^ abBerger R, Mezey E, Clancy KP, Harta G, Wright RM, Repine JE, Brown RH, Brownstein M, Patterson D (March 1995). "Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis". Somat. Cell Mol. Genet. 21 (2): 121–31. doi:10.1007/BF02255787. PMID 7570184. S2CID 24691533.
External linksedit
Human AOX1 genome location and AOX1 gene details page in the UCSC Genome Browser.
Further readingedit
Wang AG, Yoon SY, Oh JH, et al. (2006). "Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags". Biochem. Biophys. Res. Commun. 345 (3): 1022–32. doi:10.1016/j.bbrc.2006.04.175. PMID 16712791.
Smith MA, Marinaki AM, Arenas M, et al. (2009). "Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease". Aliment. Pharmacol. Ther. 30 (4): 375–84. doi:10.1111/j.1365-2036.2009.04057.x. PMID 19500084. S2CID 1292701.
Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC2896464. PMID 20379614.
Sigruener A, Buechler C, Orsó E, et al. (2007). "Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes". Horm. Metab. Res. 39 (11): 781–9. doi:10.1055/s-2007-992129. PMID 17992631. S2CID 28460089.
Ichida K, Matsumura T, Sakuma R, et al. (2001). "Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II". Biochem. Biophys. Res. Commun. 282 (5): 1194–200. doi:10.1006/bbrc.2001.4719. PMID 11302742.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Alfaro JF, Joswig-Jones CA, Ouyang W, et al. (2009). "Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli". Drug Metab. Dispos. 37 (12): 2393–8. doi:10.1124/dmd.109.029520. PMC2784701. PMID 19741035.
Rodrigues AD (1994). "Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro". Biochem. Pharmacol. 48 (1): 197–200. doi:10.1016/0006-2952(94)90240-2. PMID 8043023.
Wright RM, Vaitaitis GM, Wilson CM, et al. (1993). "cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10690–4. Bibcode:1993PNAS...9010690W. doi:10.1073/pnas.90.22.10690. PMC47843. PMID 8248161.
Buechler C, Boettcher A, Bared SM, et al. (2002). "The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex". Biochem. Biophys. Res. Commun. 293 (2): 759–65. doi:10.1016/S0006-291X(02)00303-0. PMID 12054535.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ross CJ, Katzov-Eckert H, Dubé MP, et al. (2009). "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy". Nat. Genet. 41 (12): 1345–9. doi:10.1038/ng.478. PMID 19898482. S2CID 21293339.
aldehyde, oxidase, enzyme, that, humans, encoded, aox1, gene, aox1available, structurespdbortholog, search, pdbe, rcsblist, codes4uhw, 4uhx, 5epgidentifiersaliasesaox1, aoh1, aldehyde, oxidase, 1external, idsomim, 602841, 88035, homologene, 68165, genecards, a. Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene 5 6 AOX1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4UHW 4UHX 5EPGIdentifiersAliasesAOX1 AO AOH1 aldehyde oxidase 1External IDsOMIM 602841 MGI 88035 HomoloGene 68165 GeneCards AOX1Gene location Human Chr Chromosome 2 human 1 Band2q33 1Start200 586 014 bp 1 End200 677 064 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 C1 3 1 28 86 cMStart58 069 090 bp 2 End58 145 572 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright lobe of liverbody of pancreasleft uterine tubegerminal epitheliumsubcutaneous adipose tissuekidney tubulegastric mucosakidneypopliteal arteryparietal pleuraTop expressed inleft lobe of liverbrown adipose tissuesoleus musclewhite adipose tissuefacial motor nucleusesophagusintercostal musclesubcutaneous adipose tissueright lungextraocular muscleMore reference expression dataBioGPSn aGene ontologyMolecular functionoxidoreductase activity acting on CH OH group of donors iron sulfur cluster binding NAD binding metal ion binding catalytic activity electron transfer activity oxidoreductase activity oxidoreductase activity acting on the aldehyde or oxo group of donors aldehyde oxidase activity iron ion binding protein homodimerization activity molybdopterin cofactor binding flavin adenine dinucleotide binding 2 iron 2 sulfur cluster binding identical protein binding xanthine dehydrogenase activity FAD bindingCellular componentextracellular exosome cytoplasm cytosol nuclear bodyBiological processxanthine catabolic process vitamin B6 metabolic process electron transport chainSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez31611761EnsemblENSG00000138356ENSMUSG00000063558UniProtQ06278O54754RefSeq mRNA NM 001159NM 009676RefSeq protein NP 001150NP 033806Location UCSC Chr 2 200 59 200 68 MbChr 1 58 07 58 15 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseAldehyde oxidase produces hydrogen peroxide and under certain conditions can catalyze the formation of superoxide 5 Contents 1 Clinical significance 2 See also 3 References 4 External links 5 Further readingClinical significance editAldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis 6 See also editMOCOSReferences edit a b c GRCh38 Ensembl release 89 ENSG00000138356 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000063558 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene aldehyde oxidase 1 a b Berger R Mezey E Clancy KP Harta G Wright RM Repine JE Brown RH Brownstein M Patterson D March 1995 Analysis of aldehyde oxidase and xanthine dehydrogenase oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis Somat Cell Mol Genet 21 2 121 31 doi 10 1007 BF02255787 PMID 7570184 S2CID 24691533 External links editHuman AOX1 genome location and AOX1 gene details page in the UCSC Genome Browser Further reading editWang AG Yoon SY Oh JH et al 2006 Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags Biochem Biophys Res Commun 345 3 1022 32 doi 10 1016 j bbrc 2006 04 175 PMID 16712791 Smith MA Marinaki AM Arenas M et al 2009 Novel pharmacogenetic markers for treatment outcome in azathioprine treated inflammatory bowel disease Aliment Pharmacol Ther 30 4 375 84 doi 10 1111 j 1365 2036 2009 04057 x PMID 19500084 S2CID 1292701 Rose JE Behm FM Drgon T et al 2010 Personalized smoking cessation interactions between nicotine dose dependence and quit success genotype score Mol Med 16 7 8 247 53 doi 10 2119 molmed 2009 00159 PMC 2896464 PMID 20379614 Sigruener A Buechler C Orso E et al 2007 Human aldehyde oxidase 1 interacts with ATP binding cassette transporter 1 and modulates its activity in hepatocytes Horm Metab Res 39 11 781 9 doi 10 1055 s 2007 992129 PMID 17992631 S2CID 28460089 Ichida K Matsumura T Sakuma R et al 2001 Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II Biochem Biophys Res Commun 282 5 1194 200 doi 10 1006 bbrc 2001 4719 PMID 11302742 Bonaldo MF Lennon G Soares MB 1996 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Alfaro JF Joswig Jones CA Ouyang W et al 2009 Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli Drug Metab Dispos 37 12 2393 8 doi 10 1124 dmd 109 029520 PMC 2784701 PMID 19741035 Rodrigues AD 1994 Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro Biochem Pharmacol 48 1 197 200 doi 10 1016 0006 2952 94 90240 2 PMID 8043023 Wright RM Vaitaitis GM Wilson CM et al 1993 cDNA cloning characterization and tissue specific expression of human xanthine dehydrogenase xanthine oxidase Proc Natl Acad Sci U S A 90 22 10690 4 Bibcode 1993PNAS 9010690W doi 10 1073 pnas 90 22 10690 PMC 47843 PMID 8248161 Buechler C Boettcher A Bared SM et al 2002 The carboxyterminus of the ATP binding cassette transporter A1 interacts with a beta2 syntrophin utrophin complex Biochem Biophys Res Commun 293 2 759 65 doi 10 1016 S0006 291X 02 00303 0 PMID 12054535 Strausberg RL Feingold EA Grouse LH et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ross CJ Katzov Eckert H Dube MP et al 2009 Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy Nat Genet 41 12 1345 9 doi 10 1038 ng 478 PMID 19898482 S2CID 21293339 Portal nbsp Biology nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved 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