Aldo-keto reductase family 1 member C2, also known as bile acid binding protein, 3α-hydroxysteroid dehydrogenase type 3, and dihydrodiol dehydrogenase type 2, is an enzyme that in humans is encoded by the AKR1C2gene.[5]
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3α-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.[5]
References
^ abcGRCh38: Ensembl release 89: ENSG00000151632 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021207 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)". National Center for Biotechnology Information, U.S. National Library of Medicine. This article incorporates text from this source, which is in the public domain.
External links
Human AKR1C2 genome location and AKR1C2 gene details page in the UCSC Genome Browser.
akr1c2, aldo, keto, reductase, family, member, also, known, bile, acid, binding, protein, hydroxysteroid, dehydrogenase, type, dihydrodiol, dehydrogenase, type, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, code. Aldo keto reductase family 1 member C2 also known as bile acid binding protein 3a hydroxysteroid dehydrogenase type 3 and dihydrodiol dehydrogenase type 2 is an enzyme that in humans is encoded by the AKR1C2 gene 5 AKR1C2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1IHI 1J96 1XJB 2HDJ 2IPJ 4JQ1 4JQ2 4JQ3 4JQ4 4JQA 4JTQ 4JTR 4L1W 4L1X 4XO6 4XO7IdentifiersAliasesAKR1C2 AKR1C pseudo BABP DD DD2 DDH2 HAKRD HBAB MCDR2 SRXY8 TDD DD 2 DD BABP aldo keto reductase family 1 member C2 aldo keto reductase family 1 member C2External IDsOMIM 600450 MGI 1924587 HomoloGene 134114 GeneCards AKR1C2EC number1 1 1 357Gene location Human Chr Chromosome 10 human 1 Band10p15 1Start4 987 775 bp 1 End5 018 031 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 13 A1Start4 624 074 bp 2 End4 636 540 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inislet of Langerhansright lobe of livergallbladdergastrocnemius muscleascending aortaleft coronary arteryminor salivary glandtibial nerveAchilles tendonpopliteal arteryTop expressed inkidneyproximal tubulemorulasecondary oocyteblastocystspermatidadrenal glandliverjejunumsubmandibular glandMore reference expression dataBioGPSn aGene ontologyMolecular functiontrans 1 2 dihydrobenzene 1 2 diol dehydrogenase activity alditol NADP 1 oxidoreductase activity phenanthrene 9 10 monooxygenase activity oxidoreductase activity acting on NAD P H quinone or similar compound as acceptor bile acid binding carboxylic acid binding oxidoreductase activity ketosteroid monooxygenase activity alcohol dehydrogenase NADP activity steroid dehydrogenase activityCellular componentcytoplasm cytosolBiological processprostaglandin metabolic process G protein coupled receptor signaling pathway cellular response to jasmonic acid stimulus steroid metabolic process positive regulation of protein kinase B signaling epithelial cell differentiation daunorubicin metabolic process doxorubicin metabolic process lipid metabolism progesterone metabolic process digestion cellular response to prostaglandin D stimulus positive regulation of cell population proliferationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez164677337EnsemblENSG00000151632ENSMUSG00000021207UniProtP52895Q91WR5RefSeq mRNA NM 001135241NM 001354NM 205845NM 001321027NM 001393392NM 029901RefSeq protein NP 001128713NP 001307956NP 001345NP 995317NP 084177Location UCSC Chr 10 4 99 5 02 MbChr 13 4 62 4 64 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a member of the aldo keto reductase superfamily which consists of more than 40 known enzymes and proteins These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and or NADPH as cofactors The enzymes display overlapping but distinct substrate specificity This enzyme binds bile acid with high affinity and shows minimal 3a hydroxysteroid dehydrogenase activity This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15 p14 Three transcript variants encoding two different isoforms have been found for this gene 5 References Edit a b c GRCh38 Ensembl release 89 ENSG00000151632 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021207 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene AKR1C2 aldo keto reductase family 1 member C2 dihydrodiol dehydrogenase 1 20 alpha 3 alpha hydroxysteroid dehydrogenase National Center for Biotechnology Information U S National Library of Medicine This article incorporates text from this source which is in the public domain External links EditHuman AKR1C2 genome location and AKR1C2 gene details page in the UCSC Genome Browser Portal Biology This article on a gene on human chromosome 10 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title AKR1C2 amp oldid 1075475384, wikipedia, wiki, book, books, library,
