The APC internal ribosome entry site (IRES) is an RNA element which is located in the coding sequence of the APC gene. APC is a tumour suppressor gene which is associated with the inherited diseaseadenomatous polyposis coli (APC). It is thought that IRES-mediated translation of APC is important for an apoptotic cascade.[1]
^Heppner Goss K, Trzepacz C, Tuohy TM, Groden J (June 2002). "Attenuated APC alleles produce functional protein from internal translation initiation". Proceedings of the National Academy of Sciences of the United States of America. 99 (12): 8161–8166. doi:10.1073/pnas.112072199. PMC123038. PMID 12034871.
External linksedit
Page for APC internal ribosome entry site (IRES) at Rfam
internal, ribosome, entry, site, ires, element, which, located, coding, sequence, gene, tumour, suppressor, gene, which, associated, with, inherited, disease, adenomatous, polyposis, coli, thought, that, ires, mediated, translation, important, apoptotic, casca. The APC internal ribosome entry site IRES is an RNA element which is located in the coding sequence of the APC gene APC is a tumour suppressor gene which is associated with the inherited disease adenomatous polyposis coli APC It is thought that IRES mediated translation of APC is important for an apoptotic cascade 1 APC internal ribosome entry site IRES Predicted secondary structure and sequence conservation of IRES APCIdentifiersSymbolIRES APCRfamRF00462Other dataRNA typeCis reg IRESDomain s EukaryotaGOGO 0043022SOSO 0000243PDB structuresPDBeReferences edit Heppner Goss K Trzepacz C Tuohy TM Groden J June 2002 Attenuated APC alleles produce functional protein from internal translation initiation Proceedings of the National Academy of Sciences of the United States of America 99 12 8161 8166 doi 10 1073 pnas 112072199 PMC 123038 PMID 12034871 External links editPage for APC internal ribosome entry site IRES at Rfam nbsp This molecular or cell biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title APC internal ribosome entry site IRES amp oldid 1079709090, wikipedia, wiki, book, books, library,
