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ADCYAP1R1

April 14, 2024

Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC1, is a protein that in humans is encoded by the ADCYAP1R1 gene.[5] This receptor binds pituitary adenylate cyclase activating peptide.[6][7]

ADCYAP1R1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADCYAP1R1, PAC1, PAC1R, PACAPR, PACAPRI, ADCYAP receptor type I
External IDsOMIM: 102981 MGI: 108449 HomoloGene: 870 GeneCards: ADCYAP1R1
Orthologs
SpeciesHumanMouse
Entrez

117

11517

Ensembl

ENSG00000078549

ENSMUSG00000029778

UniProt

P41586

P70205

RefSeq (mRNA)

NM_001118
NM_001199635
NM_001199636
NM_001199637

NM_001025372
NM_007407

RefSeq (protein)

NP_001109
NP_001186564
NP_001186565
NP_001186566

NP_001020543
NP_031433

Location (UCSC)Chr 7: 31.05 – 31.11 MbChr 6: 55.43 – 55.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

PAC1 is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/secretin receptor family.[8] This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.[5] PAC1 is expressed in the adrenal medulla, pancreatic acini, uterus, myenteric plexus and brain.[9][10][11] It is also expressed in the trigeminal, otic and superior cervical ganglia (prejunctional) and cerebral arteries (postjunctional).[12]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000078549 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029778 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I".
  6. ^ Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.
  7. ^ Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (Jun 2000). "Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions". Pharmacological Reviews. 52 (2): 269–324. PMID 10835102.
  8. ^ Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y (2020). "Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism". Cell Res. 30 (5): 436–445. doi:10.1038/s41422-020-0280-2. PMC 7196072. PMID 32047270.
  9. ^ Reubi JC (2000). "In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications". Annals of the New York Academy of Sciences. 921 (1): 1–25. Bibcode:2000NYASA.921....1R. doi:10.1111/j.1749-6632.2000.tb06946.x. PMID 11193811. S2CID 21204750.
  10. ^ Reubi JC, Läderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (Jun 2000). "Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin". Cancer Research. 60 (11): 3105–12. PMID 10850463.
  11. ^ Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (Apr 1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation" (PDF). The Journal of Clinical Endocrinology and Metabolism. 83 (4): 1299–305. doi:10.1210/jcem.83.4.4690. PMID 9543159.
  12. ^ Knutsson M, Edvinsson L (Mar 2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". NeuroReport. 13 (4): 507–9. doi:10.1097/00001756-200203250-00030. PMID 11930171. S2CID 30329669.

Further reading edit

  • Stoffel M, Espinosa R, Trabb JB, Le Beau MM, Bell GI (Oct 1994). "Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7". Genomics. 23 (3): 697–9. doi:10.1006/geno.1994.1560. PMID 7851900.
  • Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.
  • Ohtaki T, Masuda Y, Ishibashi Y, Kitada C, Arimura A, Fujino M (Dec 1993). "Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide". The Journal of Biological Chemistry. 268 (35): 26650–7. doi:10.1016/S0021-9258(19)74361-0. PMID 8253796.
  • Pisegna JR, Wank SA (Jul 1996). "Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C". The Journal of Biological Chemistry. 271 (29): 17267–74. doi:10.1074/jbc.271.29.17267. PMC 6721843. PMID 8663363.
  • Pantaloni C, Brabet P, Bilanges B, Dumuis A, Houssami S, Spengler D, Bockaert J, Journot L (Sep 1996). "Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation". The Journal of Biological Chemistry. 271 (36): 22146–51. doi:10.1074/jbc.271.36.22146. PMID 8703026.
  • Solano RM, Carmena MJ, Carrero I, Cavallaro S, Roman F, Hueso C, Travali S, Lopez-Fraile N, Guijarro LG, Prieto JC (Jul 1996). "Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate". Endocrinology. 137 (7): 2815–22. doi:10.1210/en.137.7.2815. PMID 8770902.
  • Wei Y, Mojsov S (Nov 1996). "Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology". Journal of Neuroendocrinology. 8 (11): 811–7. doi:10.1046/j.1365-2826.1996.05191.x. PMID 8933357. S2CID 22302790.
  • Brabet P, Diriong S, Journot L, Bockaert J, Taviaux S (Nov 1996). "Localization of the human pituitary adenylate cyclase-activating polypeptide receptor (PACAP1-R) gene to 7p15-p14 by fluorescence in situ hybridization". Genomics. 38 (1): 100–2. doi:10.1006/geno.1996.0600. PMID 8954788.
  • Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (Apr 1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation" (PDF). The Journal of Clinical Endocrinology and Metabolism. 83 (4): 1299–305. doi:10.1210/jcem.83.4.4690. PMID 9543159.
  • Steinhoff M, McGregor GP, Radleff-Schlimme A, Steinhoff A, Jarry H, Schmidt WE (Mar 1999). "Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis". Regulatory Peptides. 80 (1–2): 49–55. doi:10.1016/S0167-0115(99)00010-5. PMID 10235634. S2CID 8591698.
  • Zeng N, Athmann C, Kang T, Lyu RM, Walsh JH, Ohning GV, Sachs G, Pisegna JR (Nov 1999). "PACAP type I receptor activation regulates ECL cells and gastric acid secretion". The Journal of Clinical Investigation. 104 (10): 1383–91. doi:10.1172/JCI7537. PMC 409843. PMID 10562300.
  • Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL (Dec 1999). "N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants". Journal of Neuroendocrinology. 11 (12): 941–9. doi:10.1046/j.1365-2826.1999.00411.x. PMID 10583729. S2CID 35761617.
  • Scaldaferri ML, Modesti A, Palumbo C, Ulisse S, Fabbri A, Piccione E, Frajese G, Moretti C (Mar 2000). "Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta". Endocrinology. 141 (3): 1158–67. doi:10.1210/endo.141.3.7346. PMID 10698193.
  • Busto R, Prieto JC, Bodega G, Zapatero J, Carrero I (Feb 2000). "Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung". Peptides. 21 (2): 265–9. doi:10.1016/S0196-9781(99)00202-8. PMID 10764955. S2CID 44951090.
  • Knutsson M, Edvinsson L (Mar 2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". NeuroReport. 13 (4): 507–9. doi:10.1097/00001756-200203250-00030. PMID 11930171. S2CID 30329669.
  • Miampamba M, Germano PM, Arli S, Wong HH, Scott D, Taché Y, Pisegna JR (May 2002). "Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons". Regulatory Peptides. 105 (3): 145–54. doi:10.1016/S0167-0115(02)00003-4. PMC 6736535. PMID 11959368.
  • Le SV, Yamaguchi DJ, McArdle CA, Tachiki K, Pisegna JR, Germano P (Nov 2002). "PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells". Regulatory Peptides. 109 (1–3): 115–25. doi:10.1016/S0167-0115(02)00194-5. PMC 6736540. PMID 12409223.
  • Ronaldson E, Robertson DN, Johnson MS, Holland PJ, Mitchell R, Lutz EM (Nov 2002). "Specific interaction between the hop1 intracellular loop 3 domain of the human PAC(1) receptor and ARF". Regulatory Peptides. 109 (1–3): 193–8. doi:10.1016/S0167-0115(02)00204-5. PMID 12409233. S2CID 25745650.
  • Isobe K, Tatsuno I, Yashiro T, Nanmoku T, Takekoshi K, Kawakami Y, Nakai T (Feb 2003). "Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis". Regulatory Peptides. 110 (3): 213–7. doi:10.1016/S0167-0115(02)00209-4. PMID 12573802. S2CID 21201447.

External links edit

  • "VIP and PACAP Receptors: PAC1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  • Human ADCYAP1R1 genome location and ADCYAP1R1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

April 14, 2024
adcyap1r1, pituitary, adenylate, cyclase, activating, polypeptide, type, receptor, also, known, pac1, protein, that, humans, encoded, gene, this, receptor, binds, pituitary, adenylate, cyclase, activating, peptide, available, structurespdbortholog, search, pdb. Pituitary adenylate cyclase activating polypeptide type I receptor also known as PAC1 is a protein that in humans is encoded by the ADCYAP1R1 gene 5 This receptor binds pituitary adenylate cyclase activating peptide 6 7 ADCYAP1R1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2JODIdentifiersAliasesADCYAP1R1 PAC1 PAC1R PACAPR PACAPRI ADCYAP receptor type IExternal IDsOMIM 102981 MGI 108449 HomoloGene 870 GeneCards ADCYAP1R1Gene location Human Chr Chromosome 7 human 1 Band7p14 3Start31 052 308 bp 1 End31 111 479 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 6 B3Start55 428 963 bp 2 End55 478 436 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminencenucleus accumbenscaudate nucleusamygdalaentorhinal cortexinternal globus palliduscingulate gyruspostcentral gyrussuperior vestibular nucleushippocampus properTop expressed inparaventricular nucleus of hypothalamusarcuate nucleusdorsomedial hypothalamic nucleusventral tegmental areasubstantia nigralateral hypothalamusventromedial nucleusdorsal tegmental nucleuspontine nucleinucleus accumbensMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionG protein coupled receptor activity adenylate cyclase binding neuropeptide binding vasoactive intestinal polypeptide receptor activity signal transducer activity protein binding transmembrane signaling receptor activity signaling receptor activity G protein coupled peptide receptor activity peptide hormone bindingCellular componentcytoplasm integral component of membrane endosome rough endoplasmic reticulum membrane bicellular tight junction receptor complex plasma membrane integral component of plasma membrane cell surface caveola neuron projection intracellular membrane bounded organelleBiological processcell differentiation multicellular organismal response to stress response to estradiol positive regulation of calcium ion transport into cytosol positive regulation of inositol phosphate biosynthetic process negative regulation of cell death activation of phospholipase C activity multicellular organism development cell surface receptor signaling pathway development of primary female sexual characteristics spermatogenesis response to ethanol cAMP mediated signaling signal transduction positive regulation of small GTPase mediated signal transduction G protein coupled receptor signaling pathway positive regulation of cAMP mediated signalingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez11711517EnsemblENSG00000078549ENSMUSG00000029778UniProtP41586P70205RefSeq mRNA NM 001118NM 001199635NM 001199636NM 001199637NM 001025372NM 007407RefSeq protein NP 001109NP 001186564NP 001186565NP 001186566NP 001020543NP 031433Location UCSC Chr 7 31 05 31 11 MbChr 6 55 43 55 48 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction editPAC1 is a membrane associated protein and shares significant homology with members of the G protein coupled class B glucagon secretin receptor family 8 This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase Alternative splicing of two exons of this gene generates four major splice variants but their full length nature has not been determined 5 PAC1 is expressed in the adrenal medulla pancreatic acini uterus myenteric plexus and brain 9 10 11 It is also expressed in the trigeminal otic and superior cervical ganglia prejunctional and cerebral arteries postjunctional 12 References edit a b c GRCh38 Ensembl release 89 ENSG00000078549 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000029778 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene ADCYAP1R1 adenylate cyclase activating polypeptide 1 pituitary receptor type I Ogi K Miyamoto Y Masuda Y Habata Y Hosoya M Ohtaki T Masuo Y Onda H Fujino M Nov 1993 Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor Biochemical and Biophysical Research Communications 196 3 1511 21 doi 10 1006 bbrc 1993 2423 PMID 7902709 Vaudry D Gonzalez BJ Basille M Yon L Fournier A Vaudry H Jun 2000 Pituitary adenylate cyclase activating polypeptide and its receptors from structure to functions Pharmacological Reviews 52 2 269 324 PMID 10835102 Wang J Song X Zhang D Chen X Li X Sun Y Li C Song Y Ding Y Ren R Harrington EH Hu LA Zhong W Xu C Huang X Wang HW Ma Y 2020 Cryo EM structures of PAC1 receptor reveal ligand binding mechanism Cell Res 30 5 436 445 doi 10 1038 s41422 020 0280 2 PMC 7196072 PMID 32047270 Reubi JC 2000 In vitro evaluation of VIP PACAP receptors in healthy and diseased human tissues Clinical implications Annals of the New York Academy of Sciences 921 1 1 25 Bibcode 2000NYASA 921 1R doi 10 1111 j 1749 6632 2000 tb06946 x PMID 11193811 S2CID 21204750 Reubi JC Laderach U Waser B Gebbers JO Robberecht P Laissue JA Jun 2000 Vasoactive intestinal peptide pituitary adenylate cyclase activating peptide receptor subtypes in human tumors and their tissues of origin Cancer Research 60 11 3105 12 PMID 10850463 Yon L Breault L Contesse V Bellancourt G Delarue C Fournier A Lehoux JG Vaudry H Gallo Payet N Apr 1998 Localization characterization and second messenger coupling of pituitary adenylate cyclase activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation PDF The Journal of Clinical Endocrinology and Metabolism 83 4 1299 305 doi 10 1210 jcem 83 4 4690 PMID 9543159 Knutsson M Edvinsson L Mar 2002 Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia NeuroReport 13 4 507 9 doi 10 1097 00001756 200203250 00030 PMID 11930171 S2CID 30329669 Further reading editStoffel M Espinosa R Trabb JB Le Beau MM Bell GI Oct 1994 Human type I pituitary adenylate cyclase activating polypeptide receptor ADCYAP1R localization to chromosome band 7p14 and integration into the cytogenetic physical and genetic map of chromosome 7 Genomics 23 3 697 9 doi 10 1006 geno 1994 1560 PMID 7851900 Ogi K Miyamoto Y Masuda Y Habata Y Hosoya M Ohtaki T Masuo Y Onda H Fujino M Nov 1993 Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor Biochemical and Biophysical Research Communications 196 3 1511 21 doi 10 1006 bbrc 1993 2423 PMID 7902709 Ohtaki T Masuda Y Ishibashi Y Kitada C Arimura A Fujino M Dec 1993 Purification and characterization of the receptor for pituitary adenylate cyclase activating polypeptide The Journal of Biological Chemistry 268 35 26650 7 doi 10 1016 S0021 9258 19 74361 0 PMID 8253796 Pisegna JR Wank SA Jul 1996 Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor Evidence for dual coupling to adenylate cyclase and phospholipase C The Journal of Biological Chemistry 271 29 17267 74 doi 10 1074 jbc 271 29 17267 PMC 6721843 PMID 8663363 Pantaloni C Brabet P Bilanges B Dumuis A Houssami S Spengler D Bockaert J Journot L Sep 1996 Alternative splicing in the N terminal extracellular domain of the pituitary adenylate cyclase activating polypeptide PACAP receptor modulates receptor selectivity and relative potencies of PACAP 27 and PACAP 38 in phospholipase C activation The Journal of Biological Chemistry 271 36 22146 51 doi 10 1074 jbc 271 36 22146 PMID 8703026 Solano RM Carmena MJ Carrero I Cavallaro S Roman F Hueso C Travali S Lopez Fraile N Guijarro LG Prieto JC Jul 1996 Characterization of vasoactive intestinal peptide pituitary adenylate cyclase activating peptide receptors in human benign hyperplastic prostate Endocrinology 137 7 2815 22 doi 10 1210 en 137 7 2815 PMID 8770902 Wei Y Mojsov S Nov 1996 Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide implications for their role in human physiology Journal of Neuroendocrinology 8 11 811 7 doi 10 1046 j 1365 2826 1996 05191 x PMID 8933357 S2CID 22302790 Brabet P Diriong S Journot L Bockaert J Taviaux S Nov 1996 Localization of the human pituitary adenylate cyclase activating polypeptide receptor PACAP1 R gene to 7p15 p14 by fluorescence in situ hybridization Genomics 38 1 100 2 doi 10 1006 geno 1996 0600 PMID 8954788 Yon L Breault L Contesse V Bellancourt G Delarue C Fournier A Lehoux JG Vaudry H Gallo Payet N Apr 1998 Localization characterization and second messenger coupling of pituitary adenylate cyclase activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation PDF The Journal of Clinical Endocrinology and Metabolism 83 4 1299 305 doi 10 1210 jcem 83 4 4690 PMID 9543159 Steinhoff M McGregor GP Radleff Schlimme A Steinhoff A Jarry H Schmidt WE Mar 1999 Identification of pituitary adenylate cyclase activating polypeptide PACAP and PACAP type 1 receptor in human skin expression of PACAP 38 is increased in patients with psoriasis Regulatory Peptides 80 1 2 49 55 doi 10 1016 S0167 0115 99 00010 5 PMID 10235634 S2CID 8591698 Zeng N Athmann C Kang T Lyu RM Walsh JH Ohning GV Sachs G Pisegna JR Nov 1999 PACAP type I receptor activation regulates ECL cells and gastric acid secretion The Journal of Clinical Investigation 104 10 1383 91 doi 10 1172 JCI7537 PMC 409843 PMID 10562300 Dautzenberg FM Mevenkamp G Wille S Hauger RL Dec 1999 N terminal splice variants of the type I PACAP receptor isolation characterization and ligand binding selectivity determinants Journal of Neuroendocrinology 11 12 941 9 doi 10 1046 j 1365 2826 1999 00411 x PMID 10583729 S2CID 35761617 Scaldaferri ML Modesti A Palumbo C Ulisse S Fabbri A Piccione E Frajese G Moretti C Mar 2000 Pituitary adenylate cyclase activating polypeptide PACAP and PACAP receptor type 1 expression in rat and human placenta Endocrinology 141 3 1158 67 doi 10 1210 endo 141 3 7346 PMID 10698193 Busto R Prieto JC Bodega G Zapatero J Carrero I Feb 2000 Immunohistochemical localization and distribution of VIP PACAP receptors in human lung Peptides 21 2 265 9 doi 10 1016 S0196 9781 99 00202 8 PMID 10764955 S2CID 44951090 Knutsson M Edvinsson L Mar 2002 Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia NeuroReport 13 4 507 9 doi 10 1097 00001756 200203250 00030 PMID 11930171 S2CID 30329669 Miampamba M Germano PM Arli S Wong HH Scott D Tache Y Pisegna JR May 2002 Expression of pituitary adenylate cyclase activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons Regulatory Peptides 105 3 145 54 doi 10 1016 S0167 0115 02 00003 4 PMC 6736535 PMID 11959368 Le SV Yamaguchi DJ McArdle CA Tachiki K Pisegna JR Germano P Nov 2002 PAC1 and PACAP expression signaling and effect on the growth of HCT8 human colonic tumor cells Regulatory Peptides 109 1 3 115 25 doi 10 1016 S0167 0115 02 00194 5 PMC 6736540 PMID 12409223 Ronaldson E Robertson DN Johnson MS Holland PJ Mitchell R Lutz EM Nov 2002 Specific interaction between the hop1 intracellular loop 3 domain of the human PAC 1 receptor and ARF Regulatory Peptides 109 1 3 193 8 doi 10 1016 S0167 0115 02 00204 5 PMID 12409233 S2CID 25745650 Isobe K Tatsuno I Yashiro T Nanmoku T Takekoshi K Kawakami Y Nakai T Feb 2003 Expression of mRNA for PACAP and its receptors in intra and extra adrenal human pheochromocytomas and their relationship to catecholamine synthesis Regulatory Peptides 110 3 213 7 doi 10 1016 S0167 0115 02 00209 4 PMID 12573802 S2CID 21201447 External links edit VIP and PACAP Receptors PAC1 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology Human ADCYAP1R1 genome location and ADCYAP1R1 gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title ADCYAP1R1 amp oldid 1205224080, wikipedia, wiki, book, books, library,

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