1,3-Beta-glucan synthase is a glucosyltransferaseenzyme involved in the generation of beta-glucan in fungi. It serves as a pharmacological target for antifungal drugs such as caspofungin, anidulafungin, and micafungin, deemed 1,3-Beta-glucan synthase inhibitors. Under the CAZy classification system, fungi and plant members fall in the glycosyltransferase 48 family (GT48).[1] Some members of the glycosyltransferase 2 family (Pfam PF13632), such as the curdlan synthase CrdS (Q9X2V0), also has a similar activity.[2]
The family consists of various 1,3-beta-glucan synthase components including Gls1, Gls2, and Gls3 from yeast. 1,3-Beta-glucan synthase (EC 2.4.1.34.) also known as callose synthase catalyses the formation of a beta-1,3-glucan polymer that is a major component of the fungalcell wall.[3] The reaction catalysed is:
^Campbell JA, Davies GJ, Bulone V, Henrissat B (September 1997). "A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities". Biochem. J. 326 (3): 929–39. doi:10.1042/bj3260929u. PMC1218753. PMID 9334165.
^Karnezis T, Epa VC, Stone BA, Stanisich VA (2003). "Topological characterization of an inner membrane (1→3)-beta-D-glucan (curdlan) synthase from Agrobacterium sp. strain ATCC31749". Glycobiology. 13 (10): 693–706. doi:10.1093/glycob/cwg093. PMID 12851288.
^Mio T, Adachi-Shimizu M, Tachibana Y, Tabuchi H, Inoue SB, Yabe T, Yamada-Okabe T, Arisawa M, Watanabe T, Yamada-Okabe H (July 1997). "Cloning of the Candida albicans homolog of Saccharomyces cerevisiae GSC1/FKS1 and its involvement in beta-1,3-glucan synthesis". J. Bacteriol. 179 (13): 4096–105. doi:10.1128/jb.179.13.4096-4105.1997. PMC179227. PMID 9209021.
beta, glucan, synthase, glucosyltransferase, enzyme, involved, generation, beta, glucan, fungi, serves, pharmacological, target, antifungal, drugs, such, caspofungin, anidulafungin, micafungin, deemed, inhibitors, under, cazy, classification, system, fungi, pl. 1 3 Beta glucan synthase is a glucosyltransferase enzyme involved in the generation of beta glucan in fungi It serves as a pharmacological target for antifungal drugs such as caspofungin anidulafungin and micafungin deemed 1 3 Beta glucan synthase inhibitors Under the CAZy classification system fungi and plant members fall in the glycosyltransferase 48 family GT48 1 Some members of the glycosyltransferase 2 family Pfam PF13632 such as the curdlan synthase CrdS Q9X2V0 also has a similar activity 2 1 3 Beta glucan synthaseIdentifiersEC no 2 4 1 34CAS no 9037 30 3DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumSearchPMCarticlesPubMedarticlesNCBIproteins Glycosyl transferase family 48 GT48 IdentifiersSymbolGlucan synthasePfamPF02364Pfam clanCL0111InterProIPR003440CAZyGT48Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary The biosynthesis of disaccharides oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules forming glycosidic bonds The family consists of various 1 3 beta glucan synthase components including Gls1 Gls2 and Gls3 from yeast 1 3 Beta glucan synthase EC 2 4 1 34 also known as callose synthase catalyses the formation of a beta 1 3 glucan polymer that is a major component of the fungal cell wall 3 The reaction catalysed is UDP glucose 1 3 beta D glucosyl N UDP 1 3 beta D glucosyl N 1 See also editEchinocandin glucanExternal links editEC 2 4 1 34 glucan synthase at the U S National Library of Medicine Medical Subject Headings MeSH CAZyReferences edit Campbell JA Davies GJ Bulone V Henrissat B September 1997 A classification of nucleotide diphospho sugar glycosyltransferases based on amino acid sequence similarities Biochem J 326 3 929 39 doi 10 1042 bj3260929u PMC 1218753 PMID 9334165 Karnezis T Epa VC Stone BA Stanisich VA 2003 Topological characterization of an inner membrane 1 3 beta D glucan curdlan synthase from Agrobacterium sp strain ATCC31749 Glycobiology 13 10 693 706 doi 10 1093 glycob cwg093 PMID 12851288 Mio T Adachi Shimizu M Tachibana Y Tabuchi H Inoue SB Yabe T Yamada Okabe T Arisawa M Watanabe T Yamada Okabe H July 1997 Cloning of the Candida albicans homolog of Saccharomyces cerevisiae GSC1 FKS1 and its involvement in beta 1 3 glucan synthesis J Bacteriol 179 13 4096 105 doi 10 1128 jb 179 13 4096 4105 1997 PMC 179227 PMID 9209021 Portal nbsp Biology This article incorporates text from the public domain Pfam and InterPro IPR003440 This EC 2 4 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 1 3 Beta glucan synthase amp oldid 1218604367, wikipedia, wiki, book, books, library,
