Zinc transporter proteins (Zrt), or simply zinc transporters, are membrane transport proteins of the solute carrier family which control the membrane transport of zinc and regulate its intracellular and cytoplasmic concentrations.[1] They include two major groups: (1) the zinc transporter (ZnT) or solute carrier 30 (SLC30) family, which controls the efflux of zinc from the cytoplasm out of the cell and from the cytoplasm into vesicles; and (2) the zinc importer, Zrt- and Irt-like protein (ZIP), or solute carrier 39A (SLC39A) family, which controls the influx of zinc into the cytoplasm from outside the cell and from vesicles.[1]
ZntB Transporter Protein Structure: The left side of the image shows the full-length ZntB protein structure, without the presence of zinc. The right side shows the cytoplasmic domain of the protein and the apparent conformation change undergone by the protein to accommodate zinc transport. The conformation change is believed to be necessary for zinc ion transport. The chlorine ions (illustrated as the orange circles) support the conclusion that a change in the electrostatics and pH are necessary for transport.[3][4]
Bacterial members of the family are known to increase tolerance to high salt concentrations.
ZntB Zinc Transporter Proteinedit
Unlike some other zinc transporter proteins, the mechanism of how Zn2+ is transported via ZntB is not well understood. However, scientists have been able to speculate that the transport of Zn2+ is related to pH gradient and the electrostatics of the protein membrane.[3][4]
The structure of a bacterial ZIP protein has been resolved.[5]
Referencesedit
^ abHara T, Takeda TA, Takagishi T, Fukue K, Kambe T, Fukada T (March 2017). "Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis". The Journal of Physiological Sciences. 67 (2): 283–301. doi:10.1007/s12576-017-0521-4. PMC10717645. PMID 28130681.
^Thomas P, Converse A, Berg HA (February 2018). "ZIP9, a novel membrane androgen receptor and zinc transporter protein". General and Comparative Endocrinology. 257: 130–136. doi:10.1016/j.ygcen.2017.04.016. PMID 28479083.
^ abGati C, Stetsenko A, Slotboom DJ, Scheres SH, Guskov A (November 2017). "The structural basis of proton driven zinc transport by ZntB". Nature Communications. 8 (1): 1313. Bibcode:2017NatCo...8.1313G. doi:10.1038/s41467-017-01483-7. PMC5670123. PMID 29101379.
^ abTan K, Sather A, Robertson JL, Moy S, Roux B, Joachimiak A (October 2009). "Structure and electrostatic property of cytoplasmic domain of ZntB transporter". Protein Science. 18 (10): 2043–52. doi:10.1002/pro.215. PMC2786968. PMID 19653298.
^Zhang T, Liu J, Fellner M, Zhang C, Sui D, Hu J (August 2017). "Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway". Science Advances. 3 (8): e1700344. Bibcode:2017SciA....3E0344Z. doi:10.1126/sciadv.1700344. PMC5573306. PMID 28875161.
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zinc, transporter, protein, simply, zinc, transporters, membrane, transport, proteins, solute, carrier, family, which, control, membrane, transport, zinc, regulate, intracellular, cytoplasmic, concentrations, they, include, major, groups, zinc, transporter, so. Zinc transporter proteins Zrt or simply zinc transporters are membrane transport proteins of the solute carrier family which control the membrane transport of zinc and regulate its intracellular and cytoplasmic concentrations 1 They include two major groups 1 the zinc transporter ZnT or solute carrier 30 SLC30 family which controls the efflux of zinc from the cytoplasm out of the cell and from the cytoplasm into vesicles and 2 the zinc importer Zrt and Irt like protein ZIP or solute carrier 39A SLC39A family which controls the influx of zinc into the cytoplasm from outside the cell and from vesicles 1 At least one zinc transporter ZIP9 is also a G protein coupled receptor and membrane androgen receptor 2 Contents 1 Families 1 1 ZnT SLC30 1 1 1 ZntB Zinc Transporter Protein 1 2 ZIP SLC39 2 ReferencesFamilies editZnT SLC30 edit Cation efflux diffusion facilitator protein nbsp ZntB Transporter Protein Structure The left side of the image shows the full length ZntB protein structure without the presence of zinc The right side shows the cytoplasmic domain of the protein and the apparent conformation change undergone by the protein to accommodate zinc transport The conformation change is believed to be necessary for zinc ion transport The chlorine ions illustrated as the orange circles support the conclusion that a change in the electrostatics and pH are necessary for transport 3 4 IdentifiersSymbolCation effluxPfamPF01545InterProIPR002524Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary Members ZnT1 ZnT2 ZnT3 ZnT4 ZnT5 ZnT6 ZnT7 ZnT8 ZnT9 ZnT10Bacterial members of the family are known to increase tolerance to high salt concentrations ZntB Zinc Transporter Protein edit Unlike some other zinc transporter proteins the mechanism of how Zn2 is transported via ZntB is not well understood However scientists have been able to speculate that the transport of Zn2 is related to pH gradient and the electrostatics of the protein membrane 3 4 ZIP SLC39 edit Zinc iron permeaseIdentifiersSymbolZIPPfamPF02535InterProIPR003689Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary ZIP1 ZIP2 ZIP3 ZIP4 ZIP5 ZIP6 ZIP7 Catsup ZIP8 ZIP9 ZIP10 ZIP11 ZIP12 ZIP13 ZIP14The structure of a bacterial ZIP protein has been resolved 5 References edit a b Hara T Takeda TA Takagishi T Fukue K Kambe T Fukada T March 2017 Physiological roles of zinc transporters molecular and genetic importance in zinc homeostasis The Journal of Physiological Sciences 67 2 283 301 doi 10 1007 s12576 017 0521 4 PMC 10717645 PMID 28130681 Thomas P Converse A Berg HA February 2018 ZIP9 a novel membrane androgen receptor and zinc transporter protein General and Comparative Endocrinology 257 130 136 doi 10 1016 j ygcen 2017 04 016 PMID 28479083 a b Gati C Stetsenko A Slotboom DJ Scheres SH Guskov A November 2017 The structural basis of proton driven zinc transport by ZntB Nature Communications 8 1 1313 Bibcode 2017NatCo 8 1313G doi 10 1038 s41467 017 01483 7 PMC 5670123 PMID 29101379 a b Tan K Sather A Robertson JL Moy S Roux B Joachimiak A October 2009 Structure and electrostatic property of cytoplasmic domain of ZntB transporter Protein Science 18 10 2043 52 doi 10 1002 pro 215 PMC 2786968 PMID 19653298 Zhang T Liu J Fellner M Zhang C Sui D Hu J August 2017 Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway Science Advances 3 8 e1700344 Bibcode 2017SciA 3E0344Z doi 10 1126 sciadv 1700344 PMC 5573306 PMID 28875161 nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Zinc transporter protein amp oldid 1193822166, wikipedia, wiki, book, books, library,
