4F-MDMB-BINACA (also known as 4F-MDMB-BUTINACA or 4F-ADB) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family.[1] It has been used as an active ingredient in synthetic cannabis products and sold as a designer drug since late 2018.[2][3] 4F-MDMB-BINACA is an agonist of the CB1 receptor (EC50 = 7.39 nM),[4] though it is unclear whether it is selective for this target.[5] In December 2019, the UNODC announced scheduling recommendations placing 4F-MDMB-BINACA into Schedule II throughout the world.[6]
The corresponding indole core analogue, 4F-MDMB-BICA or 4F-MDMB-BUTICA has also been widely sold as a designer drug by chemical providers on the net, first being identified in May 2020.[7]
4F-MDMB-BICA
Legal Status
United Kingdom
It's illegal to sell, distribute, supply, transport or trade the pharmaceutical drug under the Psychoactive Substances Act 2016.
^Krotulski AJ, Mohr AL, Kacinko SL, Fogarty MF, Shuda SA, Diamond FX, et al. (September 2019). "4F-MDMB-BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework". Journal of Forensic Sciences. 64 (5): 1451–1461. doi:10.1111/1556-4029.14101. PMID 31260580. S2CID 195770459.
^Tokarczyk, Bogdan; Jurczyk, Agnieszka; Krupińska, Justyna; Adamowicz, Piotr (June 2022). "Fatal intoxication with new synthetic cannabinoids 5F-MDMB-PICA and 4F-MDMB-BINACA—parent compounds and metabolite identification in blood, urine and cerebrospinal fluid". Forensic Science, Medicine and Pathology. 18 (4): 393–402. doi:10.1007/s12024-022-00492-3. ISSN 1556-2891. PMC9194349. PMID 35699867.
^Wagmann, Lea; Stiller, Rebecca G.; Fischmann, Svenja; Westphal, Folker; Meyer, Markus R. (July 2022). "Going deeper into the toxicokinetics of synthetic cannabinoids: in vitro contribution of human carboxylesterases". Archives of Toxicology. 96 (10): 2755–2766. doi:10.1007/s00204-022-03332-z. ISSN 1432-0738. PMC9352624. PMID 35788413.
^Cannaert A, Sparkes E, Pike E, Luo JL, Fang A, Kevin RC, Ellison R, Gerona R, Banister SD, Stove CP (December 2020). "Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA". ACS Chemical Neuroscience. 11 (24): 4434–4446. doi:10.1021/acschemneuro.0c00644. PMID 33253529. S2CID 227246346.
mdmb, binaca, mdmb, binaca, also, known, mdmb, butinaca, indazole, based, synthetic, cannabinoid, from, indazole, carboxamide, family, been, used, active, ingredient, synthetic, cannabis, products, sold, designer, drug, since, late, 2018, agonist, receptor, ec. 4F MDMB BINACA also known as 4F MDMB BUTINACA or 4F ADB is an indazole based synthetic cannabinoid from the indazole 3 carboxamide family 1 It has been used as an active ingredient in synthetic cannabis products and sold as a designer drug since late 2018 2 3 4F MDMB BINACA is an agonist of the CB1 receptor EC50 7 39 nM 4 though it is unclear whether it is selective for this target 5 In December 2019 the UNODC announced scheduling recommendations placing 4F MDMB BINACA into Schedule II throughout the world 6 4F MDMB BINACALegal statusLegal statusCA Schedule II DE Anlage II Authorized trade only not prescriptible UK Class B UN Psychotropic Schedule IIIdentifiersIUPAC name Methyl S 2 1 4 fluorobutyl 1H indazole 3 carboxamido 3 3 dimethylbutanoateCAS Number2390036 46 9PubChem CID145707216ChemSpider71117201UNIIZH38UTM145Chemical and physical dataFormulaC 19H 26F N 3O 3Molar mass363 433 g mol 13D model JSmol Interactive imageSMILES O C N C H C OC O C C C C C1 NN CCCCF C2 C1C CC C2InChI InChI 1S C19H26FN3O3 c1 19 2 3 16 18 25 26 4 21 17 24 15 13 9 5 6 10 14 13 23 22 15 12 8 7 11 20 h5 6 9 10 16H 7 8 11 12H2 1 4H3 H 21 24 t16 m1 s1Key GZGKSDAMWRWYOZ MRXNPFEDSA N Contents 1 Related compounds 2 Legal Status 3 United Kingdom 4 See also 5 ReferencesRelated compounds EditThe corresponding indole core analogue 4F MDMB BICA or 4F MDMB BUTICA has also been widely sold as a designer drug by chemical providers on the net first being identified in May 2020 7 4F MDMB BICALegal Status EditUnited Kingdom EditIt s illegal to sell distribute supply transport or trade the pharmaceutical drug under the Psychoactive Substances Act 2016 See also Edit5F MDMB PINACA 5F MDMB PICA 5F MMB PINACA 5F MPP PICA AB FUBINACAReferences Edit Krotulski AJ Mohr AL Kacinko SL Fogarty MF Shuda SA Diamond FX et al September 2019 4F MDMB BINACA A New Synthetic Cannabinoid Widely Implicated in Forensic Casework Journal of Forensic Sciences 64 5 1451 1461 doi 10 1111 1556 4029 14101 PMID 31260580 S2CID 195770459 Tokarczyk Bogdan Jurczyk Agnieszka Krupinska Justyna Adamowicz Piotr June 2022 Fatal intoxication with new synthetic cannabinoids 5F MDMB PICA and 4F MDMB BINACA parent compounds and metabolite identification in blood urine and cerebrospinal fluid Forensic Science Medicine and Pathology 18 4 393 402 doi 10 1007 s12024 022 00492 3 ISSN 1556 2891 PMC 9194349 PMID 35699867 Wagmann Lea Stiller Rebecca G Fischmann Svenja Westphal Folker Meyer Markus R July 2022 Going deeper into the toxicokinetics of synthetic cannabinoids in vitro contribution of human carboxylesterases Archives of Toxicology 96 10 2755 2766 doi 10 1007 s00204 022 03332 z ISSN 1432 0738 PMC 9352624 PMID 35788413 Cannaert A Sparkes E Pike E Luo JL Fang A Kevin RC Ellison R Gerona R Banister SD Stove CP December 2020 Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F MDMB BICA 5F MPP PICA MMB 4en PICA CUMYL CBMICA ADB BINACA APP BINACA 4F MDMB BINACA MDMB 4en PINACA A CHMINACA 5F AB P7AICA 5F MDMB P7AICA and 5F AP7AICA ACS Chemical Neuroscience 11 24 4434 4446 doi 10 1021 acschemneuro 0c00644 PMID 33253529 S2CID 227246346 4F MDMB BINACA 4F MDMB BUTINACA PDF December 2019 WHO World Health Organization recommends 12 NPS for scheduling Analytical data for 4F MDMB BICA Hungarian Institute for Forensic Sciences 28 05 2020 This cannabinoid related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 4F MDMB BINACA amp oldid 1125072345, wikipedia, wiki, book, books, library,
