Irwin Fridovich (August 2, 1929 – November 2, 2019)[1] was an American biochemist who, together with his graduate student Joe M. McCord, discovered the enzymatic activity of copper-zinc superoxide dismutase (SOD),[2][3]—to protect organisms from the toxic effects of superoxide free radicals formed as a byproduct of normal oxygen metabolism.[4] Subsequently, Fridovich's research group also discovered the manganese-containing[5] and the iron-containing[6] SODs from Escherichia coli and the mitochondrial MnSOD (SOD2),[7] now known to be an essential protein in mammals.[8] He spent the rest of his career studying the biochemical mechanisms of SOD and of biological superoxide toxicity, using bacteria as model systems.[9][10][11] Fridovich was also Professor Emeritus of Biochemistry at Duke University.
Ribbon drawing of the subunit 3D structure of Cu,Zn superoxide dismutase
Academic career
From 1951 to 1952, Fridovich served as a medical research associate at Cornell Medical College. He held junior teaching positions in biochemistry at Duke University 1956 to 1961 and was a visiting research associate at Harvard University from 1961 to 1962. He became an assistant professor in biochemistry at Duke University in 1961 and a full professor in 1971. He was appointed as James B. Duke Professor of Biochemistry in 1976 and held the position as professor emeritus since 1996 until his death.
Awards and honors
Fridovich received numerous awards and recognitions for his work, including membership in the National Academy of Sciences and the American Academy of Arts and Sciences, and the Elliott Cresson Medal of the Franklin Institute, Philadelphia. According to Google Scholar, he has over 51,000 citations in the scientific literature, including 7 papers with >1000 citations, and an h-index of 97.[12] His discovery of the superoxide dismutase reaction essentially started the field of oxygen free radicals in biology and medicine,[11][13] and that influence is shown by his election as president of the American Society of Biological Chemists (for 1982–83)[1], the Oxygen Society (1987–1990), and the Society for Free Radical Research (1992–94), as well as award of the Science & Humanity Prize at the 2000 Oxygen Club World Congress.
References
^"Duke Flags Lowered: Biochemist Irwin Fridovich Dies at Age 90".
^McCord JM, Fridovich I (1969). "Superoxide Dismutase, An Enzymic Function for Erythrocuprein (Hemocuprein)". Journal of Biological Chemistry. 244 (22): 6049–6055. doi:10.1016/S0021-9258(18)63504-5. PMID 5389100.
^Fridovich I (1998). "The trail to superoxide dismutase". Protein Science. 7 (12): 2688–2690. doi:10.1002/pro.5560071225. PMC2143889. PMID 9865966.
^Bannister WH, Bannister JV (1988). "Isolation and characterization of superoxide dismutase: a personal history and tribute to Joe McCord and Irwin Fridovich". Free Radical Biology and Medicine. 5 (5–6): 371–6. doi:10.1016/0891-5849(88)90110-4. PMID 2855737.
^BB Keele Jr; JM McCord; I Fridovich (1970). "Superoxide Dismutase from Escherichia coli B: A new manganese-containing enzyme". Journal of Biological Chemistry. 245 (22): 6176–6181. doi:10.1016/S0021-9258(18)62675-4. PMID 4921969.
^FJ Yost Jr; I Fridovich (1973). "An iron-containing superoxide dismutase from Escherichia coli". Journal of Biological Chemistry. 248 (14): 4905–4908. doi:10.1016/S0021-9258(19)43649-1. PMID 4352182.
^Weisiger RA, Fridovich I (1973). "Superoxide Dismutase: Organelle specificity". Journal of Biological Chemistry. 248 (10): 3582–3592. doi:10.1016/S0021-9258(19)43969-0. PMID 4702877.
^McCord JM, Fridovich I (1988). "Superoxide dismutase: the first twenty years (1968-1988)". Free Radical Biology and Medicine. 5 (5–6): 363–9. doi:10.1016/0891-5849(88)90109-8. PMID 2855736.
^Fridovich I (1978). "The biology of oxygen radicals". Science. 201 (4359): 875–880. Bibcode:1978Sci...201..875F. doi:10.1126/science.210504. PMID 210504.
^Fridovich I (1995). (PDF). Annual Review of Biochemistry. 64: 97–112. doi:10.1146/annurev.bi.64.070195.000525. PMID 7574505. S2CID 26834871. Archived from the original (PDF) on 2019-03-06.
^ abKresge N, Simoni RD, Hill RL (2006). "Forty Years of Superoxide Dismutase Research: the Work of Irwin Fridovich (JBC Classics: Enzymology)". The Journal of Biological Chemistry. 281 (22): e17. doi:10.1016/S0021-9258(20)56010-9. Retrieved July 3, 2011.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^"Irwin Fridovich". Google Scholar. Retrieved 3 July 2012.
^Imlay JA (2011). "Redox pioneer: professor Irwin Fridovich". Antioxidants & Redox Signaling. 14 (3): 335–40. doi:10.1089/ars.2010.3264. PMC3026652. PMID 20518701.
January 07, 2023
irwin, fridovich, august, 1929, november, 2019, american, biochemist, together, with, graduate, student, mccord, discovered, enzymatic, activity, copper, zinc, superoxide, dismutase, protect, organisms, from, toxic, effects, superoxide, free, radicals, formed,. Irwin Fridovich August 2 1929 November 2 2019 1 was an American biochemist who together with his graduate student Joe M McCord discovered the enzymatic activity of copper zinc superoxide dismutase SOD 2 3 to protect organisms from the toxic effects of superoxide free radicals formed as a byproduct of normal oxygen metabolism 4 Subsequently Fridovich s research group also discovered the manganese containing 5 and the iron containing 6 SODs from Escherichia coli and the mitochondrial MnSOD SOD2 7 now known to be an essential protein in mammals 8 He spent the rest of his career studying the biochemical mechanisms of SOD and of biological superoxide toxicity using bacteria as model systems 9 10 11 Fridovich was also Professor Emeritus of Biochemistry at Duke University Irwin FridovichBorn 1929 08 02 August 2 1929New York City New York U S DiedNovember 2 2019 2019 11 02 aged 90 Alma materCity College of New York BS 1951 Duke University PhD 1955 Known forSuperoxide dismutase oxygen free radicalsAwardsElliott Cresson Medal 1997 Scientific careerFieldsBiochemistryInstitutionsCornell Medical College Duke UniversityDoctoral advisorPhilip HandlerDoctoral studentsJoe M McCord Hara P MisraRibbon drawing of the subunit 3D structure of Cu Zn superoxide dismutaseAcademic career EditFrom 1951 to 1952 Fridovich served as a medical research associate at Cornell Medical College He held junior teaching positions in biochemistry at Duke University 1956 to 1961 and was a visiting research associate at Harvard University from 1961 to 1962 He became an assistant professor in biochemistry at Duke University in 1961 and a full professor in 1971 He was appointed as James B Duke Professor of Biochemistry in 1976 and held the position as professor emeritus since 1996 until his death Awards and honors EditFridovich received numerous awards and recognitions for his work including membership in the National Academy of Sciences and the American Academy of Arts and Sciences and the Elliott Cresson Medal of the Franklin Institute Philadelphia According to Google Scholar he has over 51 000 citations in the scientific literature including 7 papers with gt 1000 citations and an h index of 97 12 His discovery of the superoxide dismutase reaction essentially started the field of oxygen free radicals in biology and medicine 11 13 and that influence is shown by his election as president of the American Society of Biological Chemists for 1982 83 1 the Oxygen Society 1987 1990 and the Society for Free Radical Research 1992 94 as well as award of the Science amp Humanity Prize at the 2000 Oxygen Club World Congress References Edit Duke Flags Lowered Biochemist Irwin Fridovich Dies at Age 90 McCord JM Fridovich I 1969 Superoxide Dismutase An Enzymic Function for Erythrocuprein Hemocuprein Journal of Biological Chemistry 244 22 6049 6055 doi 10 1016 S0021 9258 18 63504 5 PMID 5389100 Fridovich I 1998 The trail to superoxide dismutase Protein Science 7 12 2688 2690 doi 10 1002 pro 5560071225 PMC 2143889 PMID 9865966 Bannister WH Bannister JV 1988 Isolation and characterization of superoxide dismutase a personal history and tribute to Joe McCord and Irwin Fridovich Free Radical Biology and Medicine 5 5 6 371 6 doi 10 1016 0891 5849 88 90110 4 PMID 2855737 BB Keele Jr JM McCord I Fridovich 1970 Superoxide Dismutase from Escherichia coli B A new manganese containing enzyme Journal of Biological Chemistry 245 22 6176 6181 doi 10 1016 S0021 9258 18 62675 4 PMID 4921969 FJ Yost Jr I Fridovich 1973 An iron containing superoxide dismutase from Escherichia coli Journal of Biological Chemistry 248 14 4905 4908 doi 10 1016 S0021 9258 19 43649 1 PMID 4352182 Weisiger RA Fridovich I 1973 Superoxide Dismutase Organelle specificity Journal of Biological Chemistry 248 10 3582 3592 doi 10 1016 S0021 9258 19 43969 0 PMID 4702877 McCord JM Fridovich I 1988 Superoxide dismutase the first twenty years 1968 1988 Free Radical Biology and Medicine 5 5 6 363 9 doi 10 1016 0891 5849 88 90109 8 PMID 2855736 Fridovich I 1978 The biology of oxygen radicals Science 201 4359 875 880 Bibcode 1978Sci 201 875F doi 10 1126 science 210504 PMID 210504 Fridovich I 1995 Superoxide radical and superoxide dismutases PDF Annual Review of Biochemistry 64 97 112 doi 10 1146 annurev bi 64 070195 000525 PMID 7574505 S2CID 26834871 Archived from the original PDF on 2019 03 06 a b Kresge N Simoni RD Hill RL 2006 Forty Years of Superoxide Dismutase Research the Work of Irwin Fridovich JBC Classics Enzymology The Journal of Biological Chemistry 281 22 e17 doi 10 1016 S0021 9258 20 56010 9 Retrieved July 3 2011 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Irwin Fridovich Google Scholar Retrieved 3 July 2012 Imlay JA 2011 Redox pioneer professor Irwin Fridovich Antioxidants amp Redox Signaling 14 3 335 40 doi 10 1089 ars 2010 3264 PMC 3026652 PMID 20518701 Retrieved from https en wikipedia org w index php title Irwin 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