Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5APgene.[4][5]
FLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes, 5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, and specialized pro-resolving mediators of the lipoxin and resolvin classes.[6][7] It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. How FLAP activates 5-lipooxygenase is not completely understood, but there is a physical interaction between the two. [citation needed] FLAP structure consists of 4 transmembrane alpha helices, but they are found in trimer forming a barrel. The barrel is about 60 Å high and 36 Å wide.[8]
Clinical significanceedit
Leukotrienes, which require the FLAP protein to be synthesized, have an established pathological role in allergic and respiratory diseases. Animal and human genetic evidence suggests they may also have an important role in atherosclerosis, myocardial infarction, and stroke.[9] The structure of FLAP provides a tool for the development of novel therapies for respiratory and cardiovascular diseases and for the design of focused experiments to probe the cell biology of FLAP and its role in leukotriene biosynthesis.[8][10]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000060063 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kennedy BP, Diehl RE, Boie Y, Adam M, Dixon RA (May 1991). "Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP)". The Journal of Biological Chemistry. 266 (13): 8511–6. doi:10.1016/S0021-9258(18)93004-8. PMID 1673682.
^Yandava CN, Kennedy BP, Pillari A, Duncan AM, Drazen JM (February 1999). "Cytogenetic and radiation hybrid mapping of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12". Genomics. 56 (1): 131–3. doi:10.1006/geno.1998.5651. PMID 10036194.
^Peters-Golden M, Brock TG (2003). "5-lipoxygenase and FLAP". Prostaglandins, Leukotrienes, and Essential Fatty Acids. 69 (2–3): 99–109. doi:10.1016/S0952-3278(03)00070-X. PMID 12895592.
^Serhan CN, Chiang N, Dalli J, Levy BD (2015). "Lipid mediators in the resolution of inflammation". Cold Spring Harbor Perspectives in Biology. 7 (2): a016311. doi:10.1101/cshperspect.a016311. PMC4315926. PMID 25359497.
^Kaushal, Ritesh; Pal, Prodipto; Alwell, Kathleen; Haverbusch, Mary; Flaherty, Matthew; Moomaw, Charles; Sekar, Padmini; Kissela, Brett; Kleindorfer, Dawn; Chakraborty, Ranajit; Broderick, Joseph; Deka, Ranjan; Woo, Daniel (2007-06-01). "Association of ALOX5AP with ischemic stroke: a population-based case-control study". Human Genetics. 121 (5): 601–607. doi:10.1007/s00439-007-0338-y. ISSN 1432-1203. PMID 17387518. S2CID 20183625.
^Evans, Jilly F.; Ferguson, Andrew D.; Mosley, Ralph T.; Hutchinson, John H. (February 2008). "What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases". Trends in Pharmacological Sciences. 29 (2): 72–78. doi:10.1016/j.tips.2007.11.006. ISSN 0165-6147. PMID 18187210.
^Musiyenko A, Correa L, Stock N, Hutchinson JH, Lorrain DS, Bain G, Evans JF, Barik S (November 2009). "A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye". Clinical and Vaccine Immunology. 16 (11): 1654–9. doi:10.1128/CVI.00220-09. PMC2772391. PMID 19759251.
^Gillard, J.; Ford-Hutchinson, A. W.; Chan, C.; Charleson, S.; Denis, D.; Foster, A.; Fortin, R.; Leger, S.; McFarlane, C. S.; Morton, H.; Piechuta, H.; Riendeau, D.; Rouzer, C. A.; Rokach, J.; Young, R. (1989-05-01). "L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor". Canadian Journal of Physiology and Pharmacology. 67 (5): 456–464. doi:10.1139/y89-073. ISSN 0008-4212. PMID 2548691.
Further readingedit
Bevan S, Lorenz MW, Sitzer M, Markus HS (March 2009). "Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study". Stroke. 40 (3): 696–701. doi:10.1161/STROKEAHA.108.525733. PMID 19131661.
Yoshida T, Kato K, Yokoi K, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Suzuki T, Nozawa Y, Yamada Y (April 2009). "Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus". International Journal of Molecular Medicine. 23 (4): 529–37. doi:10.3892/ijmm_00000161. PMID 19288030.
He YL, Zhu M, Jin XP, Zhou YL (November 2009). "[Relationship of polymorphism of SG13S114A/T in ALOX5AP gene with atherosclerotic cerebral infarction]". Zhejiang da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 38 (6): 630–3. doi:10.3785/j.issn.1008-9292.2009.06.013. PMID 20014490.
Quarta G, Stanzione R, Evangelista A, Zanda B, Di Angelantonio E, Marchitti S, Di Castro S, Di Vavo M, Volpe M, Rubattu S (November 2009). "Phosphodiesterase 4D and 5-lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians". European Journal of Human Genetics. 17 (11): 1448–53. doi:10.1038/ejhg.2009.71. PMC2986684. PMID 19417766.
Wang Q (May 2005). "Molecular genetics of coronary artery disease". Current Opinion in Cardiology. 20 (3): 182–8. doi:10.1097/01.hco.0000160373.77190.f1. PMC1579824. PMID 15861005.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF (December 2009). "Integrative predictive model of coronary artery calcification in atherosclerosis". Circulation. 120 (24): 2448–54. doi:10.1161/CIRCULATIONAHA.109.865501. PMC2810344. PMID 19948975.
York TP, Vargas-Irwin C, Anderson WH, van den Oord EJ (May 2009). "Asthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity". Pharmacogenomics. 10 (5): 753–67. doi:10.2217/pgs.09.19. PMID 19450127.
Bizzintino JA, Khoo SK, Zhang G, Martin AC, Rueter K, Geelhoed GC, Goldblatt J, Laing IA, Le Souëf PN, Hayden CM (July 2009). "Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma". Prostaglandins, Leukotrienes, and Essential Fatty Acids. 81 (1): 9–15. doi:10.1016/j.plefa.2009.05.022. PMID 19524426.
Zintzaras E, Rodopoulou P, Sakellaridis N (March 2009). "Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis". American Journal of Epidemiology. 169 (5): 523–32. doi:10.1093/aje/kwn368. PMID 19126581.
van der Net JB, Janssens AC, Defesche JC, Kastelein JJ, Sijbrands EJ, Steyerberg EW (February 2009). "Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia". The American Journal of Cardiology. 103 (3): 375–80. doi:10.1016/j.amjcard.2008.09.093. PMID 19166692.
Liu J, Sun K, Bai Y, Zhang W, Wang X, Wang Y, Wang H, Chen J, Song X, Xin Y, Liu Z, Hui R (June 2009). "Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study". Human Genetics. 125 (5–6): 649–56. doi:10.1007/s00439-009-0659-0. PMID 19373490. S2CID 21475249.
Zhao J, Quyyumi AA, Patel R, Zafari AM, Veledar E, Onufrak S, Shallenberger LH, Jones L, Vaccarino V (September 2009). "Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene". Psychosomatic Medicine. 71 (7): 691–6. doi:10.1097/PSY.0b013e3181b05c57. PMC3113512. PMID 19622707.
Matarin M, Brown WM, Dena H, Britton A, De Vrieze FW, Brott TG, Brown RD, Worrall BB, Case LD, Chanock SJ, Metter EJ, Ferruci L, Gamble D, Hardy JA, Rich SS, Singleton A, Meschia JF (November 2009). "Candidate gene polymorphisms for ischemic stroke". Stroke. 40 (11): 3436–42. doi:10.1161/STROKEAHA.109.558015. PMC2784015. PMID 19729601.
Tsai AK, Li N, Hanson NQ, Tsai MY, Tang W (December 2009). "Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population". Atherosclerosis. 207 (2): 487–91. doi:10.1016/j.atherosclerosis.2009.06.018. PMID 19596330.
Strid T, Svartz J, Franck N, Hallin E, Ingelsson B, Söderström M, Hammarström S (April 2009). "Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein". Biochemical and Biophysical Research Communications. 381 (4): 518–22. doi:10.1016/j.bbrc.2009.02.074. PMID 19233132.
Drenos F, Talmud PJ, Casas JP, Smeeth L, Palmen J, Humphries SE, Hingorani AD (June 2009). "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Human Molecular Genetics. 18 (12): 2305–16. doi:10.1093/hmg/ddp159. PMC2685759. PMID 19336475.
Vickers PJ (October 1995). "5-Lipoxygenase-activating protein (FLAP)". Journal of Lipid Mediators and Cell Signalling. 12 (2–3): 185–94. doi:10.1016/0929-7855(95)00018-L. PMID 8777565.
Via M, De Giacomo A, Corvol H, Eng C, Seibold MA, Gillett C, Galanter J, Sen S, Tcheurekdjian H, Chapela R, Rodríguez-Santana JR, Rodríguez-Cintrón W, Thyne S, Avila PC, Choudhry S, González Burchard E (April 2010). "The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos". Clinical and Experimental Allergy. 40 (4): 582–9. doi:10.1111/j.1365-2222.2009.03438.x. PMC2866051. PMID 20067482.
Steinhilber D (July 1994). "5-Lipoxygenase: enzyme expression and regulation of activity". Pharmaceutica Acta Helvetiae. 69 (1): 3–14. doi:10.1016/0031-6865(94)90024-8. PMID 7938075.
Oosterveer DM, Versmissen J, Yazdanpanah M, van der Net JB, Defesche JC, Kastelein JJ, Sijbrands EJ (September 2009). "5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia". Atherosclerosis. 206 (1): 223–7. doi:10.1016/j.atherosclerosis.2009.02.019. PMID 19361804.
External linksedit
5-lipoxygenase-activating+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human ALOX5AP genome location and ALOX5AP gene details page in the UCSC Genome Browser.
May 08, 2024
lipoxygenase, activating, protein, arachidonate, also, known, lipoxygenase, activating, protein, flap, protein, that, humans, encoded, alox5ap, gene, alox5apavailable, structurespdbortholog, search, pdbe, rcsblist, codes2q7r, 2q7midentifiersaliasesalox5ap, fla. Arachidonate 5 lipoxygenase activating protein also known as 5 lipoxygenase activating protein or FLAP is a protein that in humans is encoded by the ALOX5AP gene 4 5 ALOX5APAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes2Q7R 2Q7MIdentifiersAliasesALOX5AP FLAP arachidonate 5 lipoxygenase activating proteinExternal IDsOMIM 603700 MGI 107505 HomoloGene 1231 GeneCards ALOX5APGene location Mouse Chr Chromosome 5 mouse 1 Band5 5 G3Start149 201 577 bp 1 End149 224 963 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inbloodtrabecular bonebone marrowright lungbone marrow cellsmonocyteupper lobe of left lungspleenlower lobe of lungperiodontal fiberTop expressed inbloodright lung lobeankleinterventricular septumcarotid bodyspleensciatic nervecervixankle jointcalvariaMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionglutathione transferase activity protein N terminus binding leukotriene C4 synthase activity glutathione peroxidase activity protein binding arachidonic acid binding enzyme activator activityCellular componentintegral component of membrane nuclear membrane endoplasmic reticulum membrane membrane nuclear envelope endoplasmic reticulum nucleusBiological processcellular response to calcium ion leukotriene metabolic process positive regulation of catalytic activity protein homotrimerization lipoxygenase pathway leukotriene biosynthetic process lipoxin metabolic process cellular oxidant detoxification lipoxin biosynthetic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez24111690Ensembln aENSMUSG00000060063UniProtP20292P30355RefSeq mRNA NM 001204406NM 001629NM 009663NM 001308462RefSeq protein NP 001191335NP 001620NP 001295391NP 033793Location UCSC n aChr 5 149 2 149 22 MbPubMed search 2 3 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Clinical significance 3 Inhibitors 4 References 5 Further reading 6 External linksFunction editFLAP is necessary for the activation of 5 lipoxygenase and therefore for the production of leukotrienes 5 hydroxyeicosatetraenoic acid 5 oxo eicosatetraenoic acid and specialized pro resolving mediators of the lipoxin and resolvin classes 6 7 It is an integral protein within the nuclear membrane FLAP is necessary in synthesis of leukotriene which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases FLAP functions as a membrane anchor for 5 lipooxygenase and as an amine acid bind protein How FLAP activates 5 lipooxygenase is not completely understood but there is a physical interaction between the two citation needed FLAP structure consists of 4 transmembrane alpha helices but they are found in trimer forming a barrel The barrel is about 60 A high and 36 A wide 8 Clinical significance editLeukotrienes which require the FLAP protein to be synthesized have an established pathological role in allergic and respiratory diseases Animal and human genetic evidence suggests they may also have an important role in atherosclerosis myocardial infarction and stroke 9 The structure of FLAP provides a tool for the development of novel therapies for respiratory and cardiovascular diseases and for the design of focused experiments to probe the cell biology of FLAP and its role in leukotriene biosynthesis 8 10 Inhibitors editAM 679 11 MK 886 12 Veliflapon BAY X1005 References edit a b c GRCm38 Ensembl release 89 ENSMUSG00000060063 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kennedy BP Diehl RE Boie Y Adam M Dixon RA May 1991 Gene characterization and promoter analysis of the human 5 lipoxygenase activating protein FLAP The Journal of Biological Chemistry 266 13 8511 6 doi 10 1016 S0021 9258 18 93004 8 PMID 1673682 Yandava CN Kennedy BP Pillari A Duncan AM Drazen JM February 1999 Cytogenetic and radiation hybrid mapping of human arachidonate 5 lipoxygenase activating protein ALOX5AP to chromosome 13q12 Genomics 56 1 131 3 doi 10 1006 geno 1998 5651 PMID 10036194 Peters Golden M Brock TG 2003 5 lipoxygenase and FLAP Prostaglandins Leukotrienes and Essential Fatty Acids 69 2 3 99 109 doi 10 1016 S0952 3278 03 00070 X PMID 12895592 Serhan CN Chiang N Dalli J Levy BD 2015 Lipid mediators in the resolution of inflammation Cold Spring Harbor Perspectives in Biology 7 2 a016311 doi 10 1101 cshperspect a016311 PMC 4315926 PMID 25359497 a b PDB 2q7r Ferguson AD McKeever BM Xu S Wisniewski D Miller DK Yamin TT Spencer RH Chu L Ujjainwalla F Cunningham BR Evans JF Becker JW July 2007 Crystal structure of inhibitor bound human 5 lipoxygenase activating protein Science 317 5837 510 2 Bibcode 2007Sci 317 510F doi 10 1126 science 1144346 PMID 17600184 S2CID 31544959 Kaushal Ritesh Pal Prodipto Alwell Kathleen Haverbusch Mary Flaherty Matthew Moomaw Charles Sekar Padmini Kissela Brett Kleindorfer Dawn Chakraborty Ranajit Broderick Joseph Deka Ranjan Woo Daniel 2007 06 01 Association of ALOX5AP with ischemic stroke a population based case control study Human Genetics 121 5 601 607 doi 10 1007 s00439 007 0338 y ISSN 1432 1203 PMID 17387518 S2CID 20183625 Evans Jilly F Ferguson Andrew D Mosley Ralph T Hutchinson John H February 2008 What s all the FLAP about 5 lipoxygenase activating protein inhibitors for inflammatory diseases Trends in Pharmacological Sciences 29 2 72 78 doi 10 1016 j tips 2007 11 006 ISSN 0165 6147 PMID 18187210 Musiyenko A Correa L Stock N Hutchinson JH Lorrain DS Bain G Evans JF Barik S November 2009 A novel 5 lipoxygenase activating protein inhibitor AM679 reduces inflammation in the respiratory syncytial virus infected mouse eye Clinical and Vaccine Immunology 16 11 1654 9 doi 10 1128 CVI 00220 09 PMC 2772391 PMID 19759251 Gillard J Ford Hutchinson A W Chan C Charleson S Denis D Foster A Fortin R Leger S McFarlane C S Morton H Piechuta H Riendeau D Rouzer C A Rokach J Young R 1989 05 01 L 663 536 MK 886 3 1 4 chlorobenzyl 3 t butyl thio 5 isopropylindol 2 yl 2 2 dimethylpropanoic acid a novel orally active leukotriene biosynthesis inhibitor Canadian Journal of Physiology and Pharmacology 67 5 456 464 doi 10 1139 y89 073 ISSN 0008 4212 PMID 2548691 Further reading editBevan S Lorenz MW Sitzer M Markus HS March 2009 Genetic variation in the leukotriene pathway and carotid intima media thickness a 2 stage replication study Stroke 40 3 696 701 doi 10 1161 STROKEAHA 108 525733 PMID 19131661 Yoshida T Kato K Yokoi K Watanabe S Metoki N Yoshida H Satoh K Aoyagi Y Nishigaki Y Suzuki T Nozawa Y Yamada Y April 2009 Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus International Journal of Molecular Medicine 23 4 529 37 doi 10 3892 ijmm 00000161 PMID 19288030 He YL Zhu M Jin XP Zhou YL November 2009 Relationship of polymorphism of SG13S114A T in ALOX5AP gene with atherosclerotic cerebral infarction Zhejiang da Xue Xue Bao Yi Xue Ban Journal of Zhejiang University Medical Sciences 38 6 630 3 doi 10 3785 j issn 1008 9292 2009 06 013 PMID 20014490 Quarta G Stanzione R Evangelista A Zanda B Di Angelantonio E Marchitti S Di Castro S Di Vavo M Volpe M Rubattu S November 2009 Phosphodiesterase 4D and 5 lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians European Journal of Human Genetics 17 11 1448 53 doi 10 1038 ejhg 2009 71 PMC 2986684 PMID 19417766 Wang Q May 2005 Molecular genetics of coronary artery disease Current Opinion in Cardiology 20 3 182 8 doi 10 1097 01 hco 0000160373 77190 f1 PMC 1579824 PMID 15861005 McGeachie M Ramoni RL Mychaleckyj JC Furie KL Dreyfuss JM Liu Y Herrington D Guo X Lima JA Post W Rotter JI Rich S Sale M Ramoni MF December 2009 Integrative predictive model of coronary artery calcification in atherosclerosis Circulation 120 24 2448 54 doi 10 1161 CIRCULATIONAHA 109 865501 PMC 2810344 PMID 19948975 York TP Vargas Irwin C Anderson WH van den Oord EJ May 2009 Asthma pharmacogenetic study using finite mixture models to handle drug response heterogeneity Pharmacogenomics 10 5 753 67 doi 10 2217 pgs 09 19 PMID 19450127 Bizzintino JA Khoo SK Zhang G Martin AC Rueter K Geelhoed GC Goldblatt J Laing IA Le Souef PN Hayden CM July 2009 Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma Prostaglandins Leukotrienes and Essential Fatty Acids 81 1 9 15 doi 10 1016 j plefa 2009 05 022 PMID 19524426 Zintzaras E Rodopoulou P Sakellaridis N March 2009 Variants of the arachidonate 5 lipoxygenase activating protein ALOX5AP gene and risk of stroke a HuGE gene disease association review and meta analysis American Journal of Epidemiology 169 5 523 32 doi 10 1093 aje kwn368 PMID 19126581 van der Net JB Janssens AC Defesche JC Kastelein JJ Sijbrands EJ Steyerberg EW February 2009 Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia The American Journal of Cardiology 103 3 375 80 doi 10 1016 j amjcard 2008 09 093 PMID 19166692 Liu J Sun K Bai Y Zhang W Wang X Wang Y Wang H Chen J Song X Xin Y Liu Z Hui R June 2009 Association of three gene interaction among MTHFR ALOX5AP and NOTCH3 with thrombotic stroke a multicenter case control study Human Genetics 125 5 6 649 56 doi 10 1007 s00439 009 0659 0 PMID 19373490 S2CID 21475249 Zhao J Quyyumi AA Patel R Zafari AM Veledar E Onufrak S Shallenberger LH Jones L Vaccarino V September 2009 Sex specific association of depression and a haplotype in leukotriene A4 hydrolase gene Psychosomatic Medicine 71 7 691 6 doi 10 1097 PSY 0b013e3181b05c57 PMC 3113512 PMID 19622707 Matarin M Brown WM Dena H Britton A De Vrieze FW Brott TG Brown RD Worrall BB Case LD Chanock SJ Metter EJ Ferruci L Gamble D Hardy JA Rich SS Singleton A Meschia JF November 2009 Candidate gene polymorphisms for ischemic stroke Stroke 40 11 3436 42 doi 10 1161 STROKEAHA 109 558015 PMC 2784015 PMID 19729601 Tsai AK Li N Hanson NQ Tsai MY Tang W December 2009 Associations of genetic polymorphisms of arachidonate 5 lipoxygenase activating protein with risk of coronary artery disease in a European American population Atherosclerosis 207 2 487 91 doi 10 1016 j atherosclerosis 2009 06 018 PMID 19596330 Strid T Svartz J Franck N Hallin E Ingelsson B Soderstrom M Hammarstrom S April 2009 Distinct parts of leukotriene C 4 synthase interact with 5 lipoxygenase and 5 lipoxygenase activating protein Biochemical and Biophysical Research Communications 381 4 518 22 doi 10 1016 j bbrc 2009 02 074 PMID 19233132 Drenos F Talmud PJ Casas JP Smeeth L Palmen J Humphries SE Hingorani AD June 2009 Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk Human Molecular Genetics 18 12 2305 16 doi 10 1093 hmg ddp159 PMC 2685759 PMID 19336475 Vickers PJ October 1995 5 Lipoxygenase activating protein FLAP Journal of Lipid Mediators and Cell Signalling 12 2 3 185 94 doi 10 1016 0929 7855 95 00018 L PMID 8777565 Via M De Giacomo A Corvol H Eng C Seibold MA Gillett C Galanter J Sen S Tcheurekdjian H Chapela R Rodriguez Santana JR Rodriguez Cintron W Thyne S Avila PC Choudhry S Gonzalez Burchard E April 2010 The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos Clinical and Experimental Allergy 40 4 582 9 doi 10 1111 j 1365 2222 2009 03438 x PMC 2866051 PMID 20067482 Steinhilber D July 1994 5 Lipoxygenase enzyme expression and regulation of activity Pharmaceutica Acta Helvetiae 69 1 3 14 doi 10 1016 0031 6865 94 90024 8 PMID 7938075 Oosterveer DM Versmissen J Yazdanpanah M van der Net JB Defesche JC Kastelein JJ Sijbrands EJ September 2009 5 Lipoxygenase activating protein ALOX5AP gene variants associate with the presence of xanthomas in familial hypercholesterolemia Atherosclerosis 206 1 223 7 doi 10 1016 j atherosclerosis 2009 02 019 PMID 19361804 External links edit5 lipoxygenase activating protein at the U S National Library of Medicine Medical Subject Headings MeSH Human ALOX5AP genome location and ALOX5AP gene details page in the UCSC Genome Browser Retrieved from https en wikipedia org w index php title 5 lipoxygenase activating protein amp oldid 1190127657, wikipedia, wiki, book, books, library,
