IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations of IGHV are associated with better responses to some treatments and with prolonged survival.[4]
^Walter MA, Dosch HM, Cox DW (Aug 1991). "A deletion map of the human immunoglobulin heavy chain variable region". J Exp Med. 174 (2): 335–49. doi:10.1084/jem.174.2.335. PMC2118905. PMID 1649888.
^Schroeder HW Jr; Walter MA; Hofker MH; Ebens A; Willems van Dijk K; Liao LC; Cox DW; Milner EC; Perlmutter RM (Dec 1988). "Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements". Proc Natl Acad Sci U S A. 85 (21): 8196–200. Bibcode:1988PNAS...85.8196S. doi:10.1073/pnas.85.21.8196. PMC282394. PMID 3141924.
^"Entrez Gene: IGHV@ immunoglobulin heavy variable group".
^Forconi F, Sozzi E, Cencini E, et al. (November 2009). "Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single agent cladribine and with more aggressive behavior". Blood. 114 (21): 4696–4702. doi:10.1182/blood-2009-03-212449. PMID 19667403.
Further readingedit
Matsuda F, Shin EK, Hirabayashi Y, et al. (1990). "Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments". EMBO J. 9 (8): 2501–6. doi:10.1002/j.1460-2075.1990.tb07429.x. PMC552279. PMID 2114977.
Cherif D, Berger R (1991). "New localizations of VH sequences by in situ hybridization with biotinylated probes". Genes Chromosomes Cancer. 2 (2): 103–8. doi:10.1002/gcc.2870020205. PMID 2126193. S2CID 22489747.
Toyonaga B, Yoshikai Y, Vadasz V, et al. (1986). "Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain". Proc. Natl. Acad. Sci. U.S.A. 82 (24): 8624–8. doi:10.1073/pnas.82.24.8624. PMC390970. PMID 3866244.
Matthyssens G, Rabbitts TH (1981). "Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region". Proc. Natl. Acad. Sci. U.S.A. 77 (11): 6561–5. doi:10.1073/pnas.77.11.6561. PMC350325. PMID 6450418.
Mariette X, Tsapis A, Brouet JC (1993). "Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein". Eur. J. Immunol. 23 (4): 846–51. doi:10.1002/eji.1830230412. PMID 7681398. S2CID 38756102.
Boursier L, Su W, Spencer J (2003). "Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments". Mol. Immunol. 39 (16): 1025–34. doi:10.1016/S0161-5890(03)00033-6. PMID 12749909.
Nakamura N, Nakamura S, Yamaguchi M, et al. (2005). "CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region". Int. J. Hematol. 81 (1): 58–61. doi:10.1532/IJH97.04119. PMID 15717690. S2CID 22639228.
Suárez E, Magadán S, Sanjuán I, et al. (2006). "Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice". Mol. Immunol. 43 (11): 1827–35. doi:10.1016/j.molimm.2005.10.015. PMID 16343622.
Balogh Z, Reiniger L, Deák L, et al. (2007). "IgVH gene mutation status and genomic imbalances in chronic lymphocytic leukaemia with increased prolymphocytes (CLL/PL)". Hematological Oncology. 25 (2): 90–5. doi:10.1002/hon.812. PMID 17410523. S2CID 19587621.
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ighv, heavy, chain, region, vh26, protein, that, humans, encoded, gene, identifiersaliasesexternal, idsgenecards, orthologsspecieshumanmouseentrezn, aensembln, auniprotnan, arefseq, mrna, arefseq, protein, alocation, ucsc, apubmed, searchn, awikidataview, edit. Ig heavy chain V III region VH26 is a protein that in humans is encoded by the IGHV gene 1 2 3 IGHV IdentifiersAliasesExternal IDsGeneCards 1 OrthologsSpeciesHumanMouseEntrezn an aEnsembln an aUniProtnan aRefSeq mRNA n an aRefSeq protein n an aLocation UCSC n an aPubMed searchn an aWikidataView Edit HumanIGHV is the immunoglobulin heavy chain variable region genes in B cell neoplasms like chronic lymphocytic leukemia mutations of IGHV are associated with better responses to some treatments and with prolonged survival 4 See also editIGH References edit Walter MA Dosch HM Cox DW Aug 1991 A deletion map of the human immunoglobulin heavy chain variable region J Exp Med 174 2 335 49 doi 10 1084 jem 174 2 335 PMC 2118905 PMID 1649888 Schroeder HW Jr Walter MA Hofker MH Ebens A Willems van Dijk K Liao LC Cox DW Milner EC Perlmutter RM Dec 1988 Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements Proc Natl Acad Sci U S A 85 21 8196 200 Bibcode 1988PNAS 85 8196S doi 10 1073 pnas 85 21 8196 PMC 282394 PMID 3141924 Entrez Gene IGHV immunoglobulin heavy variable group Forconi F Sozzi E Cencini E et al November 2009 Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single agent cladribine and with more aggressive behavior Blood 114 21 4696 4702 doi 10 1182 blood 2009 03 212449 PMID 19667403 Further reading editMatsuda F Shin EK Hirabayashi Y et al 1990 Organization of variable region segments of the human immunoglobulin heavy chain duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments EMBO J 9 8 2501 6 doi 10 1002 j 1460 2075 1990 tb07429 x PMC 552279 PMID 2114977 Cherif D Berger R 1991 New localizations of VH sequences by in situ hybridization with biotinylated probes Genes Chromosomes Cancer 2 2 103 8 doi 10 1002 gcc 2870020205 PMID 2126193 S2CID 22489747 Toyonaga B Yoshikai Y Vadasz V et al 1986 Organization and sequences of the diversity joining and constant region genes of the human T cell receptor beta chain Proc Natl Acad Sci U S A 82 24 8624 8 doi 10 1073 pnas 82 24 8624 PMC 390970 PMID 3866244 Matthyssens G Rabbitts TH 1981 Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region Proc Natl Acad Sci U S A 77 11 6561 5 doi 10 1073 pnas 77 11 6561 PMC 350325 PMID 6450418 Mariette X Tsapis A Brouet JC 1993 Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin associated glycoprotein Eur J Immunol 23 4 846 51 doi 10 1002 eji 1830230412 PMID 7681398 S2CID 38756102 Boursier L Su W Spencer J 2003 Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments Mol Immunol 39 16 1025 34 doi 10 1016 S0161 5890 03 00033 6 PMID 12749909 Nakamura N Nakamura S Yamaguchi M et al 2005 CD5 diffuse large B cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region Int J Hematol 81 1 58 61 doi 10 1532 IJH97 04119 PMID 15717690 S2CID 22639228 Suarez E Magadan S Sanjuan I et al 2006 Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice Mol Immunol 43 11 1827 35 doi 10 1016 j molimm 2005 10 015 PMID 16343622 Balogh Z Reiniger L Deak L et al 2007 IgVH gene mutation status and genomic imbalances in chronic lymphocytic leukaemia with increased prolymphocytes CLL PL Hematological Oncology 25 2 90 5 doi 10 1002 hon 812 PMID 17410523 S2CID 19587621 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title IGHV amp oldid 1079523568, wikipedia, wiki, book, books, library,
