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3F8

3F8 is a murine IgG3[1] monoclonal antibody which binds to GD2.[2]

3F8
Monoclonal antibody
Type?
SourceMouse
TargetGD2
Clinical data
Routes of
administration
intravenous
ATC code
  • none
Identifiers
CAS Number
  • 339169-93-6 Y
ChemSpider
  • none
UNII
  • 3GFS72WN4M
 NY (what is this?)  (verify)

It has been used in the detection and treatment of neuroblastoma.[3] For imaging neuroblastoma, it is labelled with one of the radioisotopes iodine-124 and iodine-131.[4][5]

See also edit

References edit

  1. ^ Kushner BH, Cheung NK (May 1989). "GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma". Blood. 73 (7): 1936–41. doi:10.1182/blood.V73.7.1936.1936. PMID 2653466.
  2. ^ "Sloan-Kettering - Neuroblastoma: 3F8 Monoclonal Antibody Therapy Q & A". Retrieved 2008-02-19.
  3. ^ Weinstein JL, Katzenstein HM, Cohn SL (1 June 2003). "Advances in the diagnosis and treatment of neuroblastoma". The Oncologist. 8 (3): 278–92. doi:10.1634/theoncologist.8-3-278. PMID 12773750. S2CID 20705441.
  4. ^ Yeh SD, Larson SM, Burch L, Kushner BH, Laquaglia M, Finn R, Cheung NK (May 1991). "Radioimmunodetection of neuroblastoma with iodine-131-3F8: correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities". Journal of Nuclear Medicine. 32 (5): 769–76. PMID 1902508.
  5. ^ Dauer LT, St Germain J, Williamson MJ, Zanzonico P, Modak S, Cheung NK, Divgi C (January 2007). "Whole-body clearance kinetics and external dosimetry of 131I-3F8 monoclonal antibody for radioimmunotherapy of neuroblastoma". Health Physics. 92 (1): 33–9. doi:10.1097/01.HP.0000231583.32904.6c. PMID 17164597. S2CID 25792466.

murine, igg3, monoclonal, antibody, which, binds, monoclonal, antibodytype, sourcemousetargetgd2clinical, dataroutes, ofadministrationintravenousatc, codenoneidentifierscas, number339169, ychemspidernoneunii3gfs72wn4m, what, this, verify, been, used, detection. 3F8 is a murine IgG3 1 monoclonal antibody which binds to GD2 2 3F8Monoclonal antibodyType SourceMouseTargetGD2Clinical dataRoutes ofadministrationintravenousATC codenoneIdentifiersCAS Number339169 93 6 YChemSpidernoneUNII3GFS72WN4M N Y what is this verify It has been used in the detection and treatment of neuroblastoma 3 For imaging neuroblastoma it is labelled with one of the radioisotopes iodine 124 and iodine 131 4 5 See also editMonoclonal antibody therapyReferences edit Kushner BH Cheung NK May 1989 GM CSF enhances 3F8 monoclonal antibody dependent cellular cytotoxicity against human melanoma and neuroblastoma Blood 73 7 1936 41 doi 10 1182 blood V73 7 1936 1936 PMID 2653466 Sloan Kettering Neuroblastoma 3F8 Monoclonal Antibody Therapy Q amp A Retrieved 2008 02 19 Weinstein JL Katzenstein HM Cohn SL 1 June 2003 Advances in the diagnosis and treatment of neuroblastoma The Oncologist 8 3 278 92 doi 10 1634 theoncologist 8 3 278 PMID 12773750 S2CID 20705441 Yeh SD Larson SM Burch L Kushner BH Laquaglia M Finn R Cheung NK May 1991 Radioimmunodetection of neuroblastoma with iodine 131 3F8 correlation with biopsy iodine 131 metaiodobenzylguanidine and standard diagnostic modalities Journal of Nuclear Medicine 32 5 769 76 PMID 1902508 Dauer LT St Germain J Williamson MJ Zanzonico P Modak S Cheung NK Divgi C January 2007 Whole body clearance kinetics and external dosimetry of 131I 3F8 monoclonal antibody for radioimmunotherapy of neuroblastoma Health Physics 92 1 33 9 doi 10 1097 01 HP 0000231583 32904 6c PMID 17164597 S2CID 25792466 nbsp This monoclonal antibody related article is a stub You can help Wikipedia by expanding it vte nbsp This antineoplastic or immunomodulatory drug article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 3F8 amp oldid 1169989523, wikipedia, wiki, book, books, library,

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