A-372159 is a drug which acts as a potent and selective partial agonist for the 5HT2Creceptor, with more than 100x selectivity over the closely related 5-HT2B receptor and a Ki of 3nM. It has been found to produce anorectic effects in animal studies and produced significant weight loss in rats with no development of tolerance or serious side effects.[1]
372159, drug, which, acts, potent, selective, partial, agonist, 5ht2c, receptor, with, more, than, 100x, selectivity, over, closely, related, ht2b, receptor, been, found, produce, anorectic, effects, animal, studies, produced, significant, weight, loss, rats, . A 372159 is a drug which acts as a potent and selective partial agonist for the 5HT2C receptor with more than 100x selectivity over the closely related 5 HT2B receptor and a Ki of 3nM It has been found to produce anorectic effects in animal studies and produced significant weight loss in rats with no development of tolerance or serious side effects 1 A 372159IdentifiersIUPAC name 8aS 12aR 2 4 isopropoxy 2 trifluoromethyl phenyl 6 7 8a 9 10 11 12 12a octahydro 5H 1 4 oxazepino 2 3 4 hi pyrido 4 3 b indoleCAS Number313543 60 1 YChemSpider9605283 YUNIINK36K7QB8GChemical and physical dataFormulaC 24H 27F 3N 2O 2Molar mass432 487 g mol 13D model JSmol Interactive imageSMILES FC F C1 C C2 CC3 C4C OCCCN4 C 5 H CCNC C 35 H C2 C CC OC C C C1 FInChI InChI 1S C24H27F3N2O2 c1 14 2 31 16 4 5 17 20 12 16 24 25 26 27 15 10 18 19 13 28 7 6 21 19 29 8 3 9 30 22 11 15 23 18 29 h4 5 10 12 14 19 21 28H 3 6 9 13H2 1 2H3 t19 21 m0 s1 YKey LADKOBQJOCFCQU FPOVZHCZSA N Y verify References edit Childers WE Robichaud AJ January 2005 Recent advances in selective serotonergic agents Annual Reports in Medicinal Chemistry 40 17 33 doi 10 1016 S0065 7743 05 40002 0 ISBN 978 0 12 040540 4 nbsp This drug article relating to the nervous system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title A 372159 amp oldid 1108874585, wikipedia, wiki, book, books, library,
