This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicleproton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits, plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d.
Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes, or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain, and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000117410 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000033379 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nishigori H, Yamada S, Tomura H, Fernald AA, Le Beau MM, Takeuchi T, Takeda J (Oct 1998). "Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F)". Genomics. 50 (2): 222–8. doi:10.1006/geno.1998.5310. PMID 9653649.
Human ATP6V0B genome location and ATP6V0B gene details page in the UCSC Genome Browser.
Further readingedit
Finbow ME, Harrison MA (1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes". Biochem. J. 324 (3): 697–712. doi:10.1042/bj3240697. PMC1218484. PMID 9210392.
Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annu. Rev. Cell Dev. Biol. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
Nelson N, Harvey WR (1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases". Physiol. Rev. 79 (2): 361–85. doi:10.1152/physrev.1999.79.2.361. PMID 10221984. S2CID 1477911.
Forgac M (1999). "Structure and properties of the vacuolar (H+)-ATPases". J. Biol. Chem. 274 (19): 12951–4. doi:10.1074/jbc.274.19.12951. PMID 10224039.
Kane PM (1999). "Introduction: V-ATPases 1992-1998". J. Bioenerg. Biomembr. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID 10340843.
Wieczorek H, Brown D, Grinstein S, et al. (1999). "Animal plasma membrane energization by proton-motive V-ATPases". BioEssays. 21 (8): 637–48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860. S2CID 23505139.
Nishi T, Forgac M (2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nat. Rev. Mol. Cell Biol. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511. S2CID 21122465.
Kawasaki-Nishi S, Nishi T, Forgac M (2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Lett. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495. S2CID 10507213.
Morel N (2004). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biol. Cell. 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Izumi H, Ise T, Murakami T, et al. (2003). "Structural and functional characterization of two human V-ATPase subunit gene promoters". Biochim. Biophys. Acta. 1628 (2): 97–104. doi:10.1016/S0167-4781(03)00119-2. PMID 12890556.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
atp6v0b, type, proton, atpase, proteolipid, subunit, enzyme, that, humans, encoded, gene, identifiersaliases, atp6f, hatpl, vma16, atpase, transporting, subunit, bexternal, idsomim, 603717, 1890510, homologene, 2986, genecards, gene, location, human, chromosom. V type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene 5 6 ATP6V0BIdentifiersAliasesATP6V0B ATP6F HATPL VMA16 ATPase H transporting V0 subunit bExternal IDsOMIM 603717 MGI 1890510 HomoloGene 2986 GeneCards ATP6V0BGene location Human Chr Chromosome 1 human 1 Band1p34 1Start43 974 487 bp 1 End43 978 295 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 4 D1Start117 741 523 bp 2 End117 744 530 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inanterior pituitarymonocyteprefrontal cortexbody of pancreasbloodperiodontal fiberright adrenal glandleft adrenal glandislet of Langerhanscingulate gyrusTop expressed infacial motor nucleussuperior frontal gyrusentorhinal cortexanterior horn of spinal cordcerebellar cortexbarrel cortexRegion I of hippocampus properretinal pigment epitheliumyolk saclacrimal glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionproton transmembrane transporter activity proton transporting ATPase activity rotational mechanism transporter activityCellular componentvacuole vacuolar membrane membrane vacuolar proton transporting V type ATPase V0 domain proton transporting V type ATPase V0 domain phagocytic vesicle membrane endosome membrane proton transporting two sector ATPase complex proton transporting domain integral component of membraneBiological processregulation of macroautophagy vacuolar acidification ion transmembrane transport insulin receptor signaling pathway ion transport transferrin transport proton transmembrane transport phagosome acidificationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez533114143EnsemblENSG00000117410ENSMUSG00000033379UniProtQ99437Q91V37RefSeq mRNA NM 004047NM 001039457NM 001294333NM 033617RefSeq protein NP 001034546NP 001281262NP 004038NP 291095Location UCSC Chr 1 43 97 43 98 MbChr 4 117 74 117 74 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This gene encodes a component of vacuolar ATPase V ATPase a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles V ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting zymogen activation receptor mediated endocytosis and synaptic vesicle proton gradient generation V ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain The V1 domain consists of three A and three B subunits two G subunits plus the C D E F and H subunits The V1 domain contains the ATP catalytic site The V0 domain consists of five different subunits a c c c and d Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16 Two alternatively spliced transcript variants that encode different proteins have been found for this gene 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000117410 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000033379 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Nishigori H Yamada S Tomura H Fernald AA Le Beau MM Takeuchi T Takeda J Oct 1998 Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H ATPase ATP6F Genomics 50 2 222 8 doi 10 1006 geno 1998 5310 PMID 9653649 a b Entrez Gene ATP6V0B ATPase H transporting lysosomal 21kDa V0 subunit b External links editHuman ATP6V0B genome location and ATP6V0B gene details page in the UCSC Genome Browser Further reading editFinbow ME Harrison MA 1997 The vacuolar H ATPase a universal proton pump of eukaryotes Biochem J 324 3 697 712 doi 10 1042 bj3240697 PMC 1218484 PMID 9210392 Stevens TH Forgac M 1998 Structure function and regulation of the vacuolar H ATPase Annu Rev Cell Dev Biol 13 779 808 doi 10 1146 annurev cellbio 13 1 779 PMID 9442887 Nelson N Harvey WR 1999 Vacuolar and plasma membrane proton adenosinetriphosphatases Physiol Rev 79 2 361 85 doi 10 1152 physrev 1999 79 2 361 PMID 10221984 S2CID 1477911 Forgac M 1999 Structure and properties of the vacuolar H ATPases J Biol Chem 274 19 12951 4 doi 10 1074 jbc 274 19 12951 PMID 10224039 Kane PM 1999 Introduction V ATPases 1992 1998 J Bioenerg Biomembr 31 1 3 5 doi 10 1023 A 1001884227654 PMID 10340843 Wieczorek H Brown D Grinstein S et al 1999 Animal plasma membrane energization by proton motive V ATPases BioEssays 21 8 637 48 doi 10 1002 SICI 1521 1878 199908 21 8 lt 637 AID BIES3 gt 3 0 CO 2 W PMID 10440860 S2CID 23505139 Nishi T Forgac M 2002 The vacuolar H ATPases nature s most versatile proton pumps Nat Rev Mol Cell Biol 3 2 94 103 doi 10 1038 nrm729 PMID 11836511 S2CID 21122465 Kawasaki Nishi S Nishi T Forgac M 2003 Proton translocation driven by ATP hydrolysis in V ATPases FEBS Lett 545 1 76 85 doi 10 1016 S0014 5793 03 00396 X PMID 12788495 S2CID 10507213 Morel N 2004 Neurotransmitter release the dark side of the vacuolar H ATPase Biol Cell 95 7 453 7 doi 10 1016 S0248 4900 03 00075 3 PMID 14597263 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Izumi H Ise T Murakami T et al 2003 Structural and functional characterization of two human V ATPase subunit gene promoters Biochim Biophys Acta 1628 2 97 104 doi 10 1016 S0167 4781 03 00119 2 PMID 12890556 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ATP6V0B amp oldid 1115438756, wikipedia, wiki, book, books, library,
