P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000058063 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037400 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
^ ab"Entrez Gene: ATP11B ATPase, Class VI, type 11B".
External linksedit
Human ATP11B genome location and ATP11B gene details page in the UCSC Genome Browser.
Further readingedit
Halleck MS, Schlegel RA, Williamson PL (Mar 2002). "Reanalysis of ATP11B, a type IV P-type ATPase". The Journal of Biological Chemistry. 277 (12): 9736–40. doi:10.1074/jbc.M200240200. PMID 11790799.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC16267. PMID 10737800.
This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.
atp11b, probable, phospholipid, transporting, atpase, enzyme, that, humans, encoded, gene, identifiersaliases, atpif, atpir, atpase, phospholipid, transporting, putative, external, idsomim, 605869, 1923545, homologene, 32919, genecards, gene, location, human, . Probable phospholipid transporting ATPase IF is an enzyme that in humans is encoded by the ATP11B gene 5 6 7 ATP11BIdentifiersAliasesATP11B ATPIF ATPIR ATPase phospholipid transporting 11B putative External IDsOMIM 605869 MGI 1923545 HomoloGene 32919 GeneCards ATP11BGene location Human Chr Chromosome 3 human 1 Band3q26 33Start182 793 503 bp 1 End182 921 629 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 3 BStart35 808 255 bp 2 End35 910 425 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inAchilles tendonbone marrow cellsspermsecondary oocyteoral cavitythymusgerminal epitheliumbloodjejunal mucosarectumTop expressed incumulus celllarge intestinecolonleft colonpyloric antrumbloodjejunumfacial motor nucleusepithelium of stomachlacrimal glandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding ion transmembrane transporter activity metal ion binding protein binding ATPase coupled intramembrane lipid transporter activity hydrolase activity ATP binding magnesium ion bindingCellular componentintegral component of membrane recycling endosome endosome Golgi apparatus membrane plasma membrane nuclear inner membrane recycling endosome membrane early endosome endoplasmic reticulum azurophil granule membrane trans Golgi networkBiological processlipid transport aminophospholipid transport phospholipid transport ion transport ion transmembrane transport phospholipid translocation neutrophil degranulation transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2320076295EnsemblENSG00000058063ENSMUSG00000037400UniProtQ9Y2G3Q6DFW5RefSeq mRNA NM 014616NM 029570RefSeq protein NP 055431NP 083846Location UCSC Chr 3 182 79 182 92 MbChr 3 35 81 35 91 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 External links 4 Further readingFunction editP type ATPases such as ATP11B are phosphorylated in their intermediate state and drive uphill transport of ions across membranes Several subfamilies of P type ATPases have been identified One subfamily transports heavy metal ions such as Cu 2 or Cd 2 Another subfamily transports non heavy metal ions such as H Na K or Ca A third subfamily transports amphipaths such as phosphatidylserine 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000058063 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000037400 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Nagase T Ishikawa K Suyama M Kikuno R Hirosawa M Miyajima N Tanaka A Kotani H Nomura N Ohara O Feb 1999 Prediction of the coding sequences of unidentified human genes XIII The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Research 6 1 63 70 doi 10 1093 dnares 6 1 63 PMID 10231032 Halleck MS Lawler JF JR Blackshaw S Gao L Nagarajan P Hacker C Pyle S Newman JT Nakanishi Y Ando H Weinstock D Williamson P Schlegel RA Nov 1999 Differential expression of putative transbilayer amphipath transporters Physiological Genomics 1 3 139 50 doi 10 1152 physiolgenomics 1999 1 3 139 PMID 11015572 S2CID 762447 a b Entrez Gene ATP11B ATPase Class VI type 11B External links editHuman ATP11B genome location and ATP11B gene details page in the UCSC Genome Browser Further reading editHalleck MS Schlegel RA Williamson PL Mar 2002 Reanalysis of ATP11B a type IV P type ATPase The Journal of Biological Chemistry 277 12 9736 40 doi 10 1074 jbc M200240200 PMID 11790799 Dias Neto E Correa RG Verjovski Almeida S Briones MR Nagai MA da Silva W Zago MA Bordin S Costa FF Goldman GH Carvalho AF Matsukuma A Baia GS Simpson DH Brunstein A de Oliveira PS Bucher P Jongeneel CV O Hare MJ Soares F Brentani RR Reis LF de Souza SJ Simpson AJ Mar 2000 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags Proceedings of the National Academy of Sciences of the United States of America 97 7 3491 6 Bibcode 2000PNAS 97 3491D doi 10 1073 pnas 97 7 3491 PMC 16267 PMID 10737800 nbsp This article on a gene on human chromosome 3 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ATP11B amp oldid 1115764039, wikipedia, wiki, book, books, library,
