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Wikipedia

ATF3

February 15, 2024

Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.[5]

ATF3
Identifiers
AliasesATF3, activating transcription factor 3
External IDsOMIM: 603148 MGI: 109384 HomoloGene: 1265 GeneCards: ATF3
Orthologs
SpeciesHumanMouse
Entrez

467

11910

Ensembl

ENSG00000162772

ENSMUSG00000026628

UniProt

P18847

Q60765

RefSeq (mRNA)

NM_007498

RefSeq (protein)

NP_031524

Location (UCSC)Chr 1: 212.57 – 212.62 MbChr 1: 190.9 – 190.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription, it is presumed, by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.[6]

Clinical significance edit

ATF-3 is induced upon physiological stress in various tissues.[7] It is also a marker of regeneration following injury of dorsal root ganglion neurons, as injured regenerating neurons activate this transcription factor. [8] Functional validation studies have shown that ATF3 can promote regeneration of peripheral neurons, but is not capable of promoting regeneration of central nervous system neurons. [9]

See also edit

Interactions edit

ATF3 has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162772 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026628 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen BP, Liang G, Whelan J, Hai T (June 1994). "ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms". The Journal of Biological Chemistry. 269 (22): 15819–26. doi:10.1016/S0021-9258(17)40754-X. PMID 7515060.
  6. ^ "Entrez Gene: ATF3 activating transcription factor 3".
  7. ^ Chen BP, Wolfgang CD, Hai T (March 1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10". Molecular and Cellular Biology. 16 (3): 1157–68. doi:10.1128/MCB.16.3.1157. PMC 231098. PMID 8622660.
  8. ^ Lindå H, Sköld MK, Ochsmann T (2011). "Activating transcription factor 3, a useful marker for regenerative response after nerve root injury". Frontiers in Neurology. 2: 30. doi:10.3389/fneur.2011.00030. PMC 3099310. PMID 21629765.
  9. ^ Mahar M, Cavalli V (June 2018). "Intrinsic mechanisms of neuronal axon regeneration". Nature Reviews. Neuroscience. 19 (6): 323–337. doi:10.1038/s41583-018-0001-8. PMC 5987780. PMID 29666508.
  10. ^ Pearson AG, Gray CW, Pearson JF, Greenwood JM, During MJ, Dragunow M (December 2003). "ATF3 enhances c-Jun-mediated neurite sprouting". Brain Research. Molecular Brain Research. 120 (1): 38–45. doi:10.1016/j.molbrainres.2003.09.014. PMID 14667575.
  11. ^ a b Chen BP, Wolfgang CD, Hai T (March 1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10". Molecular and Cellular Biology. 16 (3): 1157–68. doi:10.1128/MCB.16.3.1157. PMC 231098. PMID 8622660.
  12. ^ Hai T, Curran T (May 1991). "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3720–4. Bibcode:1991PNAS...88.3720H. doi:10.1073/pnas.88.9.3720. PMC 51524. PMID 1827203.
  13. ^ Chu HM, Tan Y, Kobierski LA, Balsam LB, Comb MJ (January 1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression". Molecular Endocrinology. 8 (1): 59–68. doi:10.1210/mend.8.1.8152431. PMID 8152431.
  14. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  15. ^ Yan C, Wang H, Boyd DD (March 2002). "ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter". The Journal of Biological Chemistry. 277 (13): 10804–12. doi:10.1074/jbc.M112069200. PMID 11792711.
  16. ^ Kang Y, Chen CR, Massagué J (April 2003). "A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells". Molecular Cell. 11 (4): 915–26. doi:10.1016/s1097-2765(03)00109-6. PMID 12718878.

Further reading edit

  • Hai TW, Liu F, Coukos WJ, Green MR (December 1989). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes & Development. 3 (12B): 2083–90. doi:10.1101/gad.3.12b.2083. PMID 2516827.
  • Kaszubska W, Hooft van Huijsduijnen R, Ghersa P, DeRaemy-Schenk AM, Chen BP, Hai T, DeLamarter JF, Whelan J (November 1993). "Cyclic AMP-independent ATF family members interact with NF-kappa B and function in the activation of the E-selectin promoter in response to cytokines". Molecular and Cellular Biology. 13 (11): 7180–90. doi:10.1128/MCB.13.11.7180. PMC 364779. PMID 7692236.
  • Chu HM, Tan Y, Kobierski LA, Balsam LB, Comb MJ (January 1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression". Molecular Endocrinology. 8 (1): 59–68. doi:10.1210/mend.8.1.8152431. PMID 8152431.
  • Liang G, Wolfgang CD, Chen BP, Chen TH, Hai T (January 1996). "ATF3 gene. Genomic organization, promoter, and regulation". The Journal of Biological Chemistry. 271 (3): 1695–701. doi:10.1074/jbc.271.3.1695. PMID 8576171.
  • Chen BP, Wolfgang CD, Hai T (March 1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10". Molecular and Cellular Biology. 16 (3): 1157–68. doi:10.1128/MCB.16.3.1157. PMC 231098. PMID 8622660.
  • Hagmeyer BM, Duyndam MC, Angel P, de Groot RP, Verlaan M, Elfferich P, van der Eb A, Zantema A (March 1996). "Altered AP-1/ATF complexes in adenovirus-E1-transformed cells due to EIA-dependent induction of ATF3". Oncogene. 12 (5): 1025–32. PMID 8649793.
  • Allan AL, Albanese C, Pestell RG, LaMarre J (July 2001). "Activating transcription factor 3 induces DNA synthesis and expression of cyclin D1 in hepatocytes". The Journal of Biological Chemistry. 276 (29): 27272–80. doi:10.1074/jbc.M103196200. PMID 11375399.
  • Zhang C, Kawauchi J, Adachi MT, Hashimoto Y, Oshiro S, Aso T, Kitajima S (December 2001). "Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine". Biochemical and Biophysical Research Communications. 289 (3): 718–24. doi:10.1006/bbrc.2001.6044. PMID 11726207.
  • Yan C, Wang H, Boyd DD (March 2002). "ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter". The Journal of Biological Chemistry. 277 (13): 10804–12. doi:10.1074/jbc.M112069200. PMID 11792711.
  • Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S (2002). "Effects of HIV-1 Nef on cellular gene expression profiles". Journal of Biomedical Science. 9 (1): 82–96. doi:10.1007/BF02256581. PMID 11810028.
  • Hashimoto Y, Zhang C, Kawauchi J, Imoto I, Adachi MT, Inazawa J, Amagasa T, Hai T, Kitajima S (June 2002). "An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli". Nucleic Acids Research. 30 (11): 2398–406. doi:10.1093/nar/30.11.2398. PMC 117192. PMID 12034827.
  • Kawauchi J, Zhang C, Nobori K, Hashimoto Y, Adachi MT, Noda A, Sunamori M, Kitajima S (October 2002). "Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription". The Journal of Biological Chemistry. 277 (41): 39025–34. doi:10.1074/jbc.M202974200. PMID 12161427.
  • Zhang C, Gao C, Kawauchi J, Hashimoto Y, Tsuchida N, Kitajima S (October 2002). "Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53". Biochemical and Biophysical Research Communications. 297 (5): 1302–10. doi:10.1016/S0006-291X(02)02382-3. PMID 12372430.
  • Fan F, Jin S, Amundson SA, Tong T, Fan W, Zhao H, Zhu X, Mazzacurati L, Li X, Petrik KL, Fornace AJ, Rajasekaran B, Zhan Q (October 2002). "ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth". Oncogene. 21 (49): 7488–96. doi:10.1038/sj.onc.1205896. PMID 12386811.
  • Nobori K, Ito H, Tamamori-Adachi M, Adachi S, Ono Y, Kawauchi J, Kitajima S, Marumo F, Isobe M (October 2002). "ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3". Journal of Molecular and Cellular Cardiology. 34 (10): 1387–97. doi:10.1006/jmcc.2002.2091. PMID 12392999.
  • Kang Y, Chen CR, Massagué J (April 2003). "A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells". Molecular Cell. 11 (4): 915–26. doi:10.1016/S1097-2765(03)00109-6. PMID 12718878.
  • Newman JR, Keating AE (June 2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. Bibcode:2003Sci...300.2097N. doi:10.1126/science.1084648. PMID 12805554. S2CID 36715183.
  • Kool J, Hamdi M, Cornelissen-Steijger P, van der Eb AJ, Terleth C, van Dam H (July 2003). "Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2". Oncogene. 22 (27): 4235–42. doi:10.1038/sj.onc.1206611. PMID 12833146.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  1. ^ Koh EH, Park JY, Park HS, Jeon MJ, Ryu JW, Kim M, Kim SY, Kim MS, Kim SW, Park IS, Youn JH, Lee KU (December 2007). "Essential role of mitochondrial function in adiponectin synthesis in adipocytes". Diabetes. 56 (12): 2973–81. doi:10.2337/db07-0510. PMID 17827403.

February 15, 2024
atf3, cyclic, dependent, transcription, factor, protein, that, humans, encoded, gene, identifiersaliases, activating, transcription, factor, 3external, idsomim, 603148, 109384, homologene, 1265, genecards, gene, location, human, chromosome, human, band1q32, 3s. Cyclic AMP dependent transcription factor ATF 3 is a protein that in humans is encoded by the ATF3 gene 5 ATF3IdentifiersAliasesATF3 activating transcription factor 3External IDsOMIM 603148 MGI 109384 HomoloGene 1265 GeneCards ATF3Gene location Human Chr Chromosome 1 human 1 Band1q32 3Start212 565 334 bp 1 End212 620 777 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 H6 1 96 28 cMStart190 902 493 bp 2 End190 950 236 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed invena cavagastric mucosagallbladdersaphenous veintracheaurethrapericardiumleft uterine tubecardiamucosa of urinary bladderTop expressed inplantaris muscleislet of Langerhansintestinal villusjejunumsciatic nerveendocardial cushionleft colonatrioventricular valvemucous cell of stomachspermatocyteMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontranscription cis regulatory region binding protein homodimerization activity protein binding RNA polymerase II transcription regulatory region sequence specific DNA binding DNA binding transcription repressor activity RNA polymerase II specific protein heterodimerization activity identical protein binding DNA binding transcription activator activity RNA polymerase II specific DNA binding transcription corepressor activity DNA binding transcription factor activity RNA polymerase II cis regulatory region sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specificCellular componentnucleolus nucleoplasm CHOP ATF3 complex nucleusBiological processregulation of transcription by RNA polymerase II positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of cell population proliferation skeletal muscle cell differentiation regulation of transcription from RNA polymerase II promoter in response to arsenic containing substance gluconeogenesis cellular response to amino acid starvation negative regulation of transcription DNA templated regulation of transcription DNA templated positive regulation of TRAIL activated apoptotic signaling pathway transcription DNA templated positive regulation of gene expression PERK mediated unfolded protein response positive regulation of transcription by RNA polymerase II negative regulation of ERK1 and ERK2 cascade negative regulation of transcription by RNA polymerase II endoplasmic reticulum unfolded protein response transcription by RNA polymerase II positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez46711910EnsemblENSG00000162772ENSMUSG00000026628UniProtP18847Q60765RefSeq mRNA NM 001030287NM 001040619NM 001206484NM 001206485NM 001206486NM 001206488NM 001674NM 004024NM 007498RefSeq protein NP 001025458NP 001035709NP 001193413NP 001193415NP 001193417NP 001665NP 031524Location UCSC Chr 1 212 57 212 62 MbChr 1 190 9 190 95 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Clinical significance 3 See also 4 Interactions 5 References 6 Further reading 7 External linksFunction editActivating transcription factor 3 is a member of the mammalian activation transcription factor cAMP responsive element binding CREB protein family of transcription factors Multiple transcript variants encoding two different isoforms have been found for this gene The longer isoform represses rather than activates transcription from promoters with ATF binding elements The shorter isoform deltaZip2 lacks the leucine zipper protein dimerization motif and does not bind to DNA and it stimulates transcription it is presumed by sequestering inhibitory co factors away from the promoter It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes 6 Clinical significance editATF 3 is induced upon physiological stress in various tissues 7 It is also a marker of regeneration following injury of dorsal root ganglion neurons as injured regenerating neurons activate this transcription factor 8 Functional validation studies have shown that ATF3 can promote regeneration of peripheral neurons but is not capable of promoting regeneration of central nervous system neurons 9 See also editActivating transcription factorInteractions editATF3 has been shown to interact with C jun 10 11 12 DDIT3 11 JunD 13 P53 14 15 and SMAD3 16 References edit a b c GRCh38 Ensembl release 89 ENSG00000162772 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000026628 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Chen BP Liang G Whelan J Hai T June 1994 ATF3 and ATF3 delta Zip Transcriptional repression versus activation by alternatively spliced isoforms The Journal of Biological Chemistry 269 22 15819 26 doi 10 1016 S0021 9258 17 40754 X PMID 7515060 Entrez Gene ATF3 activating transcription factor 3 Chen BP Wolfgang CD Hai T March 1996 Analysis of ATF3 a transcription factor induced by physiological stresses and modulated by gadd153 Chop10 Molecular and Cellular Biology 16 3 1157 68 doi 10 1128 MCB 16 3 1157 PMC 231098 PMID 8622660 Linda H Skold MK Ochsmann T 2011 Activating transcription factor 3 a useful marker for regenerative response after nerve root injury Frontiers in Neurology 2 30 doi 10 3389 fneur 2011 00030 PMC 3099310 PMID 21629765 Mahar M Cavalli V June 2018 Intrinsic mechanisms of neuronal axon regeneration Nature Reviews Neuroscience 19 6 323 337 doi 10 1038 s41583 018 0001 8 PMC 5987780 PMID 29666508 Pearson AG Gray CW Pearson JF Greenwood JM During MJ Dragunow M December 2003 ATF3 enhances c Jun mediated neurite sprouting Brain Research Molecular Brain Research 120 1 38 45 doi 10 1016 j molbrainres 2003 09 014 PMID 14667575 a b Chen BP Wolfgang CD Hai T March 1996 Analysis of ATF3 a transcription factor induced by physiological stresses and modulated by gadd153 Chop10 Molecular and Cellular Biology 16 3 1157 68 doi 10 1128 MCB 16 3 1157 PMC 231098 PMID 8622660 Hai T Curran T May 1991 Cross family dimerization of transcription factors Fos Jun and ATF CREB alters DNA binding specificity Proceedings of the National Academy of Sciences of the United States of America 88 9 3720 4 Bibcode 1991PNAS 88 3720H doi 10 1073 pnas 88 9 3720 PMC 51524 PMID 1827203 Chu HM Tan Y Kobierski LA Balsam LB Comb MJ January 1994 Activating transcription factor 3 stimulates 3 5 cyclic adenosine monophosphate dependent gene expression Molecular Endocrinology 8 1 59 68 doi 10 1210 mend 8 1 8152431 PMID 8152431 Stelzl U Worm U Lalowski M Haenig C Brembeck FH Goehler H Stroedicke M Zenkner M Schoenherr A Koeppen S Timm J Mintzlaff S Abraham C Bock N Kietzmann S Goedde A Toksoz E Droege A Krobitsch S Korn B Birchmeier W Lehrach H Wanker EE September 2005 A human protein protein interaction network a resource for annotating the proteome Cell 122 6 957 68 doi 10 1016 j cell 2005 08 029 hdl 11858 00 001M 0000 0010 8592 0 PMID 16169070 S2CID 8235923 Yan C Wang H Boyd DD March 2002 ATF3 represses 72 kDa type IV collagenase MMP 2 expression by antagonizing p53 dependent trans activation of the collagenase promoter The Journal of Biological Chemistry 277 13 10804 12 doi 10 1074 jbc M112069200 PMID 11792711 Kang Y Chen CR Massague J April 2003 A self enabling TGFbeta response coupled to stress signaling Smad engages stress response factor ATF3 for Id1 repression in epithelial cells Molecular Cell 11 4 915 26 doi 10 1016 s1097 2765 03 00109 6 PMID 12718878 Further reading editHai TW Liu F Coukos WJ Green MR December 1989 Transcription factor ATF cDNA clones an extensive family of leucine zipper proteins able to selectively form DNA binding heterodimers Genes amp Development 3 12B 2083 90 doi 10 1101 gad 3 12b 2083 PMID 2516827 Kaszubska W Hooft van Huijsduijnen R Ghersa P DeRaemy Schenk AM Chen BP Hai T DeLamarter JF Whelan J November 1993 Cyclic AMP independent ATF family members interact with NF kappa B and function in the activation of the E selectin promoter in response to cytokines Molecular and Cellular Biology 13 11 7180 90 doi 10 1128 MCB 13 11 7180 PMC 364779 PMID 7692236 Chu HM Tan Y Kobierski LA Balsam LB Comb MJ January 1994 Activating transcription factor 3 stimulates 3 5 cyclic adenosine monophosphate dependent gene expression Molecular Endocrinology 8 1 59 68 doi 10 1210 mend 8 1 8152431 PMID 8152431 Liang G Wolfgang CD Chen BP Chen TH Hai T January 1996 ATF3 gene Genomic organization promoter and regulation The Journal of Biological Chemistry 271 3 1695 701 doi 10 1074 jbc 271 3 1695 PMID 8576171 Chen BP Wolfgang CD Hai T March 1996 Analysis of ATF3 a transcription factor induced by physiological stresses and modulated by gadd153 Chop10 Molecular and Cellular Biology 16 3 1157 68 doi 10 1128 MCB 16 3 1157 PMC 231098 PMID 8622660 Hagmeyer BM Duyndam MC Angel P de Groot RP Verlaan M Elfferich P van der Eb A Zantema A March 1996 Altered AP 1 ATF complexes in adenovirus E1 transformed cells due to EIA dependent induction of ATF3 Oncogene 12 5 1025 32 PMID 8649793 Allan AL Albanese C Pestell RG LaMarre J July 2001 Activating transcription factor 3 induces DNA synthesis and expression of cyclin D1 in hepatocytes The Journal of Biological Chemistry 276 29 27272 80 doi 10 1074 jbc M103196200 PMID 11375399 Zhang C Kawauchi J Adachi MT Hashimoto Y Oshiro S Aso T Kitajima S December 2001 Activation of JNK and transcriptional repressor ATF3 LRF1 through the IRE1 TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine Biochemical and Biophysical Research Communications 289 3 718 24 doi 10 1006 bbrc 2001 6044 PMID 11726207 Yan C Wang H Boyd DD March 2002 ATF3 represses 72 kDa type IV collagenase MMP 2 expression by antagonizing p53 dependent trans activation of the collagenase promoter The Journal of Biological Chemistry 277 13 10804 12 doi 10 1074 jbc M112069200 PMID 11792711 Shaheduzzaman S Krishnan V Petrovic A Bittner M Meltzer P Trent J Venkatesan S Zeichner S 2002 Effects of HIV 1 Nef on cellular gene expression profiles Journal of Biomedical Science 9 1 82 96 doi 10 1007 BF02256581 PMID 11810028 Hashimoto Y Zhang C Kawauchi J Imoto I Adachi MT Inazawa J Amagasa T Hai T Kitajima S June 2002 An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli Nucleic Acids Research 30 11 2398 406 doi 10 1093 nar 30 11 2398 PMC 117192 PMID 12034827 Kawauchi J Zhang C Nobori K Hashimoto Y Adachi MT Noda A Sunamori M Kitajima S October 2002 Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor alpha induced apoptosis through down regulation of p53 transcription The Journal of Biological Chemistry 277 41 39025 34 doi 10 1074 jbc M202974200 PMID 12161427 Zhang C Gao C Kawauchi J Hashimoto Y Tsuchida N Kitajima S October 2002 Transcriptional activation of the human stress inducible transcriptional repressor ATF3 gene promoter by p53 Biochemical and Biophysical Research Communications 297 5 1302 10 doi 10 1016 S0006 291X 02 02382 3 PMID 12372430 Fan F Jin S Amundson SA Tong T Fan W Zhao H Zhu X Mazzacurati L Li X Petrik KL Fornace AJ Rajasekaran B Zhan Q October 2002 ATF3 induction following DNA damage is regulated by distinct signaling pathways and over expression of ATF3 protein suppresses cells growth Oncogene 21 49 7488 96 doi 10 1038 sj onc 1205896 PMID 12386811 Nobori K Ito H Tamamori Adachi M Adachi S Ono Y Kawauchi J Kitajima S Marumo F Isobe M October 2002 ATF3 inhibits doxorubicin induced apoptosis in cardiac myocytes a novel cardioprotective role of ATF3 Journal of Molecular and Cellular Cardiology 34 10 1387 97 doi 10 1006 jmcc 2002 2091 PMID 12392999 Kang Y Chen CR Massague J April 2003 A self enabling TGFbeta response coupled to stress signaling Smad engages stress response factor ATF3 for Id1 repression in epithelial cells Molecular Cell 11 4 915 26 doi 10 1016 S1097 2765 03 00109 6 PMID 12718878 Newman JR Keating AE June 2003 Comprehensive identification of human bZIP interactions with coiled coil arrays Science 300 5628 2097 101 Bibcode 2003Sci 300 2097N doi 10 1126 science 1084648 PMID 12805554 S2CID 36715183 Kool J Hamdi M Cornelissen Steijger P van der Eb AJ Terleth C van Dam H July 2003 Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM Nibrin1 stress induced MAPkinases and ATF 2 Oncogene 22 27 4235 42 doi 10 1038 sj onc 1206611 PMID 12833146 External links editHuman ATF3 genome location and ATF3 gene details page in the UCSC Genome Browser ATF3 protein human at the U S National Library of Medicine Medical Subject Headings MeSH FactorBook ATF3This article incorporates text from the United States National Library of Medicine which is in the public domain Koh EH Park JY Park HS Jeon MJ Ryu JW Kim M Kim SY Kim MS Kim SW Park IS Youn JH Lee KU December 2007 Essential role of mitochondrial function in adiponectin synthesis in adipocytes Diabetes 56 12 2973 81 doi 10 2337 db07 0510 PMID 17827403 Retrieved from https en wikipedia org w index php title ATF3 amp oldid 1183984532, wikipedia, wiki, book, books, library,

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