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Wikipedia

AGPAT5

August 28, 2023

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon is an enzyme that in humans is encoded by the AGPAT5 gene.[5]

AGPAT5
Identifiers
AliasesAGPAT5, 1LPAATE, 1-acylglycerol-3-phosphate O-acyltransferase 5
External IDsOMIM: 614796 MGI: 1196345 HomoloGene: 10153 GeneCards: AGPAT5
Orthologs
SpeciesHumanMouse
Entrez

55326

52123

Ensembl

ENSG00000155189
ENSG00000284980

ENSMUSG00000031467

UniProt

Q9NUQ2

Q9D1E8

RefSeq (mRNA)

NM_018361

NM_026792

RefSeq (protein)

NP_060831

NP_081068

Location (UCSC)Chr 8: 6.71 – 6.76 MbChr 8: 18.9 – 18.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis.[5]

References Edit

  1. ^ a b c ENSG00000284980 GRCh38: Ensembl release 89: ENSG00000155189, ENSG00000284980 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031467 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)".

External links Edit

Further reading Edit

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lu B, Jiang YJ, Zhou Y, et al. (2005). "Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart". Biochem. J. 385 (Pt 2): 469–77. doi:10.1042/BJ20041348. PMC 1134718. PMID 15367102.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Agarwal AK, Barnes RI, Garg A (2006). "Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity". Arch. Biochem. Biophys. 449 (1–2): 64–76. doi:10.1016/j.abb.2006.03.014. PMID 16620771.


 

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

August 28, 2023
agpat5, acyl, glycerol, phosphate, acyltransferase, epsilon, enzyme, that, humans, encoded, gene, identifiersaliases, 1lpaate, acylglycerol, phosphate, acyltransferase, 5external, idsomim, 614796, 1196345, homologene, 10153, genecards, gene, location, human, c. 1 acyl sn glycerol 3 phosphate acyltransferase epsilon is an enzyme that in humans is encoded by the AGPAT5 gene 5 AGPAT5IdentifiersAliasesAGPAT5 1LPAATE 1 acylglycerol 3 phosphate O acyltransferase 5External IDsOMIM 614796 MGI 1196345 HomoloGene 10153 GeneCards AGPAT5Gene location Human Chr Chromosome 8 human 1 Band8p23 1Start6 708 642 bp 1 End6 761 503 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 A1 3 8 10 3 cMStart18 896 293 bp 2 End18 941 377 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed incorpus callosumganglionic eminenceendometriumAchilles tendoncaudate nucleusislet of Langerhansnucleus accumbensputamentemporal lobeamygdalaTop expressed intriceps brachii musclesternocleidomastoid muscletemporal muscledigastric muscleseminal vesiculapineal glandbelly cordlacrimal glandskin of backPaneth cellMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransferase activity protein binding acyltransferase activity 1 acylglycerol 3 phosphate O acyltransferase activityCellular componentintegral component of membrane nuclear envelope membrane endoplasmic reticulum membrane mitochondrial outer membrane mitochondrion endoplasmic reticulum nucleusBiological processphosphatidic acid biosynthetic process CDP diacylglycerol biosynthetic process lipid metabolism hematopoietic progenitor cell differentiation phospholipid biosynthetic process metabolism acylglycerol metabolic process phospholipid metabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5532652123EnsemblENSG00000155189ENSG00000284980ENSMUSG00000031467UniProtQ9NUQ2Q9D1E8RefSeq mRNA NM 018361NM 026792RefSeq protein NP 060831NP 081068Location UCSC Chr 8 6 71 6 76 MbChr 8 18 9 18 94 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a member of the 1 acylglycerol 3 phosphate O acyltransferase family This integral membrane protein converts lysophosphatidic acid to phosphatidic acid the second step in de novo phospholipid biosynthesis 5 References Edit a b c ENSG00000284980 GRCh38 Ensembl release 89 ENSG00000155189 ENSG00000284980 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000031467 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene AGPAT5 1 acylglycerol 3 phosphate O acyltransferase 5 lysophosphatidic acid acyltransferase epsilon External links EditHuman AGPAT5 genome location and AGPAT5 gene details page in the UCSC Genome Browser Further reading EditHartley JL Temple GF Brasch MA 2001 DNA cloning using in vitro site specific recombination Genome Res 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 PMID 11076863 Wiemann S Weil B Wellenreuther R et al 2001 Toward a catalog of human genes and proteins sequencing and analysis of 500 novel complete protein coding human cDNAs Genome Res 11 3 422 35 doi 10 1101 gr GR1547R PMC 311072 PMID 11230166 Simpson JC Wellenreuther R Poustka A et al 2001 Systematic subcellular localization of novel proteins identified by large scale cDNA sequencing EMBO Rep 1 3 287 92 doi 10 1093 embo reports kvd058 PMC 1083732 PMID 11256614 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Lu B Jiang YJ Zhou Y et al 2005 Cloning and characterization of murine 1 acyl sn glycerol 3 phosphate acyltransferases and their regulation by PPARalpha in murine heart Biochem J 385 Pt 2 469 77 doi 10 1042 BJ20041348 PMC 1134718 PMID 15367102 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Wiemann S Arlt D Huber W et al 2004 From ORFeome to biology a functional genomics pipeline Genome Res 14 10B 2136 44 doi 10 1101 gr 2576704 PMC 528930 PMID 15489336 Oh JH Yang JO Hahn Y et al 2006 Transcriptome analysis of human gastric cancer Mamm Genome 16 12 942 54 doi 10 1007 s00335 005 0075 2 PMID 16341674 S2CID 69278 Mehrle A Rosenfelder H Schupp I et al 2006 The LIFEdb database in 2006 Nucleic Acids Res 34 Database issue D415 8 doi 10 1093 nar gkj139 PMC 1347501 PMID 16381901 Agarwal AK Barnes RI Garg A 2006 Functional characterization of human 1 acylglycerol 3 phosphate acyltransferase isoform 8 cloning tissue distribution gene structure and enzymatic activity Arch Biochem Biophys 449 1 2 64 76 doi 10 1016 j abb 2006 03 014 PMID 16620771 This article on a gene on human chromosome 8 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title AGPAT5 amp oldid 1115863334, wikipedia, wiki, book, books, library,

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