This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lungepithelium.[7] In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain.[7] Zinc-alpha-2-glycoprotein levels also rise with onset of diabetes 2, which accounts for weight loss thereafter.[citation needed]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000160862 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037053 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ueyama H, Niwa M, Tada T, Sasaki M, Ohkubo I (Jul 1991). "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene". Biochem Biophys Res Commun. 177 (2): 696–703. doi:10.1016/0006-291X(91)91844-3. PMID 2049092.
^ abVanni H, Kazeros A, Wang R, Harvey BG, Ferris B, De BP, Carolan BJ, Hübner RH, et al. (2009). "Cigarette Smoking Induces Overexpression of a Fat-Depleting Gene AZGP1 in the Human". Chest. 135 (5): 1197–208. doi:10.1378/chest.08-1024. PMC2679098. PMID 19188554.
External linksedit
Human AZGP1 genome location and AZGP1 gene details page in the UCSC Genome Browser.
Further readingedit
Freije JP, Fueyo A, Uría J, López-Otín C (1991). "Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues". FEBS Lett. 290 (1–2): 247–9. doi:10.1016/0014-5793(91)81271-9. PMID 1915885. S2CID 2058665.
Tada T, Ohkubo I, Niwa M, et al. (1991). "Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues". J. Histochem. Cytochem. 39 (9): 1221–6. doi:10.1177/39.9.1918940. PMID 1918940. S2CID 687025.
Araki T, Gejyo F, Takagaki K, et al. (1988). "Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens". Proc. Natl. Acad. Sci. U.S.A. 85 (3): 679–83. doi:10.1073/pnas.85.3.679. PMC279618. PMID 3422450.
Shibata S, Miura K (1982). "Nephritogenic glycoprotein. IX. Plasma Zn-alpha2-glycoprotein as a second source of nephritogenic glycoprotein in urine". Nephron. 31 (2): 170–6. doi:10.1159/000182638. PMID 6896906.
Ueyama H, Deng HX, Ohkubo I (1994). "Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein". Biochemistry. 32 (48): 12968–76. doi:10.1021/bi00211a004. PMID 8241150.
Freije JP, Fueyo A, Uría JA, et al. (1994). "Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes". Genomics. 18 (3): 575–87. doi:10.1016/S0888-7543(05)80359-3. PMID 8307568.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sánchez LM, López-Otín C, Bjorkman PJ (1997). "Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4626–30. doi:10.1073/pnas.94.9.4626. PMC20774. PMID 9114041.
Brysk MM, Lei G, Rajaraman S, et al. (1997). "Gene expression of zinc-alpha 2-glycoprotein in normal human epidermal and buccal epithelia". In Vivo. 11 (3): 271–4. PMID 9239523.
Lei G, Arany I, Selvanayagam P, et al. (1997). "Detection and cloning of epidermal zinc-alpha 2-glycoprotein cDNA and expression in normal human skin and in tumors". J. Cell. Biochem. 67 (2): 216–22. doi:10.1002/(SICI)1097-4644(19971101)67:2<216::AID-JCB6>3.0.CO;2-#. PMID 9328826. S2CID 196585165.
Ogikubo O, Maeda T, Yamane T, et al. (1998). "Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives". Biochem. Biophys. Res. Commun. 252 (1): 257–62. doi:10.1006/bbrc.1998.9614. PMID 9813179.
Sánchez LM, Chirino AJ, Bjorkman P (1999). "Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules". Science. 283 (5409): 1914–9. Bibcode:1999Sci...283.1914S. doi:10.1126/science.283.5409.1914. PMID 10206894.
Lei G, Brysk H, Arany I, et al. (1999). "Characterization of zinc-alpha(2)-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line". J. Cell. Biochem. 75 (1): 160–9. doi:10.1002/(SICI)1097-4644(19991001)75:1<160::AID-JCB16>3.0.CO;2-B. PMID 10462714. S2CID 11549967.
Davidsson P, Nilsson CL (2000). "Peptide mapping of proteins in cerebrospinal fluid utilizing a rapid preparative two-dimensional electrophoretic procedure and matrix-assisted laser desorption/ionization mass spectrometry". Biochim. Biophys. Acta. 1473 (2–3): 391–9. doi:10.1016/s0304-4165(99)00197-x. PMID 10594376.
Kennedy MW, Heikema AP, Cooper A, et al. (2001). "Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins". J. Biol. Chem. 276 (37): 35008–13. doi:10.1074/jbc.C100301200. PMID 11425849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
BURGI W, SCHMID K (1998). "Preparation and properties of Zn-alpha 2-glycoprotein of normal human plasma". J. Biol. Chem. 236 (4): 1066–74. doi:10.1016/S0021-9258(18)64243-7. PMID 13689030.
This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
azgp1, zinc, alpha, glycoprotein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1t7v, 1t7w, 1t7x, 1t7y, 1t7z, 1t80, 1zag, 3es6identifiersaliases, za2g, alpha, glycoprotein, zinc, bindingexternal, idsomim, . Zinc alpha 2 glycoprotein is a protein that in humans is encoded by the AZGP1 gene 5 6 AZGP1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1T7V 1T7W 1T7X 1T7Y 1T7Z 1T80 1ZAG 3ES6IdentifiersAliasesAZGP1 ZA2G ZAG alpha 2 glycoprotein 1 zinc bindingExternal IDsOMIM 194460 MGI 103163 HomoloGene 915 GeneCards AZGP1Gene location Human Chr Chromosome 7 human 1 Band7q22 1Start99 966 720 bp 1 End99 976 042 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 G2 5 76 92 cMStart137 979 782 bp 2 End137 988 495 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inparotid glandright lobe of livertracheabody of pancreaslactiferous ductskin of abdomenprostateminor salivary glandsurethranippleTop expressed inleft lobe of livergallbladderlacrimal glandsuperior surface of tongueparotid glandproximal tubuleolfactory epitheliumepithelium of stomachkidneypyloric antrumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein transmembrane transporter activity ribonuclease activity protein bindingCellular componentplasma membrane extracellular exosome nucleus extracellular space extracellular matrix extracellular region collagen containing extracellular matrix external side of plasma membraneBiological processdetection of chemical stimulus involved in sensory perception of bitter taste retina homeostasis cell adhesion transmembrane transport negative regulation of cell population proliferation protein transmembrane transport RNA phosphodiester bond hydrolysis immune responseSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez56312007EnsemblENSG00000160862ENSMUSG00000037053UniProtP25311Q64726RefSeq mRNA NM 001185NM 013478RefSeq protein NP 001176NP 038506Location UCSC Chr 7 99 97 99 98 MbChr 5 137 98 137 99 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This gene expresses a soluble protein that stimulates lipolysis induces a reduction in body fat in mice is associated with the cachexia related to cancer and is known to be expressed in secretory cells of lung epithelium 7 In 2009 it was found that smoking increases expression of this gene which is why smoking cessation leads to weight gain 7 Zinc alpha 2 glycoprotein levels also rise with onset of diabetes 2 which accounts for weight loss thereafter citation needed References edit a b c GRCh38 Ensembl release 89 ENSG00000160862 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000037053 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ueyama H Niwa M Tada T Sasaki M Ohkubo I Jul 1991 Cloning and nucleotide sequence of a human Zn alpha 2 glycoprotein cDNA and chromosomal assignment of its gene Biochem Biophys Res Commun 177 2 696 703 doi 10 1016 0006 291X 91 91844 3 PMID 2049092 Entrez Gene AZGP1 alpha 2 glycoprotein 1 zinc binding a b Vanni H Kazeros A Wang R Harvey BG Ferris B De BP Carolan BJ Hubner RH et al 2009 Cigarette Smoking Induces Overexpression of a Fat Depleting Gene AZGP1 in the Human Chest 135 5 1197 208 doi 10 1378 chest 08 1024 PMC 2679098 PMID 19188554 External links editHuman AZGP1 genome location and AZGP1 gene details page in the UCSC Genome Browser Further reading editFreije JP Fueyo A Uria J Lopez Otin C 1991 Human Zn alpha 2 glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues FEBS Lett 290 1 2 247 9 doi 10 1016 0014 5793 91 81271 9 PMID 1915885 S2CID 2058665 Tada T Ohkubo I Niwa M et al 1991 Immunohistochemical localization of Zn alpha 2 glycoprotein in normal human tissues J Histochem Cytochem 39 9 1221 6 doi 10 1177 39 9 1918940 PMID 1918940 S2CID 687025 Araki T Gejyo F Takagaki K et al 1988 Complete amino acid sequence of human plasma Zn alpha 2 glycoprotein and its homology to histocompatibility antigens Proc Natl Acad Sci U S A 85 3 679 83 doi 10 1073 pnas 85 3 679 PMC 279618 PMID 3422450 Shibata S Miura K 1982 Nephritogenic glycoprotein IX Plasma Zn alpha2 glycoprotein as a second source of nephritogenic glycoprotein in urine Nephron 31 2 170 6 doi 10 1159 000182638 PMID 6896906 Ueyama H Deng HX Ohkubo I 1994 Molecular cloning and chromosomal assignment of the gene for human Zn alpha 2 glycoprotein Biochemistry 32 48 12968 76 doi 10 1021 bi00211a004 PMID 8241150 Freije JP Fueyo A Uria JA et al 1994 Human Zn alpha 2 glycoprotein complete genomic sequence identification of a related pseudogene and relationship to class I major histocompatibility complex genes Genomics 18 3 575 87 doi 10 1016 S0888 7543 05 80359 3 PMID 8307568 Bonaldo MF Lennon G Soares MB 1997 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Sanchez LM Lopez Otin C Bjorkman PJ 1997 Biochemical characterization and crystalization of human Zn alpha2 glycoprotein a soluble class I major histocompatibility complex homolog Proc Natl Acad Sci U S A 94 9 4626 30 doi 10 1073 pnas 94 9 4626 PMC 20774 PMID 9114041 Brysk MM Lei G Rajaraman S et al 1997 Gene expression of zinc alpha 2 glycoprotein in normal human epidermal and buccal epithelia In Vivo 11 3 271 4 PMID 9239523 Lei G Arany I Selvanayagam P et al 1997 Detection and cloning of epidermal zinc alpha 2 glycoprotein cDNA and expression in normal human skin and in tumors J Cell Biochem 67 2 216 22 doi 10 1002 SICI 1097 4644 19971101 67 2 lt 216 AID JCB6 gt 3 0 CO 2 PMID 9328826 S2CID 196585165 Ogikubo O Maeda T Yamane T et al 1998 Regulation of Zn alpha2 glycoprotein mediated cell adhesion by kininogens and their derivatives Biochem Biophys Res Commun 252 1 257 62 doi 10 1006 bbrc 1998 9614 PMID 9813179 Sanchez LM Chirino AJ Bjorkman P 1999 Crystal structure of human ZAG a fat depleting factor related to MHC molecules Science 283 5409 1914 9 Bibcode 1999Sci 283 1914S doi 10 1126 science 283 5409 1914 PMID 10206894 Lei G Brysk H Arany I et al 1999 Characterization of zinc alpha 2 glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line J Cell Biochem 75 1 160 9 doi 10 1002 SICI 1097 4644 19991001 75 1 lt 160 AID JCB16 gt 3 0 CO 2 B PMID 10462714 S2CID 11549967 Davidsson P Nilsson CL 2000 Peptide mapping of proteins in cerebrospinal fluid utilizing a rapid preparative two dimensional electrophoretic procedure and matrix assisted laser desorption ionization mass spectrometry Biochim Biophys Acta 1473 2 3 391 9 doi 10 1016 s0304 4165 99 00197 x PMID 10594376 Kennedy MW Heikema AP Cooper A et al 2001 Hydrophobic ligand binding by Zn alpha 2 glycoprotein a soluble fat depleting factor related to major histocompatibility complex proteins J Biol Chem 276 37 35008 13 doi 10 1074 jbc C100301200 PMID 11425849 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Scherer SW Cheung J MacDonald JR et al 2003 Human chromosome 7 DNA sequence and biology Science 300 5620 767 72 Bibcode 2003Sci 300 767S doi 10 1126 science 1083423 PMC 2882961 PMID 12690205 Hillier LW Fulton RS Fulton LA et al 2003 The DNA sequence of human chromosome 7 Nature 424 6945 157 64 Bibcode 2003Natur 424 157H doi 10 1038 nature01782 PMID 12853948 BURGI W SCHMID K 1998 Preparation and properties of Zn alpha 2 glycoprotein of normal human plasma J Biol Chem 236 4 1066 74 doi 10 1016 S0021 9258 18 64243 7 PMID 13689030 nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title AZGP1 amp oldid 1213345840, wikipedia, wiki, book, books, library,
