AS03 (for "Adjuvant System 03") is the trade name for a squalene-based immunologic adjuvant used in various vaccine products by GlaxoSmithKline (GSK). It is used, for example, in GSK's A/H1N1pandemic flu vaccine Pandemrix. It is also in Arepanrix and the Q-pan for H5N1 influenza.[1] A dose of AS03 adjuvant contains[2]
In the 2009 influenza pandemic, vaccines containing AS03 delivered a stronger immunogene response against pandemic H1N1 influenza than non-adjuvanted vaccines, despite their containing lower levels of viral antigen.[3]
Small observational studies reported from Finland and Sweden in 2012, and larger studies from Ireland reported in 2012, and reported in each of England, Norway and France in 2013, found an association between narcolepsy and an A(H1N1)pdm09 vaccine that used AS03 adjuvant; the rates ranged from one in 16,000 doses to one in 50,000 doses.[4] As of 2016 it was unclear whether or not the adjuvant was responsible; other suspected causes include genetic susceptibility, exposure to A(H1N1)pdm09, manufacturing impurities, or combinations of these factors.[4]
^Yin JK, Khandaker G, Rashid H, Heron L, Ridda I, Booy R (September 2011). "Immunogenicity and safety of pandemic influenza A (H1N1) 2009 vaccine: systematic review and meta-analysis". Influenza and Other Respiratory Viruses. 5 (5): 299–305. doi:10.1111/j.1750-2659.2011.00229.x. PMC4986623. PMID 21668694.
^ abAhmed, SS; Montomoli, E; Pasini, FL; Steinman, L (2016). "The Safety of Adjuvanted Vaccines Revisited: Vaccine-Induced Narcolepsy" (PDF). The Israel Medical Association Journal. 18 (3–4): 216–20. PMID 27228647.
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as03, adjuvant, system, trade, name, squalene, based, immunologic, adjuvant, used, various, vaccine, products, glaxosmithkline, used, example, h1n1, pandemic, vaccine, pandemrix, also, arepanrix, h5n1, influenza, dose, adjuvant, contains, squalene, tocopherol,. AS03 for Adjuvant System 03 is the trade name for a squalene based immunologic adjuvant used in various vaccine products by GlaxoSmithKline GSK It is used for example in GSK s A H1N1 pandemic flu vaccine Pandemrix It is also in Arepanrix and the Q pan for H5N1 influenza 1 A dose of AS03 adjuvant contains 2 10 69 mg squalene 11 86 mg DL a tocopherol 4 86 mg polysorbate 80In the 2009 influenza pandemic vaccines containing AS03 delivered a stronger immunogene response against pandemic H1N1 influenza than non adjuvanted vaccines despite their containing lower levels of viral antigen 3 Small observational studies reported from Finland and Sweden in 2012 and larger studies from Ireland reported in 2012 and reported in each of England Norway and France in 2013 found an association between narcolepsy and an A H1N1 pdm09 vaccine that used AS03 adjuvant the rates ranged from one in 16 000 doses to one in 50 000 doses 4 As of 2016 it was unclear whether or not the adjuvant was responsible other suspected causes include genetic susceptibility exposure to A H1N1 pdm09 manufacturing impurities or combinations of these factors 4 See also edit2009 flu pandemic MF59 another squalene based adjuvant by Novartis AS04 another adjuvant by GSKReferences edit FDA panel endorses H5N1 vaccine with adjuvant 15 Nov 2012 Pandemrix Summary of product characteristics Archived October 7 2009 at the Wayback Machine European Medicines Agency websiteEuropean Medicines Agency website Archived 2013 07 15 at the Wayback Machine Yin JK Khandaker G Rashid H Heron L Ridda I Booy R September 2011 Immunogenicity and safety of pandemic influenza A H1N1 2009 vaccine systematic review and meta analysis Influenza and Other Respiratory Viruses 5 5 299 305 doi 10 1111 j 1750 2659 2011 00229 x PMC 4986623 PMID 21668694 a b Ahmed SS Montomoli E Pasini FL Steinman L 2016 The Safety of Adjuvanted Vaccines Revisited Vaccine Induced Narcolepsy PDF The Israel Medical Association Journal 18 3 4 216 20 PMID 27228647 nbsp This article about vaccines or vaccination is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title AS03 amp oldid 1166174367, wikipedia, wiki, book, books, library,
