159 000133693 PMID 8125015 Forray C Bard JA Wetzel JM et al 1994 The alpha 1 adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype Mol Pharmacol 45 4 703 8 PMID 8183249 Minneman KP Lee D Zhong H et al 2000 Transcriptional responses to growth factor and G protein coupled receptors in PC12 cells comparison of alpha 1 adrenergic receptor subtypes J Neurochem 74 6 2392 400 doi 10 1046 j 1471 4159 2000 0742392 x PMID 10820200 S2CID 16002509 Keffel S Alexandrov A Goepel M Michel MC 2000 alpha 1 adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells Biochem Biophys Res Commun 272 3 906 11 doi 10 1006 bbrc 2000 2850 PMID 10860850 Kyprianou N Benning CM 2000 Suppression of human prostate cancer cell growth by alpha1 adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis Cancer Res 60 16 4550 5 PMID 10969806 Deloukas P Matthews LH Ashurst J et al 2002 The DNA sequence and comparative analysis of human chromosome 20 Nature 414 6866 865 71 Bibcode 2001Natur 414 865D doi 10 1038 414865a PMID 11780052 Shibata K Katsuma S Koshimizu T et al 2003 alpha 1 Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP dependent mechanism involving p27Kip1 J Biol Chem 278 1 672 8 doi 10 1074 jbc M201375200 PMID 12409310 Pupo AS Minneman KP 2004 Specific interactions between gC1qR and alpha1 adrenoceptor subtypes J Recept Signal Transduct Res 23 2 3 185 95 doi 10 1081 RRS 120025200 PMID 14626446 S2CID 29600903 Hague C Uberti MA Chen Z et al 2004 Cell surface expression of alpha1D adrenergic receptors is controlled by heterodimerization with alpha1B adrenergic receptors J Biol Chem 279 15 15541 9 doi 10 1074 jbc M314014200 PMID 14736874 Gonzalez Cabrera PJ Shi T Yun J et al 2004 Differential regulation of the cell cycle by alpha1 adrenergic receptor subtypes Endocrinology 145 11 5157 67 doi 10 1210 en 2004 0728 PMID 15297446 Zhang T Xu Q Chen FR et al 2005 Yeast two hybrid screening for proteins that interact with alpha1 adrenergic receptors Acta Pharmacol Sin 25 11 1471 8 PMID 15525470 Sigala S Dellabella M Milanese G et al 2005 Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter Neurourol Urodyn 24 2 142 8 doi 10 1002 nau 20097 PMID 15690361 S2CID 23187341 Chen Z Hague C Hall RA Minneman KP 2006 Syntrophins regulate alpha1D adrenergic receptors through a PDZ domain mediated interaction J Biol Chem 281 18 12414 20 doi 10 1074 jbc M508651200 PMID 16533813 Michelotti GA Brinkley DM Morris DP et al 2007 Epigenetic regulation of human a1d adrenergic receptor gene expression a role for DNA methylation in Sp1 dependent regulation FASEB J 21 9 1979 93 doi 10 1096 fj 06 7118com PMC 2279228 PMID 17384146 nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Alpha 1D adrenergic receptor amp oldid 1212492119, wikipedia, wiki, book, books, library,
