1-(2-Diphenyl)piperazine, also known as RA-7, is a drug which acts as a potent and selective antagonist at the 5HT7serotoninreceptor. It was discovered as an active metabolite of the synthetic 5-HT7 agonists LP-12 and LP-211, and unexpectedly turned out to be a potent antagonist with selectivity approaching that of the parent molecules, despite its much simpler structure.[1]
^Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R (August 2010). "LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor". Neuroscience Letters. 481 (1): 12–6. doi:10.1016/j.neulet.2010.06.036. PMC2910240. PMID 20600619.
January 01, 1970
diphenyl, piperazine, also, known, drug, which, acts, potent, selective, antagonist, 5ht7, serotonin, receptor, discovered, active, metabolite, synthetic, agonists, unexpectedly, turned, potent, antagonist, with, selectivity, approaching, that, parent, molecul. 1 2 Diphenyl piperazine also known as RA 7 is a drug which acts as a potent and selective antagonist at the 5HT7 serotonin receptor It was discovered as an active metabolite of the synthetic 5 HT7 agonists LP 12 and LP 211 and unexpectedly turned out to be a potent antagonist with selectivity approaching that of the parent molecules despite its much simpler structure 1 1 2 Diphenyl piperazineIdentifiersIUPAC name 1 2 diphenyl piperazineCAS Number180698 18 4 YPubChem CID2737389ChemSpider2019031 YUNIIT5S5265H6VChEMBLChEMBL494675 YChemical and physical dataFormulaC 16H 18N 2Molar mass238 334 g mol 13D model JSmol Interactive imageSMILES C3CNCCN3c1ccccc1 c2ccccc2InChI InChI 1S C16H18N2 c1 2 6 14 7 3 1 15 8 4 5 9 16 15 18 12 10 17 11 13 18 h1 9 17H 10 13H2 YKey RKRVRTJVCWZOQS UHFFFAOYSA N Y verify See also editBenzylpiperazine Naphthylpiperazine PhenylpiperazineReferences edit Hedlund PB Leopoldo M Caccia S Sarkisyan G Fracasso C Martelli G Lacivita E Berardi F Perrone R August 2010 LP 211 is a brain penetrant selective agonist for the serotonin 5 HT 7 receptor Neuroscience Letters 481 1 12 6 doi 10 1016 j neulet 2010 06 036 PMC 2910240 PMID 20600619 Retrieved from https en wikipedia org w index php title 1 2 Diphenyl piperazine amp oldid 1166939753, wikipedia, wiki, book, books, library,
