Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, FO, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The FO seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the FO complex, required for F1 and FO interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[7]
The F6 subunit is part of the peripheral stalk that links the F1 and FO complexes together, and which acts as a stator to prevent certain subunits from rotating with the central rotary element. The peripheral stalk differs in subunit composition between mitochondrial, chloroplast and bacterialF-ATPases. In mitochondria, the peripheral stalk is composed of one copy each of subunits OSCP (oligomycin sensitivity conferral protein), F6, b and d.[8] There is no homologue of subunit F6 in bacterial or chloroplast F-ATPase, whose peripheral stalks are composed of one copy of the delta subunit (homologous to OSCP), and two copies of subunit b in bacteria, or one copy each of subunits b and b' in chloroplasts and photosyntheticbacteria.
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000154723 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022890 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Higuti T, Tsurumi C, Kawamura Y, Tsujita H, Osaka F, Yoshihara Y, Tani I, Tanaka K, Ichihara A (Jul 1991). "Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria". Biochemical and Biophysical Research Communications. 178 (2): 793–9. doi:10.1016/0006-291X(91)90178-A. PMID 1830479.
^Javed AA, Ogata K, Sanadi DR (Jan 1991). "Human mitochondrial ATP synthase: cloning cDNA for the nuclear-encoded precursor of coupling factor 6". Gene. 97 (2): 307–10. doi:10.1016/0378-1119(91)90068-M. PMID 1825642.
^ ab"Entrez Gene: ATP5PF ATP synthase peripheral stalk subunit F6".
^Carbajo RJ, Kellas FA, Runswick MJ, Montgomery MG, Walker JE, Neuhaus D (Aug 2005). "Structure of the F1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit". Journal of Molecular Biology. 351 (4): 824–38. doi:10.1016/j.jmb.2005.06.012. PMID 16045926.
External linksedit
Human ATP5PF genome location and ATP5PF gene details page in the UCSC Genome Browser.
Further readingedit
Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine". Essays in Biochemistry. 35: 3–18. doi:10.1042/bse0350003. PMID 12471886.
Oster G, Wang H (Mar 2003). "Rotary protein motors". Trends in Cell Biology. 13 (3): 114–21. doi:10.1016/S0962-8924(03)00004-7. PMID 12628343.
Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)". Molecular Membrane Biology. 20 (1): 27–33. doi:10.1080/0968768031000066532. PMID 12745923. S2CID 218895820.
Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (Dec 1992). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. S2CID 23518983.
Yan WL, Lerner TJ, Haines JL, Gusella JF (Nov 1994). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)". Genomics. 24 (2): 375–7. doi:10.1006/geno.1994.1631. PMID 7698763.
Elston T, Wang H, Oster G (Jan 1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. Bibcode:1998Natur.391..510E. doi:10.1038/35185. PMID 9461222. S2CID 4406161.
Webster KA, Oliver NA, Wallace DC (Mar 1982). "Assignment of an oligomycin-resistance locus to human chromosome 10". Somatic Cell Genetics. 8 (2): 223–44. doi:10.1007/BF01538679. PMID 9732751. S2CID 12445064.
Wang H, Oster G (Nov 1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. Bibcode:1998Natur.396..279W. doi:10.1038/24409. PMID 9834036. S2CID 4424498.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC311072. PMID 11230166.
Osanai T, Nakamura M, Sasaki S, Tomita H, Saitoh M, Osawa H, Yamabe H, Murakami S, Magota K, Okumura K (Dec 2003). "Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease". Kidney International. 64 (6): 2291–7. doi:10.1046/j.1523-1755.2003.00334.x. PMID 14633154.
Cross RL (Jan 2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. Bibcode:2004Natur.427..407C. doi:10.1038/427407b. PMID 14749816. S2CID 52819856.
Jacobs LJ, de Coo IF, Nijland JG, Galjaard RJ, Los FJ, Schoonderwoerd K, Niermeijer MF, Geraedts JP, Scholte HR, Smeets HJ (Mar 2005). "Transmission and prenatal diagnosis of the T9176C mitochondrial DNA mutation". Molecular Human Reproduction. 11 (3): 223–8. CiteSeerX10.1.1.603.8165. doi:10.1093/molehr/gah152. PMID 15709156.
This article incorporates text from the public domain Pfam and InterPro: IPR008387
This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.
atp5pf, synthase, coupling, factor, mitochondrial, enzyme, subunit, that, humans, encoded, gene, identifiersaliases, atp5, atp5a, atpm, synthase, transporting, mitochondrial, complex, subunit, synthase, peripheral, stalk, subunit, atp5jexternal, idsomim, 60315. ATP synthase coupling factor 6 mitochondrial is an enzyme subunit that in humans is encoded by the ATP5PF gene 5 6 7 ATP5PFIdentifiersAliasesATP5PF ATP5 ATP5A ATPM CF6 F6 ATP synthase H transporting mitochondrial Fo complex subunit F6 ATP synthase peripheral stalk subunit F6 ATP5JExternal IDsOMIM 603152 MGI 107777 HomoloGene 1272 GeneCards ATP5PFGene location Human Chr Chromosome 21 human 1 Band21q21 3Start25 716 503 bp 1 End25 735 673 bp 1 Gene location Mouse Chr Chromosome 16 mouse 2 Band16 16 C3 3Start84 624 754 bp 2 End84 632 513 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright ventriclebiceps brachiibody of tonguevena cavavastus lateralis musclerenal medullathoracic diaphragmjejunumkidney tubulejejunal mucosaTop expressed indigastric musclesacculemyocardium of ventriclethoracic diaphragmatrioventricular valvecardiac musclesfacial motor nucleustriceps brachii muscleotic placodesternocleidomastoid muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransporter activity proton transmembrane transporter activity transmembrane transporter activity ATPase activity protein containing complex bindingCellular componentmitochondrial proton transporting ATP synthase complex coupling factor F o proton transporting ATP synthase complex coupling factor F o membrane mitochondrial proton transporting ATP synthase complex mitochondrial inner membrane mitochondrion extracellular space cell surfaceBiological processATP synthesis coupled proton transport ion transport substantia nigra development ATP metabolic process mitochondrial ATP synthesis coupled proton transport ATP biosynthetic process cristae formation transport positive regulation of heart rate response to muscle activity negative regulation of prostaglandin secretion positive regulation of blood pressure negative regulation of arachidonic acid secretionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez52211957EnsemblENSG00000154723ENSMUSG00000022890UniProtP18859P97450RefSeq mRNA NM 001003696NM 001003697NM 001003701NM 001003703NM 001685NM 001320266NM 001320267NM 016755NM 001302213NM 001302214NM 001302215NM 001302216NM 001358499NM 001358500RefSeq protein NP 001003696NP 001003697NP 001003701NP 001003703NP 001307195NP 001307196NP 001676NP 001289142NP 001289143NP 001289144NP 001289145NP 058035NP 001345428NP 001345429Location UCSC Chr 21 25 72 25 74 MbChr 16 84 62 84 63 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Mitochondrial ATP synthase coupling factor 6 F6 solution structure of subunit f6 from the peripheral stalk region of atp synthase from bovine heart mitochondriaIdentifiersSymbolATP synt F6PfamPF05511InterProIPR008387Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary Contents 1 Function 2 References 3 External links 4 Further readingFunction editMitochondrial ATP synthase catalyzes ATP synthesis utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation It is composed of two linked multi subunit complexes the soluble catalytic core F1 and the membrane spanning component FO which comprises the proton channel The F1 complex consists of 5 different subunits alpha beta gamma delta and epsilon assembled in a ratio of 3 alpha 3 beta and a single representative of the other 3 The FO seems to have nine subunits a b c d e f g F6 and 8 This gene encodes the F6 subunit of the FO complex required for F1 and FO interactions Alternatively spliced transcript variants encoding different isoforms have been identified for this gene 7 The F6 subunit is part of the peripheral stalk that links the F1 and FO complexes together and which acts as a stator to prevent certain subunits from rotating with the central rotary element The peripheral stalk differs in subunit composition between mitochondrial chloroplast and bacterial F ATPases In mitochondria the peripheral stalk is composed of one copy each of subunits OSCP oligomycin sensitivity conferral protein F6 b and d 8 There is no homologue of subunit F6 in bacterial or chloroplast F ATPase whose peripheral stalks are composed of one copy of the delta subunit homologous to OSCP and two copies of subunit b in bacteria or one copy each of subunits b and b in chloroplasts and photosynthetic bacteria References edit a b c GRCh38 Ensembl release 89 ENSG00000154723 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000022890 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Higuti T Tsurumi C Kawamura Y Tsujita H Osaka F Yoshihara Y Tani I Tanaka K Ichihara A Jul 1991 Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H ATP synthase in mitochondria Biochemical and Biophysical Research Communications 178 2 793 9 doi 10 1016 0006 291X 91 90178 A PMID 1830479 Javed AA Ogata K Sanadi DR Jan 1991 Human mitochondrial ATP synthase cloning cDNA for the nuclear encoded precursor of coupling factor 6 Gene 97 2 307 10 doi 10 1016 0378 1119 91 90068 M PMID 1825642 a b Entrez Gene ATP5PF ATP synthase peripheral stalk subunit F6 Carbajo RJ Kellas FA Runswick MJ Montgomery MG Walker JE Neuhaus D Aug 2005 Structure of the F1 binding domain of the stator of bovine F1Fo ATPase and how it binds an alpha subunit Journal of Molecular Biology 351 4 824 38 doi 10 1016 j jmb 2005 06 012 PMID 16045926 External links editHuman ATP5PF genome location and ATP5PF gene details page in the UCSC Genome Browser Further reading editKinosita K Yasuda R Noji H 2003 F1 ATPase a highly efficient rotary ATP machine Essays in Biochemistry 35 3 18 doi 10 1042 bse0350003 PMID 12471886 Oster G Wang H Mar 2003 Rotary protein motors Trends in Cell Biology 13 3 114 21 doi 10 1016 S0962 8924 03 00004 7 PMID 12628343 Leyva JA Bianchet MA Amzel LM 2003 Understanding ATP synthesis structure and mechanism of the F1 ATPase Review Molecular Membrane Biology 20 1 27 33 doi 10 1080 0968768031000066532 PMID 12745923 S2CID 218895820 Hochstrasser DF Frutiger S Paquet N Bairoch A Ravier F Pasquali C Sanchez JC Tissot JD Bjellqvist B Vargas R Dec 1992 Human liver protein map a reference database established by microsequencing and gel comparison Electrophoresis 13 12 992 1001 doi 10 1002 elps 11501301201 PMID 1286669 S2CID 23518983 Yan WL Lerner TJ Haines JL Gusella JF Nov 1994 Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA ATP5G3 Genomics 24 2 375 7 doi 10 1006 geno 1994 1631 PMID 7698763 Elston T Wang H Oster G Jan 1998 Energy transduction in ATP synthase Nature 391 6666 510 3 Bibcode 1998Natur 391 510E doi 10 1038 35185 PMID 9461222 S2CID 4406161 Webster KA Oliver NA Wallace DC Mar 1982 Assignment of an oligomycin resistance locus to human chromosome 10 Somatic Cell Genetics 8 2 223 44 doi 10 1007 BF01538679 PMID 9732751 S2CID 12445064 Wang H Oster G Nov 1998 Energy transduction in the F1 motor of ATP synthase Nature 396 6708 279 82 Bibcode 1998Natur 396 279W doi 10 1038 24409 PMID 9834036 S2CID 4424498 Wiemann S Weil B Wellenreuther R Gassenhuber J Glassl S Ansorge W Bocher M Blocker H Bauersachs S Blum H Lauber J Dusterhoft A Beyer A Kohrer K Strack N Mewes HW Ottenwalder B Obermaier B Tampe J Heubner D Wambutt R Korn B Klein M Poustka A Mar 2001 Toward a catalog of human genes and proteins sequencing and analysis of 500 novel complete protein coding human cDNAs Genome Research 11 3 422 35 doi 10 1101 gr GR1547R PMC 311072 PMID 11230166 Osanai T Nakamura M Sasaki S Tomita H Saitoh M Osawa H Yamabe H Murakami S Magota K Okumura K Dec 2003 Plasma concentration of coupling factor 6 and cardiovascular events in patients with end stage renal disease Kidney International 64 6 2291 7 doi 10 1046 j 1523 1755 2003 00334 x PMID 14633154 Cross RL Jan 2004 Molecular motors turning the ATP motor Nature 427 6973 407 8 Bibcode 2004Natur 427 407C doi 10 1038 427407b PMID 14749816 S2CID 52819856 Jacobs LJ de Coo IF Nijland JG Galjaard RJ Los FJ Schoonderwoerd K Niermeijer MF Geraedts JP Scholte HR Smeets HJ Mar 2005 Transmission and prenatal diagnosis of the T9176C mitochondrial DNA mutation Molecular Human Reproduction 11 3 223 8 CiteSeerX 10 1 1 603 8165 doi 10 1093 molehr gah152 PMID 15709156 This article incorporates text from the public domain Pfam and InterPro IPR008387 nbsp This article on a gene on human chromosome 21 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ATP5PF amp oldid 1136127382, wikipedia, wiki, book, books, library,
