This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000125375 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000054894 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Belogrudov GI, Hatefi Y (Feb 2002). "Factor B and the mitochondrial ATP synthase complex". J Biol Chem. 277 (8): 6097–103. doi:10.1074/jbc.M111256200. PMID 11744738.
^Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
^ ab"Entrez Gene: ATP5S ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)".
External linksedit
Human ATP5S genome location and ATP5S gene details page in the UCSC Genome Browser.
ATP5S: ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)
Further readingedit
Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine". Essays Biochem. 35: 3–18. doi:10.1042/bse0350003. PMID 12471886.
Oster G, Wang H (2003). "Rotary protein motors". Trends Cell Biol. 13 (3): 114–21. doi:10.1016/S0962-8924(03)00004-7. PMID 12628343.
Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)". Mol. Membr. Biol. 20 (1): 27–33. doi:10.1080/0968768031000066532. PMID 12745923. S2CID 218895820.
Sanadi DR, Pringle M, Kantham L, et al. (1984). "Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase". Proc. Natl. Acad. Sci. U.S.A. 81 (5): 1371–4. Bibcode:1984PNAS...81.1371S. doi:10.1073/pnas.81.5.1371. PMC344835. PMID 6143319.
Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. Bibcode:1998Natur.391..510E. doi:10.1038/35185. PMID 9461222. S2CID 4406161.
Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. Bibcode:1998Natur.396..279W. doi:10.1038/24409. PMID 9834036. S2CID 4424498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Cross RL (2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. Bibcode:2004Natur.427..407C. doi:10.1038/427407b. PMID 14749816.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.
atp5s, synthase, subunit, mitochondrial, enzyme, that, humans, encoded, gene, dmac2lidentifiersaliasesdmac2l, atpw, hsu79253, synthase, transporting, mitochondrial, complex, subunit, factor, distal, membrane, assembly, complex, like, distal, membrane, assembly. ATP synthase subunit s mitochondrial is an enzyme that in humans is encoded by the ATP5S gene 5 6 7 DMAC2LIdentifiersAliasesDMAC2L ATPW FB HSU79253 ATP synthase H transporting mitochondrial Fo complex subunit s factor B ATP5S distal membrane arm assembly complex 2 like distal membrane arm assembly component 2 likeExternal IDsMGI 1915305 HomoloGene 12232 GeneCards DMAC2LGene location Human Chr Chromosome 14 human 1 Band14q21 3Start50 312 324 bp 1 End50 335 558 bp 1 Gene location Mouse Chr Chromosome 12 mouse 2 Band12 12 C2Start69 771 724 bp 2 End69 791 434 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspermright uterine tubeendothelial celltriceps brachii muscleoocytethoracic diaphragmright ventriclehuman penismuscle of leggastrocnemius muscleTop expressed ininterventricular septumspermatidright ventriclespermatocytesternocleidomastoid muscledigastric musclemyocardium of ventricletriceps brachii muscletemporal muscleproximal tubuleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionproton transmembrane transporter activity metal ion bindingCellular componentmitochondrion membrane proton transporting ATP synthase complex coupling factor F o mitochondrial inner membraneBiological procession transport ATP biosynthetic process cristae formation proton transmembrane transport mitochondrial ATP synthesis coupled proton transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2710968055EnsemblENSG00000125375ENSMUSG00000054894UniProtQ99766Q9CRA7RefSeq mRNA NM 001003803NM 001003805NM 015684NM 001370605NM 001382507NM 001382509NM 001382510NM 026536NM 001361690NM 001361691RefSeq protein NP 001003803NP 001003805NP 056499NP 001357534NP 001369436NP 001369438NP 001369439NP 080812NP 001348619NP 001348620Location UCSC Chr 14 50 31 50 34 MbChr 12 69 77 69 79 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This gene encodes a subunit of mitochondrial ATP synthase Mitochondrial ATP synthase catalyzes ATP synthesis utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation ATP synthase is composed of two linked multi subunit complexes the soluble catalytic core F1 and the membrane spanning component Fo comprising the proton channel This gene encodes the subunit s also known as factor B of the proton channel This subunit is necessary for the energy transduction activity of the ATP synthase complexes Alternatively spliced transcript variants encoding different isoforms have been identified 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000125375 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000054894 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Belogrudov GI Hatefi Y Feb 2002 Factor B and the mitochondrial ATP synthase complex J Biol Chem 277 8 6097 103 doi 10 1074 jbc M111256200 PMID 11744738 Andersson B Wentland MA Ricafrente JY Liu W Gibbs RA Jun 1996 A double adaptor method for improved shotgun library construction Anal Biochem 236 1 107 13 doi 10 1006 abio 1996 0138 PMID 8619474 a b Entrez Gene ATP5S ATP synthase H transporting mitochondrial F0 complex subunit s factor B External links editHuman ATP5S genome location and ATP5S gene details page in the UCSC Genome Browser ATP5S ATP synthase H transporting mitochondrial Fo complex subunit s factor B Further reading editKinosita K Yasuda R Noji H 2003 F1 ATPase a highly efficient rotary ATP machine Essays Biochem 35 3 18 doi 10 1042 bse0350003 PMID 12471886 Oster G Wang H 2003 Rotary protein motors Trends Cell Biol 13 3 114 21 doi 10 1016 S0962 8924 03 00004 7 PMID 12628343 Leyva JA Bianchet MA Amzel LM 2003 Understanding ATP synthesis structure and mechanism of the F1 ATPase Review Mol Membr Biol 20 1 27 33 doi 10 1080 0968768031000066532 PMID 12745923 S2CID 218895820 Sanadi DR Pringle M Kantham L et al 1984 Evidence for the involvement of coupling factor B in the H channel of the mitochondrial H ATPase Proc Natl Acad Sci U S A 81 5 1371 4 Bibcode 1984PNAS 81 1371S doi 10 1073 pnas 81 5 1371 PMC 344835 PMID 6143319 Yu W Andersson B Worley KC et al 1997 Large Scale Concatenation cDNA Sequencing Genome Res 7 4 353 8 doi 10 1101 gr 7 4 353 PMC 139146 PMID 9110174 Elston T Wang H Oster G 1998 Energy transduction in ATP synthase Nature 391 6666 510 3 Bibcode 1998Natur 391 510E doi 10 1038 35185 PMID 9461222 S2CID 4406161 Wang H Oster G 1998 Energy transduction in the F1 motor of ATP synthase Nature 396 6708 279 82 Bibcode 1998Natur 396 279W doi 10 1038 24409 PMID 9834036 S2CID 4424498 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Cross RL 2004 Molecular motors turning the ATP motor Nature 427 6973 407 8 Bibcode 2004Natur 427 407C doi 10 1038 427407b PMID 14749816 Ma J Dempsey AA Stamatiou D et al 2007 Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects Atherosclerosis 191 1 63 72 doi 10 1016 j atherosclerosis 2006 05 032 PMID 16806233 nbsp This article on a gene on human chromosome 14 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ATP5S amp oldid 1136247981, wikipedia, wiki, book, books, library,
