Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000159461 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031751 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A (Aug 1991). "Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor". J Biol Chem. 266 (20): 13442–8. doi:10.1016/S0021-9258(18)98859-9. PMID 1649192.
^Zhong, Xiaoyan; Shen Yuxian; Ballar Petek; Apostolou Andria; Agami Reuven; Fang Shengyun (Oct 2004). "AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation". J. Biol. Chem. 279 (44). United States: 45676–84. doi:10.1074/jbc.M409034200. ISSN 0021-9258. PMID 15331598.
^Lee, Joon No; Zhang Xiangyu; Feramisco Jamison D; Gong Yi; Ye Jin (Nov 2008). "Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step". J. Biol. Chem. 283 (48). United States: 33772–83. doi:10.1074/jbc.M806108200. ISSN 0021-9258. PMC2586246. PMID 18835813.
External linksedit
Human AMFR genome location and AMFR gene details page in the UCSC Genome Browser.
Further readingedit
Huang B, Xie Y, Raz A (1995). "Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor". Biochem. Biophys. Res. Commun. 212 (3): 727–42. doi:10.1006/bbrc.1995.2031. PMID 7626106.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Shimizu K, Tani M, Watanabe H, et al. (1999). "The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein". FEBS Lett. 456 (2): 295–300. doi:10.1016/S0014-5793(99)00966-7. PMID 10456327. S2CID 39270348.
Fang S, Ferrone M, Yang C, et al. (2002). "The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum". Proc. Natl. Acad. Sci. U.S.A. 98 (25): 14422–7. Bibcode:2001PNAS...9814422F. doi:10.1073/pnas.251401598. PMC64697. PMID 11724934.
Luo Y, Long JM, Lu C, et al. (2002). "A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78". J. Neurochem. 80 (2): 354–61. doi:10.1046/j.0022-3042.2001.00707.x. PMID 11902125. S2CID 29857457.
Tímár J, Rásó E, Döme B, et al. (2002). "Expression and function of the AMF receptor by human melanoma in experimental and clinical systems". Clin. Exp. Metastasis. 19 (3): 225–32. doi:10.1023/A:1015595708241. PMID 12067203. S2CID 453423.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Liang JS, Kim T, Fang S, et al. (2003). "Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells". J. Biol. Chem. 278 (26): 23984–8. doi:10.1074/jbc.M302683200. PMID 12670940.
Takanami I, Takeuchi K (2003). "Autocrine motility factor-receptor gene expression in lung cancer". Jpn. J. Thorac. Cardiovasc. Surg. 51 (8): 368–73. doi:10.1007/BF02719469. PMID 12962414.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Registre M, Goetz JG, St Pierre P, et al. (2004). "The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum". Biochem. Biophys. Res. Commun. 320 (4): 1316–22. doi:10.1016/j.bbrc.2004.06.089. PMID 15303277.
Zhong X, Shen Y, Ballar P, et al. (2004). "AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation". J. Biol. Chem. 279 (44): 45676–84. doi:10.1074/jbc.M409034200. PMID 15331598.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Song BL, Sever N, DeBose-Boyd RA (2005). "Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase". Mol. Cell. 19 (6): 829–40. doi:10.1016/j.molcel.2005.08.009. PMID 16168377.
Kaynak K, Kara M, Oz B, et al. (2006). "Autocrine motility factor receptor expression implies an unfavourable prognosis in resected stage I pulmonary adenocarcinomas". Acta Chir. Belg. 105 (4): 378–82. doi:10.1080/00015458.2005.11679740. PMID 16184720. S2CID 3032480.
Ye Y, Shibata Y, Kikkert M, et al. (2006). "Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14132–8. Bibcode:2005PNAS..10214132Y. doi:10.1073/pnas.0505006102. PMC1242302. PMID 16186510.
Chen B, Mariano J, Tsai YC, et al. (2006). "The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site". Proc. Natl. Acad. Sci. U.S.A. 103 (2): 341–6. Bibcode:2006PNAS..103..341C. doi:10.1073/pnas.0506618103. PMC1326157. PMID 16407162.
Haga A, Tanaka N, Funasaka T, et al. (2006). "The autocrine motility factor (AMF) and AMF-receptor combination needs sugar chain recognition ability and interaction using the C-terminal region of AMF". J. Mol. Biol. 358 (3): 741–53. doi:10.1016/j.jmb.2006.02.046. PMID 16563432.
Shen Y, Ballar P, Fang S (2006). "Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin". Biochem. Biophys. Res. Commun. 349 (4): 1285–93. doi:10.1016/j.bbrc.2006.08.173. PMID 16979136.
May 08, 2024
amfr, autocrine, motility, factor, receptor, isoform, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2ejs, 2lvn, 2lvo, 2lvp, 2lvq, 2lxh, 2lxp, 3fsh, 3h8k, 3tiw, 4g3o, 4ladidentifiersaliases, gp78, rnf45, au. Autocrine motility factor receptor isoform 2 is a protein that in humans is encoded by the AMFR gene 5 6 AMFRAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LADIdentifiersAliasesAMFR GP78 RNF45 autocrine motility factor receptorExternal IDsOMIM 603243 MGI 1345634 HomoloGene 888 GeneCards AMFRGene location Human Chr Chromosome 16 human 1 Band16q13Start56 361 452 bp 1 End56 425 545 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 C5 8 45 96 cMStart94 698 216 bp 2 End94 739 470 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed instromal cell of endometriumgastrocnemius muscleAchilles tendonleft adrenal glandright lobe of livercanal of the cervixgallbladderislet of Langerhanstibial nerveright coronary arteryTop expressed inspermatocytespermatidsecondary oocyteankletriceps brachii muscledigastric muscleleft lobe of liversternocleidomastoid muscletemporal musclecerebellar vermisMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein macromolecule adaptor activity chaperone binding ubiquitin protein ligase activity metal ion binding ubiquitin protein transferase activity ubiquitin ubiquitin ligase activity protein binding ubiquitin specific protease binding transferase activity identical protein binding BAT3 complex binding signaling receptor activityCellular componentcytoplasm integral component of membrane membrane growth cone integral component of endoplasmic reticulum membrane neuronal cell body dendrite Derlin 1 retrotranslocation complex perinuclear region of cytoplasm nucleus endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus endoplasmic reticulum quality control compartment protein containing complex ubiquitin ligase complex cytosolBiological processERAD pathway ubiquitin dependent protein catabolic process human ageing protein polyubiquitination endoplasmic reticulum unfolded protein response protein K48 linked ubiquitination protein complex oligomerization protein ubiquitination ubiquitin dependent ERAD pathway learning or memory positive regulation of protein binding signal transduction protein autoubiquitination protein folding endoplasmic reticulum mannose trimmingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez26723802EnsemblENSG00000159461ENSMUSG00000031751UniProtQ9UKV5Q9R049RefSeq mRNA NM 001144NM 138958NM 001323511NM 001323512NM 011787RefSeq protein NP 001135NP 001310440NP 001310441NP 035917Location UCSC Chr 16 56 36 56 43 MbChr 8 94 7 94 74 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Autocrine motility factor is a tumor motility stimulating protein secreted by tumor cells The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor The receptor which shows some sequence similarity to tumor protein p53 is localized to the leading and trailing edges of carcinoma cells 6 Contents 1 Interactions 2 References 3 External links 4 Further readingInteractions editAMFR has been shown to interact with Valosin containing protein 7 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000159461 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000031751 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Watanabe H Carmi P Hogan V Raz T Silletti S Nabi IR Raz A Aug 1991 Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor J Biol Chem 266 20 13442 8 doi 10 1016 S0021 9258 18 98859 9 PMID 1649192 a b Entrez Gene AMFR autocrine motility factor receptor Zhong Xiaoyan Shen Yuxian Ballar Petek Apostolou Andria Agami Reuven Fang Shengyun Oct 2004 AAA ATPase p97 valosin containing protein interacts with gp78 a ubiquitin ligase for endoplasmic reticulum associated degradation J Biol Chem 279 44 United States 45676 84 doi 10 1074 jbc M409034200 ISSN 0021 9258 PMID 15331598 Lee Joon No Zhang Xiangyu Feramisco Jamison D Gong Yi Ye Jin Nov 2008 Unsaturated fatty acids inhibit proteasomal degradation of Insig 1 at a postubiquitination step J Biol Chem 283 48 United States 33772 83 doi 10 1074 jbc M806108200 ISSN 0021 9258 PMC 2586246 PMID 18835813 External links editHuman AMFR genome location and AMFR gene details page in the UCSC Genome Browser Further reading editHuang B Xie Y Raz A 1995 Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor Biochem Biophys Res Commun 212 3 727 42 doi 10 1006 bbrc 1995 2031 PMID 7626106 Hillier LD Lennon G Becker M et al 1997 Generation and analysis of 280 000 human expressed sequence tags Genome Res 6 9 807 28 doi 10 1101 gr 6 9 807 PMID 8889549 Shimizu K Tani M Watanabe H et al 1999 The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein FEBS Lett 456 2 295 300 doi 10 1016 S0014 5793 99 00966 7 PMID 10456327 S2CID 39270348 Fang S Ferrone M Yang C et al 2002 The tumor autocrine motility factor receptor gp78 is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum Proc Natl Acad Sci U S A 98 25 14422 7 Bibcode 2001PNAS 9814422F doi 10 1073 pnas 251401598 PMC 64697 PMID 11724934 Luo Y Long JM Lu C et al 2002 A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78 J Neurochem 80 2 354 61 doi 10 1046 j 0022 3042 2001 00707 x PMID 11902125 S2CID 29857457 Timar J Raso E Dome B et al 2002 Expression and function of the AMF receptor by human melanoma in experimental and clinical systems Clin Exp Metastasis 19 3 225 32 doi 10 1023 A 1015595708241 PMID 12067203 S2CID 453423 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Liang JS Kim T Fang S et al 2003 Overexpression of the tumor autocrine motility factor receptor Gp78 a ubiquitin protein ligase results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells J Biol Chem 278 26 23984 8 doi 10 1074 jbc M302683200 PMID 12670940 Takanami I Takeuchi K 2003 Autocrine motility factor receptor gene expression in lung cancer Jpn J Thorac Cardiovasc Surg 51 8 368 73 doi 10 1007 BF02719469 PMID 12962414 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Registre M Goetz JG St Pierre P et al 2004 The gene product of the gp78 AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum Biochem Biophys Res Commun 320 4 1316 22 doi 10 1016 j bbrc 2004 06 089 PMID 15303277 Zhong X Shen Y Ballar P et al 2004 AAA ATPase p97 valosin containing protein interacts with gp78 a ubiquitin ligase for endoplasmic reticulum associated degradation J Biol Chem 279 44 45676 84 doi 10 1074 jbc M409034200 PMID 15331598 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Song BL Sever N DeBose Boyd RA 2005 Gp78 a membrane anchored ubiquitin ligase associates with Insig 1 and couples sterol regulated ubiquitination to degradation of HMG CoA reductase Mol Cell 19 6 829 40 doi 10 1016 j molcel 2005 08 009 PMID 16168377 Kaynak K Kara M Oz B et al 2006 Autocrine motility factor receptor expression implies an unfavourable prognosis in resected stage I pulmonary adenocarcinomas Acta Chir Belg 105 4 378 82 doi 10 1080 00015458 2005 11679740 PMID 16184720 S2CID 3032480 Ye Y Shibata Y Kikkert M et al 2006 Inaugural Article Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane Proc Natl Acad Sci U S A 102 40 14132 8 Bibcode 2005PNAS 10214132Y doi 10 1073 pnas 0505006102 PMC 1242302 PMID 16186510 Chen B Mariano J Tsai YC et al 2006 The activity of a human endoplasmic reticulum associated degradation E3 gp78 requires its Cue domain RING finger and an E2 binding site Proc Natl Acad Sci U S A 103 2 341 6 Bibcode 2006PNAS 103 341C doi 10 1073 pnas 0506618103 PMC 1326157 PMID 16407162 Haga A Tanaka N Funasaka T et al 2006 The autocrine motility factor AMF and AMF receptor combination needs sugar chain recognition ability and interaction using the C terminal region of AMF J Mol Biol 358 3 741 53 doi 10 1016 j jmb 2006 02 046 PMID 16563432 Shen Y Ballar P Fang S 2006 Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha 1 antitrypsin Biochem Biophys Res Commun 349 4 1285 93 doi 10 1016 j bbrc 2006 08 173 PMID 16979136 Retrieved from https en wikipedia org w index php title AMFR amp oldid 1222754477, wikipedia, wiki, book, books, library,
