ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1gene.[5][6][7] It is a homolog of the well-known Drosophila gene white.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily (subfamily G). It is involved in macrophagecholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000160179 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024030 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chen H, Rossier C, Lalioti MD, Lynn A, Chakravarti A, Perrin G, Antonarakis SE (Jul 1996). "Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3". American Journal of Human Genetics. 59 (1): 66–75. PMC1915121. PMID 8659545.
^Engel T, Bode G, Lueken A, Knop M, Kannenberg F, Nofer JR, Assmann G, Seedorf U (Aug 2006). "Expression and functional characterization of ABCG1 splice variant ABCG1(666)". FEBS Letters. 580 (18): 4551–9. doi:10.1016/j.febslet.2006.07.006. PMID 16870176. S2CID 22947257.
^ ab"Entrez Gene: ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1".
Further reading
Schmitz G, Langmann T, Heimerl S (Oct 2001). "Role of ABCG1 and other ABCG family members in lipid metabolism". Journal of Lipid Research. 42 (10): 1513–20. doi:10.1016/S0022-2275(20)32205-7. PMID 11590207.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Savary S, Denizot F, Luciani M, Mattei M, Chimini G (Sep 1996). "Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene". Mammalian Genome. 7 (9): 673–6. doi:10.1007/s003359900203. PMID 8703120. S2CID 1077887.
Croop JM, Tiller GE, Fletcher JA, Lux ML, Raab E, Goldenson D, Son D, Arciniegas S, Wu RL (Jan 1997). "Isolation and characterization of a mammalian homolog of the Drosophila white gene". Gene. 185 (1): 77–85. doi:10.1016/S0378-1119(96)00633-6. PMID 9034316.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC139146. PMID 9110174.
Klucken J, Büchler C, Orsó E, Kaminski WE, Porsch-Ozcürümez M, Liebisch G, Kapinsky M, Diederich W, Drobnik W, Dean M, Allikmets R, Schmitz G (Jan 2000). "ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport". Proceedings of the National Academy of Sciences of the United States of America. 97 (2): 817–22. Bibcode:2000PNAS...97..817K. doi:10.1073/pnas.97.2.817. PMC15414. PMID 10639163.
Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA (May 2000). "Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols". The Journal of Biological Chemistry. 275 (19): 14700–7. doi:10.1074/jbc.275.19.14700. PMID 10799558.
Berry A, Scott HS, Kudoh J, Talior I, Korostishevsky M, Wattenhofer M, Guipponi M, Barras C, Rossier C, Shibuya K, Wang J, Kawasaki K, Asakawa S, Minoshima S, Shimizu N, Antonarakis S, Bonné-Tamir B (Aug 2000). "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region". Genomics. 68 (1): 22–9. doi:10.1006/geno.2000.6253. PMID 10950923.
Langmann T, Porsch-Ozcürümez M, Unkelbach U, Klucken J, Schmitz G (Nov 2000). "Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1494 (1–2): 175–80. doi:10.1016/s0167-4781(00)00215-3. PMID 11072082.
Lorkowski S, Rust S, Engel T, Jung E, Tegelkamp K, Galinski EA, Assmann G, Cullen P (Jan 2001). "Genomic sequence and structure of the human ABCG1 (ABC8) gene". Biochemical and Biophysical Research Communications. 280 (1): 121–31. doi:10.1006/bbrc.2000.4089. PMID 11162488.
Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G (Apr 2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". The Journal of Biological Chemistry. 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031.
Lorkowski S, Kratz M, Wenner C, Schmidt R, Weitkamp B, Fobker M, Reinhardt J, Rauterberg J, Galinski EA, Cullen P (May 2001). "Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease". Biochemical and Biophysical Research Communications. 283 (4): 821–30. doi:10.1006/bbrc.2001.4863. PMID 11350058.
Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N, Edwards PA (Oct 2001). "Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein". The Journal of Biological Chemistry. 276 (42): 39438–47. doi:10.1074/jbc.M105863200. PMID 11500512.
Kaplan R, Gan X, Menke JG, Wright SD, Cai TQ (Jun 2002). "Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway". Journal of Lipid Research. 43 (6): 952–9. doi:10.1016/S0022-2275(20)30470-3. PMID 12032171.
Cserepes J, Szentpétery Z, Seres L, Ozvegy-Laczka C, Langmann T, Schmitz G, Glavinas H, Klein I, Homolya L, Váradi A, Sarkadi B, Elkind NB (Jul 2004). "Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization". Biochemical and Biophysical Research Communications. 320 (3): 860–7. doi:10.1016/j.bbrc.2004.06.037. PMID 15240127.
abcg1, binding, cassette, family, member, protein, that, humans, encoded, gene, homolog, well, known, drosophila, gene, white, identifiersaliases, abc8, white1, binding, cassette, subfamily, member, 1external, idsomim, 603076, 107704, homologene, 21022, geneca. ATP binding cassette sub family G member 1 is a protein that in humans is encoded by the ABCG1 gene 5 6 7 It is a homolog of the well known Drosophila gene white ABCG1IdentifiersAliasesABCG1 ABC8 WHITE1 ATP binding cassette subfamily G member 1External IDsOMIM 603076 MGI 107704 HomoloGene 21022 GeneCards ABCG1Gene location Human Chr Chromosome 21 human 1 Band21q22 3Start42 199 689 bp 1 End42 297 244 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 17 A3 3Start31 276 649 bp 2 End31 336 962 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inRight adrenal glandLeft adrenal glandjejunal mucosaspleenlower lobe of lungamniotic fluidinternal globus pallidusupper lobe of left lungright lungretinal pigment epitheliumTop expressed inglobus pallidusright lung lobeolfactory tuberclestria vascularismedial dorsal nucleusmedian eminencearcuate nucleusolfactory epitheliumlateral geniculate nucleusinferior colliculusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding protein dimerization activity protein homodimerization activity ADP binding phospholipid transporter activity ABC type sterol transporter activity cholesterol binding ATPase activity toxin transmembrane transporter activity protein binding protein heterodimerization activity phospholipid binding ATP binding cholesterol transfer activity ATPase coupled transmembrane transporter activityCellular componentintegral component of membrane recycling endosome endosome Golgi apparatus endoplasmic reticulum membrane membrane Golgi membrane plasma membrane integral component of plasma membrane endoplasmic reticulum mitochondrion external side of plasma membraneBiological processphospholipid homeostasis lipid transport regulation of transcription DNA templated detection of hormone stimulus phospholipid efflux glycoprotein transport cholesterol transport cholesterol metabolic process response to organic substance negative regulation of cholesterol storage response to lipid intracellular cholesterol transport low density lipoprotein particle remodeling positive regulation of cholesterol efflux transmembrane transport cholesterol efflux positive regulation of cholesterol biosynthetic process negative regulation of lipid storage cholesterol homeostasis regulation of cholesterol esterification negative regulation of macrophage derived foam cell differentiation amyloid precursor protein catabolic process reverse cholesterol transport toxin transport high density lipoprotein particle remodeling transport cellular response to high density lipoprotein particle stimulus positive regulation of protein secretion positive regulation of amyloid beta formationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez961911307EnsemblENSG00000160179ENSMUSG00000024030UniProtP45844Q64343RefSeq mRNA NM 004915NM 016818NM 207174NM 207627NM 207628NM 207629NM 207630NM 009593RefSeq protein NP 004906NP 058198NP 997057NP 997510NP 997511NP 997512NP 033723Location UCSC Chr 21 42 2 42 3 MbChr 17 31 28 31 34 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 See also 3 References 4 Further reading 5 External linksFunction EditThe protein encoded by this gene is a member of the superfamily of ATP binding cassette ABC transporters ABC proteins transport various molecules across extra and intra cellular membranes ABC genes are divided into seven distinct subfamilies ABC1 MDR TAP MRP ALD OABP GCN20 White This protein is a member of the White subfamily subfamily G It is involved in macrophage cholesterol and phospholipids transport and may regulate cellular lipid homeostasis in other cell types Several alternative splice variants have been identified 7 See also EditATP binding cassette transporterReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000160179 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024030 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Chen H Rossier C Lalioti MD Lynn A Chakravarti A Perrin G Antonarakis SE Jul 1996 Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22 3 American Journal of Human Genetics 59 1 66 75 PMC 1915121 PMID 8659545 Engel T Bode G Lueken A Knop M Kannenberg F Nofer JR Assmann G Seedorf U Aug 2006 Expression and functional characterization of ABCG1 splice variant ABCG1 666 FEBS Letters 580 18 4551 9 doi 10 1016 j febslet 2006 07 006 PMID 16870176 S2CID 22947257 a b Entrez Gene ABCG1 ATP binding cassette sub family G WHITE member 1 Further reading EditSchmitz G Langmann T Heimerl S Oct 2001 Role of ABCG1 and other ABCG family members in lipid metabolism Journal of Lipid Research 42 10 1513 20 doi 10 1016 S0022 2275 20 32205 7 PMID 11590207 Andersson B Wentland MA Ricafrente JY Liu W Gibbs RA Apr 1996 A double adaptor method for improved shotgun library construction Analytical Biochemistry 236 1 107 13 doi 10 1006 abio 1996 0138 PMID 8619474 Savary S Denizot F Luciani M Mattei M Chimini G Sep 1996 Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene Mammalian Genome 7 9 673 6 doi 10 1007 s003359900203 PMID 8703120 S2CID 1077887 Croop JM Tiller GE Fletcher JA Lux ML Raab E Goldenson D Son D Arciniegas S Wu RL Jan 1997 Isolation and characterization of a mammalian homolog of the Drosophila white gene Gene 185 1 77 85 doi 10 1016 S0378 1119 96 00633 6 PMID 9034316 Yu W Andersson B Worley KC Muzny DM Ding Y Liu W Ricafrente JY Wentland MA Lennon G Gibbs RA Apr 1997 Large scale concatenation cDNA sequencing Genome Research 7 4 353 8 doi 10 1101 gr 7 4 353 PMC 139146 PMID 9110174 Klucken J Buchler C Orso E Kaminski WE Porsch Ozcurumez M Liebisch G Kapinsky M Diederich W Drobnik W Dean M Allikmets R Schmitz G Jan 2000 ABCG1 ABC8 the human homolog of the Drosophila white gene is a regulator of macrophage cholesterol and phospholipid transport Proceedings of the National Academy of Sciences of the United States of America 97 2 817 22 Bibcode 2000PNAS 97 817K doi 10 1073 pnas 97 2 817 PMC 15414 PMID 10639163 Venkateswaran A Repa JJ Lobaccaro JM Bronson A Mangelsdorf DJ Edwards PA May 2000 Human white murine ABC8 mRNA levels are highly induced in lipid loaded macrophages A transcriptional role for specific oxysterols The Journal of Biological Chemistry 275 19 14700 7 doi 10 1074 jbc 275 19 14700 PMID 10799558 Berry A Scott HS Kudoh J Talior I Korostishevsky M Wattenhofer M Guipponi M Barras C Rossier C Shibuya K Wang J Kawasaki K Asakawa S Minoshima S Shimizu N Antonarakis S Bonne Tamir B Aug 2000 Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers genomic structure and exclusion of six known genes in the region Genomics 68 1 22 9 doi 10 1006 geno 2000 6253 PMID 10950923 Langmann T Porsch Ozcurumez M Unkelbach U Klucken J Schmitz G Nov 2000 Genomic organization and characterization of the promoter of the human ATP binding cassette transporter G1 ABCG1 gene Biochimica et Biophysica Acta BBA Gene Structure and Expression 1494 1 2 175 80 doi 10 1016 s0167 4781 00 00215 3 PMID 11072082 Lorkowski S Rust S Engel T Jung E Tegelkamp K Galinski EA Assmann G Cullen P Jan 2001 Genomic sequence and structure of the human ABCG1 ABC8 gene Biochemical and Biophysical Research Communications 280 1 121 31 doi 10 1006 bbrc 2000 4089 PMID 11162488 Porsch Ozcurumez M Langmann T Heimerl S Borsukova H Kaminski WE Drobnik W Honer C Schumacher C Schmitz G Apr 2001 The zinc finger protein 202 ZNF202 is a transcriptional repressor of ATP binding cassette transporter A1 ABCA1 and ABCG1 gene expression and a modulator of cellular lipid efflux The Journal of Biological Chemistry 276 15 12427 33 doi 10 1074 jbc M100218200 PMID 11279031 Lorkowski S Kratz M Wenner C Schmidt R Weitkamp B Fobker M Reinhardt J Rauterberg J Galinski EA Cullen P May 2001 Expression of the ATP binding cassette transporter gene ABCG1 ABC8 in Tangier disease Biochemical and Biophysical Research Communications 283 4 821 30 doi 10 1006 bbrc 2001 4863 PMID 11350058 Kennedy MA Venkateswaran A Tarr PT Xenarios I Kudoh J Shimizu N Edwards PA Oct 2001 Characterization of the human ABCG1 gene liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein The Journal of Biological Chemistry 276 42 39438 47 doi 10 1074 jbc M105863200 PMID 11500512 Kaplan R Gan X Menke JG Wright SD Cai TQ Jun 2002 Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR independent pathway Journal of Lipid Research 43 6 952 9 doi 10 1016 S0022 2275 20 30470 3 PMID 12032171 Cserepes J Szentpetery Z Seres L Ozvegy Laczka C Langmann T Schmitz G Glavinas H Klein I Homolya L Varadi A Sarkadi B Elkind NB Jul 2004 Functional expression and characterization of the human ABCG1 and ABCG4 proteins indications for heterodimerization Biochemical and Biophysical Research Communications 320 3 860 7 doi 10 1016 j bbrc 2004 06 037 PMID 15240127 External links EditABCG1 protein human at the US National Library of Medicine Medical Subject Headings MeSH Human ABCG1 genome location and ABCG1 gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ABCG1 amp oldid 1129212098, wikipedia, wiki, book, books, library,
