Members of the parvin family, including PARVB, PARVA and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM][7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000188677 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022438 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC310876. PMID 10810093.
^Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily". J Cell Sci. 114 (Pt 3): 525–38. doi:10.1242/jcs.114.3.525. PMID 11171322.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Yamaji S, Suzuki A, Sugiyama Y, et al. (2001). "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction". J. Cell Biol. 153 (6): 1251–64. doi:10.1083/jcb.153.6.1251. PMC2192033. PMID 11402068.
Korenbaum E, Olski TM, Noegel AA (2002). "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans". Gene. 279 (1): 69–79. doi:10.1016/S0378-1119(01)00743-0. PMID 11722847.
Yamaji S, Suzuki A, Kanamori H, et al. (2002). "Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation". Biochem. Biophys. Res. Commun. 297 (5): 1324–31. doi:10.1016/S0006-291X(02)02381-1. PMID 12372433.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling". Hum. Mol. Genet. 12 (2): 155–67. doi:10.1093/hmg/ddg019. PMID 12499396.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC430954. PMID 12529303.
Mishima W, Suzuki A, Yamaji S, et al. (2004). "The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor". Genes Cells. 9 (3): 193–204. doi:10.1111/j.1356-9597.2004.00717.x. PMID 15005707.
Yamaji S, Suzuki A, Kanamori H, et al. (2004). "Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction". J. Cell Biol. 165 (4): 539–51. doi:10.1083/jcb.200308141. PMC2172344. PMID 15159419.
Zhang Y, Chen K, Tu Y, Wu C (2004). "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival". J. Biol. Chem. 279 (40): 41695–705. doi:10.1074/jbc.M401563200. PMID 15284246.
Mongroo PS, Johnstone CN, Naruszewicz I, et al. (2004). "Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer". Oncogene. 23 (55): 8959–70. doi:10.1038/sj.onc.1208112. PMID 15467740.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Matsuda C, Kameyama K, Tagawa K, et al. (2005). "Dysferlin interacts with affixin (beta-parvin) at the sarcolemma". J. Neuropathol. Exp. Neurol. 64 (4): 334–40. doi:10.1093/jnen/64.4.334. PMID 15835269.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.
parvb, beta, parvin, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes4edl, 4edm, 4ednidentifiersaliases, parvin, betaexternal, idsomim, 608121, 2153063, homologene, 8342, genecards, gene, location, human, ch. Beta parvin is a protein that in humans is encoded by the PARVB gene 5 6 7 PARVBAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4EDL 4EDM 4EDNIdentifiersAliasesPARVB CGI 56 parvin betaExternal IDsOMIM 608121 MGI 2153063 HomoloGene 8342 GeneCards PARVBGene location Human Chr Chromosome 22 human 1 Band22q13 31Start43 999 211 bp 1 End44 172 939 bp 1 Gene location Mouse Chr Chromosome 15 mouse 2 Band15 15 E2Start84 116 244 bp 2 End84 199 889 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastrocnemius musclemonocyteleft ventricleislet of Langerhansright lungright adrenal glandupper lobe of left lungleft adrenal glandsural nerveskeletal muscle tissueTop expressed inbloodmolarright lobe of liverextraocular musclesoleus muscledigastric muscleatriumyolk sacmyocardium of ventricleleft ventricleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionactin binding protein bindingCellular componentcytoplasm cytosol cell junction plasma membrane cell projection sarcomere Z disc cytoskeleton membrane focal adhesion lamellipodium actin cytoskeletonBiological processactin cytoskeleton reorganization cell adhesion cell projection assembly lamellipodium assembly establishment or maintenance of cell polarity regulating cell shape establishment or maintenance of cell polarity substrate adhesion dependent cell spreadingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez29780170736EnsemblENSG00000188677ENSMUSG00000022438UniProtQ9HBI1Q9ES46RefSeq mRNA NM 001003828NM 001243385NM 001243386NM 013327NM 133167RefSeq protein NP 001003828NP 001230314NP 001230315NP 037459NP 573395Location UCSC Chr 22 44 44 17 MbChr 15 84 12 84 2 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseMembers of the parvin family including PARVB PARVA and PARVG are actin binding proteins associated with focal contacts supplied by OMIM 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000188677 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000022438 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lai CH Chou CY Ch ang LY Liu CS Lin W Aug 2000 Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics Genome Res 10 5 703 13 doi 10 1101 gr 10 5 703 PMC 310876 PMID 10810093 Olski TM Noegel AA Korenbaum E Feb 2001 Parvin a 42 kDa focal adhesion protein related to the alpha actinin superfamily J Cell Sci 114 Pt 3 525 38 doi 10 1242 jcs 114 3 525 PMID 11171322 a b Entrez Gene PARVB parvin beta Further reading editDunham I Shimizu N Roe BA et al 1999 The DNA sequence of human chromosome 22 Nature 402 6761 489 95 Bibcode 1999Natur 402 489D doi 10 1038 990031 PMID 10591208 Yamaji S Suzuki A Sugiyama Y et al 2001 A novel integrin linked kinase binding protein affixin is involved in the early stage of cell substrate interaction J Cell Biol 153 6 1251 64 doi 10 1083 jcb 153 6 1251 PMC 2192033 PMID 11402068 Korenbaum E Olski TM Noegel AA 2002 Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans Gene 279 1 69 79 doi 10 1016 S0378 1119 01 00743 0 PMID 11722847 Yamaji S Suzuki A Kanamori H et al 2002 Possible role of ILK affixin complex in integrin cytoskeleton linkage during platelet aggregation Biochem Biophys Res Commun 297 5 1324 31 doi 10 1016 S0006 291X 02 02381 1 PMID 12372433 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Rosenberger G Jantke I Gal A Kutsche K 2003 Interaction of alphaPIX ARHGEF6 with beta parvin PARVB suggests an involvement of alphaPIX in integrin mediated signaling Hum Mol Genet 12 2 155 67 doi 10 1093 hmg ddg019 PMID 12499396 Collins JE Goward ME Cole CG et al 2003 Reevaluating human gene annotation a second generation analysis of chromosome 22 Genome Res 13 1 27 36 doi 10 1101 gr 695703 PMC 430954 PMID 12529303 Mishima W Suzuki A Yamaji S et al 2004 The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX a Cdc42 Rac1 specific guanine nucleotide exchanging factor Genes Cells 9 3 193 204 doi 10 1111 j 1356 9597 2004 00717 x PMID 15005707 Yamaji S Suzuki A Kanamori H et al 2004 Affixin interacts with alpha actinin and mediates integrin signaling for reorganization of F actin induced by initial cell substrate interaction J Cell Biol 165 4 539 51 doi 10 1083 jcb 200308141 PMC 2172344 PMID 15159419 Zhang Y Chen K Tu Y Wu C 2004 Distinct roles of two structurally closely related focal adhesion proteins alpha parvins and beta parvins in regulation of cell morphology and survival J Biol Chem 279 40 41695 705 doi 10 1074 jbc M401563200 PMID 15284246 Mongroo PS Johnstone CN Naruszewicz I et al 2004 Beta parvin inhibits integrin linked kinase signaling and is downregulated in breast cancer Oncogene 23 55 8959 70 doi 10 1038 sj onc 1208112 PMID 15467740 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Matsuda C Kameyama K Tagawa K et al 2005 Dysferlin interacts with affixin beta parvin at the sarcolemma J Neuropathol Exp Neurol 64 4 334 40 doi 10 1093 jnen 64 4 334 PMID 15835269 Ewing RM Chu P Elisma F et al 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 nbsp This article on a gene on human chromosome 22 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PARVB amp oldid 1142791870, wikipedia, 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