The 2023 Nobel Prize in Physiology or Medicine was awarded to Katalin Karikó (born 1955) and Drew Weissman (born 1959) "for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19".[2][3]
The 2023 Nobel Prize in Physiology or Medicine
Karikó (left) and Weissman (right) "for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19"
Katalin Karikó was born on January 17, 1955, in Szolnok, Hungary.[4] From the University of Szeged, she received a Ph.D. in biochemistry in 1982.[5] From 2013 to 2022, she was associated with BioNTech RNA Pharmaceuticals, first as a vice president and promoted to senior vice president in 2019. This company, a division of BioNTech, commercialized mRNA vaccines at a global scale.
Karikó, K., Buckstein, M., Ni, H. and Weissman, D.Suppression of RNA Recognition by Toll-like Receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23, 165–175 (2005).
Karikó, K., Muramatsu, H., Welsh, F.A., Ludwig, J., Kato, H., Akira, S. and Weissman, D.Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol Ther 16, 1833–1840 (2008).
Anderson, B.R., Muramatsu, H., Nallagatla, S.R., Bevilacqua, P.C., Sansing, L.H., Weissman, D. and Karikó, K.Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Res. 38, 5884–5892 (2010).
Referencesedit
^Burger, Ludwig; Pollard, Niklas (2 October 2023). "Nobel Prize for Medicine goes to Kariko and Weissman, pioneers of COVID vaccine". Reuters.com. from the original on 3 October 2023. Retrieved 3 Oct 2023.
^"The Nobel Prize in Physiology or Medicine 2023". NobelPrize.org. from the original on 2023-10-02. Retrieved 2023-10-03.
^Mueller, Benjamin; Kolata, Gina (2023-10-02). "Nobel Prize Awarded to Covid Vaccine Pioneers". The New York Times. ISSN 0362-4331. from the original on 2023-10-02. Retrieved 2023-10-03.
^Young, Lauren J. "Scientists behind mRNA COVID Vaccines Win 2023 Nobel Prize in Physiology or Medicine". Scientific American. from the original on 2023-10-02. Retrieved 2023-10-03.
^Hargittai, Istvan; Hargittai, Magdolna (25 May 2021). "Our science and the Covid-19 pandemic—Katalin Karikó's research idea and her perseverance". Structural Chemistry. 32 (4): 1353–1356. doi:10.1007/s11224-021-01797-9. PMC8143802. PMID 34054260.
^"Drew Weissman". nobelprize.org. October 2, 2023. from the original on October 2, 2023. Retrieved October 2, 2023.
^"Drew Weissman | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of Pennsylvania". www.med.upenn.edu. from the original on July 29, 2010. Retrieved January 8, 2021.
^"Drew Weissman, MD, PhD profile". www.pennmedicine.org. Retrieved January 8, 2021.
^"Drew Weissman, l'architecte des vaccins contre le Covid-19". LEFIGARO (in French). December 24, 2020. Retrieved January 8, 2021.
^Press release: The Nobel Prize in Physiology or Medicine 2023 2023-10-03 at the Wayback Machine nobelprize.org
External linksedit
Official website of the Nobel Foundation
April 12, 2024
2023, nobel, prize, physiology, medicine, awarded, katalin, karikó, born, 1955, drew, weissman, born, 1959, their, discoveries, concerning, nucleoside, base, modifications, that, enabled, development, effective, mrna, vaccines, against, covid, karikó, left, we. The 2023 Nobel Prize in Physiology or Medicine was awarded to Katalin Kariko born 1955 and Drew Weissman born 1959 for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID 19 2 3 The 2023 Nobel Prize in Physiology or MedicineKariko left and Weissman right for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID 19 Date2 October 2023 2023 10 02 LocationStockholmCountrySwedenPresented byNobel Assembly at Karolinska InstitutetHosted byThomas PerlmannReward s 11 million SEK 2023 1 First awarded1901Website2023 Nobel Prize in Physiology or Medicine 2022 Nobel Prize in Physiology or Medicine 2024 Contents 1 Laureates 1 1 Katalin Kariko 1 2 Drew Weissman 2 Key publications 3 References 4 External linksLaureates editKatalin Kariko edit Main article Katalin Kariko Katalin Kariko was born on January 17 1955 in Szolnok Hungary 4 From the University of Szeged she received a Ph D in biochemistry in 1982 5 From 2013 to 2022 she was associated with BioNTech RNA Pharmaceuticals first as a vice president and promoted to senior vice president in 2019 This company a division of BioNTech commercialized mRNA vaccines at a global scale Drew Weissman edit Main article Drew Weissman Drew Weissman was born on September 7 1959 in Lexington Massachusetts 6 and received a Ph D in 1987 at Boston University 7 He started studying RNA at the University of Pennsylvania in 1997 8 where he met Kariko 9 Key publications editThe following publications were the fundamental researches that motivated the Nobel Assembly at Karolinska Institutet to award the 2023 Prize to Kariko and Weissman 10 Kariko K Buckstein M Ni H and Weissman D Suppression of RNA Recognition by Toll like Receptors The impact of nucleoside modification and the evolutionary origin of RNA Immunity 23 165 175 2005 Kariko K Muramatsu H Welsh F A Ludwig J Kato H Akira S and Weissman D Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability Mol Ther 16 1833 1840 2008 Anderson B R Muramatsu H Nallagatla S R Bevilacqua P C Sansing L H Weissman D and Kariko K Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation Nucleic Acids Res 38 5884 5892 2010 References edit Burger Ludwig Pollard Niklas 2 October 2023 Nobel Prize for Medicine goes to Kariko and Weissman pioneers of COVID vaccine Reuters com Archived from the original on 3 October 2023 Retrieved 3 Oct 2023 The Nobel Prize in Physiology or Medicine 2023 NobelPrize org Archived from the original on 2023 10 02 Retrieved 2023 10 03 Mueller Benjamin Kolata Gina 2023 10 02 Nobel Prize Awarded to Covid Vaccine Pioneers The New York Times ISSN 0362 4331 Archived from the original on 2023 10 02 Retrieved 2023 10 03 Young Lauren J Scientists behind mRNA COVID Vaccines Win 2023 Nobel Prize in Physiology or Medicine Scientific American Archived from the original on 2023 10 02 Retrieved 2023 10 03 Hargittai Istvan Hargittai Magdolna 25 May 2021 Our science and the Covid 19 pandemic Katalin Kariko s research idea and her perseverance Structural Chemistry 32 4 1353 1356 doi 10 1007 s11224 021 01797 9 PMC 8143802 PMID 34054260 Drew Weissman nobelprize org October 2 2023 Archived from the original on October 2 2023 Retrieved October 2 2023 Drew Weissman Faculty About Us Perelman School of Medicine Perelman School of Medicine at the University of Pennsylvania www med upenn edu Archived from the original on July 29 2010 Retrieved January 8 2021 Drew Weissman MD PhD profile www pennmedicine org Retrieved January 8 2021 Drew Weissman l architecte des vaccins contre le Covid 19 LEFIGARO in French December 24 2020 Retrieved January 8 2021 Press release The Nobel Prize in Physiology or Medicine 2023 Archived 2023 10 03 at the Wayback Machine nobelprize orgExternal links editOfficial website of the Nobel Foundation Retrieved from https en wikipedia org w index php title 2023 Nobel Prize in Physiology or Medicine amp oldid 1208545231, wikipedia, wiki, book, books, library,
