Wikipedia
2alpha-hydroxytaxane 2-O-benzoyltransferase
In enzymology, a 2alpha-hydroxytaxane 2-O-benzoyltransferase (EC 2.3.1.166) is an enzyme that catalyzes the chemical reaction
| 2-alpha-hydroxytaxane 2-O-benzoyltransferase | |
|---|---|
| Identifiers | |
| EC no. | 2.3.1.166 |
| CAS no. | 329318-50-5 |
| Databases | |
| IntEnz | IntEnz view |
| BRENDA | BRENDA entry |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
| PRIAM | profile |
| PDB structures | RCSB PDB PDBe PDBsum |
| Gene Ontology | AmiGO / QuickGO |
- benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III CoA + 10-deacetylbaccatin III
Thus, the two substrates of this enzyme are benzoyl-CoA and 10-deacetyl-2-debenzoylbaccatin III, whereas its two products are CoA and 10-deacetylbaccatin III.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase. This enzyme is also called benzoyl-CoA:taxane 2alpha-O-benzoyltransferase. This enzyme participates in diterpenoid biosynthesis.
References edit
- Walker K, Croteau R (2000). "Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13591–6. Bibcode:2000PNAS...9713591W. doi:10.1073/pnas.250491997. PMC 17620. PMID 11095755.