ADB-5'Br-PINACA (5'-Br-ADB-PINACA) is an indazole-3-carboxamide based synthetic cannabinoid receptor agonist that has been sold as a designer drug. It was first identified in Abu Dhabi in September 2022,[1] but has subsequently been found in the US and Europe.[2] While formal pharmacology studies have not yet been carried out, ADB-5'Br-PINACA is believed to be a highly potent synthetic cannabinoid with similar potency to compounds such as MDMB-FUBINACA and 5F-ADB which have been responsible for numerous fatal and non-fatal drug overdoses, consistent with previously reported compounds from the patent literature showing bromination of the indazole ring at the 5-, 6- or 7- positions to increase potency over the unsubstituted analogues.[3] ADB-5'Br-PINACA is the 5'-bromo analog of ADB-PINACA.
ADB-5'Br-PINACA can be synthesized from a "half finished" synthesis precursor known as ADB-5-Br-INACA, related to MDMB-5Br-INACA.[4]
Legalityedit
ADB-5'Br-PINACA is not specifically scheduled in the United States at the federal level as of October 20, 2023 but may be considered illegal under the federal analogue act if intended for consumption as a structural analog of the Schedule I cannabinoid ADB-PINACA.
^"The ADJD's Centre of Forensic and Digital Sciences Discovers a New Synthetic Cannabinoid Substance". Emirates 24/7. 15 May 2023.
^"ADB-5'Br-PINACA Monograph". The Center For Forensic Science Research & Education. April 2023.
^WO 2009106982, Buchler IP, Hayes MJ, Hedge SG, Hockerman SL, Jones DE, Kortum SW, Rico JG, Tenbrink RE, Wu KK, "Indazole Derivatives", published 3 September 2009, assigned to Pfizer Inc.
^Deventer MH, Persson M, Norman C, Liu H, Connolly MJ, Daéid NN, et al. (October 2023). "In vitro cannabinoid activity profiling of generic ban-evading brominated synthetic cannabinoid receptor agonists and their analogs". Drug Testing and Analysis. doi:10.1002/dta.3592. PMID 37903509. S2CID 264671035.
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pinaca, pinaca, indazole, carboxamide, based, synthetic, cannabinoid, receptor, agonist, that, been, sold, designer, drug, first, identified, dhabi, september, 2022, subsequently, been, found, europe, while, formal, pharmacology, studies, have, been, carried, . ADB 5 Br PINACA 5 Br ADB PINACA is an indazole 3 carboxamide based synthetic cannabinoid receptor agonist that has been sold as a designer drug It was first identified in Abu Dhabi in September 2022 1 but has subsequently been found in the US and Europe 2 While formal pharmacology studies have not yet been carried out ADB 5 Br PINACA is believed to be a highly potent synthetic cannabinoid with similar potency to compounds such as MDMB FUBINACA and 5F ADB which have been responsible for numerous fatal and non fatal drug overdoses consistent with previously reported compounds from the patent literature showing bromination of the indazole ring at the 5 6 or 7 positions to increase potency over the unsubstituted analogues 3 ADB 5 Br PINACA is the 5 bromo analog of ADB PINACA ADB 5 Br PINACALegal statusLegal statusDE NpSG Industrial and scientific use only UK Class BIdentifiersIUPAC name N 1 Amino 3 3 dimethyl 1 oxo 2 butanyl 1 pentyl 1H 5 bromoindazole 3 carboxamidePubChem CID168310461ChemSpider115285280Chemical and physical dataFormulaC 19H 27Br N 4O 2Molar mass423 355 g mol 13D model JSmol Interactive imageSMILES NC O C H NC O c1nn CCCCC c2ccc Br cc21 C C C CInChI InChI 1S C19H27BrN4O2 c1 5 6 7 10 24 14 9 8 12 20 11 13 14 15 23 24 18 26 22 16 17 21 25 19 2 3 4 h8 9 11 16H 5 7 10H2 1 4H3 H2 21 25 H 22 26 t16 m1 s1Key OUVRBTCXLMBRLT MRXNPFEDSA N Contents 1 Synthesis 2 Legality 3 See also 4 ReferencesSynthesis editADB 5 Br PINACA can be synthesized from a half finished synthesis precursor known as ADB 5 Br INACA related to MDMB 5Br INACA 4 Legality editADB 5 Br PINACA is not specifically scheduled in the United States at the federal level as of October 20 2023 but may be considered illegal under the federal analogue act if intended for consumption as a structural analog of the Schedule I cannabinoid ADB PINACA See also edit6 Bromopravadoline ADB PINACA ADB 5 F BUTINACA ADSB FUB 187 MDMB 5 Br INACA MDMB 5 Br BUTINACAReferences edit The ADJD s Centre of Forensic and Digital Sciences Discovers a New Synthetic Cannabinoid Substance Emirates 24 7 15 May 2023 ADB 5 Br PINACA Monograph The Center For Forensic Science Research amp Education April 2023 WO 2009106982 Buchler IP Hayes MJ Hedge SG Hockerman SL Jones DE Kortum SW Rico JG Tenbrink RE Wu KK Indazole Derivatives published 3 September 2009 assigned to Pfizer Inc Deventer MH Persson M Norman C Liu H Connolly MJ Daeid NN et al October 2023 In vitro cannabinoid activity profiling of generic ban evading brominated synthetic cannabinoid receptor agonists and their analogs Drug Testing and Analysis doi 10 1002 dta 3592 PMID 37903509 S2CID 264671035 nbsp This cannabinoid related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ADB 5 27Br PINACA amp oldid 1213653764, wikipedia, wiki, book, books, library,
