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HSD17B2

December 15, 2023

17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in humans is encoded by the HSD17B2 gene.[5][6][7]

HSD17B2
Identifiers
AliasesHSD17B2, EDH17B2, HSD17, SDR9C2, hydroxysteroid (17-beta) dehydrogenase 2, hydroxysteroid 17-beta dehydrogenase 2
External IDsOMIM: 109685 MGI: 1096386 HomoloGene: 99709 GeneCards: HSD17B2
EC number1.1.1.239
Orthologs
SpeciesHumanMouse
Entrez

3294

15486

Ensembl

ENSG00000086696

ENSMUSG00000031844

UniProt

P37059

P51658

RefSeq (mRNA)

NM_002153

NM_008290

RefSeq (protein)

NP_002144

NP_032316

Location (UCSC)Chr 16: 82.04 – 82.1 MbChr 8: 118.43 – 118.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

17β-HSD2 is involved in inactivation of androgens and estrogens,[8] being accurately describable as "antiandrogenic" and "antiestrogenic",[9] and is the key 17β-HSD isozyme in androgen and estrogen inactivation.[8][additional citation(s) needed] Specific reactions catalyzed by 17β-HSD2 include estradiol to estrone, testosterone to androstenedione, and androstenediol to DHEA.[8][10] In addition to 17β-HSD activity, this enzyme also shows high 20α-hydroxysteroid dehydrogenase activity and can activate the weak progestogen 20α-hydroxyprogesterone into the potent progestogen progesterone.[8][10]

Expression edit

17β-HSD2 is widely expressed throughout the body including in the placenta, liver, intestines, endometrium, kidney, pancreas, breast, prostate, bone, and many other tissues.[11][12]

Clinical significance edit

Polymorphisms in HSD17B2 have been associated with breast cancer and prostate cancer.[13] 17β-HSD2 activity has also been associated with endometriosis and osteoporosis,[14] and inhibitors of the enzyme are of potential interest in the treatment of the latter condition.[15][16] Inactivating mutations resulting in a syndrome of congenital deficiency of 17β-HSD2 have not been reported to date.[17]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000086696 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031844 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Durocher F, Morissette J, Labrie Y, Labrie F, Simard J (Feb 1995). "Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2". Genomics. 25 (3): 724–6. doi:10.1016/0888-7543(95)80017-G. PMID 7759109.
  6. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Mar 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  7. ^ "Entrez Gene: HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2".
  8. ^ a b c d Moeller G, Adamski J (2006). "Multifunctionality of human 17beta-hydroxysteroid dehydrogenases". Mol. Cell. Endocrinol. 248 (1–2): 47–55. doi:10.1016/j.mce.2005.11.031. PMID 16413960. S2CID 54235551. 17β-HSD types 1–3, the key enzymes in homeostasis of steroid hormones (Andersson, 1995, Blomquist, 1995) seem to have their role solely in steroid metabolism catalysing reactions on steroid substrates only. [...] 17β-HSD2, an enzyme with broad tissue distribution (Casey et al., 1994), plays its major role in the inactivation of potent steroid hormones oxidising estradiol and testosterone to estrone and androstenedione, respectively (Wu et al., 1993). Beside this, 17β-oxidation of intermediates of steroid metabolism, e.g. 5α-androstane-3α,17β-diol, dihydrotestosterone and Δ5-androstene-3β,17β-diol is described (for review see Mindnich et al. (2004b). Additionally, human 17β-HSD type 2 has high 20α-HSD activity with progestins (Puranen et al., 1999).
  9. ^ Wang CT, Li CF, Wu WJ, Huang CN, Li CC, Li WM, Chan TC, Liang PI, Hsing CH, Liao KM (2016). "High Expression of 17β-hydroxysteroid Dehydrogenase Type 2 is Associated with a Better Prognosis in Urothelial Carcinoma of the Urinary Tract". Journal of Cancer. 7 (15): 2221–2230. doi:10.7150/jca.16777. PMC 5166531. PMID 27994658. HSD17B2 has both anti-estrogenic and anti-androgenic functions.
  10. ^ a b Mindnich R, Möller G, Adamski J (2004). "The role of 17 beta-hydroxysteroid dehydrogenases". Mol. Cell. Endocrinol. 218 (1–2): 7–20. doi:10.1016/j.mce.2003.12.006. PMID 15130507. S2CID 26877571.
  11. ^ Hilborn E, Stål O, Jansson A (May 2017). "Estrogen and androgen-converting enzymes 17β-hydroxysteroid dehydrogenase and their involvement in cancer: with a special focus on 17β-hydroxysteroid dehydrogenase type 1, 2, and breast cancer". Oncotarget. 8 (18): 30552–30562. doi:10.18632/oncotarget.15547. PMC 5444764. PMID 28430630.
  12. ^ Zhu Y, Imperato-McGinley JL (9 November 2016). "4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition". In Lightman S (ed.). Hormones, Brain and Behavior. Vol. 4: Clinical Important Effects of Hormones on Brain and Behavior. Elsevier Science. p. 69. ISBN 978-0-12-803608-2.
  13. ^ Moeller G, Adamski J (2009). "Integrated view on 17beta-hydroxysteroid dehydrogenases". Mol. Cell. Endocrinol. 301 (1–2): 7–19. doi:10.1016/j.mce.2008.10.040. PMID 19027824. S2CID 30321495.
  14. ^ Bulun SE, Cheng YH, Pavone ME, Yin P, Imir G, Utsunomiya H, Thung S, Xue Q, Marsh EE, Tokunaga H, Ishikawa H, Kurita T, Su EJ (2010). "17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis". Semin. Reprod. Med. 28 (1): 44–50. doi:10.1055/s-0029-1242992. PMC 4511594. PMID 20108182.
  15. ^ Marchais-Oberwinkler S, Henn C, Möller G, Klein T, Negri M, Oster A, Spadaro A, Werth R, Wetzel M, Xu K, Frotscher M, Hartmann RW, Adamski J (2011). "17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development". J. Steroid Biochem. Mol. Biol. 125 (1–2): 66–82. doi:10.1016/j.jsbmb.2010.12.013. PMID 21193039. S2CID 23767100.
  16. ^ Soubhye J, Alard IC, van Antwerpen P, Dufrasne F (2015). "Type 2 17-β hydroxysteroid dehydrogenase as a novel target for the treatment of osteoporosis". Future Med Chem. 7 (11): 1431–56. doi:10.4155/fmc.15.74. PMID 26230882.
  17. ^ J. Larry Jameson (13 July 1998). Principles of Molecular Medicine. Springer Science & Business Media. pp. 549–. ISBN 978-1-59259-726-0.

Further reading edit

  • Labrie Y, Durocher F, Lachance Y, Turgeon C, Simard J, Labrie C, Labrie F (Oct 1995). "The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species". DNA and Cell Biology. 14 (10): 849–61. doi:10.1089/dna.1995.14.849. PMID 7546291.
  • Andersson S, Geissler WM, Patel S, Wu L (Jun 1995). "The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases". The Journal of Steroid Biochemistry and Molecular Biology. 53 (1–6): 37–9. doi:10.1016/0960-0760(95)00039-3. PMID 7626483. S2CID 54417090.
  • Carsol JL, Martin PM, de Launoit Y (Oct 1994). "Characterization of 17 beta-hydroxysteroid dehydrogenase activity and mRNA abundance in human meningioma tumors". Neuroendocrinology. 60 (4): 445–51. doi:10.1159/000126779. PMID 7824086.
  • Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S (Jun 1993). "Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity". The Journal of Biological Chemistry. 268 (17): 12964–9. doi:10.1016/S0021-9258(18)31480-7. PMID 8099587.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Zhang Y, Word RA, Fesmire S, Carr BR, Rainey WE (Oct 1996). "Human ovarian expression of 17 beta-hydroxysteroid dehydrogenase types 1, 2, and 3". The Journal of Clinical Endocrinology and Metabolism. 81 (10): 3594–8. doi:10.1210/jcem.81.10.8855807. PMID 8855807.
  • Moghrabi N, Head JR, Andersson S (Nov 1997). "Cell type-specific expression of 17 beta-hydroxysteroid dehydrogenase type 2 in human placenta and fetal liver". The Journal of Clinical Endocrinology and Metabolism. 82 (11): 3872–8. doi:10.1210/jcem.82.11.4391. PMID 9360554.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Corbould AM, Judd SJ, Rodgers RJ (Jan 1998). "Expression of types 1, 2, and 3 17 beta-hydroxysteroid dehydrogenase in subcutaneous abdominal and intra-abdominal adipose tissue of women". The Journal of Clinical Endocrinology and Metabolism. 83 (1): 187–94. doi:10.1210/jcem.83.1.4495. PMID 9435439.
  • Dong Y, Qiu QQ, Debear J, Lathrop WF, Bertolini DR, Tamburini PP (Oct 1998). "17Beta-hydroxysteroid dehydrogenases in human bone cells". Journal of Bone and Mineral Research. 13 (10): 1539–46. doi:10.1359/jbmr.1998.13.10.1539. PMID 9783542. S2CID 85168465.
  • Kitawaki J, Koshiba H, Ishihara H, Kusuki I, Tsukamoto K, Honjo H (Sep 2000). "Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium". The Journal of Clinical Endocrinology and Metabolism. 85 (9): 3292–6. doi:10.1210/jcem.85.9.6829. PMID 10999824. S2CID 23016515.
  • Sano T, Hirasawa G, Takeyama J, Darnel AD, Suzuki T, Moriya T, Kato K, Sekine H, Ohara S, Shimosegawa T, Nakamura J, Yoshihama M, Harada N, Sasano H (Nov 2001). "17 beta-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract". Clinical Science. 101 (5): 485–91. doi:10.1042/CS20010052. PMID 11672453.
  • Lu ML, Huang YW, Lin SX (Jun 2002). "Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2". The Journal of Biological Chemistry. 277 (25): 22123–30. doi:10.1074/jbc.M111726200. PMID 11940569.
  • Provost PR, Blomquist CH, Drolet R, Flamand N, Tremblay Y (Aug 2002). "Androgen inactivation in human lung fibroblasts: variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen inactivation". The Journal of Clinical Endocrinology and Metabolism. 87 (8): 3883–92. doi:10.1210/jcem.87.8.8764. PMID 12161528.
  • Oliveira IO, Lhullier C, Brum IS, Spritzer PM (Sep 2003). "Gene expression of type 2 17 beta hydroxysteroid dehydrogenase in scalp hairs of hirsute women". Steroids. 68 (7–8): 641–9. doi:10.1016/S0039-128X(03)00093-X. PMID 12957669. S2CID 22194313.
  • Oduwole OO, Mäkinen JM, Isomaa VV, Karttunen TJ, Vihko PT (2004). "Sex steroid metabolism in human gastric mucosa: 17 beta-hydroxysteroid dehydrogenase type 2 in normal, inflamed and neoplastic gastric tissues". Anticancer Research. 23 (5A): 3889–97. PMID 14666693.
  • Matsuzaki S, Canis M, Pouly JL, Déchelotte PJ, Mage G (Feb 2006). "Analysis of aromatase and 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression in deep endometriosis and eutopic endometrium using laser capture microdissection". Fertility and Sterility. 85 (2): 308–13. doi:10.1016/j.fertnstert.2005.08.017. PMID 16595205.

December 15, 2023
hsd17b2, 17β, hydroxysteroid, dehydrogenase, 17β, hsd2, enzyme, 17β, hydroxysteroid, dehydrogenase, 17β, family, that, humans, encoded, gene, identifiersaliases, edh17b2, hsd17, sdr9c2, hydroxysteroid, beta, dehydrogenase, hydroxysteroid, beta, dehydrogenase, . 17b Hydroxysteroid dehydrogenase 2 17b HSD2 is an enzyme of the 17b hydroxysteroid dehydrogenase 17b HSD family that in humans is encoded by the HSD17B2 gene 5 6 7 HSD17B2IdentifiersAliasesHSD17B2 EDH17B2 HSD17 SDR9C2 hydroxysteroid 17 beta dehydrogenase 2 hydroxysteroid 17 beta dehydrogenase 2External IDsOMIM 109685 MGI 1096386 HomoloGene 99709 GeneCards HSD17B2EC number1 1 1 239Gene location Human Chr Chromosome 16 human 1 Band16q23 3Start82 035 004 bp 1 End82 098 534 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 E1Start118 428 643 bp 2 End118 485 766 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed injejunal mucosaduodenumright lobe of liverrectumplacentamucosa of urinary bladdergallbladderislet of Langerhansbody of pancreasminor salivary glandTop expressed inleft lobe of liverleft colonesophaguspyloric antrumyolk sacileumepithelium of stomachjejunumcorneal stromaduodenumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionoxidoreductase activity testosterone dehydrogenase NAD activity 17 alpha 20 alpha dihydroxypregn 4 en 3 one dehydrogenase activity estradiol 17 beta dehydrogenase activityCellular componentintegral component of membrane endoplasmic reticulum membrane membraneBiological processin utero embryonic development response to retinoic acid steroid biosynthetic process placenta development lipid metabolism estrogen biosynthetic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez329415486EnsemblENSG00000086696ENSMUSG00000031844UniProtP37059P51658RefSeq mRNA NM 002153NM 008290RefSeq protein NP 002144NP 032316Location UCSC Chr 16 82 04 82 1 MbChr 8 118 43 118 49 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Expression 3 Clinical significance 4 References 5 Further readingFunction edit17b HSD2 is involved in inactivation of androgens and estrogens 8 being accurately describable as antiandrogenic and antiestrogenic 9 and is the key 17b HSD isozyme in androgen and estrogen inactivation 8 additional citation s needed Specific reactions catalyzed by 17b HSD2 include estradiol to estrone testosterone to androstenedione and androstenediol to DHEA 8 10 In addition to 17b HSD activity this enzyme also shows high 20a hydroxysteroid dehydrogenase activity and can activate the weak progestogen 20a hydroxyprogesterone into the potent progestogen progesterone 8 10 Expression edit17b HSD2 is widely expressed throughout the body including in the placenta liver intestines endometrium kidney pancreas breast prostate bone and many other tissues 11 12 Clinical significance editPolymorphisms in HSD17B2 have been associated with breast cancer and prostate cancer 13 17b HSD2 activity has also been associated with endometriosis and osteoporosis 14 and inhibitors of the enzyme are of potential interest in the treatment of the latter condition 15 16 Inactivating mutations resulting in a syndrome of congenital deficiency of 17b HSD2 have not been reported to date 17 References edit a b c GRCh38 Ensembl release 89 ENSG00000086696 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000031844 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Durocher F Morissette J Labrie Y Labrie F Simard J Feb 1995 Mapping of the HSD17B2 gene encoding type II 17 beta hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24 1 q24 2 Genomics 25 3 724 6 doi 10 1016 0888 7543 95 80017 G PMID 7759109 Persson B Kallberg Y Bray JE Bruford E Dellaporta SL Favia AD Duarte RG Jornvall H Kavanagh KL Kedishvili N Kisiela M Maser E Mindnich R Orchard S Penning TM Thornton JM Adamski J Oppermann U Mar 2009 The SDR short chain dehydrogenase reductase and related enzymes nomenclature initiative Chemico Biological Interactions 178 1 3 94 8 doi 10 1016 j cbi 2008 10 040 PMC 2896744 PMID 19027726 Entrez Gene HSD17B2 hydroxysteroid 17 beta dehydrogenase 2 a b c d Moeller G Adamski J 2006 Multifunctionality of human 17beta hydroxysteroid dehydrogenases Mol Cell Endocrinol 248 1 2 47 55 doi 10 1016 j mce 2005 11 031 PMID 16413960 S2CID 54235551 17b HSD types 1 3 the key enzymes in homeostasis of steroid hormones Andersson 1995 Blomquist 1995 seem to have their role solely in steroid metabolism catalysing reactions on steroid substrates only 17b HSD2 an enzyme with broad tissue distribution Casey et al 1994 plays its major role in the inactivation of potent steroid hormones oxidising estradiol and testosterone to estrone and androstenedione respectively Wu et al 1993 Beside this 17b oxidation of intermediates of steroid metabolism e g 5a androstane 3a 17b diol dihydrotestosterone and D5 androstene 3b 17b diol is described for review see Mindnich et al 2004b Additionally human 17b HSD type 2 has high 20a HSD activity with progestins Puranen et al 1999 Wang CT Li CF Wu WJ Huang CN Li CC Li WM Chan TC Liang PI Hsing CH Liao KM 2016 High Expression of 17b hydroxysteroid Dehydrogenase Type 2 is Associated with a Better Prognosis in Urothelial Carcinoma of the Urinary Tract Journal of Cancer 7 15 2221 2230 doi 10 7150 jca 16777 PMC 5166531 PMID 27994658 HSD17B2 has both anti estrogenic and anti androgenic functions a b Mindnich R Moller G Adamski J 2004 The role of 17 beta hydroxysteroid dehydrogenases Mol Cell Endocrinol 218 1 2 7 20 doi 10 1016 j mce 2003 12 006 PMID 15130507 S2CID 26877571 Hilborn E Stal O Jansson A May 2017 Estrogen and androgen converting enzymes 17b hydroxysteroid dehydrogenase and their involvement in cancer with a special focus on 17b hydroxysteroid dehydrogenase type 1 2 and breast cancer Oncotarget 8 18 30552 30562 doi 10 18632 oncotarget 15547 PMC 5444764 PMID 28430630 Zhu Y Imperato McGinley JL 9 November 2016 4 02 Disorders of Sexual Development in Males Molecular Genetics Epigenetics Gender Identity and Cognition In Lightman S ed Hormones Brain and Behavior Vol 4 Clinical Important Effects of Hormones on Brain and Behavior Elsevier Science p 69 ISBN 978 0 12 803608 2 Moeller G Adamski J 2009 Integrated view on 17beta hydroxysteroid dehydrogenases Mol Cell Endocrinol 301 1 2 7 19 doi 10 1016 j mce 2008 10 040 PMID 19027824 S2CID 30321495 Bulun SE Cheng YH Pavone ME Yin P Imir G Utsunomiya H Thung S Xue Q Marsh EE Tokunaga H Ishikawa H Kurita T Su EJ 2010 17Beta hydroxysteroid dehydrogenase 2 deficiency and progesterone resistance in endometriosis Semin Reprod Med 28 1 44 50 doi 10 1055 s 0029 1242992 PMC 4511594 PMID 20108182 Marchais Oberwinkler S Henn C Moller G Klein T Negri M Oster A Spadaro A Werth R Wetzel M Xu K Frotscher M Hartmann RW Adamski J 2011 17b Hydroxysteroid dehydrogenases 17b HSDs as therapeutic targets protein structures functions and recent progress in inhibitor development J Steroid Biochem Mol Biol 125 1 2 66 82 doi 10 1016 j jsbmb 2010 12 013 PMID 21193039 S2CID 23767100 Soubhye J Alard IC van Antwerpen P Dufrasne F 2015 Type 2 17 b hydroxysteroid dehydrogenase as a novel target for the treatment of osteoporosis Future Med Chem 7 11 1431 56 doi 10 4155 fmc 15 74 PMID 26230882 J Larry Jameson 13 July 1998 Principles of Molecular Medicine Springer Science amp Business Media pp 549 ISBN 978 1 59259 726 0 Further reading editLabrie Y Durocher F Lachance Y Turgeon C Simard J Labrie C Labrie F Oct 1995 The human type II 17 beta hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species DNA and Cell Biology 14 10 849 61 doi 10 1089 dna 1995 14 849 PMID 7546291 Andersson S Geissler WM Patel S Wu L Jun 1995 The molecular biology of androgenic 17 beta hydroxysteroid dehydrogenases The Journal of Steroid Biochemistry and Molecular Biology 53 1 6 37 9 doi 10 1016 0960 0760 95 00039 3 PMID 7626483 S2CID 54417090 Carsol JL Martin PM de Launoit Y Oct 1994 Characterization of 17 beta hydroxysteroid dehydrogenase activity and mRNA abundance in human meningioma tumors Neuroendocrinology 60 4 445 51 doi 10 1159 000126779 PMID 7824086 Wu L Einstein M Geissler WM Chan HK Elliston KO Andersson S Jun 1993 Expression cloning and characterization of human 17 beta hydroxysteroid dehydrogenase type 2 a microsomal enzyme possessing 20 alpha hydroxysteroid dehydrogenase activity The Journal of Biological Chemistry 268 17 12964 9 doi 10 1016 S0021 9258 18 31480 7 PMID 8099587 Maruyama K Sugano S Jan 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Zhang Y Word RA Fesmire S Carr BR Rainey WE Oct 1996 Human ovarian expression of 17 beta hydroxysteroid dehydrogenase types 1 2 and 3 The Journal of Clinical Endocrinology and Metabolism 81 10 3594 8 doi 10 1210 jcem 81 10 8855807 PMID 8855807 Moghrabi N Head JR Andersson S Nov 1997 Cell type specific expression of 17 beta hydroxysteroid dehydrogenase type 2 in human placenta and fetal liver The Journal of Clinical Endocrinology and Metabolism 82 11 3872 8 doi 10 1210 jcem 82 11 4391 PMID 9360554 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S Oct 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Corbould AM Judd SJ Rodgers RJ Jan 1998 Expression of types 1 2 and 3 17 beta hydroxysteroid dehydrogenase in subcutaneous abdominal and intra abdominal adipose tissue of women The Journal of Clinical Endocrinology and Metabolism 83 1 187 94 doi 10 1210 jcem 83 1 4495 PMID 9435439 Dong Y Qiu QQ Debear J Lathrop WF Bertolini DR Tamburini PP Oct 1998 17Beta hydroxysteroid dehydrogenases in human bone cells Journal of Bone and Mineral Research 13 10 1539 46 doi 10 1359 jbmr 1998 13 10 1539 PMID 9783542 S2CID 85168465 Kitawaki J Koshiba H Ishihara H Kusuki I Tsukamoto K Honjo H Sep 2000 Progesterone induction of 17beta hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen dependent benign diseases but not in normal endometrium The Journal of Clinical Endocrinology and Metabolism 85 9 3292 6 doi 10 1210 jcem 85 9 6829 PMID 10999824 S2CID 23016515 Sano T Hirasawa G Takeyama J Darnel AD Suzuki T Moriya T Kato K Sekine H Ohara S Shimosegawa T Nakamura J Yoshihama M Harada N Sasano H Nov 2001 17 beta Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract Clinical Science 101 5 485 91 doi 10 1042 CS20010052 PMID 11672453 Lu ML Huang YW Lin SX Jun 2002 Purification reconstitution and steady state kinetics of the trans membrane 17 beta hydroxysteroid dehydrogenase 2 The Journal of Biological Chemistry 277 25 22123 30 doi 10 1074 jbc M111726200 PMID 11940569 Provost PR Blomquist CH Drolet R Flamand N Tremblay Y Aug 2002 Androgen inactivation in human lung fibroblasts variations in levels of 17 beta hydroxysteroid dehydrogenase type 2 and 5 alpha reductase activity compatible with androgen inactivation The Journal of Clinical Endocrinology and Metabolism 87 8 3883 92 doi 10 1210 jcem 87 8 8764 PMID 12161528 Oliveira IO Lhullier C Brum IS Spritzer PM Sep 2003 Gene expression of type 2 17 beta hydroxysteroid dehydrogenase in scalp hairs of hirsute women Steroids 68 7 8 641 9 doi 10 1016 S0039 128X 03 00093 X PMID 12957669 S2CID 22194313 Oduwole OO Makinen JM Isomaa VV Karttunen TJ Vihko PT 2004 Sex steroid metabolism in human gastric mucosa 17 beta hydroxysteroid dehydrogenase type 2 in normal inflamed and neoplastic gastric tissues Anticancer Research 23 5A 3889 97 PMID 14666693 Matsuzaki S Canis M Pouly JL Dechelotte PJ Mage G Feb 2006 Analysis of aromatase and 17beta hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression in deep endometriosis and eutopic endometrium using laser capture microdissection Fertility and Sterility 85 2 308 13 doi 10 1016 j fertnstert 2005 08 017 PMID 16595205 Retrieved from https en wikipedia org w index php title HSD17B2 amp oldid 1170008861, wikipedia, wiki, book, books, library,

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