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Wikipedia

AKT1S1

November 26, 2023

Proline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene.[5][6]

AKT1S1
Identifiers
AliasesAKT1S1, Lobe, PRAS40, AKT1 substrate 1
External IDsOMIM: 610221 MGI: 1914855 HomoloGene: 12162 GeneCards: AKT1S1
Orthologs
SpeciesHumanMouse
Entrez

84335

67605

Ensembl

ENSG00000204673

ENSMUSG00000011096

UniProt

Q96B36

Q9D1F4

RefSeq (mRNA)

NM_032375
NM_001098632
NM_001098633
NM_001278159
NM_001278160

RefSeq (protein)

NP_001092102
NP_001092103
NP_001265088
NP_001265089
NP_115751

Location (UCSC)Chr 19: 49.87 – 49.88 MbChr 7: 44.5 – 44.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204673 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011096 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA (Mar 2003). "Identification of a proline-rich Akt substrate as a 14-3-3 binding partner". The Journal of Biological Chemistry. 278 (12): 10189–94. doi:10.1074/jbc.M210837200. PMID 12524439.
  6. ^ "Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich)".

Further reading edit

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH (Feb 2004). "Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor". The Journal of Neuroscience. 24 (7): 1584–93. doi:10.1523/JNEUROSCI.5209-03.2004. PMC 6730448. PMID 14973226.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Huang B, Porter G (Oct 2005). "Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis". Acta Pharmacologica Sinica. 26 (10): 1253–8. doi:10.1111/j.1745-7254.2005.00184.x. PMID 16174443.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH (Mar 2007). "Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40". Nature Cell Biology. 9 (3): 316–23. doi:10.1038/ncb1547. PMID 17277771. S2CID 12827916.
  • Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM (Mar 2007). "PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase". Molecular Cell. 25 (6): 903–15. doi:10.1016/j.molcel.2007.03.003. PMID 17386266.
  • Wang L, Harris TE, Roth RA, Lawrence JC (Jul 2007). "PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding". The Journal of Biological Chemistry. 282 (27): 20036–44. doi:10.1074/jbc.M702376200. PMID 17510057.
  • Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG (Aug 2007). "PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex". The Journal of Biological Chemistry. 282 (34): 24514–24. doi:10.1074/jbc.M704406200. PMID 17604271.

External links edit


 

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

November 26, 2023
akt1s1, proline, rich, akt1, substrate, pras, protein, that, humans, encoded, gene, identifiersaliases, lobe, pras40, akt1, substrate, 1external, idsomim, 610221, 1914855, homologene, 12162, genecards, gene, location, human, chromosome, human, band19q13, 33sta. Proline rich AKT1 substrate 1 PRAS is a protein that in humans is encoded by the AKT1S1 gene 5 6 AKT1S1IdentifiersAliasesAKT1S1 Lobe PRAS40 AKT1 substrate 1External IDsOMIM 610221 MGI 1914855 HomoloGene 12162 GeneCards AKT1S1Gene location Human Chr Chromosome 19 human 1 Band19q13 33Start49 869 033 bp 1 End49 878 459 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 7 B3Start44 498 415 bp 2 End44 504 845 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastrocnemius muscleright adrenal glandleft adrenal glandgastric mucosaright lobe of liverskin of abdomenbody of stomachright coronary arteryleft ventricleleft coronary arteryTop expressed inyolk sacextensor digitorum longus muscleknee jointmolarlipvastus lateralis muscleatriumesophagusplantaris muscletriceps brachii muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein bindingCellular componentTORC1 complex nucleus nucleoplasm cytoplasm cytosol protein containing complexBiological processregulation of cellular response to heat negative regulation of TOR signaling regulation of neuron apoptotic process negative regulation of protein kinase activity negative regulation of cell size neurotrophin TRK receptor signaling pathway TORC1 signaling regulation of apoptotic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8433567605EnsemblENSG00000204673ENSMUSG00000011096UniProtQ96B36Q9D1F4RefSeq mRNA NM 032375NM 001098632NM 001098633NM 001278159NM 001278160NM 001253920NM 001290694NM 001290695NM 026270NM 001382480NM 001382481NM 001382482NM 001382483NM 001382484RefSeq protein NP 001092102NP 001092103NP 001265088NP 001265089NP 115751NP 001240849NP 001277623NP 001277624NP 080546NP 001369409NP 001369410NP 001369411NP 001369412NP 001369413Location UCSC Chr 19 49 87 49 88 MbChr 7 44 5 44 5 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000204673 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000011096 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kovacina KS Park GY Bae SS Guzzetta AW Schaefer E Birnbaum MJ Roth RA Mar 2003 Identification of a proline rich Akt substrate as a 14 3 3 binding partner The Journal of Biological Chemistry 278 12 10189 94 doi 10 1074 jbc M210837200 PMID 12524439 Entrez Gene AKT1S1 AKT1 substrate 1 proline rich Further reading editMaruyama K Sugano S Jan 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S Oct 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Saito A Narasimhan P Hayashi T Okuno S Ferrand Drake M Chan PH Feb 2004 Neuroprotective role of a proline rich Akt substrate in apoptotic neuronal cell death after stroke relationships with nerve growth factor The Journal of Neuroscience 24 7 1584 93 doi 10 1523 JNEUROSCI 5209 03 2004 PMC 6730448 PMID 14973226 Beausoleil SA Jedrychowski M Schwartz D Elias JE Villen J Li J Cohn MA Cantley LC Gygi SP Aug 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proceedings of the National Academy of Sciences of the United States of America 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 Jin J Smith FD Stark C Wells CD Fawcett JP Kulkarni S Metalnikov P O Donnell P Taylor P Taylor L Zougman A Woodgett JR Langeberg LK Scott JD Pawson T Aug 2004 Proteomic functional and domain based analysis of in vivo 14 3 3 binding proteins involved in cytoskeletal regulation and cellular organization Current Biology 14 16 1436 50 doi 10 1016 j cub 2004 07 051 PMID 15324660 Huang B Porter G Oct 2005 Expression of proline rich Akt substrate PRAS40 in cell survival pathway and carcinogenesis Acta Pharmacologica Sinica 26 10 1253 8 doi 10 1111 j 1745 7254 2005 00184 x PMID 16174443 Kimura K Wakamatsu A Suzuki Y Ota T Nishikawa T Yamashita R Yamamoto J Sekine M Tsuritani K Wakaguri H Ishii S Sugiyama T Saito K Isono Y Irie R Kushida N Yoneyama T Otsuka R Kanda K Yokoi T Kondo H Wagatsuma M Murakawa K Ishida S Ishibashi T Takahashi Fujii A Tanase T Nagai K Kikuchi H Nakai K Isogai T Sugano S Jan 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Research 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Olsen JV Blagoev B Gnad F Macek B Kumar C Mortensen P Mann M Nov 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 Vander Haar E Lee SI Bandhakavi S Griffin TJ Kim DH Mar 2007 Insulin signalling to mTOR mediated by the Akt PKB substrate PRAS40 Nature Cell Biology 9 3 316 23 doi 10 1038 ncb1547 PMID 17277771 S2CID 12827916 Sancak Y Thoreen CC Peterson TR Lindquist RA Kang SA Spooner E Carr SA Sabatini DM Mar 2007 PRAS40 is an insulin regulated inhibitor of the mTORC1 protein kinase Molecular Cell 25 6 903 15 doi 10 1016 j molcel 2007 03 003 PMID 17386266 Wang L Harris TE Roth RA Lawrence JC Jul 2007 PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding The Journal of Biological Chemistry 282 27 20036 44 doi 10 1074 jbc M702376200 PMID 17510057 Fonseca BD Smith EM Lee VH MacKintosh C Proud CG Aug 2007 PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex The Journal of Biological Chemistry 282 34 24514 24 doi 10 1074 jbc M704406200 PMID 17604271 External links editHuman AKT1S1 genome location and AKT1S1 gene details page in the UCSC Genome Browser nbsp This article on a gene on human chromosome 19 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title AKT1S1 amp oldid 1170982485, wikipedia, wiki, book, books, library,

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