The protein encoded by this gene is a member of the TGF-β superfamily. It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in the hippocampus of murineembryos.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.[5]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000116985 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ozkaynak E, Schnegelsberg PN, Jin DF, Clifford GM, Warren FD, Drier EA, Oppermann H (Jan 1993). "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis". J Biol Chem. 267 (35): 25220–7. doi:10.1016/S0021-9258(19)74028-9. PMID 1460021.
^DiLeone RJ, King JA, Storm EE, Copeland NG, Jenkins NA, Kingsley DM (Jun 1997). "The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4". Genomics. 40 (1): 196–8. doi:10.1006/geno.1996.4533. PMID 9070944.
^ ab"Entrez Gene: BMP8B bone morphogenetic protein 8b (osteogenic protein 2)".
Further readingedit
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Wen XZ, Akiyama Y, Baylin SB, Yuasa Y (2006). "Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas". Oncogene. 25 (18): 2666–73. doi:10.1038/sj.onc.1209297. PMID 16314833.
Saito T, Ji G, Shinzawa H, et al. (2004). "Genetic variations in humans associated with differences in the course of hepatitis C". Biochem. Biophys. Res. Commun. 317 (2): 335–41. doi:10.1016/j.bbrc.2004.03.056. PMID 15063762.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ying Y, Qi X, Zhao GQ (2001). "Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways". Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7858–62. Bibcode:2001PNAS...98.7858Y. doi:10.1073/pnas.151242798. PMC35432. PMID 11427739.
Ying Y, Liu XM, Marble A, et al. (2000). "Requirement of Bmp8b for the generation of primordial germ cells in the mouse". Mol. Endocrinol. 14 (7): 1053–63. doi:10.1210/mend.14.7.0479. PMID 10894154.
Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
External linksedit
Human BMP8B genome location and BMP8B gene details page in the UCSC Genome Browser.
bone, morphogenetic, protein, protein, that, humans, encoded, bmp8b, gene, bmp8bidentifiersaliasesbmp8b, bmp8, bone, morphogenetic, protein, 8bexternal, idsomim, 602284, homologene, 74865, genecards, bmp8bgene, location, human, chromosome, human, band1p34, 2st. Bone morphogenetic protein 8B is a protein that in humans is encoded by the BMP8B gene 3 4 5 BMP8BIdentifiersAliasesBMP8B BMP8 OP2 bone morphogenetic protein 8bExternal IDsOMIM 602284 HomoloGene 74865 GeneCards BMP8BGene location Human Chr Chromosome 1 human 1 Band1p34 2Start39 757 182 bp 1 End39 788 865 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed intibiaspinal gangliatrigeminal ganglionjejunal mucosatibial nerveretinal pigment epitheliumsural nervespongy boneduodenumspermn aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransforming growth factor beta receptor binding cytokine activity BMP receptor binding growth factor activityCellular componentextracellular region extracellular spaceBiological processregulation of apoptotic process multicellular organism development skeletal system development positive regulation of pathway restricted SMAD protein phosphorylation cartilage development cell differentiation regulation of MAPK cascade SMAD protein signal transduction cell development BMP signaling pathway ossification regulation of signaling receptor activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez656n aEnsemblENSG00000116985n aUniProtP34820n aRefSeq mRNA NM 001720n aRefSeq protein NP 001711n aLocation UCSC Chr 1 39 76 39 79 Mbn aPubMed search 2 n aWikidataView Edit HumanThe protein encoded by this gene is a member of the TGF b superfamily It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development It has been shown to be expressed in the hippocampus of murine embryos The bone morphogenetic proteins BMPs are a family of secreted signaling molecules that can induce ectopic bone growth Many BMPs are part of the transforming growth factor beta TGFB superfamily BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site Based on its expression early in embryogenesis the BMP encoded by this gene has a proposed role in early development In addition the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000116985 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ozkaynak E Schnegelsberg PN Jin DF Clifford GM Warren FD Drier EA Oppermann H Jan 1993 Osteogenic protein 2 A new member of the transforming growth factor beta superfamily expressed early in embryogenesis J Biol Chem 267 35 25220 7 doi 10 1016 S0021 9258 19 74028 9 PMID 1460021 DiLeone RJ King JA Storm EE Copeland NG Jenkins NA Kingsley DM Jun 1997 The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4 Genomics 40 1 196 8 doi 10 1006 geno 1996 4533 PMID 9070944 a b Entrez Gene BMP8B bone morphogenetic protein 8b osteogenic protein 2 Further reading editGregory SG Barlow KF McLay KE et al 2006 The DNA sequence and biological annotation of human chromosome 1 Nature 441 7091 315 21 Bibcode 2006Natur 441 315G doi 10 1038 nature04727 PMID 16710414 Wen XZ Akiyama Y Baylin SB Yuasa Y 2006 Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas Oncogene 25 18 2666 73 doi 10 1038 sj onc 1209297 PMID 16314833 Saito T Ji G Shinzawa H et al 2004 Genetic variations in humans associated with differences in the course of hepatitis C Biochem Biophys Res Commun 317 2 335 41 doi 10 1016 j bbrc 2004 03 056 PMID 15063762 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ying Y Qi X Zhao GQ 2001 Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways Proc Natl Acad Sci U S A 98 14 7858 62 Bibcode 2001PNAS 98 7858Y doi 10 1073 pnas 151242798 PMC 35432 PMID 11427739 Ying Y Liu XM Marble A et al 2000 Requirement of Bmp8b for the generation of primordial germ cells in the mouse Mol Endocrinol 14 7 1053 63 doi 10 1210 mend 14 7 0479 PMID 10894154 Auffray C Behar G Bois F et al 1995 IMAGE molecular integration of the analysis of the human genome and its expression Comptes Rendus de l Academie des Sciences Serie III 318 2 263 72 PMID 7757816 External links editHuman BMP8B genome location and BMP8B gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Bone morphogenetic protein 8B amp oldid 1170010130, wikipedia, wiki, book, 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