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Wikipedia

ARIH1

August 28, 2023

Protein ariadne-1 homolog is a protein that in humans is encoded by the ARIH1 gene.[5][6]

ARIH1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARIH1, ARI, HARI, HHARI, UBCH7BP, ariadne RBR E3 ubiquitin protein ligase 1
External IDsOMIM: 605624 MGI: 1344363 HomoloGene: 111871 GeneCards: ARIH1
Orthologs
SpeciesHumanMouse
Entrez

25820

23806

Ensembl

ENSG00000166233

ENSMUSG00000025234

UniProt

Q9Y4X5

Q9Z1K5

RefSeq (mRNA)

NM_005744

NM_019927

RefSeq (protein)

NP_005735

NP_064311

Location (UCSC)Chr 15: 72.47 – 72.6 MbChr 9: 59.3 – 59.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions Edit

ARIH1 has been shown to interact with:

References Edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166233 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025234 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (November 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492.
  6. ^ "Entrez Gene: ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)".
  7. ^ a b Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/s0014-5793(03)01235-3. PMID 14623119.
  8. ^ Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA (June 2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7". J. Biol. Chem. 276 (22): 19640–7. doi:10.1074/jbc.M011028200. PMID 11278816.

External links Edit

Further reading Edit

  • Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A (2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins". Genetics. 155 (3): 1231–44. doi:10.1093/genetics/155.3.1231. PMC 1461160. PMID 10880484.
  • Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA (2001). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them". J. Biol. Chem. 275 (45): 35224–32. doi:10.1074/jbc.M003329200. PMID 10926929.
  • Tan NG, Ardley HC, Rose SA, Leek JP, Markham AF, Robinson PA (2001). "Characterisation of the human and mouse orthologues of the Drosophila ariadne gene". Cytogenet. Cell Genet. 90 (3–4): 242–5. doi:10.1159/000056780. PMID 11124525. S2CID 12113119.
  • Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703. S2CID 21397515.
  • Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA (2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7". J. Biol. Chem. 276 (22): 19640–7. doi:10.1074/jbc.M011028200. PMID 11278816.
  • Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. doi:10.1093/emboj/cdf493. PMC 126289. PMID 12234920.
  • Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119.
  • Capili AD, Edghill EL, Wu K, Borden KL (2004). "Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING". J. Mol. Biol. 340 (5): 1117–29. doi:10.1016/j.jmb.2004.05.035. PMID 15236971.
  • Parelkar SS, Cadena JG, Kim C, Wang Z, Sugal R, Bentley B, Moral L, Ardley HC, Schwartz LM (2012). "The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies". J. Mol. Neurosci. 46 (1): 109–21. doi:10.1007/s12031-011-9535-1. PMID 21590270. S2CID 17276111.


 

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

August 28, 2023
arih1, protein, ariadne, homolog, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1wd2, 2m9y, 4kbl, 4kc9identifiersaliases, hari, hhari, ubch7bp, ariadne, ubiquitin, protein, ligase, 1external, idsomim, 6056. Protein ariadne 1 homolog is a protein that in humans is encoded by the ARIH1 gene 5 6 ARIH1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1WD2 2M9Y 4KBL 4KC9IdentifiersAliasesARIH1 ARI HARI HHARI UBCH7BP ariadne RBR E3 ubiquitin protein ligase 1External IDsOMIM 605624 MGI 1344363 HomoloGene 111871 GeneCards ARIH1Gene location Human Chr Chromosome 15 human 1 Band15q24 1Start72 474 330 bp 1 End72 602 987 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 BStart59 295 541 bp 2 End59 393 901 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocytesural nerveganglionic eminencestromal cell of endometriumAchilles tendongastrocnemius musclepopliteal arteryskin of abdomeninternal globus pallidushuman penisTop expressed insecondary oocyteseminiferous tubuleextensor digitorum longus musclespermatidplantaris muscletriceps brachii muscletemporal musclesternocleidomastoid muscleankledigastric muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionubiquitin like protein transferase activity protein binding metal ion binding ubiquitin protein ligase activity ubiquitin protein ligase binding ubiquitin protein transferase activity transferase activity ubiquitin conjugating enzyme binding zinc ion bindingCellular componentcytoplasm ubiquitin ligase complex cytosol nucleus Cajal body nuclear body SCF ubiquitin ligase complex Cul2 RING ubiquitin ligase complex Cul3 RING ubiquitin ligase complex Cul4A RING E3 ubiquitin ligase complex Lewy bodyBiological processprotein polyubiquitination positive regulation of proteasomal ubiquitin dependent protein catabolic process protein ubiquitination ubiquitin dependent protein catabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2582023806EnsemblENSG00000166233ENSMUSG00000025234UniProtQ9Y4X5Q9Z1K5RefSeq mRNA NM 005744NM 019927RefSeq protein NP 005735NP 064311Location UCSC Chr 15 72 47 72 6 MbChr 9 59 3 59 39 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 References 3 External links 4 Further readingInteractions EditARIH1 has been shown to interact with EIF4E2 7 and UBE2L3 5 7 8 References Edit a b c GRCh38 Ensembl release 89 ENSG00000166233 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000025234 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Moynihan TP Ardley HC Nuber U Rose SA Jones PF Markham AF Scheffner M Robinson PA November 1999 The ubiquitin conjugating enzymes UbcH7 and UbcH8 interact with RING finger IBR motif containing domains of HHARI and H7 AP1 J Biol Chem 274 43 30963 8 doi 10 1074 jbc 274 43 30963 PMID 10521492 Entrez Gene ARIH1 ariadne homolog ubiquitin conjugating enzyme E2 binding protein 1 Drosophila a b Tan NG Ardley HC Scott GB Rose SA Markham AF Robinson PA November 2003 Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein 4EHP FEBS Lett 554 3 501 4 doi 10 1016 s0014 5793 03 01235 3 PMID 14623119 Ardley HC Tan NG Rose SA Markham AF Robinson PA June 2001 Features of the parkin ariadne like ubiquitin ligase HHARI that regulate its interaction with the ubiquitin conjugating enzyme Ubch7 J Biol Chem 276 22 19640 7 doi 10 1074 jbc M011028200 PMID 11278816 External links EditHuman ARIH1 genome location and ARIH1 gene details page in the UCSC Genome Browser Further reading EditAguilera M Oliveros M Martinez Padron M Barbas JA Ferrus A 2000 Ariadne 1 a vital Drosophila gene is required in development and defines a new conserved family of ring finger proteins Genetics 155 3 1231 44 doi 10 1093 genetics 155 3 1231 PMC 1461160 PMID 10880484 Zhang Y Redina O Altshuller YM Yamazaki M Ramos J Chneiweiss H Kanaho Y Frohman MA 2001 Regulation of expression of phospholipase D1 and D2 by PEA 15 a novel protein that interacts with them J Biol Chem 275 45 35224 32 doi 10 1074 jbc M003329200 PMID 10926929 Tan NG Ardley HC Rose SA Leek JP Markham AF Robinson PA 2001 Characterisation of the human and mouse orthologues of the Drosophila ariadne gene Cytogenet Cell Genet 90 3 4 242 5 doi 10 1159 000056780 PMID 11124525 S2CID 12113119 Stanchi F Bertocco E Toppo S Dioguardi R Simionati B Cannata N Zimbello R Lanfranchi G Valle G 2001 Characterization of 16 novel human genes showing high similarity to yeast sequences Yeast 18 1 69 80 doi 10 1002 1097 0061 200101 18 1 lt 69 AID YEA647 gt 3 0 CO 2 H PMID 11124703 S2CID 21397515 Ardley HC Tan NG Rose SA Markham AF Robinson PA 2001 Features of the parkin ariadne like ubiquitin ligase HHARI that regulate its interaction with the ubiquitin conjugating enzyme Ubch7 J Biol Chem 276 22 19640 7 doi 10 1074 jbc M011028200 PMID 11278816 Wong ES Fong CW Lim J Yusoff P Low BC Langdon WY Guy GR 2002 Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis and consequently enhances Ras ERK signalling EMBO J 21 18 4796 808 doi 10 1093 emboj cdf493 PMC 126289 PMID 12234920 Tan NG Ardley HC Scott GB Rose SA Markham AF Robinson PA 2003 Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein 4EHP FEBS Lett 554 3 501 4 doi 10 1016 S0014 5793 03 01235 3 PMID 14623119 Capili AD Edghill EL Wu K Borden KL 2004 Structure of the C terminal RING finger from a RING IBR RING TRIAD motif reveals a novel zinc binding domain distinct from a RING J Mol Biol 340 5 1117 29 doi 10 1016 j jmb 2004 05 035 PMID 15236971 Parelkar SS Cadena JG Kim C Wang Z Sugal R Bentley B Moral L Ardley HC Schwartz LM 2012 The parkin like human homolog of Drosophila ariadne 1 HHARI can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies J Mol Neurosci 46 1 109 21 doi 10 1007 s12031 011 9535 1 PMID 21590270 S2CID 17276111 This article on a gene on human chromosome 15 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ARIH1 amp oldid 1171068730, wikipedia, wiki, book, books, library,

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