3′,5′-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name3′,5′-cyclic-AMP 5′-nucleotidohydrolase.[1][2][3][4][5][6] It catalyses the following reaction
^Alonso GD, Schoijet AC, Torres HN, Flawiá MM (January 2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Molecular and Biochemical Parasitology. 145 (1): 40–9. doi:10.1016/j.molbiopara.2005.09.005. hdl:11336/79656. PMID 16225937.
^Bader S, Kortholt A, Snippe H, Van Haastert PJ (July 2006). "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". The Journal of Biological Chemistry. 281 (29): 20018–26. doi:10.1074/jbc.M600040200. PMID 16644729.
^Rascón A, Soderling SH, Schaefer JB, Beavo JA (April 2002). "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proceedings of the National Academy of Sciences of the United States of America. 99 (7): 4714–9. Bibcode:2002PNAS...99.4714R. doi:10.1073/pnas.002031599. PMC123713. PMID 11930017.
^Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (March 2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiology. 6: 25. doi:10.1186/1471-2180-6-25. PMC1431542. PMID 16522215.
^Lugnier C, Keravis T, Le Bec A, Pauvert O, Proteau S, Rousseau E (November 1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochimica et Biophysica Acta (BBA) - General Subjects. 1472 (3): 431–446. doi:10.1016/S0304-4165(99)00145-2. PMID 10564757.
^Imamura R, Yamanaka K, Ogura T, Hiraga S, Fujita N, Ishihama A, Niki H (October 1996). "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". The Journal of Biological Chemistry. 271 (41): 25423–9. doi:10.1074/jbc.271.41.25423. PMID 8810311.
External linksedit
3',5'-cyclic-AMP+phosphodiesterase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
cyclic, phosphodiesterase, cyclic, phosphodiesterase, camp, specific, phosphodiesterase, camp, specific, pde1, pde2a, pde2b, pde4, pde7, pde8, pdeb1, pdeb2, enzyme, with, systematic, name, cyclic, nucleotidohydrolase, catalyses, following, reaction3, cyclic, p. 3 5 cyclic AMP phosphodiesterase EC 3 1 4 53 cAMP specific phosphodiesterase cAMP specific PDE PDE1 PDE2A PDE2B PDE4 PDE7 PDE8 PDEB1 PDEB2 is an enzyme with systematic name 3 5 cyclic AMP 5 nucleotidohydrolase 1 2 3 4 5 6 It catalyses the following reaction3 5 cyclic AMP phosphodiesteraseIdentifiersEC no 3 1 4 53DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumSearchPMCarticlesPubMedarticlesNCBIproteins adenosine 3 5 cyclic phosphate H2O displaystyle rightleftharpoons AMPThis enzyme requires Mg2 or Mn2 for activity References edit Alonso GD Schoijet AC Torres HN Flawia MM January 2006 TcPDE4 a novel membrane associated cAMP specific phosphodiesterase from Trypanosoma cruzi Molecular and Biochemical Parasitology 145 1 40 9 doi 10 1016 j molbiopara 2005 09 005 hdl 11336 79656 PMID 16225937 Bader S Kortholt A Snippe H Van Haastert PJ July 2006 DdPDE4 a novel cAMP specific phosphodiesterase at the surface of Dictyostelium cells The Journal of Biological Chemistry 281 29 20018 26 doi 10 1074 jbc M600040200 PMID 16644729 Rascon A Soderling SH Schaefer JB Beavo JA April 2002 Cloning and characterization of a cAMP specific phosphodiesterase TbPDE2B from Trypanosoma brucei Proceedings of the National Academy of Sciences of the United States of America 99 7 4714 9 Bibcode 2002PNAS 99 4714R doi 10 1073 pnas 002031599 PMC 123713 PMID 11930017 Johner A Kunz S Linder M Shakur Y Seebeck T March 2006 Cyclic nucleotide specific phosphodiesterases of Leishmania major BMC Microbiology 6 25 doi 10 1186 1471 2180 6 25 PMC 1431542 PMID 16522215 Lugnier C Keravis T Le Bec A Pauvert O Proteau S Rousseau E November 1999 Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei Biochimica et Biophysica Acta BBA General Subjects 1472 3 431 446 doi 10 1016 S0304 4165 99 00145 2 PMID 10564757 Imamura R Yamanaka K Ogura T Hiraga S Fujita N Ishihama A Niki H October 1996 Identification of the cpdA gene encoding cyclic 3 5 adenosine monophosphate phosphodiesterase in Escherichia coli The Journal of Biological Chemistry 271 41 25423 9 doi 10 1074 jbc 271 41 25423 PMID 8810311 External links edit3 5 cyclic AMP phosphodiesterase at the U S National Library of Medicine Medical Subject Headings MeSH Portal nbsp Biology Retrieved from https en wikipedia org w index php title 3 27 5 27 cyclic AMP phosphodiesterase amp oldid 1187270726, wikipedia, wiki, book, books, library,
