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Alexandros Makriyannis

January 01, 1970

Alexandros Makriyannis (born September 9, 1939) is an American biochemist and professor of chemistry and chemical biology in the department of medicinal chemistry at Northeastern University in Boston, Massachusetts, where he directs the Center for Drug Discovery and holds the George Behrakis Chair of Pharmaceutical Biotechnology.[1] His research has focused on the biochemical basis of the endocannabinoid system and on the development of synthetic cannabinoids.

Scientific career edit

Makriyannis studied chemistry at the University of Cairo.[2] He then earned his Ph.D. in medicinal chemistry at the University of Kansas and went on to research synthetic organic chemistry at the University of California, Berkeley. He worked at Smith, Kline & French Laboratories and Tufts Medical School and then at the University of Connecticut, where he was later appointed Distinguished Professor of Medicinal Chemistry and Professor of Molecular and Cell Biology and Pharmacology.[3][4] He moved to Northeastern University in 2005.[4]

Makriyannis is director of the Center for Drug Discovery at Northeastern University, which he founded in 2005.[3] His work has identified the structure of cannabinoid receptors in the brain, helping to elucidate the psychoactive properties of some of these substances[5][6] and to point towards modifications in the receptors so as to retain the positive effects of cannabinoids while eliminating the negative ones.[7] These studies have informed the development by Makriyannis and his collaborators of synthetic compounds with a view to their use as cannabinergic probes or as medications in drug addiction[8] and in obesity and metabolic disorders.[4] A more recent research interest has been the study of drug interactions with protein targets in membranes.[4] His research has been reported in over 470 publications and his group has filed more than 40 patents.[3]

Subsequent novel inventions include:

2008       “Heteroaryl Urea Compunds as Endocannablnold enzyme Deactivators and a Method of Their Evaluation” – A. Makriyannis, L. Pandarinathan, N. Zvonok, T. Pakkari, L. Chapman

2011        “Method of Developing Cannablnoids with Controlled Duration of Action and Uses Thereof” – A. Makriyannis, G.A Thakur, R. Sharma

2011        “Cannabinergic Resorcinol Analogs” – A. Makriyannis, S. Bajaj, M.R D’Souza, S. Nikas, G. Thakur

2012        “Novel Cannabinerglc Nitrate Esters and Related Analogs” – A. Makriyannis, V.K. Vemuri

2014         Novel urea and carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and their uses thereof” – A. Makriyannis, V.G. Shukla, S.O. Alapafuja

2014        “N·Acylethanolamlne Hydrolyzing Acid Amldase (NAAA) Inhibitors and Their Use Thereof” – A. Makriyannis, M. Malamas, K.V Subramanian, K. Whitten, N. Zvonok, J.M West, S. Pavlopoulos

2017        “Carbarnates ABHD6 and dual ABHD6/MGL Inhibitors and their use thereof”- A. Makriyannis, M. Malamas, M. Lamani, S.I Farah

Biotechnology Startups edit

Makriyannis has founded two biotechnology startups in Burlington, MA dedicated to bringing new and innovative drugs to the market place for human diseases that can be modulated by the endocannabinoid system:

  • MAKScientific (2004)
  • PafosPharma (2014)

Awards edit

  • McNeil Endowment Fellowship (1964–67)
  • Research Scientist Award, NIDA (1990–95, 1995-2000)
  • Fellow, American Association for the Advancement of Science (1993)
  • President, International Cannabinoid Research Society (ICRS) (1993)      
  • Distinguished Scientist Award, University of Connecticut Alumni (1996)
  • Fellow, American Association of Pharmaceutical Sciences (1997)
  • National Institute of Health MERIT Awards (1997-2007, 2007-2017)
  • Senior Scientist NIDA Award (2000-2011)
  • Distinguished professor, University of Connecticut, Board of Trustees (2002)
  • Research Achievement Award in Drug Design and Discovery, American Association of
  • Pharmaceutical Scientists (AAPS) (2002)
  • Behrakis Trustee Chair in Pharmaceutical Biotechnology, Northeastern University (2004)
  • Honorary Doctorate of Philosophy, University of Athens, Greece (2005)
  • Recognition of Scholarly or Creative Work by Northeastern Faculty and Staff, Northeastern University (2005)
  • Mechoulam Life Achievement Award in Cannabinoid Research (ICRS) (2006)
  • Distinguished Patent Award, University of Connecticut (2007)
  • Kenneth E. Avis Award in Medicinal Chemistry (2007)
  • Marquis Who’s Who in Science and Engineering (2007)
  • ACS Research Lifetime Achievement Award in Medicinal Chemistry (2012)
  • Annual NU Award for Excellence in Research and Creativity (2012)
  • ACS Medicinal Chemistry Hall of Fame (2013)
  • Highly Cited Researcher, Thomson Reuters (2014)
  • Distinguished professor, Northeastern University (2015)
  • AAPS Distinguished Pharmaceutical Scientist Award (2015)
  • Honorary Doctorate of Philosophy, University of Crete Medical School, Greece (2018)
  • CPDD Nathan B. Eddy Memorial Award (2018)

See also edit

References edit

  1. ^ "Alexandros Makriyannis". Northeastern University College of Science. Retrieved 2 December 2018.
  2. ^ "Pioneer in Chemical Biology". Ellines. Retrieved 3 January 2019.
  3. ^ a b c . Advancing Drug Development Forum. 2018-08-06. Archived from the original on 3 January 2019. Retrieved 2 December 2018.
  4. ^ a b c d "Alexandros Makriyannis, Ph.D." American Chemical Society, Division of Medicinal Chemistry. Retrieved 2 December 2018.
  5. ^ "Cannabinoid receptor structure revealed". National Institutes of Health (NIH). November 1, 2016.
  6. ^ Singer, Thea (October 20, 2016). "Structure of the brain's 'marijuana receptor' revealed". News@Northeastern. Northeastern University.
  7. ^ Perrier, Jean (October 19, 2017). "Peut-on fumer de l'herbe sans être stone ?" [Could we smoke weed without getting stoned?]. GQ France (in French).
  8. ^ Davi, Christine Regan (August 3, 2018). "Can the opioid crisis be fixed?". News@Northeastern. Northeastern University.

Further reading edit

  • Kiran Vemuri, V.; Makriyannis, Alexandros (2008). "Endocannabinoids and their Synthetic Analogs". In Reggio, Patricia H. (ed.). The Cannabinoid Receptors. Springer Science & Business Media. pp. 21–48. ISBN 978-1-59745-503-9.
  • Stockton, Nick (July 6, 2017). "Scientists Map the Receptor That Makes Weed Work". Wired.

January 01, 1970
alexandros, makriyannis, born, september, 1939, american, biochemist, professor, chemistry, chemical, biology, department, medicinal, chemistry, northeastern, university, boston, massachusetts, where, directs, center, drug, discovery, holds, george, behrakis, . Alexandros Makriyannis born September 9 1939 is an American biochemist and professor of chemistry and chemical biology in the department of medicinal chemistry at Northeastern University in Boston Massachusetts where he directs the Center for Drug Discovery and holds the George Behrakis Chair of Pharmaceutical Biotechnology 1 His research has focused on the biochemical basis of the endocannabinoid system and on the development of synthetic cannabinoids Contents 1 Scientific career 2 Biotechnology Startups 3 Awards 4 See also 5 References 6 Further readingScientific career editMakriyannis studied chemistry at the University of Cairo 2 He then earned his Ph D in medicinal chemistry at the University of Kansas and went on to research synthetic organic chemistry at the University of California Berkeley He worked at Smith Kline amp French Laboratories and Tufts Medical School and then at the University of Connecticut where he was later appointed Distinguished Professor of Medicinal Chemistry and Professor of Molecular and Cell Biology and Pharmacology 3 4 He moved to Northeastern University in 2005 4 Makriyannis is director of the Center for Drug Discovery at Northeastern University which he founded in 2005 3 His work has identified the structure of cannabinoid receptors in the brain helping to elucidate the psychoactive properties of some of these substances 5 6 and to point towards modifications in the receptors so as to retain the positive effects of cannabinoids while eliminating the negative ones 7 These studies have informed the development by Makriyannis and his collaborators of synthetic compounds with a view to their use as cannabinergic probes or as medications in drug addiction 8 and in obesity and metabolic disorders 4 A more recent research interest has been the study of drug interactions with protein targets in membranes 4 His research has been reported in over 470 publications and his group has filed more than 40 patents 3 Subsequent novel inventions include 2008 Heteroaryl Urea Compunds as Endocannablnold enzyme Deactivators and a Method of Their Evaluation A Makriyannis L Pandarinathan N Zvonok T Pakkari L Chapman2011 Method of Developing Cannablnoids with Controlled Duration of Action and Uses Thereof A Makriyannis G A Thakur R Sharma2011 Cannabinergic Resorcinol Analogs A Makriyannis S Bajaj M R D Souza S Nikas G Thakur2012 Novel Cannabinerglc Nitrate Esters and Related Analogs A Makriyannis V K Vemuri2014 Novel urea and carbamates FAAH MAGL or dual FAAH MAGL inhibitors and their uses thereof A Makriyannis V G Shukla S O Alapafuja2014 N Acylethanolamlne Hydrolyzing Acid Amldase NAAA Inhibitors and Their Use Thereof A Makriyannis M Malamas K V Subramanian K Whitten N Zvonok J M West S Pavlopoulos2017 Carbarnates ABHD6 and dual ABHD6 MGL Inhibitors and their use thereof A Makriyannis M Malamas M Lamani S I FarahBiotechnology Startups editMakriyannis has founded two biotechnology startups in Burlington MA dedicated to bringing new and innovative drugs to the market place for human diseases that can be modulated by the endocannabinoid system MAKScientific 2004 PafosPharma 2014 Awards editMcNeil Endowment Fellowship 1964 67 Research Scientist Award NIDA 1990 95 1995 2000 Fellow American Association for the Advancement of Science 1993 President International Cannabinoid Research Society ICRS 1993 Distinguished Scientist Award University of Connecticut Alumni 1996 Fellow American Association of Pharmaceutical Sciences 1997 National Institute of Health MERIT Awards 1997 2007 2007 2017 Senior Scientist NIDA Award 2000 2011 Distinguished professor University of Connecticut Board of Trustees 2002 Research Achievement Award in Drug Design and Discovery American Association of Pharmaceutical Scientists AAPS 2002 Behrakis Trustee Chair in Pharmaceutical Biotechnology Northeastern University 2004 Honorary Doctorate of Philosophy University of Athens Greece 2005 Recognition of Scholarly or Creative Work by Northeastern Faculty and Staff Northeastern University 2005 Mechoulam Life Achievement Award in Cannabinoid Research ICRS 2006 Distinguished Patent Award University of Connecticut 2007 Kenneth E Avis Award in Medicinal Chemistry 2007 Marquis Who s Who in Science and Engineering 2007 ACS Research Lifetime Achievement Award in Medicinal Chemistry 2012 Annual NU Award for Excellence in Research and Creativity 2012 ACS Medicinal Chemistry Hall of Fame 2013 Highly Cited Researcher Thomson Reuters 2014 Distinguished professor Northeastern University 2015 AAPS Distinguished Pharmaceutical Scientist Award 2015 Honorary Doctorate of Philosophy University of Crete Medical School Greece 2018 CPDD Nathan B Eddy Memorial Award 2018 See also editList of AM cannabinoidsReferences edit Alexandros Makriyannis Northeastern University College of Science Retrieved 2 December 2018 Pioneer in Chemical Biology Ellines Retrieved 3 January 2019 a b c Alexandros Makriyannis Advancing Drug Development Forum 2018 08 06 Archived from the original on 3 January 2019 Retrieved 2 December 2018 a b c d Alexandros Makriyannis Ph D American Chemical Society Division of Medicinal Chemistry Retrieved 2 December 2018 Cannabinoid receptor structure revealed National Institutes of Health NIH November 1 2016 Singer Thea October 20 2016 Structure of the brain s marijuana receptor revealed News Northeastern Northeastern University Perrier Jean October 19 2017 Peut on fumer de l herbe sans etre stone Could we smoke weed without getting stoned GQ France in French Davi Christine Regan August 3 2018 Can the opioid crisis be fixed News Northeastern Northeastern University Further reading editKiran Vemuri V Makriyannis Alexandros 2008 Endocannabinoids and their Synthetic Analogs In Reggio Patricia H ed The Cannabinoid Receptors Springer Science amp Business Media pp 21 48 ISBN 978 1 59745 503 9 Stockton Nick July 6 2017 Scientists Map the Receptor That Makes Weed Work Wired Retrieved from https en wikipedia org w index php title Alexandros Makriyannis amp oldid 1162921548, wikipedia, wiki, book, books, library,

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