This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000082146 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026027 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (January 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
^Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG (Jul 2004). "Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade". Journal of Biology. 2 (4): 28. doi:10.1186/1475-4924-2-28. PMC333410. PMID 14511394.
^Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ (August 2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". The Journal of Biological Chemistry. 277 (34): 30454–62. doi:10.1074/jbc.M203312200. PMID 12048196.
External linksedit
Human STRADB genome location and STRADB gene details page in the UCSC Genome Browser.
Further readingedit
Alessi DR, Sakamoto K, Bayascas JR (2007). "LKB1-dependent signaling pathways". Annual Review of Biochemistry. 75: 137–63. doi:10.1146/annurev.biochem.75.103004.142702. PMID 16756488.
Boudeau J, Miranda-Saavedra D, Barton GJ, Alessi DR (September 2006). "Emerging roles of pseudokinases". Trends in Cell Biology. 16 (9): 443–52. doi:10.1016/j.tcb.2006.07.003. PMID 16879967.
Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ (August 2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". The Journal of Biological Chemistry. 277 (34): 30454–62. doi:10.1074/jbc.M203312200. PMID 12048196.
Nishigaki K, Thompson D, Yugawa T, Rulli K, Hanson C, Cmarik J, Gutkind JS, Teramoto H, Ruscetti S (April 2003). "Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase". The Journal of Biological Chemistry. 278 (15): 13520–30. doi:10.1074/jbc.M208601200. PMID 12574163.
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR (October 2003). "MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". The EMBO Journal. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC204473. PMID 14517248.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (March 2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". The Journal of Biological Chemistry. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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als2cr2, ste20, related, kinase, adapter, protein, beta, enzyme, that, humans, encoded, stradb, gene, stradbidentifiersaliasesstradb, ste20, related, kinase, adaptor, beta, cals, ilpip, ilpipa, papk, pro1038, ste20, related, adaptor, betaexternal, idsomim, 607. STE20 related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene 5 6 7 STRADBIdentifiersAliasesSTRADB STE20 related kinase adaptor beta CALS 21 ILPIP ILPIPA PAPK PRO1038 ALS2CR2 STE20 related adaptor betaExternal IDsOMIM 607333 MGI 2144047 HomoloGene 10237 GeneCards STRADBGene location Human Chr Chromosome 2 human 1 Band2q33 1Start201 387 858 bp 1 End201 480 846 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 C1 3 1 29 2 cMStart59 012 681 bp 2 End59 034 874 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbloodleft adrenal glandgastrocnemius muscleright lobe of liverskeletal muscle tissueduodenumrectumkidneybone marrowleft ventricleTop expressed invastus lateralis muscletriceps brachii muscleknee jointsternocleidomastoid muscletemporal muscleblooddigastric muscletibialis anterior muscleskeletal muscle tissuesoleus muscleMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein kinase activity nucleotide binding protein binding ATP binding protein serine threonine kinase activityCellular componentcytoplasm nucleus cytosol aggresomeBiological processprotein phosphorylation cell cycle negative regulation of extrinsic apoptotic signaling pathway in absence of ligand activation of protein kinase activity cell morphogenesis protein export from nucleus regulation of mitotic cell cycle stress activated protein kinase signaling cascade regulation of apoptotic process MAPK cascade signal transduction neuron projection morphogenesisSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez55437227154EnsemblENSG00000082146ENSMUSG00000026027UniProtQ9C0K7Q8K4T3RefSeq mRNA NM 001206864NM 018571NM 172656NM 173155RefSeq protein NP 001193793NP 061041NP 766244Location UCSC Chr 2 201 39 201 48 MbChr 1 59 01 59 03 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This gene encodes a protein that belongs to the serine threonine protein kinase STE20 subfamily One of the active site residues in the protein kinase domain of this protein is altered and it is thus a pseudokinase This protein is a component of a complex involved in the activation of serine threonine kinase 11 a master kinase that regulates cell polarity and energy generating metabolism This complex regulates the relocation of this kinase from the nucleus to the cytoplasm and it is essential for G1 cell cycle arrest mediated by this kinase The protein encoded by this gene can also interact with the X chromosome linked inhibitor of apoptosis protein and this interaction enhances the anti apoptotic activity of this protein via the JNK1 signal transduction pathway Two pseudogenes located on chromosomes 1 and 7 have been found for this gene 7 Contents 1 Interactions 2 References 3 External links 4 Further readingInteractions editALS2CR2 has been shown to interact with XIAP 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000082146 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000026027 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Hadano S Yanagisawa Y Skaug J Fichter K Nasir J Martindale D Koop BF Scherer SW Nicholson DW Rouleau GA Ikeda J Hayden MR January 2001 Cloning and characterization of three novel genes ALS2CR1 ALS2CR2 and ALS2CR3 in the juvenile amyotrophic lateral sclerosis ALS2 critical region at chromosome 2q33 q34 candidate genes for ALS2 Genomics 71 2 200 13 doi 10 1006 geno 2000 6392 PMID 11161814 Hawley SA Boudeau J Reid JL Mustard KJ Udd L Makela TP Alessi DR Hardie DG Jul 2004 Complexes between the LKB1 tumor suppressor STRAD alpha beta and MO25 alpha beta are upstream kinases in the AMP activated protein kinase cascade Journal of Biology 2 4 28 doi 10 1186 1475 4924 2 28 PMC 333410 PMID 14511394 a b Entrez Gene ALS2CR2 amyotrophic lateral sclerosis 2 juvenile chromosome region candidate 2 Sanna MG da Silva Correia J Luo Y Chuang B Paulson LM Nguyen B Deveraux QL Ulevitch RJ August 2002 ILPIP a novel anti apoptotic protein that enhances XIAP mediated activation of JNK1 and protection against apoptosis The Journal of Biological Chemistry 277 34 30454 62 doi 10 1074 jbc M203312200 PMID 12048196 External links editHuman STRADB genome location and STRADB gene details page in the UCSC Genome Browser Further reading editAlessi DR Sakamoto K Bayascas JR 2007 LKB1 dependent signaling pathways Annual Review of Biochemistry 75 137 63 doi 10 1146 annurev biochem 75 103004 142702 PMID 16756488 Boudeau J Miranda Saavedra D Barton GJ Alessi DR September 2006 Emerging roles of pseudokinases Trends in Cell Biology 16 9 443 52 doi 10 1016 j tcb 2006 07 003 PMID 16879967 Sanna MG da Silva Correia J Luo Y Chuang B Paulson LM Nguyen B Deveraux QL Ulevitch RJ August 2002 ILPIP a novel anti apoptotic protein that enhances XIAP mediated activation of JNK1 and protection against apoptosis The Journal of Biological Chemistry 277 34 30454 62 doi 10 1074 jbc M203312200 PMID 12048196 Nishigaki K Thompson D Yugawa T Rulli K Hanson C Cmarik J Gutkind JS Teramoto H Ruscetti S April 2003 Identification and characterization of a novel Ste20 germinal center kinase related kinase polyploidy associated protein kinase The Journal of Biological Chemistry 278 15 13520 30 doi 10 1074 jbc M208601200 PMID 12574163 Boudeau J Baas AF Deak M Morrice NA Kieloch A Schutkowski M Prescott AR Clevers HC Alessi DR October 2003 MO25alpha beta interact with STRADalpha beta enhancing their ability to bind activate and localize LKB1 in the cytoplasm The EMBO Journal 22 19 5102 14 doi 10 1093 emboj cdg490 PMC 204473 PMID 14517248 Brajenovic M Joberty G Kuster B Bouwmeester T Drewes G March 2004 Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network The Journal of Biological Chemistry 279 13 12804 11 doi 10 1074 jbc M312171200 PMID 14676191 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M October 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ALS2CR2 amp oldid 1187414779, wikipedia, wiki, book, books, library,
