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Wikipedia

ADARB1

December 18, 2023

Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.[5][6][7] The enzyme is a member of ADAR family.

ADARB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADARB1, ADAR2, DRABA2, DRADA2, RED1, adenosine deaminase, RNA specific B1, adenosine deaminase RNA specific B1, NEDHYMS
External IDsOMIM: 601218 MGI: 891999 HomoloGene: 8280 GeneCards: ADARB1
Orthologs
SpeciesHumanMouse
Entrez

104

110532

Ensembl

ENSG00000197381

ENSMUSG00000020262

UniProt

P78563

Q91ZS8

RefSeq (mRNA)

NM_001024837
NM_001024838
NM_001024839
NM_001024840
NM_130895

RefSeq (protein)

NP_001020008
NP_570965
NP_001020009

Location (UCSC)Chr 21: 45.07 – 45.23 MbChr 10: 77.13 – 77.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rats found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an Alu cassette insert and a short or long C-terminal region.[7]

ADARB1 requires the small molecule inositol hexakisphosphate (IP6) for proper function.[8] ADARB1 is an A-to-I RNA-editing enzyme that mostly acts on protein-coding substrates.[9]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197381 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020262 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mittaz L, Scott HS, Rossier C, Seeburg PH, Higuchi M, Antonarakis SE (April 1997). "Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3". Genomics. 41 (2): 210–7. doi:10.1006/geno.1997.4655. PMID 9143496.
  6. ^ Keegan LP, Leroy A, Sproul D, O'Connell MA (Feb 2004). "Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes". Genome Biology. 5 (2): 209. doi:10.1186/gb-2004-5-2-209. PMC 395743. PMID 14759252.
  7. ^ a b "Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)".
  8. ^ Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL (September 2005). "Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing". Science. 309 (5740): 1534–9. Bibcode:2005Sci...309.1534M. doi:10.1126/science.1113150. PMC 1850959. PMID 16141067.
  9. ^ Licht K, Jantsch MF (April 2016). "Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications". The Journal of Cell Biology. 213 (1): 15–22. doi:10.1083/jcb.201511041. PMC 4828693. PMID 27044895.

Further reading edit

  • Valenzuela A, Blanco J, Callebaut C, Jacotot E, Lluis C, Hovanessian AG, Franco R (1997). "HIV-1 Envelope gp120 and Viral Particles Block Adenosine Deaminase Binding to Human CD26". Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology. Vol. 421. pp. 185–92. doi:10.1007/978-1-4757-9613-1_24. ISBN 978-1-4757-9615-5. PMID 9330696.
  • Melcher T, Maas S, Herb A, Sprengel R, Seeburg PH, Higuchi M (February 1996). "A mammalian RNA editing enzyme". Nature. 379 (6564): 460–4. Bibcode:1996Natur.379..460M. doi:10.1038/379460a0. PMID 8559253. S2CID 4326456.
  • O'Connell MA, Gerber A, Keller W (January 1997). "Purification of human double-stranded RNA-specific editase 1 (hRED1) involved in editing of brain glutamate receptor B pre-mRNA". The Journal of Biological Chemistry. 272 (1): 473–8. doi:10.1074/jbc.272.1.473. PMID 8995285.
  • Valenzuela A, Blanco J, Callebaut C, Jacotot E, Lluis C, Hovanessian AG, Franco R (April 1997). "Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles". Journal of Immunology. 158 (8): 3721–9. PMID 9103436.
  • Lai F, Chen CX, Carter KC, Nishikura K (May 1997). "Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases". Molecular and Cellular Biology. 17 (5): 2413–24. doi:10.1128/MCB.17.5.2413. PMC 232090. PMID 9111310.
  • Yang JH, Sklar P, Axel R, Maniatis T (April 1997). "Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4354–9. Bibcode:1997PNAS...94.4354Y. doi:10.1073/pnas.94.9.4354. PMC 20726. PMID 9113993.
  • Gerber A, O'Connell MA, Keller W (May 1997). "Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette". RNA. 3 (5): 453–63. PMC 1369496. PMID 9149227.
  • Villard L, Tassone F, Haymowicz M, Welborn R, Gardiner K (March 1997). "Map location, genomic organization and expression patterns of the human RED1 RNA editase". Somatic Cell and Molecular Genetics. 23 (2): 135–45. doi:10.1007/BF02679972. PMID 9330641. S2CID 45104326.
  • Blanco J, Valenzuela A, Herrera C, Lluís C, Hovanessian AG, Franco R (July 2000). "The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression". FEBS Letters. 477 (1–2): 123–8. doi:10.1016/S0014-5793(00)01751-8. PMID 10899322. S2CID 22229481.
  • Herrera C, Morimoto C, Blanco J, Mallol J, Arenzana F, Lluis C, Franco R (June 2001). "Comodulation of CXCR4 and CD26 in human lymphocytes". The Journal of Biological Chemistry. 276 (22): 19532–9. doi:10.1074/jbc.M004586200. PMID 11278278.
  • Maas S, Patt S, Schrey M, Rich A (December 2001). "Underediting of glutamate receptor GluR-B mRNA in malignant gliomas". Proceedings of the National Academy of Sciences of the United States of America. 98 (25): 14687–92. Bibcode:2001PNAS...9814687M. doi:10.1073/pnas.251531398. PMC 64742. PMID 11717408.
  • Jayan GC, Casey JL (April 2002). "Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2". Journal of Virology. 76 (8): 3819–27. doi:10.1128/JVI.76.8.3819-3827.2002. PMC 136091. PMID 11907222.
  • Jaikaran DC, Collins CH, MacMillan AM (October 2002). "Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site". The Journal of Biological Chemistry. 277 (40): 37624–9. doi:10.1074/jbc.M204126200. PMID 12163487.
  • Jayan GC, Casey JL (December 2002). "Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression". Journal of Virology. 76 (23): 12399–404. doi:10.1128/JVI.76.23.12399-12404.2002. PMC 136899. PMID 12414985.
  • Slavov D, Gardiner K (October 2002). "Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns". Gene. 299 (1–2): 83–94. doi:10.1016/S0378-1119(02)01016-8. PMID 12459255.

External links edit


 

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

December 18, 2023
adarb1, double, stranded, specific, editase, enzyme, that, humans, encoded, gene, enzyme, member, adar, family, available, structurespdbortholog, search, pdbe, rcsblist, codes1zy7, 5ed1, 5ed2, 5hp3, 5hp2identifiersaliases, adar2, draba2, drada2, red1, adenosin. Double stranded RNA specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene 5 6 7 The enzyme is a member of ADAR family ADARB1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1ZY7 5ED1 5ED2 5HP3 5HP2IdentifiersAliasesADARB1 ADAR2 DRABA2 DRADA2 RED1 adenosine deaminase RNA specific B1 adenosine deaminase RNA specific B1 NEDHYMSExternal IDsOMIM 601218 MGI 891999 HomoloGene 8280 GeneCards ADARB1Gene location Human Chr Chromosome 21 human 1 Band21q22 3Start45 073 853 bp 1 End45 226 560 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 C1 10 39 72 cMStart77 126 560 bp 2 End77 254 104 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastric mucosaright coronary arterycerebellar vermissaphenous veinascending aortaAchilles tendonleft coronary arteryponsvena cavaright lungTop expressed inmedial dorsal nucleusmedial geniculate nucleuslateral geniculate nucleusinferior colliculuscerebellar cortexmedulla oblongatapontine nucleivisual cortexmedial vestibular nucleusascending aortaMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionmetal ion binding adenosine deaminase activity protein binding RNA binding double stranded RNA binding mRNA binding hydrolase activity double stranded RNA adenosine deaminase activity tRNA specific adenosine deaminase activityCellular componentnucleoplasm nucleolus nucleus cytosol cytoplasmBiological processRNA processing immune system process mRNA processing base conversion or substitution editing regulation of cell cycle negative regulation of cell migration defense response to virus negative regulation of protein kinase activity by regulation of protein phosphorylation positive regulation of viral genome replication innate immune response adenosine to inosine editing negative regulation of cell population proliferation neuromuscular synaptic transmission facial nerve morphogenesis hypoglossal nerve morphogenesis spinal cord ventral commissure morphogenesis multicellular organism growth neuromuscular process controlling posture innervation muscle tissue morphogenesis motor behavior motor neuron apoptotic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez104110532EnsemblENSG00000197381ENSMUSG00000020262UniProtP78563Q91ZS8RefSeq mRNA NM 001033049NM 001112NM 001160230NM 015833NM 015834NM 001346687NM 001346688NM 001024837NM 001024838NM 001024839NM 001024840NM 130895RefSeq protein NP 001103NP 001153702NP 001333616NP 001333617NP 056648NP 056649NP 001020008NP 570965NP 001020009Location UCSC Chr 21 45 07 45 23 MbChr 10 77 13 77 25 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 See also 3 References 4 Further reading 5 External linksFunction editThis gene encodes the enzyme responsible for pre mRNA editing of the glutamate receptor subunit B by site specific deamination of adenosines Studies in rats found that this enzyme acted on its own pre mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site Alternative splicing of this gene results in several transcript variants some of which have been characterized by the presence or absence of an Alu cassette insert and a short or long C terminal region 7 ADARB1 requires the small molecule inositol hexakisphosphate IP6 for proper function 8 ADARB1 is an A to I RNA editing enzyme that mostly acts on protein coding substrates 9 See also editAdenosine deaminase ADA an enzyme acting on isolated adenosineReferences edit a b c GRCh38 Ensembl release 89 ENSG00000197381 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020262 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mittaz L Scott HS Rossier C Seeburg PH Higuchi M Antonarakis SE April 1997 Cloning of a human RNA editing deaminase ADARB1 of glutamate receptors that maps to chromosome 21q22 3 Genomics 41 2 210 7 doi 10 1006 geno 1997 4655 PMID 9143496 Keegan LP Leroy A Sproul D O Connell MA Feb 2004 Adenosine deaminases acting on RNA ADARs RNA editing enzymes Genome Biology 5 2 209 doi 10 1186 gb 2004 5 2 209 PMC 395743 PMID 14759252 a b Entrez Gene ADARB1 adenosine deaminase RNA specific B1 RED1 homolog rat Macbeth MR Schubert HL Vandemark AP Lingam AT Hill CP Bass BL September 2005 Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing Science 309 5740 1534 9 Bibcode 2005Sci 309 1534M doi 10 1126 science 1113150 PMC 1850959 PMID 16141067 Licht K Jantsch MF April 2016 Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications The Journal of Cell Biology 213 1 15 22 doi 10 1083 jcb 201511041 PMC 4828693 PMID 27044895 Further reading editValenzuela A Blanco J Callebaut C Jacotot E Lluis C Hovanessian AG Franco R 1997 HIV 1 Envelope gp120 and Viral Particles Block Adenosine Deaminase Binding to Human CD26 Cellular Peptidases in Immune Functions and Diseases Advances in Experimental Medicine and Biology Vol 421 pp 185 92 doi 10 1007 978 1 4757 9613 1 24 ISBN 978 1 4757 9615 5 PMID 9330696 Melcher T Maas S Herb A Sprengel R Seeburg PH Higuchi M February 1996 A mammalian RNA editing enzyme Nature 379 6564 460 4 Bibcode 1996Natur 379 460M doi 10 1038 379460a0 PMID 8559253 S2CID 4326456 O Connell MA Gerber A Keller W January 1997 Purification of human double stranded RNA specific editase 1 hRED1 involved in editing of brain glutamate receptor B pre mRNA The Journal of Biological Chemistry 272 1 473 8 doi 10 1074 jbc 272 1 473 PMID 8995285 Valenzuela A Blanco J Callebaut C Jacotot E Lluis C Hovanessian AG Franco R April 1997 Adenosine deaminase binding to human CD26 is inhibited by HIV 1 envelope glycoprotein gp120 and viral particles Journal of Immunology 158 8 3721 9 PMID 9103436 Lai F Chen CX Carter KC Nishikura K May 1997 Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double stranded RNA adenosine deaminases Molecular and Cellular Biology 17 5 2413 24 doi 10 1128 MCB 17 5 2413 PMC 232090 PMID 9111310 Yang JH Sklar P Axel R Maniatis T April 1997 Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre mRNA editing Proceedings of the National Academy of Sciences of the United States of America 94 9 4354 9 Bibcode 1997PNAS 94 4354Y doi 10 1073 pnas 94 9 4354 PMC 20726 PMID 9113993 Gerber A O Connell MA Keller W May 1997 Two forms of human double stranded RNA specific editase 1 hRED1 generated by the insertion of an Alu cassette RNA 3 5 453 63 PMC 1369496 PMID 9149227 Villard L Tassone F Haymowicz M Welborn R Gardiner K March 1997 Map location genomic organization and expression patterns of the human RED1 RNA editase Somatic Cell and Molecular Genetics 23 2 135 45 doi 10 1007 BF02679972 PMID 9330641 S2CID 45104326 Blanco J Valenzuela A Herrera C Lluis C Hovanessian AG Franco R July 2000 The HIV 1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression FEBS Letters 477 1 2 123 8 doi 10 1016 S0014 5793 00 01751 8 PMID 10899322 S2CID 22229481 Herrera C Morimoto C Blanco J Mallol J Arenzana F Lluis C Franco R June 2001 Comodulation of CXCR4 and CD26 in human lymphocytes The Journal of Biological Chemistry 276 22 19532 9 doi 10 1074 jbc M004586200 PMID 11278278 Maas S Patt S Schrey M Rich A December 2001 Underediting of glutamate receptor GluR B mRNA in malignant gliomas Proceedings of the National Academy of Sciences of the United States of America 98 25 14687 92 Bibcode 2001PNAS 9814687M doi 10 1073 pnas 251531398 PMC 64742 PMID 11717408 Jayan GC Casey JL April 2002 Increased RNA editing and inhibition of hepatitis delta virus replication by high level expression of ADAR1 and ADAR2 Journal of Virology 76 8 3819 27 doi 10 1128 JVI 76 8 3819 3827 2002 PMC 136091 PMID 11907222 Jaikaran DC Collins CH MacMillan AM October 2002 Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR B R G site The Journal of Biological Chemistry 277 40 37624 9 doi 10 1074 jbc M204126200 PMID 12163487 Jayan GC Casey JL December 2002 Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA mediated knockdown of ADAR1 but not ADAR2 expression Journal of Virology 76 23 12399 404 doi 10 1128 JVI 76 23 12399 12404 2002 PMC 136899 PMID 12414985 Slavov D Gardiner K October 2002 Phylogenetic comparison of the pre mRNA adenosine deaminase ADAR2 genes and transcripts conservation and diversity in editing site sequence and alternative splicing patterns Gene 299 1 2 83 94 doi 10 1016 S0378 1119 02 01016 8 PMID 12459255 External links editHuman ADARB1 genome location and ADARB1 gene details page in the UCSC Genome Browser Portal nbsp Biology nbsp This article on a gene on human chromosome 21 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ADARB1 amp oldid 1172321417, wikipedia, wiki, book, books, library,

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