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Adenosine reuptake inhibitor

March 14, 2024

An adenosine reuptake inhibitor (AdoRI) is a type of drug which acts as a reuptake inhibitor for the purine nucleoside and neurotransmitter adenosine by blocking the action of one or more of the equilibrative nucleoside transporters (ENTs).[1][2][3] This in turn leads to increased extracellular concentrations of adenosine and therefore an increase in adenosinergic neurotransmission.

Adenosine
Main article: Reuptake inhibitor

List of AdoRIs edit

See also edit

References edit

  1. ^ a b c d SenGupta DJ, Unadkat JD (2004). "Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep". Biochem Pharmacol. 67 (3): 453–458. doi:10.1016/j.bcp.2003.09.018. PMID 15037197.
  2. ^ Endres CJ, Sengupta DJ, Unadkat JD (2004). "Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1". Biochem J. 380 (1): 131–137. doi:10.1042/BJ20031880. PMC 1224139. PMID 14759222.
  3. ^ Chaudary N, Naydenova Z, Shuralyova I, Coe IR (2004). "The adenosine transporter, mENT1, is a target for adenosine receptor signaling and protein kinase Cepsilon in hypoxic and pharmacological preconditioning in the mouse cardiomyocyte cell line, HL-1". J Pharmacol Exp Ther. 310 (3): 1190–1198. doi:10.1124/jpet.104.067157. PMID 15131243. S2CID 21804556.
  4. ^ a b c d e f Goldfrank LR, Neal Flomenbaum, Mary Ann Howland, Robert S. (2006). Goldfrank's toxicologic emergencies. p. 243.
  5. ^ a b c Narimatsu E, Niiya T, Kawamata M, Namiki A (2006). "[The mechanisms of depression by benzodiazepines, barbiturates and propofol of excitatory synaptic transmissions mediated by adenosine neuromodulation]". Masui. 55 (6): 684–691. PMID 16780077.
  6. ^ Tohdoh Y, Narimatsu E, Kawamata M, Namiki A (2000). "The involvement of adenosine neuromodulation in pentobarbital-induced field excitatory postsynaptic potentials depression in rat hippocampal slices". Anesth Analg. 91 (6): 1537–1541. doi:10.1097/00000539-200012000-00044. PMID 11094014.
  7. ^ Patel J, Marangos PJ, Skolnick P, Paul SM, Martino AM (1982). "Benzodiazepines are weak inhibitors of [3H]nitrobenzylthioinosine binding to adenosine uptake sites in brain". Neurosci Lett. 29 (1): 79–82. doi:10.1016/0304-3940(82)90368-8. PMID 7070715. S2CID 39089007.
  8. ^ York MJ, Davies LP (1982). "The effect of diazepam on adenosine uptake and adenosine-stimulated adenylate cyclase in guinea-pig brain". Can J Physiol Pharmacol. 60 (3): 302–307. doi:10.1139/y82-041. PMID 6280826.
  9. ^ Ujfalusi A, Cseppentö A, Nagy E, Szabó JZ, Kovács P, Szentmiklósi AJ (1999). "Sensitization by chronic diazepam treatment of A2A adenosine receptor-mediated relaxation in rat pulmonary artery". Life Sci. 64 (2): PL19–25. doi:10.1016/S0024-3205(98)00547-5. PMID 10069495.
  10. ^ Narimatsu E, Niiya T, Kawamata M, Namiki A (2008). "Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A(1) receptors in isolated rat diaphragms". Acta Anaesthesiol Scand. 52 (10): 1415–1422. doi:10.1111/j.1399-6576.2008.01714.x. PMID 19025536. S2CID 21837865.
  11. ^ Bender AS, Hertz L (1986). "Similarities of adenosine uptake systems in astrocytes and neurons in primary cultures". Neurochem Res. 11 (11): 1507–1524. doi:10.1007/BF00965770. PMID 2891057. S2CID 8585637.
  12. ^ O'Regan MH, Phillis JW (1988). "Potentiation of adenosine-evoked depression of rat cerebral cortical neurons by triazolam". Brain Res. 445 (2): 376–379. doi:10.1016/0006-8993(88)91203-6. PMID 3370471. S2CID 33550022.
  13. ^ a b Phillis JW, Delong RE (1984). "A purinergic component in the central actions of meprobamate". Eur J Pharmacol. 101 (3–4): 295–297. doi:10.1016/0014-2999(84)90174-2. PMID 6468504.
  14. ^ a b DeLong RE, Phillis JW, Barraco RA (1985). "A possible role of endogenous adenosine in the sedative action of meprobamate". Eur J Pharmacol. 118 (3): 359–362. doi:10.1016/0014-2999(85)90149-9. PMID 4085561.
  15. ^ Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH (2009). "[Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies". J Pharmacol Exp Ther. 329 (2): 827–837. doi:10.1124/jpet.109.151142. PMC 2672873. PMID 19244096.
  16. ^ Wang S, Cone J, Fong M, Yoshitake M, Kambayashi Ji, Liu Y (2001). "Interplay between inhibition of adenosine uptake and phosphodiesterase type 3 on cardiac function by cilostazol, an agent to treat intermittent claudication". J Cardiovasc Pharmacol. 38 (5): 775–783. doi:10.1097/00005344-200111000-00014. PMID 11602824.
  17. ^ a b c d e Phillis JW, Wu PH (1982). "The effect of various centrally active drugs on adenosine uptake by the central nervous system". Comp Biochem Physiol C. 72 (2): 179–187. doi:10.1016/0306-4492(82)90082-X. PMID 6128137.
  18. ^ a b Phillis J.W. (1984). "Potentiation of the action of adenosine on cerebral cortical neurones by the tricyclic antidepressants". Br J Pharmacol. 83 (2): 567–575. doi:10.1111/j.1476-5381.1984.tb16521.x. PMC 1987110. PMID 6487906.
  19. ^ Stein MB, Black B, Brown TM, Uhde TW (1993). "Lack of efficacy of the adenosine reuptake inhibitor dipyridamole in the treatment of anxiety disorders". Biol Psychiatry. 33 (8–9): 647–650. doi:10.1016/0006-3223(93)90105-M. PMID 8329495. S2CID 54364716.
  20. ^ a b Phillis JW, Bender AS, Marszalec W (1985). "Estradiol and progesterone potentiate adenosine's depressant action on rat cerebral cortical neurons". Gen Pharmacol. 16 (6): 609–612. doi:10.1016/0306-3623(85)90151-x. PMID 2935451.
  21. ^ Allen-Gipson DS, Jarrell JC, Bailey KL, Robinson JE, Kharbanda KK, Sisson JH, Wyatt TA (2009). "Ethanol Blocks Adenosine Uptake via Inhibiting the Nucleoside Transport System in Bronchial Epithelial Cells". Alcohol Clin Exp Res. 33 (5): 791–8. doi:10.1111/j.1530-0277.2009.00897.x. PMC 2940831. PMID 19298329.
  22. ^ Verma A, Houston M, Marangos PJ (1985). "Solubilization of an adenosine uptake site in brain". J Neurochem. 45 (2): 596–603. doi:10.1111/j.1471-4159.1985.tb04028.x. PMID 2989430. S2CID 42431981.
  23. ^ a b Phillis JW, Wu PH, Coffin VL (1983). "Inhibition of adenosine uptake into rat brain synaptosomes by prostaglandins, benzodiazepines and other centrally active compounds". Gen Pharmacol. 14 (5): 475–479. doi:10.1016/0306-3623(83)90106-4. PMID 6416920.
  24. ^ Ngai AC, Monsen MR, Ibayashi S, Ko KR, Winn HR (1989). "Effect of inosine on pial arterioles: potentiation of adenosine-induced vasodilation". Am J Physiol. 256 (3 (Pt2)): H603–H606. doi:10.1152/ajpheart.1989.256.3.H603. PMID 2923227.
  25. ^ Noji T, Nan-ya K, Mizutani M, Katagiri C, Sano J, Takada C, Nishikawa S, Karasawa A, Kusaka H (2002). "KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice". Eur J Pharmacol. 454 (1): 85–93. doi:10.1016/S0014-2999(02)02476-7. PMID 12409009.
  26. ^ Lee CM, Cheung WT (1985). "Inhibitory effect of adenosine on electrically evoked contractions in the rat vas deferens: pharmacological characterization". Neurosci Lett. 59 (1): 47–52. doi:10.1016/0304-3940(85)90213-7. PMID 2995881. S2CID 42019444.
  27. ^ Marangos PJ, Patel J, Clark-Rosenberg R, Martino AM (1982). "[3H]nitrobenzylthioinosine binding as a probe for the study of adenosine uptake sites in brain". J. Neurochem. 39 (1): 184–191. doi:10.1111/j.1471-4159.1982.tb04717.x. PMID 7086410. S2CID 25920625.
  28. ^ Coffin VL, Taylor JA, Phillis JW, Altman HJ, Barraco RA (1984). "Behavioral interaction of adenosine and methylxanthines on central purinergic systems". Neurosci Lett. 47 (2): 91–98. doi:10.1016/0304-3940(84)90412-9. PMID 6205333. S2CID 19628381.
  29. ^ Shi D, Daly JW (1999). "Chronic effects of xanthines on levels of central receptors in mice". Cell Mol Neurobiol. 19 (6): 719–732. doi:10.1023/A:1006901005925. PMID 10456233. S2CID 10644334.
  30. ^ Phillis J.W. (1985). "Chlorpromazine and trifluoperazine potentiate the action of adenosine on rat cerebral cortical neurons". Gen Pharmacol. 16 (1): 19–24. doi:10.1016/0306-3623(85)90264-2. PMID 2984085.
  31. ^ Phillis J.W. (1984). "Interactions of the anticonvulsants diphenylhydantoin and carbamazepine with adenosine on cerebral cortical neurons". Epilepsia. 25 (6): 765–772. doi:10.1111/j.1528-1157.1984.tb03489.x. PMID 6510384. S2CID 30358234.
  32. ^ Andiné P, Rudolphi KA, Fredholm BB, Hagberg H (1990). "Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia". Br J Pharmacol. 100 (4): 814–818. doi:10.1111/j.1476-5381.1990.tb14097.x. PMC 1917600. PMID 2207501.
  33. ^ Ohmori H, Sato Y, Namiki A (2004). "The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices". Anesth Analg. 99 (4): 1095–1101. doi:10.1213/01.ANE.0000130356.22414.2B. PMID 15385357.
  34. ^ Noji T, Nan-ya K, Katagiri C, Mizutani M, Sano J, Nishikawa S, Karasawa A, Kusaka H (2002). "Adenosine uptake inhibition ameliorates cerulein-induced acute pancreatitis in mice". Pancreas. 25 (4): 387–392. doi:10.1097/00006676-200211000-00011. PMID 12409834. S2CID 24260175.
  35. ^ Gresele P, Arnout J, Deckmyn H, Vermylen J (1986). "Mechanism of the antiplatelet action of dipyridamole in whole blood: modulation of adenosine concentration and activity". Thromb Haemost. 55 (1): 12–18. doi:10.1055/s-0038-1661437. PMID 3704998. S2CID 7318055.
  36. ^ Bauman LA, Mahle CD, Boissard CG, Gribkoff VK (1992). "Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices". J Neurophysiol. 68 (2): 629–638. doi:10.1152/jn.1992.68.2.629. PMID 1388201.
  37. ^ Boissard CG, Gribkoff VK (1993). "The effects of the adenosine reuptake inhibitor soluflazine on synaptic potentials and population hypoxic depolarizations in area CA1 of rat hippocampus in vitro". Neuropharmacology. 32 (2): 149–155. doi:10.1016/0028-3908(93)90095-K. PMID 8383814. S2CID 10716297.

March 14, 2024
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An adenosine reuptake inhibitor AdoRI is a type of drug which acts as a reuptake inhibitor for the purine nucleoside and neurotransmitter adenosine by blocking the action of one or more of the equilibrative nucleoside transporters ENTs 1 2 3 This in turn leads to increased extracellular concentrations of adenosine and therefore an increase in adenosinergic neurotransmission Adenosine Main article Reuptake inhibitorList of AdoRIs editAcadesine 4 Acetate 4 Barbiturates 5 6 Benzodiazepines 5 7 8 9 10 11 12 Calcium channel blockers 4 Carbamazepine 4 Carisoprodol 13 14 15 Cilostazol 16 Cyclobenzaprine 17 18 Dilazep 1 Dipyridamole 1 19 Estradiol 20 Ethanol 21 Flumazenil 4 Hexobendine 22 Hydroxyzine 23 Indomethacin 4 Inosine 24 KF24345 25 Meprobamate 13 14 Nitrobenzylthioguanosine 26 Nitrobenzylthioinosine 1 27 Papaverine 28 Pentoxifylline 29 Phenothiazines 17 30 Phenytoin 31 Progesterone 20 Propentofylline 32 Propofol 5 33 Puromycin 17 R75231 34 RE 102 BS 35 Soluflazine 36 37 Toyocamycin 17 Tracazolate 23 Tricyclic antidepressants 17 18 See also editAdenosinergic Reuptake inhibitorReferences edit a b c d SenGupta DJ Unadkat JD 2004 Glycine 154 of the equilibrative nucleoside transporter hENT1 is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine dipyridamole and dilazep Biochem Pharmacol 67 3 453 458 doi 10 1016 j bcp 2003 09 018 PMID 15037197 Endres CJ Sengupta DJ Unadkat JD 2004 Mutation of leucine 92 selectively reduces the apparent affinity of inosine guanosine NBMPR S6 4 nitrobenzyl mercaptopurine riboside and dilazep for the human equilibrative nucleoside transporter hENT1 Biochem J 380 1 131 137 doi 10 1042 BJ20031880 PMC 1224139 PMID 14759222 Chaudary N Naydenova Z Shuralyova I Coe IR 2004 The adenosine transporter mENT1 is a target for adenosine receptor signaling and protein kinase Cepsilon in hypoxic and pharmacological preconditioning in the mouse cardiomyocyte cell line HL 1 J Pharmacol Exp Ther 310 3 1190 1198 doi 10 1124 jpet 104 067157 PMID 15131243 S2CID 21804556 a b c d e f Goldfrank LR Neal Flomenbaum Mary Ann Howland Robert S 2006 Goldfrank s toxicologic emergencies p 243 a b c Narimatsu E Niiya T Kawamata M Namiki A 2006 The mechanisms of depression by benzodiazepines barbiturates and propofol of excitatory synaptic transmissions mediated by adenosine neuromodulation Masui 55 6 684 691 PMID 16780077 Tohdoh Y Narimatsu E Kawamata M Namiki A 2000 The involvement of adenosine neuromodulation in pentobarbital induced field excitatory postsynaptic potentials depression in rat hippocampal slices Anesth Analg 91 6 1537 1541 doi 10 1097 00000539 200012000 00044 PMID 11094014 Patel J Marangos PJ Skolnick P Paul SM Martino AM 1982 Benzodiazepines are weak inhibitors of 3H nitrobenzylthioinosine binding to adenosine uptake sites in brain Neurosci Lett 29 1 79 82 doi 10 1016 0304 3940 82 90368 8 PMID 7070715 S2CID 39089007 York MJ Davies LP 1982 The effect of diazepam on adenosine uptake and adenosine stimulated adenylate cyclase in guinea pig brain Can J Physiol Pharmacol 60 3 302 307 doi 10 1139 y82 041 PMID 6280826 Ujfalusi A Cseppento A Nagy E Szabo JZ Kovacs P Szentmiklosi AJ 1999 Sensitization by chronic diazepam treatment of A2A adenosine receptor mediated relaxation in rat pulmonary artery Life Sci 64 2 PL19 25 doi 10 1016 S0024 3205 98 00547 5 PMID 10069495 Narimatsu E Niiya T Kawamata M Namiki A 2008 Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A 1 receptors in isolated rat diaphragms Acta Anaesthesiol Scand 52 10 1415 1422 doi 10 1111 j 1399 6576 2008 01714 x PMID 19025536 S2CID 21837865 Bender AS Hertz L 1986 Similarities of adenosine uptake systems in astrocytes and neurons in primary cultures Neurochem Res 11 11 1507 1524 doi 10 1007 BF00965770 PMID 2891057 S2CID 8585637 O Regan MH Phillis JW 1988 Potentiation of adenosine evoked depression of rat cerebral cortical neurons by triazolam Brain Res 445 2 376 379 doi 10 1016 0006 8993 88 91203 6 PMID 3370471 S2CID 33550022 a b Phillis JW Delong RE 1984 A purinergic component in the central actions of meprobamate Eur J Pharmacol 101 3 4 295 297 doi 10 1016 0014 2999 84 90174 2 PMID 6468504 a b DeLong RE Phillis JW Barraco RA 1985 A possible role of endogenous adenosine in the sedative action of meprobamate Eur J Pharmacol 118 3 359 362 doi 10 1016 0014 2999 85 90149 9 PMID 4085561 Gonzalez LA Gatch MB Taylor CM Bell Horner CL Forster MJ Dillon GH 2009 Carisoprodol mediated modulation of GABAA receptors in vitro and in vivo studies J Pharmacol Exp Ther 329 2 827 837 doi 10 1124 jpet 109 151142 PMC 2672873 PMID 19244096 Wang S Cone J Fong M Yoshitake M Kambayashi Ji Liu Y 2001 Interplay between inhibition of adenosine uptake and phosphodiesterase type 3 on cardiac function by cilostazol an agent to treat intermittent claudication J Cardiovasc Pharmacol 38 5 775 783 doi 10 1097 00005344 200111000 00014 PMID 11602824 a b c d e Phillis JW Wu PH 1982 The effect of various centrally active drugs on adenosine uptake by the central nervous system Comp Biochem Physiol C 72 2 179 187 doi 10 1016 0306 4492 82 90082 X PMID 6128137 a b Phillis J W 1984 Potentiation of the action of adenosine on cerebral cortical neurones by the tricyclic antidepressants Br J Pharmacol 83 2 567 575 doi 10 1111 j 1476 5381 1984 tb16521 x PMC 1987110 PMID 6487906 Stein MB Black B Brown TM Uhde TW 1993 Lack of efficacy of the adenosine reuptake inhibitor dipyridamole in the treatment of anxiety disorders Biol Psychiatry 33 8 9 647 650 doi 10 1016 0006 3223 93 90105 M PMID 8329495 S2CID 54364716 a b Phillis JW Bender AS Marszalec W 1985 Estradiol and progesterone potentiate adenosine s depressant action on rat cerebral cortical neurons Gen Pharmacol 16 6 609 612 doi 10 1016 0306 3623 85 90151 x PMID 2935451 Allen Gipson DS Jarrell JC Bailey KL Robinson JE Kharbanda KK Sisson JH Wyatt TA 2009 Ethanol Blocks Adenosine Uptake via Inhibiting the Nucleoside Transport System in Bronchial Epithelial Cells Alcohol Clin Exp Res 33 5 791 8 doi 10 1111 j 1530 0277 2009 00897 x PMC 2940831 PMID 19298329 Verma A Houston M Marangos PJ 1985 Solubilization of an adenosine uptake site in brain J Neurochem 45 2 596 603 doi 10 1111 j 1471 4159 1985 tb04028 x PMID 2989430 S2CID 42431981 a b Phillis JW Wu PH Coffin VL 1983 Inhibition of adenosine uptake into rat brain synaptosomes by prostaglandins benzodiazepines and other centrally active compounds Gen Pharmacol 14 5 475 479 doi 10 1016 0306 3623 83 90106 4 PMID 6416920 Ngai AC Monsen MR Ibayashi S Ko KR Winn HR 1989 Effect of inosine on pial arterioles potentiation of adenosine induced vasodilation Am J Physiol 256 3 Pt2 H603 H606 doi 10 1152 ajpheart 1989 256 3 H603 PMID 2923227 Noji T Nan ya K Mizutani M Katagiri C Sano J Takada C Nishikawa S Karasawa A Kusaka H 2002 KF24345 an adenosine uptake inhibitor ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice Eur J Pharmacol 454 1 85 93 doi 10 1016 S0014 2999 02 02476 7 PMID 12409009 Lee CM Cheung WT 1985 Inhibitory effect of adenosine on electrically evoked contractions in the rat vas deferens pharmacological characterization Neurosci Lett 59 1 47 52 doi 10 1016 0304 3940 85 90213 7 PMID 2995881 S2CID 42019444 Marangos PJ Patel J Clark Rosenberg R Martino AM 1982 3H nitrobenzylthioinosine binding as a probe for the study of adenosine uptake sites in brain J Neurochem 39 1 184 191 doi 10 1111 j 1471 4159 1982 tb04717 x PMID 7086410 S2CID 25920625 Coffin VL Taylor JA Phillis JW Altman HJ Barraco RA 1984 Behavioral interaction of adenosine and methylxanthines on central purinergic systems Neurosci Lett 47 2 91 98 doi 10 1016 0304 3940 84 90412 9 PMID 6205333 S2CID 19628381 Shi D Daly JW 1999 Chronic effects of xanthines on levels of central receptors in mice Cell Mol Neurobiol 19 6 719 732 doi 10 1023 A 1006901005925 PMID 10456233 S2CID 10644334 Phillis J W 1985 Chlorpromazine and trifluoperazine potentiate the action of adenosine on rat cerebral cortical neurons Gen Pharmacol 16 1 19 24 doi 10 1016 0306 3623 85 90264 2 PMID 2984085 Phillis J W 1984 Interactions of the anticonvulsants diphenylhydantoin and carbamazepine with adenosine on cerebral cortical neurons Epilepsia 25 6 765 772 doi 10 1111 j 1528 1157 1984 tb03489 x PMID 6510384 S2CID 30358234 Andine P Rudolphi KA Fredholm BB Hagberg H 1990 Effect of propentofylline HWA 285 on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia Br J Pharmacol 100 4 814 818 doi 10 1111 j 1476 5381 1990 tb14097 x PMC 1917600 PMID 2207501 Ohmori H Sato Y Namiki A 2004 The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices Anesth Analg 99 4 1095 1101 doi 10 1213 01 ANE 0000130356 22414 2B PMID 15385357 Noji T Nan ya K Katagiri C Mizutani M Sano J Nishikawa S Karasawa A Kusaka H 2002 Adenosine uptake inhibition ameliorates cerulein induced acute pancreatitis in mice Pancreas 25 4 387 392 doi 10 1097 00006676 200211000 00011 PMID 12409834 S2CID 24260175 Gresele P Arnout J Deckmyn H Vermylen J 1986 Mechanism of the antiplatelet action of dipyridamole in whole blood modulation of adenosine concentration and activity Thromb Haemost 55 1 12 18 doi 10 1055 s 0038 1661437 PMID 3704998 S2CID 7318055 Bauman LA Mahle CD Boissard CG Gribkoff VK 1992 Age dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices J Neurophysiol 68 2 629 638 doi 10 1152 jn 1992 68 2 629 PMID 1388201 Boissard CG Gribkoff VK 1993 The effects of the adenosine reuptake inhibitor soluflazine on synaptic potentials and population hypoxic depolarizations in area CA1 of rat hippocampus in vitro Neuropharmacology 32 2 149 155 doi 10 1016 0028 3908 93 90095 K PMID 8383814 S2CID 10716297 Retrieved from https en wikipedia org w index php title Adenosine reuptake inhibitor amp oldid 1213032636, 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