(R)-69 (3IQ) is a tetrahydropyridine derivative which acts as a 5-HT2A receptor agonist, with 4.6x selectivity over 5-HT2B and 49x selectivity over 5-HT2C. It has a 5-HT2A Ki of 680nM and an EC50 of 41nM. (R)-69 is a biased agonist selective for activation of the Gq coupled signalling pathway, with much weaker activation of the β-arrestin 2 coupled pathway. In animal studies it produces antidepressant-like activity but without producing the head-twitch response associated with psychedelic effects.[1]
tetrahydropyridine, derivative, which, acts, ht2a, receptor, agonist, with, selectivity, over, ht2b, selectivity, over, ht2c, ht2a, 680nm, ec50, 41nm, biased, agonist, selective, activation, coupled, signalling, pathway, with, much, weaker, activation, arresti. R 69 3IQ is a tetrahydropyridine derivative which acts as a 5 HT2A receptor agonist with 4 6x selectivity over 5 HT2B and 49x selectivity over 5 HT2C It has a 5 HT2A Ki of 680nM and an EC50 of 41nM R 69 is a biased agonist selective for activation of the Gq coupled signalling pathway with much weaker activation of the b arrestin 2 coupled pathway In animal studies it produces antidepressant like activity but without producing the head twitch response associated with psychedelic effects 1 R 69IdentifiersIUPAC name 3 5R 5 methyl 1 2 5 6 tetrahydropyridin 3 yl 1H pyrrolo 2 3 b pyridinePubChem CID164513426Chemical and physical dataFormulaC 13H 15N 3Molar mass213 284 g mol 13D model JSmol Interactive imageSMILES C C H 1C C CNC1 c1c NH c2ncccc12InChI InChI 1S C13H15N3 c1 9 5 10 7 14 6 9 12 8 16 13 11 12 3 2 4 15 13 h2 5 8 9 14H 6 7H2 1H3 H 15 16 t9 m1 s1Key HNDPIXZRQWKEFZ SECBINFHSA NSee also edit25N N1 Nap AAZ A 154 RU 24969 SN 22 VU6067416 Z3517967757References edit Kaplan AL Confair DN Kim K Barros Alvarez X Rodriguiz RM Yang Y et al September 2022 Bespoke library docking for 5 HT2A receptor agonists with antidepressant activity Nature 610 7932 582 591 Bibcode 2022Natur 610 582K doi 10 1038 s41586 022 05258 z PMC 9996387 PMID 36171289 S2CID 252598838 nbsp This drug article relating to the nervous system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title R 69 amp oldid 1202524938, wikipedia, wiki, book, books, library,
