The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellulareukaryotes. The function of this protein has not yet been determined.[5]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000141338 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020620 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8".
Further readingedit
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mammalian Gene Collection Program Team, Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Tsuruoka S, Ishibashi K, Yamamoto H, et al. (2002). "Functional analysis of ABCA8, a new drug transporter". Biochem. Biophys. Res. Commun. 298 (1): 41–5. doi:10.1016/S0006-291X(02)02389-6. PMID 12379217.
Iida A, Saito S, Sekine A, et al. (2002). "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8". J. Hum. Genet. 47 (6): 285–310. doi:10.1007/s100380200041. PMID 12111378.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
abca8, binding, cassette, family, member, protein, that, humans, encoded, gene, identifiersaliases, binding, cassette, subfamily, member, 8external, idsomim, 612505, 1351668, homologene, 56029, genecards, gene, location, human, chromosome, human, band17q24, 2s. ATP binding cassette sub family A member 8 is a protein that in humans is encoded by the ABCA8 gene 5 ABCA8IdentifiersAliasesABCA8 ATP binding cassette subfamily A member 8External IDsOMIM 612505 MGI 1351668 HomoloGene 56029 GeneCards ABCA8Gene location Human Chr Chromosome 17 human 1 Band17q24 2Start68 867 289 bp 1 End68 955 392 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 E1 11 72 88 cMStart109 823 016 bp 2 End109 886 671 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspinal gangliatrigeminal ganglionparietal pleurapericardiumtibial nervegerminal epitheliumcorpus callosumsural nervevena cavaolfactory bulbTop expressed inliverleft lobe of liveresophagusextraocular muscleupper armtriceps brachii musclevisual cortexsuperior frontal gyruscarotid bodysciatic nerveMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding ATPase activity ATP binding ABC type xenobiotic transporter activity ATPase coupled transmembrane transporter activity lipid transporter activityCellular componentintegral component of membrane plasma membrane membrane mitochondrial inner membrane intracellular membrane bounded organelleBiological processlipid transport xenobiotic transport xenobiotic transmembrane transport transmembrane transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1035127404EnsemblENSG00000141338ENSMUSG00000020620UniProtO94911Q8K440RefSeq mRNA NM 001288985NM 001288986NM 007168NM 001375771NM 001375772NM 013851NM 001362749RefSeq protein NP 001275914NP 001275915NP 009099NP 001362700NP 001362701NP 038879NP 001349678Location UCSC Chr 17 68 87 68 96 MbChr 11 109 82 109 89 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe membrane associated protein encoded by this gene is a member of the superfamily of ATP binding cassette ABC transporters ABC proteins transport various molecules across extra and intracellular membranes ABC genes are divided into seven distinct subfamilies ABC1 MDR TAP MRP ALD OABP GCN20 White This protein is a member of the ABC1 subfamily Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes The function of this protein has not yet been determined 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000141338 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020620 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene ABCA8 ATP binding cassette sub family A ABC1 member 8 Further reading editGerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Mammalian Gene Collection Program Team Strausberg RL Feingold EA Grouse LH et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proceedings of the National Academy of Sciences 99 26 16899 16903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Tsuruoka S Ishibashi K Yamamoto H et al 2002 Functional analysis of ABCA8 a new drug transporter Biochem Biophys Res Commun 298 1 41 5 doi 10 1016 S0006 291X 02 02389 6 PMID 12379217 Iida A Saito S Sekine A et al 2002 Catalog of 605 single nucleotide polymorphisms SNPs among 13 genes encoding human ATP binding cassette transporters ABCA4 ABCA7 ABCA8 ABCD1 ABCD3 ABCD4 ABCE1 ABCF1 ABCG1 ABCG2 ABCG4 ABCG5 and ABCG8 J Hum Genet 47 6 285 310 doi 10 1007 s100380200041 PMID 12111378 Harrington JJ Sherf B Rundlett S et al 2001 Creation of genome wide protein expression libraries using random activation of gene expression Nat Biotechnol 19 5 440 5 doi 10 1038 88107 PMID 11329013 S2CID 25064683 Nagase T Ishikawa K Suyama M et al 1999 Prediction of the coding sequences of unidentified human genes XII The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Res 5 6 355 64 doi 10 1093 dnares 5 6 355 PMID 10048485 Bonaldo MF Lennon G Soares MB 1997 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 External links editABCA8 human gene location in the UCSC Genome Browser ABCA8 human gene details in the UCSC Genome Browser nbsp This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ABCA8 amp oldid 1198568194, wikipedia, wiki, book, books, library,
