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Wikipedia

ADH7

January 01, 1970

Alcohol dehydrogenase class 4 mu/sigma chain is an enzyme that in humans is encoded by the ADH7 gene.[5][6]

ADH7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADH7, ADH4, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
External IDsOMIM: 600086 MGI: 87926 HomoloGene: 37333 GeneCards: ADH7
Orthologs
SpeciesHumanMouse
Entrez

131

11529

Ensembl

ENSG00000196344

ENSMUSG00000055301

UniProt

P40394

Q64437

RefSeq (mRNA)

NM_001166504
NM_000673

NM_009626

RefSeq (protein)

NP_000664
NP_001159976

NP_033756

Location (UCSC)Chr 4: 99.41 – 99.44 MbChr 3: 137.92 – 137.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene makes it much more abundant in the stomach than the liver, thus it differs from the other known gene family members.[6]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196344 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055301 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Satre MA, Zgombić-Knight M, Duester G (Jun 1994). "The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene". The Journal of Biological Chemistry. 269 (22): 15606–12. doi:10.1016/S0021-9258(17)40724-1. PMID 8195208.
  6. ^ a b "Entrez Gene: ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide".

Further reading edit

  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Xie P, Parsons SH, Speckhard DC, Bosron WF, Hurley TD (Jul 1997). "X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity". The Journal of Biological Chemistry. 272 (30): 18558–63. doi:10.1074/jbc.272.30.18558. PMID 9228021.
  • Yokoyama H, Baraona E, Lieber CS (Jan 1996). "Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH". Genomics. 31 (2): 243–5. doi:10.1006/geno.1996.0040. PMID 8824810.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Yokoyama S, Matsuo Y, Ramsbotham R, Yokoyama R (Sep 1994). "Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7)". FEBS Letters. 351 (3): 411–5. doi:10.1016/0014-5793(94)00895-7. PMID 8082805. S2CID 31829053.
  • Yokoyama H, Baraona E, Lieber CS (Aug 1994). "Molecular cloning of human class IV alcohol dehydrogenase cDNA". Biochemical and Biophysical Research Communications. 203 (1): 219–24. doi:10.1006/bbrc.1994.2170. PMID 8074657.
  • Farrés J, Moreno A, Crosas B, Peralba JM, Allali-Hassani A, Hjelmqvist L, Jörnvall H, Parés X (Sep 1994). "Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships". European Journal of Biochemistry. 224 (2): 549–57. doi:10.1111/j.1432-1033.1994.00549.x. PMID 7925371.
  • Zgombić-Knight M, Foglio MH, Duester G (Mar 1995). "Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro". The Journal of Biological Chemistry. 270 (9): 4305–11. doi:10.1074/jbc.270.9.4305. PMID 7876191.
  • Kedishvili NY, Bosron WF, Stone CL, Hurley TD, Peggs CF, Thomasson HR, Popov KM, Carr LG, Edenberg HJ, Li TK (Feb 1995). "Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes". The Journal of Biological Chemistry. 270 (8): 3625–30. doi:10.1074/jbc.270.8.3625. PMID 7876099.
  • Cheung B, Anderson JK, Holmes RS, Beacham IR (Feb 1995). "Human stomach class IV alcohol dehydrogenase: molecular genetic analysis". Alcoholism: Clinical and Experimental Research. 19 (1): 185–6. doi:10.1111/j.1530-0277.1995.tb01490.x. PMID 7771649.
  • Parés X, Cederlund E, Moreno A, Saubi N, Höög JO, Jörnvall H (May 1992). "Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class". FEBS Letters. 303 (1): 69–72. doi:10.1016/0014-5793(92)80479-Z. PMID 1592118. S2CID 41630387.

External links edit


 

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
adh7, alcohol, dehydrogenase, class, sigma, chain, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1agn, 1d1s, 1d1tidentifiersaliases, adh4, alcohol, dehydrogenase, class, sigma, polypeptideexternal, idsomim,. Alcohol dehydrogenase class 4 mu sigma chain is an enzyme that in humans is encoded by the ADH7 gene 5 6 ADH7Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1AGN 1D1S 1D1TIdentifiersAliasesADH7 ADH4 alcohol dehydrogenase 7 class IV mu or sigma polypeptideExternal IDsOMIM 600086 MGI 87926 HomoloGene 37333 GeneCards ADH7Gene location Human Chr Chromosome 4 human 1 Band4q23Start99 412 261 bp 1 End99 435 510 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 G3 3 64 13 cMStart137 923 521 bp 2 End137 939 143 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inoral cavitygumspalpebral conjunctivabody of tonguebronchusbronchial epithelial celltracheacervix epitheliumsuperior surface of tonguegastric mucosaTop expressed inesophagussuperior surface of tonguegastric mucosamucous cell of stomachepithelium of stomachpyloric antrumlipcorneal stromaconjunctival fornixrespiratory epitheliumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionaldehyde oxidase activity zinc ion binding metal ion binding NAD retinol dehydrogenase activity ethanol binding retinol binding oxidoreductase activity receptor antagonist activity alcohol dehydrogenase NAD activity alcohol dehydrogenase activity zinc dependentCellular componentcytoplasm intracellular anatomical structure extracellular region cytosol plasma membraneBiological processethanol catabolic process response to bacterium retinol metabolic process retinoic acid metabolic process fatty acid omega oxidation retinoid metabolic process response to ethanol ethanol oxidation extracellular negative regulation of signal transduction negative regulation of signaling receptor activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez13111529EnsemblENSG00000196344ENSMUSG00000055301UniProtP40394Q64437RefSeq mRNA NM 001166504NM 000673NM 009626RefSeq protein NP 000664NP 001159976NP 033756Location UCSC Chr 4 99 41 99 44 MbChr 3 137 92 137 94 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction editThis gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit which is a member of the alcohol dehydrogenase family Members of this family metabolize a wide variety of substrates including ethanol retinol other aliphatic alcohols hydroxysteroids and lipid peroxidation products The enzyme encoded by this gene is inefficient in ethanol oxidation but is the most active as a retinol dehydrogenase thus it may participate in the synthesis of retinoic acid a hormone important for cellular differentiation The expression of this gene makes it much more abundant in the stomach than the liver thus it differs from the other known gene family members 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000196344 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000055301 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Satre MA Zgombic Knight M Duester G Jun 1994 The complete structure of human class IV alcohol dehydrogenase retinol dehydrogenase determined from the ADH7 gene The Journal of Biological Chemistry 269 22 15606 12 doi 10 1016 S0021 9258 17 40724 1 PMID 8195208 a b Entrez Gene ADH7 alcohol dehydrogenase 7 class IV mu or sigma polypeptide Further reading editSuzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S Oct 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Xie P Parsons SH Speckhard DC Bosron WF Hurley TD Jul 1997 X ray structure of human class IV sigmasigma alcohol dehydrogenase Structural basis for substrate specificity The Journal of Biological Chemistry 272 30 18558 63 doi 10 1074 jbc 272 30 18558 PMID 9228021 Yokoyama H Baraona E Lieber CS Jan 1996 Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV sigma ADH Genomics 31 2 243 5 doi 10 1006 geno 1996 0040 PMID 8824810 Maruyama K Sugano S Jan 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Yokoyama S Matsuo Y Ramsbotham R Yokoyama R Sep 1994 Molecular characterization of a class IV human alcohol dehydrogenase gene ADH7 FEBS Letters 351 3 411 5 doi 10 1016 0014 5793 94 00895 7 PMID 8082805 S2CID 31829053 Yokoyama H Baraona E Lieber CS Aug 1994 Molecular cloning of human class IV alcohol dehydrogenase cDNA Biochemical and Biophysical Research Communications 203 1 219 24 doi 10 1006 bbrc 1994 2170 PMID 8074657 Farres J Moreno A Crosas B Peralba JM Allali Hassani A Hjelmqvist L Jornvall H Pares X Sep 1994 Alcohol dehydrogenase of class IV sigma sigma ADH from human stomach cDNA sequence and structure function relationships European Journal of Biochemistry 224 2 549 57 doi 10 1111 j 1432 1033 1994 00549 x PMID 7925371 Zgombic Knight M Foglio MH Duester G Mar 1995 Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase the form most efficient for retinol metabolism in vitro The Journal of Biological Chemistry 270 9 4305 11 doi 10 1074 jbc 270 9 4305 PMID 7876191 Kedishvili NY Bosron WF Stone CL Hurley TD Peggs CF Thomasson HR Popov KM Carr LG Edenberg HJ Li TK Feb 1995 Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase Active site amino acid sequence explains substrate specificity compared with liver isozymes The Journal of Biological Chemistry 270 8 3625 30 doi 10 1074 jbc 270 8 3625 PMID 7876099 Cheung B Anderson JK Holmes RS Beacham IR Feb 1995 Human stomach class IV alcohol dehydrogenase molecular genetic analysis Alcoholism Clinical and Experimental Research 19 1 185 6 doi 10 1111 j 1530 0277 1995 tb01490 x PMID 7771649 Pares X Cederlund E Moreno A Saubi N Hoog JO Jornvall H May 1992 Class IV alcohol dehydrogenase the gastric enzyme Structural analysis of human sigma sigma ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class FEBS Letters 303 1 69 72 doi 10 1016 0014 5793 92 80479 Z PMID 1592118 S2CID 41630387 External links editHuman ADH4 genome location and ADH4 gene details page in the UCSC Genome Browser Human ADH7 genome location and ADH7 gene details page in the UCSC Genome Browser nbsp This article on a gene on human chromosome 4 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ADH7 amp oldid 1118644575, wikipedia, wiki, book, books, library,

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