Mutation studies have revealed ARID2 to be a significant tumor suppressor in many cancer subtypes. ARID2 mutations are prevalent in hepatocellular carcinoma[7] and melanoma.[8][9] Mutations are present in a smaller but significant fraction in a wide range of other tumors.[10]ARID2 mutations are enriched in hepatitis C virus-associated hepatocellular carcinoma in the US and European patient populations compared with the overall mutation frequency.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000189079 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000033237 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abZhao H, Wang J, Han Y, Huang Z, Ying J, Bi X, Zhao J, Fang Y, Zhou H, Zhou J, Li Z, Zhang Y, Yang X, Yan T, Wang L, Torbenson MS, Cai J (Nov 2011). "ARID2: a new tumor suppressor gene in hepatocellular carcinoma". Oncotarget. 2 (11): 886–91. doi:10.18632/oncotarget.355. PMC3259997. PMID 22095441.
^Li M, Zhao H, Zhang X, Wood LD, Anders RA, Choti MA, Pawlik TM, Daniel HD, Kannangai R, Offerhaus GJ, Velculescu VE, Wang L, Zhou S, Vogelstein B, Hruban RH, Papadopoulos N, Cai J, Torbenson MS, Kinzler KW (Sep 2011). "Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma". Nature Genetics. 43 (9): 828–9. doi:10.1038/ng.903. PMC3163746. PMID 21822264.
^Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP, Nickerson E, Auclair D, Li L, Place C, Dicara D, Ramos AH, Lawrence MS, Cibulskis K, Sivachenko A, Voet D, Saksena G, Stransky N, Onofrio RC, Winckler W, Ardlie K, Wagle N, Wargo J, Chong K, Morton DL, Stemke-Hale K, Chen G, Noble M, Meyerson M, Ladbury JE, Davies MA, Gershenwald JE, Wagner SN, Hoon DS, Schadendorf D, Lander ES, Gabriel SB, Getz G, Garraway LA, Chin L (Jul 2012). "A landscape of driver mutations in melanoma". Cell. 150 (2): 251–63. doi:10.1016/j.cell.2012.06.024. PMC3600117. PMID 22817889.
^Krauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker JP, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ, Halaban R (Sep 2012). "Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma". Nature Genetics. 44 (9): 1006–14. doi:10.1038/ng.2359. PMC3432702. PMID 22842228.
^Shain AH, Pollack JR (2013). "The spectrum of SWI/SNF mutations, ubiquitous in human cancers". PLOS ONE. 8 (1): e55119. Bibcode:2013PLoSO...855119S. doi:10.1371/journal.pone.0055119. PMC3552954. PMID 23355908.
Further readingedit
Martens JA, Winston F (Apr 2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes". Current Opinion in Genetics & Development. 13 (2): 136–42. doi:10.1016/S0959-437X(03)00022-4. PMID 12672490.
Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C (Aug 2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". The Journal of Biological Chemistry. 279 (32): 33727–41. doi:10.1074/jbc.M401708200. PMID 15159402.
Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins". Nucleic Acids Research. 33 (1): 66–80. doi:10.1093/nar/gki145. PMC546134. PMID 15640446.
Wilsker D, Probst L, Wain HM, Maltais L, Tucker PW, Moran E (Aug 2005). "Nomenclature of the ARID family of DNA-binding proteins". Genomics. 86 (2): 242–51. doi:10.1016/j.ygeno.2005.03.013. PMID 15922553.
Yan Z, Cui K, Murray DM, Ling C, Xue Y, Gerstein A, Parsons R, Zhao K, Wang W (Jul 2005). "PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes". Genes & Development. 19 (14): 1662–7. doi:10.1101/gad.1323805. PMC1176002. PMID 15985610.
Zhang X, Azhar G, Zhong Y, Wei JY (Aug 2006). "Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation". Biochemical and Biophysical Research Communications. 346 (3): 794–801. doi:10.1016/j.bbrc.2006.05.211. PMID 16782067.
arid2, rich, interactive, domain, containing, protein, protein, that, humans, encoded, gene, identifiersaliases, baf200, p200, rich, interaction, domain, css6, smarcf3external, idsomim, 609539, 1924294, homologene, 14601, genecards, gene, location, human, chro. AT rich interactive domain containing protein 2 ARID2 is a protein that in humans is encoded by the ARID2 gene 5 ARID2IdentifiersAliasesARID2 BAF200 p200 AT rich interaction domain 2 CSS6 SMARCF3External IDsOMIM 609539 MGI 1924294 HomoloGene 14601 GeneCards ARID2Gene location Human Chr Chromosome 12 human 1 Band12q12Start45 729 706 bp 1 End45 908 040 bp 1 Gene location Mouse Chr Chromosome 15 mouse 2 Band15 15 F1Start96 185 399 bp 2 End96 302 873 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspermpancreatic ductal cellsecondary oocytebone marrow cellsthymusganglionic eminencetrabecular boneAchilles tendonnippletibialis anterior muscleTop expressed inhair follicleprimitive streakciliary bodyinternal carotid arteryexternal carotid arteryhandvas deferensirisPaneth cellcumulus cellMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding protein binding metal ion binding nucleic acid binding DNA binding transcription factor activity RNA polymerase II specificCellular componentplasma membrane nucleus nucleoplasmBiological processnucleosome disassembly regulation of transcription DNA templated transcription DNA templated negative regulation of cell migration negative regulation of cell population proliferation heart morphogenesis homeostatic process embryonic organ development cardiac muscle cell proliferation coronary artery morphogenesis chromatin organization regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez19652877044EnsemblENSG00000189079ENSMUSG00000033237UniProtQ68CP9E9Q7E2RefSeq mRNA NM 152641NM 001347839NM 175251RefSeq protein NP 001334768NP 689854NP 780460Location UCSC Chr 12 45 73 45 91 MbChr 15 96 19 96 3 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Structure 3 Clinical significance 4 References 5 Further reading 6 External linksFunction editARID2 is a subunit of the PBAF chromatin remodeling complex which facilitates ligand dependent transcriptional activation by nuclear receptors 5 Structure editThe ARID2 protein contains two conserved C terminal C2H2 zinc fingers motifs a region rich in the amino acid residues proline and glutamine a RFX regulatory factor X type winged helix DNA binding domain and a conserved N terminal AT rich DNA interaction domain the last domain for which the protein is named 6 Clinical significance editMutation studies have revealed ARID2 to be a significant tumor suppressor in many cancer subtypes ARID2 mutations are prevalent in hepatocellular carcinoma 7 and melanoma 8 9 Mutations are present in a smaller but significant fraction in a wide range of other tumors 10 ARID2 mutations are enriched in hepatitis C virus associated hepatocellular carcinoma in the US and European patient populations compared with the overall mutation frequency 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000189079 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000033237 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene ARID2 AT rich interactive domain 2 ARID RFX like a b Zhao H Wang J Han Y Huang Z Ying J Bi X Zhao J Fang Y Zhou H Zhou J Li Z Zhang Y Yang X Yan T Wang L Torbenson MS Cai J Nov 2011 ARID2 a new tumor suppressor gene in hepatocellular carcinoma Oncotarget 2 11 886 91 doi 10 18632 oncotarget 355 PMC 3259997 PMID 22095441 Li M Zhao H Zhang X Wood LD Anders RA Choti MA Pawlik TM Daniel HD Kannangai R Offerhaus GJ Velculescu VE Wang L Zhou S Vogelstein B Hruban RH Papadopoulos N Cai J Torbenson MS Kinzler KW Sep 2011 Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma Nature Genetics 43 9 828 9 doi 10 1038 ng 903 PMC 3163746 PMID 21822264 Hodis E Watson IR Kryukov GV Arold ST Imielinski M Theurillat JP Nickerson E Auclair D Li L Place C Dicara D Ramos AH Lawrence MS Cibulskis K Sivachenko A Voet D Saksena G Stransky N Onofrio RC Winckler W Ardlie K Wagle N Wargo J Chong K Morton DL Stemke Hale K Chen G Noble M Meyerson M Ladbury JE Davies MA Gershenwald JE Wagner SN Hoon DS Schadendorf D Lander ES Gabriel SB Getz G Garraway LA Chin L Jul 2012 A landscape of driver mutations in melanoma Cell 150 2 251 63 doi 10 1016 j cell 2012 06 024 PMC 3600117 PMID 22817889 Krauthammer M Kong Y Ha BH Evans P Bacchiocchi A McCusker JP Cheng E Davis MJ Goh G Choi M Ariyan S Narayan D Dutton Regester K Capatana A Holman EC Bosenberg M Sznol M Kluger HM Brash DE Stern DF Materin MA Lo RS Mane S Ma S Kidd KK Hayward NK Lifton RP Schlessinger J Boggon TJ Halaban R Sep 2012 Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma Nature Genetics 44 9 1006 14 doi 10 1038 ng 2359 PMC 3432702 PMID 22842228 Shain AH Pollack JR 2013 The spectrum of SWI SNF mutations ubiquitous in human cancers PLOS ONE 8 1 e55119 Bibcode 2013PLoSO 855119S doi 10 1371 journal pone 0055119 PMC 3552954 PMID 23355908 Further reading editMartens JA Winston F Apr 2003 Recent advances in understanding chromatin remodeling by Swi Snf complexes Current Opinion in Genetics amp Development 13 2 136 42 doi 10 1016 S0959 437X 03 00022 4 PMID 12672490 Nagase T Kikuno R Nakayama M Hirosawa M Ohara O Aug 2000 Prediction of the coding sequences of unidentified human genes XVIII The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Research 7 4 273 81 doi 10 1093 dnares 7 4 271 PMID 10997877 Mohrmann L Langenberg K Krijgsveld J Kal AJ Heck AJ Verrijzer CP Apr 2004 Differential targeting of two distinct SWI SNF related Drosophila chromatin remodeling complexes Molecular and Cellular Biology 24 8 3077 88 doi 10 1128 MCB 24 8 3077 3088 2004 PMC 381637 PMID 15060132 Brandenberger R Wei H Zhang S Lei S Murage J Fisk GJ Li Y Xu C Fang R Guegler K Rao MS Mandalam R Lebkowski J Stanton LW Jun 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation Nature Biotechnology 22 6 707 16 doi 10 1038 nbt971 PMID 15146197 S2CID 27764390 Diederichs S Baumer N Ji P Metzelder SK Idos GE Cauvet T Wang W Moller M Pierschalski S Gromoll J Schrader MG Koeffler HP Berdel WE Serve H Muller Tidow C Aug 2004 Identification of interaction partners and substrates of the cyclin A1 CDK2 complex The Journal of Biological Chemistry 279 32 33727 41 doi 10 1074 jbc M401708200 PMID 15159402 Patsialou A Wilsker D Moran E 2005 DNA binding properties of ARID family proteins Nucleic Acids Research 33 1 66 80 doi 10 1093 nar gki145 PMC 546134 PMID 15640446 Wilsker D Probst L Wain HM Maltais L Tucker PW Moran E Aug 2005 Nomenclature of the ARID family of DNA binding proteins Genomics 86 2 242 51 doi 10 1016 j ygeno 2005 03 013 PMID 15922553 Yan Z Cui K Murray DM Ling C Xue Y Gerstein A Parsons R Zhao K Wang W Jul 2005 PBAF chromatin remodeling complex requires a novel specificity subunit BAF200 to regulate expression of selective interferon responsive genes Genes amp Development 19 14 1662 7 doi 10 1101 gad 1323805 PMC 1176002 PMID 15985610 Zhang X Azhar G Zhong Y Wei JY Aug 2006 Zipzap p200 is a novel zinc finger protein contributing to cardiac gene regulation Biochemical and Biophysical Research Communications 346 3 794 801 doi 10 1016 j bbrc 2006 05 211 PMID 16782067 External links editARID2 protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human ARID2 genome location and ARID2 gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title ARID2 amp oldid 1190501304, wikipedia, wiki, book, books, library,
