25TFM-NBOMe (also known as NBOMe-2C-TFM, 2C-TFM-NBOMe, and Cimbi-138) is a derivative of the phenethylaminehallucinogen2C-TFM, discovered in 2004 by Ralf Heim at the Free University of Berlin.[1] It acts as a potent partial agonist for the 5-HT2Areceptor, though its relative potency is disputed, with some studies finding it to be of lower potency than 25I-NBOMe,[2][3] while others show it to be of similar or higher potency,[4] possibly because of differences in the assay used.[5] 2C-TFM-NB2OMe can be taken to produce psychedelic effects similar to 2C-I-NB2OMe and 2C-D-NB2OMe.
^Heim R (2004). Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts [Synthesis and pharmacology of potent 5-HT2A receptor agonists with N-2-methoxybenzyl substructure. Development of a new structure-activity relationship] (PhD thesis) (in German).
^Silva M (2009). Theoretical study of the interaction of agonists with the 5-HT2A receptor (PhD thesis). Universität Regensburg.
^Silva ME, Heim R, Strasser A, Elz S, Dove S (January 2011). "Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor". Journal of Computer-Aided Molecular Design. 25 (1): 51–66. Bibcode:2011JCAMD..25...51S. CiteSeerX10.1.1.688.2670. doi:10.1007/s10822-010-9400-2. PMID 21088982. S2CID 3103050.
^Ettrup A, Hansen M, Santini MA, Paine J, Gillings N, Palner M, et al. (April 2011). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT (2A) agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging. 38 (4): 681–693. doi:10.1007/s00259-010-1686-8. PMID 21174090. S2CID 12467684.
^Hansen M (2010-12-16). Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain (Ph.D. thesis). University of Copenhagen. doi:10.13140/RG.2.2.33671.14245.
^"The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014". UK Statutory Instruments 2014 No. 1106. www.legislation.gov.uk.
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25tfm, nbome, also, known, nbome, nbome, cimbi, derivative, phenethylamine, hallucinogen, discovered, 2004, ralf, heim, free, university, berlin, acts, potent, partial, agonist, ht2a, receptor, though, relative, potency, disputed, with, some, studies, finding,. 25TFM NBOMe also known as NBOMe 2C TFM 2C TFM NBOMe and Cimbi 138 is a derivative of the phenethylamine hallucinogen 2C TFM discovered in 2004 by Ralf Heim at the Free University of Berlin 1 It acts as a potent partial agonist for the 5 HT2A receptor though its relative potency is disputed with some studies finding it to be of lower potency than 25I NBOMe 2 3 while others show it to be of similar or higher potency 4 possibly because of differences in the assay used 5 2C TFM NB2OMe can be taken to produce psychedelic effects similar to 2C I NB2OMe and 2C D NB2OMe 25TFM NBOMeIdentifiersIUPAC name 2 4 trifluoromethyl 2 5 dimethoxyphenyl N 2 methoxyphenyl methyl ethanamineCAS Number1027161 33 6 YPubChem CID10067667ChemSpider8243207 YUNIIX3V8LI2TUVCompTox Dashboard EPA DTXSID40435135Chemical and physical dataFormulaC 19H 22F 3N O 3Molar mass369 384 g mol 13D model JSmol Interactive imageSMILES FC F F c1c OC cc c OC c1 CCNCc2ccccc2OCInChI InChI 1S C19H22F3NO3 c1 24 16 7 5 4 6 14 16 12 23 9 8 13 10 18 26 3 15 19 20 21 22 11 17 13 25 2 h4 7 10 11 23H 8 9 12H2 1 3H3 YKey FBHVTQIAHOTPAM UHFFFAOYSA N Y N Y what is this verify Contents 1 Legality 1 1 United Kingdom 2 See also 3 ReferencesLegality editUnited Kingdom edit This substance is a Class A drug in the United Kingdom as a result of the N benzylphenethylamine catch all clause in the Misuse of Drugs Act 1971 6 See also editDOTFM TFMFly 2CBCB NBOMe NBOMe TCB 2 2CBFly NBOMe NBOMe 2CB Fly 25C NBOMe NBOMe 2CC 25B NBOMe NBOMe 2CB 25D NBOMe NBOMe 2CD 25I NBOMe NBOMe 2CI 25I NBMD NBMD 2CI 25B NBOH 25I NBOH NBOH 2CI 25I NBF NBF 2CI References edit Heim R 2004 Synthese und Pharmakologie potenter 5 HT2A Rezeptoragonisten mit N 2 Methoxybenzyl Partialstruktur Entwicklung eines neuen Struktur Wirkungskonzepts Synthesis and pharmacology of potent 5 HT2A receptor agonists with N 2 methoxybenzyl substructure Development of a new structure activity relationship PhD thesis in German Silva M 2009 Theoretical study of the interaction of agonists with the 5 HT2A receptor PhD thesis Universitat Regensburg Silva ME Heim R Strasser A Elz S Dove S January 2011 Theoretical studies on the interaction of partial agonists with the 5 HT2A receptor Journal of Computer Aided Molecular Design 25 1 51 66 Bibcode 2011JCAMD 25 51S CiteSeerX 10 1 1 688 2670 doi 10 1007 s10822 010 9400 2 PMID 21088982 S2CID 3103050 Ettrup A Hansen M Santini MA Paine J Gillings N Palner M et al April 2011 Radiosynthesis and in vivo evaluation of a series of substituted 11C phenethylamines as 5 HT 2A agonist PET tracers European Journal of Nuclear Medicine and Molecular Imaging 38 4 681 693 doi 10 1007 s00259 010 1686 8 PMID 21174090 S2CID 12467684 Hansen M 2010 12 16 Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain Ph D thesis University of Copenhagen doi 10 13140 RG 2 2 33671 14245 The Misuse of Drugs Act 1971 Ketamine etc Amendment Order 2014 UK Statutory Instruments 2014 No 1106 www legislation gov uk nbsp This hallucinogen related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 25TFM NBOMe amp oldid 1203383440, wikipedia, wiki, book, books, library,
